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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Special Exercises after Weight Loss and its Effect on Skin Wrinkles and Body Beauty Hussein Hassoun Abbas
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Many individuals, especially in these days, suffer from weight gain due to lack of movement and intake of food. They are not burned by exercise, which generates some wrinkles in the body. The researchers tried to find a suitable training program according to the characteristics of the research sample based on diversity. The use of exercises and the use of means and tools, as well as change the environment for the sample of the subjects in terms of practicing in the gym and then go to the swimming pool and then give special medical ointments, which helped the desire to perform exercises and create a spirit of competition and the goal of research to The preparation of special exercises and the use of swimming and medical ointments and health food systems for specific areas in the body to remove body wrinkles after weight loss and know the effect of special exercises to tighten the layers of skin and body beauty after weight loss.  The hypothesis was research, to special exercises and various means, such as swimming, the use of medical ointments and health food systems, has a positive effect on skin layers and body mass after weight loss. Different areas of the body were selected and the areas where the fat accumulation was increased after taking the opinions of experts and specialists.  The tests were carried out in the pretest and the training program was implemented and followed closely in the form of two groups take the usual training program and the other exercises were used to develop muscle strength and swimming and put ointments after and after the end of the application of the training program was conducted after the tests and after the results were calculated and analyzed and discussed the development of the members of the research sample through the loss of weights of their bodies as well as raising their physical capacity and development of the first experimental group that used the training program prepared by researchers and improve their body through a decrease physical wrinkles and then the researchers concluded that exercise contributes significantly to maintaining fitness and increase physical capacity.Keywords: Special exercises, Weight loss skin wrinkles and body beauty.
Relationship Plasma Concentration of Zonulin with Severity Level of Autism Based on Criteria of Diagnostic and Statistical Manual of Mental Disorders-5 (Dsm-5) Nanik Setijowati
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Background: This study was aimed to prove whether there is relationship between plasma concentration of zonulin and severity level of autism based on criteria of diagnostic and statistical manual of mental disorders-5 (DSM-5). In Indonesia, this kind of research has never been done, considering the incidence of autism is also increasing. Methods: The participants of this research were 38 autistic (level 1=17, level 2=12 and level 3= 9) and 35 control children. The blood plasma of all participants was taken to determine the plasma concentration of zonulin. The observation sheet was based on the DSM-5 as an instrument to determine the diagnosis of autistic children. Data were analyzed using Mann-Whitney and Anova test. Results: There was a significant difference plasma concentration of zonulin between autism and control (p = 0.002) with 32 ± 18 vs 47 ± 22.5, respectively. There was slightly different between plasma concentration of zonulin and severity level of autisme (p=0.239) with 32±19, 27±18, 40±15, respectively. Cut-off point 8 ng/mL (Sensitivity 97.4%, Spesificity 2.9%). Conclusion: This finding can be concluded that plasma concentrations  of zonulin were slightly related with severity, and the highest is at level 3.
Synthesis and Characterization of Graphene Oxide Nanosheets by Electrochemical Exfoliation Method and its Antibiofilm Activity against Pseudomonas aeruginosa Husam N. Abbas
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

In this work, the Graphene oxide (GO) nanosheets were synthesized by a electrochemical exfoliation method. The morphological, structure and optical properties were investigated by using Field emission scanning electron microscope (FE-SEM), X-ray diffraction (XRD), Raman spectroscopy, FTIR and UV-VIS spectroscopy. FE-SEM images of GO nanosheets confirmed the presence of layered structure. The crystalline size and number of layers of GO nanosheets were estimated by XRD analysis.  The UV-VIS spectrum of GO nanosheets shows maximum and shoulder absorption peaks. The oxidation of graphene was confirmed via FTIR analysis by the appearance of functional groups of oxygen. Raman analysis showed the formation of peaks D, G and 2D. The antibiofilm activity of different concentrations of GO nansheets against Pseudomonas aeruginosa (P. aeruginosa) as a model of more antibiotics resistant Gram-negative bacteria was investigated. These results confirm that the GO nanosheets material damages the biofilm of P. aeruginosa. Therefore, It can be considered as an anti-bacterial material.Keywords: Graphene Oxide, Nanosheet, Electrochemical Exfoliation, Antibiofilm, Pseudomonas aeruginosa.
Preparation, Spectral Investigation, Thermal Analysis, Biochemical Studying of New (Oxadiazole - Five Membered Ring)- Ligands Nagham Mahmood Aljamali
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

