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INDONESIA
Indonesian Journal of Pharmacy and Natural Product
Published by Universitas Ngudi Waluyo
ISSN : 26563215     EISSN : 26156903     DOI : 10.35473
Core Subject : Health,
Medicine & Pharmacology
This journal is aimed as promoting principled approach to research on pharmacy that covers a broad range of topics engaging a good relationship in theoretical and practical. This journal covers: Pharmacology Pharmacognosy Analytical Chemistry Pharmaceutical Technology Social and Management Pharmacy
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 5 Documents
 1 
Search results for , issue "Vol. 2 No. 2 (2019)" : 5 Documents clear
Formulasi Spray Gel Ekstrak Etil Asetat Bunga Melati (Jasminum sambac (L.) Ait.) Sebagai Antijerawat Rima Hayati; Amelia Sari; Chairunnisa Chairunnisa
Indonesian Journal of Pharmacy and Natural Product Vol. 2 No. 2 (2019)
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.416 KB) | DOI: 10.35473/ijpnp.v2i2.256

Abstract

Bunga melati (Jasminum sambac (L.) Ait.) mengandung linalool, geraniol, eugeniol, eugenol yang dikenal dengan zat penolak serangga. Pada penelitian ini peneliti ingin memformulasikan ekstrak bunga melati menjadi sediaan spray gel yang berfungsi sebagai antijerawat. Dalam penelitian ini dibuat 3 kali pengulangan sediaan spray gel dengan konsentrasi ekstrak etil asetat bunga melati 10%. Eksipien yang digunakan dalam formulasi ini adalah karbopol, gliserin, NaOH, dinatrium EDTA dan NaCl. Spray gel ekstrak bunga melati yang dihasilkan berwarna kuning kecoklatan, berbentuk cair dan berbau khas bunga melati. Selain itu sediaan ini juga menunjukkan uji daya sebar 6 cm (P1), 5,5 cm (P2), 5,75 cm (P3). Uji kondisi semprotan ketiga batch baik, sifat ketahanan melekat. Waktu kering 3,01 menit (P1), 2,50 menit (P2), 2,46 menit (P3) dan memiliki pH 4,59 (P1), 4,58 (P2), 4,48 (P3). Ketiga pengulangan formula memenuhi persyaratan uji viskositas dan tidak mengiritasi.Kata Kunci : Spray gel, Bunga Melati, KarbopolJasmine (Jasminum sambac (L.) Ait.) contains linalool, geraniol, eugeniol, eugenol which are known as insect repellents. In this study, researchers wanted to formulate jasmine flower extract into spray gel preparations that function as anti-acne. In this study, 3 repetitions of spray gel preparations were made with 10% jasmine flower ethyl acetate extract concentration. The excipients used in this formulation were carbopol, glycerin, NaOH, disodium EDTA and NaCl. The resulting jasmine flower extract spray gel is brownish yellow, liquid and has the characteristic smell of jasmine. In addition, this preparation also showed a spread test of 6 cm (P1), 5.5 cm (P2), 5.75 cm (P3). Test the spray conditions of the three batches is good, inherent resistance properties. Dry time was 3,01 minutes (P1), 2,50 minutes (P2), 2,46 minutes (P3) and had a pH of 4,59 (P1), 4,58 (P2), 4,48 (P3). Three repetitions formulas meet the viscosity test requirements and do not irritate.Keywords: Spray gel, Jasmine, Karbopol
Kesesuaian Obat Hipoglikemik Oral pada Pasien Diabetes Mellitus Tipe 2 di Fasilitas Kesehatan Tingkat Pertama X di Surakarta Khotimatul Khusna; Rita Septiana
Indonesian Journal of Pharmacy and Natural Product Vol. 2 No. 2 (2019)
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (391.214 KB) | DOI: 10.35473/ijpnp.v2i2.261

