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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,438 Documents
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Preparation of a Novel Cartridge of SPE Column using a new Surface of Hetrocyclic Azo Ligand with Modified Activated Carbon Faiq F. Karam
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

Disposable cartridges have been created using low-cost activated carbon produced from waste as solid support via using a chemical activation method, and modified with the new tridentate [N.N.O] donor azo ligand to yield a solid-phase sorbent, the thiazole azo 2-[2ــ -( 5-nitro thiazolyl) azo]-4-methyl-5-nitro phenol ( 5-NTAMNP) derived from 2-amino-5-nitrothiazole and 3-methyl-4-nitrophenol by the diazotization operation and the adizonium chloride salt solution of 2-amino-5-nitrothiazole reacting with 3-methyl-4-nitrophenol as a coupling compound in alkaline alcoholic solution. The structure of ligand was identified and confirmed via resorting to various spectroscopic techniques which included, Proton nuclear magnetic resonance, Mass spectrum, UV–visible, Fourier-transform infrared (FTIR), X-Rays diffraction (XRD), the surface nature and morphology and size average and elemental composition of individual ligand particles were examined using a field emission scanning electron microscope (FE-SEM) coupled with an energy dispersive X-ray system (EDX), novel (5-NTAMNP)-modified activated carbon solid-phase sorbent were synthesized and characterized by chemical analysis by using, FT-IR, and XRD techniques and chelating sorbent were used as an adsorbent for the removal and for the determination of a hazardous heavy metallic ions Mn(II), Fe(III), Pb(II), Cu(II), in water under the optimum pH value for complexation with this azo ligand. The new (5-NTAMNP)-modified activated carbon showed highly effective solid phase extraction properties for these metallic ions.Keywords: Activated carbon, NNO donor azo ligand, Solid-phase extraction, Disposable cartridges, SPE.
Methyl Violet Dye as Corrosion Inhibitor for Carbon Steel in Acidic Medium" Hamida Edan Salman
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

The present work involves study the Methyl Violet dye as a corrosion inhibitor with concentrations rang (25- 200) ppm for their influence on carbon steel corrosion in 1M H2SO4 at temperature range (303-323) K utilize"potentiodynamic polarization technique."Corrosion rates, Corrosion potential, current corrosion, inhibition efficiency, cathodic and anodic Tafel islopes were found."The study also examined influence of concentration and temperature on inhibition efficiency the results manifest that the dye utilized could be good and active inhibitor for carbon steel. Thus, the dwindle in the rate of corrosion is due to the of forming of a protective strata formed on the surface electode that which adsorbed physically and chemically on the surface of carbon steel. Energy values of activation (Ea), enthalpy (ΔH*), energies of Gibbs (ΔG*), and activation entropy (ΔS*), alongside along"thermodynamic amounts of corrosion and adsorption provision indicating the dye effect as a good inhibitor. The isotherm langmuir paradigm be obvious shaped well to enhanced the adsorption operation on carbon steel surface in acidic solution. 
The Adsorptive Removal of Sulfadiazine Drug from Aqueous Solution Using Poly (Acryl Amide-co-Crotonic Acid) Hydro Gels Layth Sameer Jasim
Journal of Global Pharma Technology Volume 09 Issue 12
Publisher : Journal of Global Pharma Technology