A series of oxadiazole- Azo ligands have been synthesized via  many  steps  sequence. Oxadiazole -azo  ligands   were prepared through   reacting  azo–oxadiazole  derivatives  with phenol  heterocyclic  derivatives  diazotized   then  coupled   via   coupling  reaction  followed  by  cyclization  reaction   to  yield   azo- heterocycles   derivatives   which  act   five  membered  ring. The structures of the newly  prepared    Ligands  were  identified   through  more  than   technique  like (1H NMR, IR and Mass spectra) ,(Thermal ,microbial  assay ) for  all  ligands.Keywords: Oxadiazole, Thiosemicarbazide, Thiadiazol, Cyclization, Azo,Imidazole, Oxazole, Thiazole.
Hepatitis B Virus Surface Antigen Subtype in Positive HBsAg Subjects in Mengwi District, Badung, Bali-Indonesia Made Agus Hendrayana
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Indonesia is a country with a high prevalence of hepatitis B virus infection and can develop into chronic hepatitis in the community. Indonesia is a multiethnic country with a vast territory, so it is estimated that the prevalence of each hepatitis B virus subtype varies greatly in different regions. Sequences in the S region gene encoding amino acids can show hepatitis b virus subtypes through exclusive variations in subtype determinants of HBsAg. This hepatitis B virus subtype is epidemiologically important, because it can show differences in geography and ethnicity in its spread. This study aims to analyze the hepatitis B virus subtype in HBsAg positive subjects in Mengwi, Badung, and Bali-Indonesia. The subjects of the study were 75 patients who came to the Mengwi I Badung Primary Health Center. All serum samples were examined for HBsAg by the ELISA method. In HBsAg positive serum samples, hepatitis B virus subtypes are determined. The DNA is extracted from serum samples that are HBsAg positive. Amplification of portions of DNA S gene from serum HBsAg positive was performed by polymerase chain reaction first-round and second-round. The nucleotide sequence of the hepatitis B virus is converted into amino acid sequences and multiple alignments are performed. The hepatitis B virus subtype was determined by amino acid substitution analysis at positions 122, 127, 134, 159, 160 and 177 in the S gene assisted by using a computer program. The subjects with HBsAg positive were obtained from 11 out of 75 samples (14.7%). The results of hepatitis B virus subtype analysis found that almost all samples, 10 of 11 samples (90.9%) had adw2 subtypes, while one sample (9.1%) had adrq + subtype.Keywords: HBsAg, Subtype, HBV, Mengwi.
The Effect of Dewandaru (Eugenia uniflora L.) Fruits Extracts on Testes Heat-induced Rats Ika Widi Astuti
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Background: Spermatogenesis can run optimally if the testes temperature is 2-8o C lower than body temperature. Higher testicular temperature causes oxidative stress, which results in infertility. The purple-red colour of Dewandaru (Eugenia uniflora L.) fruits have very high of flavonoid. The study aimed to examine the effect of Dewandaru (Eugenia uniflora L.) fruit extract on testis in heat-induced rats. Methods: The study was conducted at Integrated Biomedical Laboratory, Faculty of Medicine, Universitas Udayana between March until July 2019. This True experimental with randomised post-test only control group design consisted of a total of 24 rats. These were divided into four groups, with the group I and II was a negative and positive control. Group III and IV were treatment pre and post heat induction. Lipid peroxidation (MDA) level, Bcl-2, serum testosterone, and testis weight were measured. Data were presented as mean, and one-way ANOVA was used as a statistical tool with significant p<0.05. Result: Treatment with Dewandaru (Eugenia uniflora L.) fruit extract before and after heat induction, respectively showed a decrease significantly in the serum lipid peroxidase level, increase in the Bcl-2 expression, testosterone level, and testis weight. There is no significant difference between treatment pre and post heat induction. Conclusion: This study shows that Dewandaru (Eugenia uniflora L.) fruit extract altered the lipid peroxidase level, Bcl-2, testosterone level, and testis weight.Keywords: Bcl-2, Dewandaru fruits extract, Heat induction, MDA, Oxidative stress, Testosterone, Testis weight.
Correlation of IL-10 Gene Polymorphisms and Serum Level with Hepatitis C Virus Infection in Iraq Hassan M. Naif
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Hepatitis C virus (HCV) infection is a major health problem worldwide where130-150 million people are chronically infected with HCV, which progress to cirrhosis or hepatocellular carcinoma. A total of 120 subjects were recruited to assess the correlation between gene polymorphisms (IL-10-1082 and -819) with the susceptibility to HCV infection in Iraqi patients by using allele specific PCR. The serum level of IL-10 was assessed by ELISA. Gene polymorphism results of IL-10-1082A/G (rs1800896) showed significant increase in AA distribution (P=0.0076) and allele A frequency (P=0.049) among the control group while AG distribution were significantly higher in patients (P=0.0082). Although, G allele frequency had but an association (P=0.049), but the homozygous GG mutant genotype had no significant differences between the two groups. While the genotype analysis of the second SNPs of IL-10-819C/T (rs1800872) showed that neither CC nor CT genotypes distribution were associated with HCV infection (0.1627 and 0.2559, respectively) but the TT distribution and allele frequency had a suggestive association in patients (P=0.0483 and 0.0257, respectively). Results of IL-10 serum levels were higher by two-fold in patients than in healthy controls. It appeared that the IL-10-1082 AA genotype had a protective effect against HCV infection but the TT genotype of -819 mutations had a suggestive association with susceptibility to infection with HCV in Iraqi patients. Such correlation may indicate a protective role for IL-10 and could be used as a predictive risk susceptibility biomarker for progressive infection with HCV. Keywords: Hepatitis C virus, IL-10, Polymorphism, Cytokine, Iraq.
Validating and Validate the Persian Version of International Social Survey Programme Reihaneh Mahallati
Journal of Global Pharma Technology .
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Abstract