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Abstract

The adsorption of Sulfadiazine drug from aqueous solution has been investigated using acryl amide-co-crotonic acid croos-linked as the adsorbents. Batch kinetics and thermodynamics studies were carried out to evaluate the effect of contact time, ionic strength, pH and temperature. The calculated data were in accordance with Freundlich equation and the adsorption isotherms are of S-curve type according to Giles classification. The results obtained show greater adsorption uptake of the Sulfadiazine than Sulfathiazole on the hydro gels. The adsorption phenomenon was examined as a function of temperature (15, 25, 30 and 35oC). The extents of adsorption of durg on the hydro gels were found to decrease with increasing temperature (exothermic process). The basic thermodynamic functions have also been calculated. Adsorption on hydro gels surfaces was examined as a function of ph. The adsorbed amount of drug on surface was increased as the pH decreased. The adsorption process is affected by the electrolyte concentration. The results indicated an increase adsorption of drug in the presence of sodium hydrochloride.Keywords: Adsorption, Hydro gels, Sulfadiazine, Isotherms, Thermodynamic.
A Security Conceptual On Android Platform for Mobile Health Applications Kanaan Jalal Brakas Kaky
Journal of Global Pharma Technology Volume 10 Issue 12.
Publisher : Journal of Global Pharma Technology

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Abstract

Mobile Health application are readily accessible to the average uses of mobile devices, and despite the potential of mHealth applications to enhance the availability, affordability and effectiveness of delivering healthcare services, that take care of touchy medical data, or as such, have also the strength to carry enormous gambles according to the safety and privacy concerning their users. Developers on applications are commonly unknown, yet users are ignorant over what their data are animal managed and used. The proliferation of mobile phones together with built-in sensors makes large-scale sensing viable at low cost. During cellular sensing, information hourly includes user-sensitive facts certain as much its real-time location. We analyzed 40 downloaded apps beyond the Google Play save and confirmed that of run-on in accordance with health reasons, the outcomes were 100% successful, certain namely blockading traffic, revealing touchy consumer information, and affecting the heartbeat. Toughness Based on the composition comment that advised the need because the supposed protection framework, three-distinct or according to phases are presented, each concerning which is described among a resolve section. First, discussed the layout system about the preceding segment according to increase a protection frame for m Health apps to ensure the safety or privateness concerning sensitive medical data. The 2nd section is mentioned whoever in accordance with acquiring the implementation concerning a prototypic proof-of-concept version over the framework. Finally, the third segment finish mentioned the comparison procedure of terms on usefulness then efficiency for the proposed framework.Keywords: Mobile Heath, Health Effects, Android Security
Synthesis, Characterization and Spectral Studies of Azo Dyes Ligands Complexes with Some Metal Ions and Their Industrial and Bacterial Application Wedian Mansor Obaid
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

1-[4-(4-Acetyl-2-hydroxy-phenylazo)-phenyl]-ethanone (HL1) and1-[3-Hydroxy-4(4-nitro-phenylazo)-phenyl]-ethanone (HL2) were produced by combination the diazonium salts of amines with 3-hydroxyacetophenone. (C.H.N) analyses, FT-IR, UV-Vis, 1H and 13CNMR spectral are use to identified for the ligands. Complexes for Zn+2,Cd+2 and Hg+2 were prepared as well specified through using atomic absorption of flame, analysis of elements, spectral methods also conductivity quantification. The nature of production complexes were studied continued mole ratio as well continued variance ways, Beer's law followed over condensation scope (1×10-4- 3×10-4)M. High molar absorption for compound solutions have been noticed. Analytical datum showed that in every the complexes offered 1:2 metal-ligand ratios. Depending physicochemical data a tetrahedral geometry were described of the metal chelates. Biological efficacy from compounds has been tested. Other than, dyeing completed of the produced compounds has been workable on fabric of cotton.Keywords: Complexes, azo dyes, microbial activity, dyeing.
In Silico Study of Anti-Inflammatory Potential of 1.8-Cineole against Cox-2 and TLR-2 Sianiwati Goenharto
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: To determine the anti-inflammatory activity of 1.8-cineole against COX-2 and TLR-2 using an in silico approach. Methods: In silico studies were conducted using the Molegro Virtual Docker (MolDoc) program to predict the anti-inflammatory potency of 1.8-cineole against COX-2 and TLR-2 receptors. Results: MolDoc score showed that 1,8-cineole (-49.1236) could be predicted to be an anti-inflammatory ligand demonstrating lower activity than diclofenac or COX-2 (-106.8010) ligand. 1,8-cineole (-42.7930) can also be predicted to be an anti-inflammatory ligand with lower activity than TLR-2 / CAS_673 ligand (-56.5640). Conclusion: 1.8-cineole possesses anti-inflammatory potential against COX-2 and TLR-2 receptors based on an in silico predictive study.
Assessment of Mothers' Knowledge upon their Children with Enzyme Deficiency (G6PD) in Pediatric Teaching Hospital at AL-Hilla City/Iraq Abdul Mahdi. A. Hasan
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Aims of the study to identify knowledge of mother's toward their children with G6pd. And to find out demographic characteristic of mother's children with G6pd like age level of education. Methodology: 1 .design of the study: descriptive study of mother and child. 2. Setting of the study: the study was carried out of maternal and child Babylon hospital.    3. Time of the study: the study period extended from 20 november2016 to 12 January 2017. Results: Glucose-6-phosphate dehydrogenase (G6PD) regulates production of the reduced form of Nicotinamide adenine dinucleotide phosphate   (NADPH) through the pentose phosphate pathway. G6PD may therefore affect superoxide anion production via vascular NADPH oxidase, which is key in mediating the vascular response to angiotensin II (Ang II). We determined the hypertensive and vascular hypertrophic response to Ang II in G6PD-deficient mice. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy and in Babylon Iraq, is a significant cause of infection- and drug-induced hemolysis and neonatal jaundice. Our goals were to determine the prevalence of G6PD deficiency among Babylon children of different ethnic backgrounds and to identify predictors of G6PD deficiency by analyzing vital signs and hematocrit and by asking screening questions about symptoms of hemolysis. We studied 200 children (100 males and 100 females) aged 1 month to 15 years. We found that the overall prevalence of G6PD deficiency was 15.3% (38.5% in males, 61.5% in females). Mean oxygen saturation, heart rate and hematocrit were not significantly different in G6PD deficient and G6PD sufficient children In conclusion; we determined the prevalence of G6PD deficiency in Nigerian sub-populations. The odds of G6PD deficiency were decreased in Igbo children compared to Yoruba children. There was no association between vital parameters or hematocrit and G6PD deficiency. We found that a history of scleral icterus may increase the odds of G6PD deficiency, but we did not exclude other common causes of icterus such as sickle cell disease or malarial infection. Recommendations Molecular screening for all deficient patient admitted to pediatric hospitals due to hemolytic crises.so establishing and conducting educational awareness programs for G6PD deficiency especially among mother's .and specific clinical follow up program for the deficient children and their families and establishing nationwide program of newborn screening for G6PD deficiency.Keywords: Mother, Knowledge, Effect, Glucose 6 phosphate deficiencies, School age.
CYTOTOXIC ACTIVITY OF SOURSOP (Annona muricata) LEAVES EXTRACTS AND THEIR PHYTOCHEMICAL CONTENTS Lili Indrawati
Journal of Global Pharma Technology Volume 09 Issue 02
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Abstract