The aim of this study was to validate and validate the International Social Survey Program me (ISSP) single significant pride. National pride of economy, politics, art, history of a country known to play a role in the daily lives of individuals and determine their attitude Methods: The study population all male and female high school students in regions 1 and 2 in Yazd second academic year 2014-15 number was 14069. This study was a multi-stage random sampling method. The sample size of 525 patients was estimated by Cohen's table. However, after the removal of incomplete questionnaires and remove data threw a total of 474 participants entered the data were analyzed.This questionnaire measures at both national prides. The first, ISSP in the successes especially proud that the people in the 10 areas assessed The second part of the questionnaire, measures of general national pride and includes 5 components that evaluates the patriotism and sense of national superiority. The reliability of national pride in the success and national pride, especially from 0.72 to 0.81 0.33 to 0.70 along been public Results: Confirmatory factor analysis in this study showed that the test of ISSP in the population has two components Basic pride and pride is special. Public national from 0.33 to 0.70 has been along.Keywords: Validating, International social survey program me, Persian version.
Spectrophotometric Determination of Mercury (ІІ) With Michler’sthioketon Reagent Alaa Frak Hussain
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

A new simple, rapid and sensitive spectrophotometric method has been develop to determine mercury (ІІ) ions by using Michlerۥs thioketone reagent (Ligand) to formed a dark blue complex at ( pH=7), The complex was found to be with stability for(120 min)at the given pH , The complex formed in this method give obeys Beer’s law over the concentration  range (1.473x10-5 M–10.313x10-5M) with a detection limit of (5.235x10 -7 M)and molar absorptivity (0.339x104 L mol-1cm-1) ,The Stoichiometry of the complex was confirmed by using(Mole Ratio method &Molard method) the two methods using indicated the ratio of reagent to metal is 1:1,The effect of the presence of different cations and anions as interference in the determination of mercury (ІІ) under the given condition were investigated, The mercury complex formed has been characterize by UV- visible ray , Precision and accuracy of the new method has been study by terms of  Relative standard deviations  (RSD%), and analytical error.Keywords: Michler’sthioketon Reagent, Stoichometry, Absorptivity.
The Relationship between Chemotherapy and Level of IL-10 in Patients with Breast Cancer Hamid Naji Obied
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Background: Cancer is a group of diseases that cause cells in the body to change and grow out of control and most types of cancer cells eventually form a lump or mass called a tumor. Aim of this study; A descriptive study was conducting to determine the level of IL-10 and the lymphocytes as well as monocytes count in women with breast cancer, and to investigate the effect of chemotherapy on these two parameters. Methods: A non-probability (purposive sample) of (30) patients diagnosed previously with breast cancer were selected before (pre-chemotherapy) and after taking the first dose of chemotherapy, and 30 samples of healthy females as control group. Blood sampling were collecting and tested to estimate the level of IL-10(ELISA) and CBC to numerate the lymphocyte and monocyte.  The results of this study indicated that there was a significant increase in the level of IL-10in pre-chemotherapy patients group compared with control group, also there was elevated in lymphocytes count pre-chemotherapy group in comparisons with control group. Conclusion: In this study can conclude the amount of IL-10 and lymphocyte count in the women with breast cancer before chemotherapy were increased level than after chemotherapy.Keywords: Breast cancer, Chemotherapy, Lymphocyte, IL-10.

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