Objective:Annona muricata (soursop) leaves belong to Annonaceae family, has been used as traditional medicine in Indonesia. Several plant  polyphenols, such as flavonoid quercetin and flavone (2-phenyl-4H-1-benzopyran-4-one) may  have chemoprevention  property  by reducing  the incidence of many types of cancer, especially in colon epithelia. This study aims to determine cytotoxic activity of the extracts and their total flavonoid content of the leaves extract. Methods: Extract used in flavonoid level determinaion are  standardized water extract (Zirzak Orac), ethanol-soluble fraction (ESFAM) and ethanol-insoluble fraction (EIFAM). The level of flavonoid content were determined by spectrophotometer UV-Vis with quercetin  and rutin as standard. Antiproliferative effect was evaluated against colorectal cancer cell line (DLD-1 and COLO 205), and normal cell (HEK) using microculture assay based on the metabolic reduction of 3- (4, 5-dimethylthiazol- 2-yl) -2,5-diphenyltetrazolium bromide (MTT). Results: Flavonoid concentrations of  Zirzak Orac, ESFAM, EIFAM are 0.15%, 0.83% and 0.07%, respectively. EIFAM shows the lowest IC50 value against DLD 1. The value of IC50 on the normal cells HEK is expected to be as  high as possible, EIFAM has the highest. Conclusion.EIFAM showed selective cytotoxic activities in vitro, while it contains the lowest concentration of flavonoid and annonacinKeywords - Annona muticata L., cytotoxicity, flavonoid
Differential Profile of Cytokine TNF-Α, MDA and SOD Level in Sepsis Induced By Cecal Ligation and Puncture Compared with Induced By LPS Dian Samudra
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Objective: The aim of this study is to analyse the differential of TNF-α cytokine profile, MDA, and SOD levels between sepsis-induced in mice by cecal ligation and puncture (CLP) which were then compared with lipopolysaccharide (LPS) injection. Methods: This study made use of experimental animals, 28 mice divided into 4 groups: control (healthy mice), mice model of sepsis due to cecal ligation and puncture (CLP), a group of mice modeled sepsis due to LPS i.p injection of 103 (LPS1) and LPS 105 CFU i.p injection dose (LPS2). Afterward, TNF-α levels were examined using a sandwich enzyme immunoassay technique and calculation of MDA and SOD levels in blood, liver, and kidneys. Results: The results showed that the level of TNF-α cytokines in mice model of sepsis with LPS induction of 105 CFU (LPS2) increased significantly (p <0.05) compared to the sepsis model with CLP (LPS2: 1.11 ng/ml vs 0.34 ng/ml). MDA levels in serums, livers, and kidneys of the experimental animals were also found to increase after LPS induction of 103 and 105 CFU doses. In contrast, SOD levels experienced a significant decrease due to LPS injection of dose 105 CFU in comparison with the CLP sepsis model. Conclusion: This study found that the best sepsis model was the one with LPS induction of 105 CFU doses which was characterized by a high production of TNFα cytokines, excessive MDA levels, and low levels of SOD antioxidant enzymes. By finding the best sepsis model, it can be used for therapeutic needs by targeting the inhibition of TNF-α proinflammatory cytokines and oxidative stress indicators MDA and SOD. Keywords: cecal ligation and puncture (CLP), LPS, MDA, sepsis, SOD, TNF-α
The Difference in Immunoglobulin M Anti-Phenolic Glycolipid-1 Antibody Levels in Leprosy Patient, Household Contacts, and Control Ramona Dumasari Lubis
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Background: Leprosy is a disease caused by M. leprae infection, may affect the peripheral nervous system, skin and other tissues. Until recently, leprosy is still a health problem in Indonesia. Phenolic Glycolipid-1 (PGL-1) is a stable and unique component of M. leprae, and an antibody examination against this antigen may play a role in assisting early detection of subclinical stage leprosy (SSL) and treatment monitoring. Objective: This study aims to define the level of IgM anti-PGL-1 antibody in leprosy patients, household contacts and controls and their serology status  Methods: The examination of IgM anti-PGL-1 antibody was carried out on 52 leprosy patients, 95 people household contacts and 95 healthy controls. The data from subjects were then analyzed and tested using Kruskal-Wallis statistical test and a p-value <0.001 was obtained. Results: It was obtained that the levels of IgM anti-PGL-1 antibody significantly differed between leprosy, household contact and control groups (p<0.05). Most of the leprosy patients had seropositive status, contrary to dominant seronegative that was found in household contacts and control groups. In subgroup analysis, the IgM titer level did not significantly differ between household contacts and control groups (p=0.122). Conclusion: the IgM anti-PGL-1 antibody differed between leprosy and household contacts and control. IgM antibody titer may also depict a person's exposure status to M. leprae bacilli.Keywords: M. leprae, Leprosy, IGM anti-PGL-1 antibody, Household contacts.

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