Abstract

ABSTRAKDiabetes mellitus (DM) didefinisikan sebagai penyakit kronis yang disebabkan karena keturunan atau kurangnya produksi insulin oleh pankreas, atau tidak efektifnya insulin yang dihasilkan. Pelayanan obat untuk peserta Jaminan Kesehatan Nasional pada fasilitas kesehatan mengacu pada daftar obat yang tercantum dalam Formularium Nasional (Fornas). Selain itu, pelayanan kesehatan juga harus sesuai dengan algoritma terapi. Pemilihan obat hipoglikemik oral (OHO) yang tepat sangat menentukan keberhasilan terapi DM. Penelitian ini bertujuan untuk mengetahui gambaran kesesuaian penggunaan OHO berdasarkan Fornas dan algoritma terapi DM tipe 2 di Faskes Tingkat Pertama X di Surakarta. Penelitian ini termasuk jenis penelitian deskriptif. Pengambilan data dilakukan secara retrospektif dari catatan rekam medik pasien. Sampel dalam penelitian ini adalah OHO di Faskes Tingkat Pertama X di Surakarta pada periode Januari sampai Mei 2019. Hasil penelitian menunjukkan bahwa pasien yang mendapatkan OHO sesuai rekomendasi Fornas sebanyak 105 dan pasien yang mendapatkan OHO sesuai rekomendasi Algoritma Terapi DM sebanyak 75. Kesimpulan penelitian ini adalah 100% penggunaan OHO sesuai rekomendasi Fornas dan 71,43 % penggunaan OHO sesuai rekomendasi Algoritma Terapi DM.Kata kunci : Kesesuaian, Diabetes, Fornas, Algoritma terapiDiabetes mellitus (DM) is a chronic disease caused by heredity or when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. Medication services for National Health Insurance participants in health facilities refer to the list of drugs listed in the National Formulary. In addition, health services must also be in accordance with the therapy algorithm. The selection of the right oral hypoglycemic (OH) drug greatly determines the success of DM therapy. This study aimed to know the description of conformity of OH drug use based on the national formulary and type 2 diabetes mellitus therapy algorithm at primary health facility X in Surakarta. This research was a descriptive research with data collection in Retrospective from medical record patient. Sample in this research was OH drug in Primary Health Facilities X at Surakarta period January to May 2019. The results showed that patients who received OH drug according to Fornas recommendations were 105. Patients who received OH drug according to the recommendations of the DM Therapy Algorithm were 75. The conclusion of this study is 100% OH drug according to National recommendations and 71,43% OH drug according to DM Therapy Algorithm recommendations Keywords: Conformity, Diabetes, National Formulary, Therapy Algorithm
Penetapan Kadar Flavonoid Dan Uji Aktivitas Antibakteri Ekstrak Sereh (Cymbopogon nardus) Dan Temu Kunci (Boesnbergia pandurata Roxb) Terhadap Bakteri Streptococcus Mutans Anita Kumala Hati; Niken Dyahariesti; Richa Yuswantina
Indonesian Journal of Pharmacy and Natural Product Vol. 2 No. 2 (2019)
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (346.104 KB) | DOI: 10.35473/ijpnp.v2i2.264

Abstract

Indonesia is rich in medicinal plants, including those that have the ability to inhibit bacterial growth, lemongrass (Cymbopogon nardus) and Fingerroots (Boesenbergia pandurata). Streptococcus mutans is a bacterium that causes dental caries. This Experiment want to determine the content of chemical compounds and the antibacterial activity of Lemongrass extract (Cymbopogon nardus) and Fingerroots (Boesenbergia pandurata) against Streptococcus mutans. The study was conducted experimentally with samples of lemongrass and Fingerroots. Extraction using maceration method using 70% Ethanol solvent. Phytochemical screening test with color test and determination of total flavonoid levels using a spectrophotometer. Antibacterial activity test uses the disk diffusion method against Streptococcus mutans. Phytochemical screening results of lemongrass extract and fingerroots with color test qualitative test showed positive containing flavonoids, saponins and tannins. In the test determination of total flavonoid levels, showed an average total flavonoid levels in lemongrass extracts of 48.61 mgQE / g and in Fingerroots extracts of 24.71 mgQE / g. The results of the antibacterial test against Streptococcus mutans obtained the largest average diameter of inhibitory zone in the extract of Fingerroots 5% w / v (11.167 mm), then the concentration of 5% w / v combination of lemongrass: Fingerroots 1: 2 (10.83 mm ), 2: 1 combination (10,067 mm). lemongrass (9.33 mm), 1: 1 combination (9,133 mm), Based on the Post Hoc test results that were comparable to positive controls were 5% fingerrots, combination of lemongrass: 1: 2 Fingerroots, and 2: 1 combination. The average total flavonoid level in lemongrass extract is more than the average total flavonoid content in Fingerroots. But in the same concentration 5% Fingerroots extract provides the greatest antibacterial inhibitory activities.
Pengaruh Pemberian Informasi Obat Dengan Media Video Terhadap Kepatuhan Minum Obat Pasien Hipertensi Di Ungaran Dian Oktianti; Nova Hasani Furdiyanti; Sikni Retno Karminingtyas
Indonesian Journal of Pharmacy and Natural Product Vol. 2 No. 2 (2019)
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (422.642 KB) | DOI: 10.35473/ijpnp.v2i2.268

Abstract

Hipertensi merupakan salah satu penyakit kronis yang menjadi satu prioritas masalah  kesehatan  di  Indonesia  maupun  di  dunia. penyakit hipertensi dapat menyebabkan komplikasi seperti dapat menyebabkan oklusi arteri, cedera iskemik dan stroke sebagai komplikasi  jangka  panjang. Maka diperlukannya pemahaman oleh pasien tentang instruksi pengobatan dan peningkatan kepatuhan pasien melalui pemberian informasi obat dengan media video. Penelitian dilakukan secara prospektif dengan pretest-posttest design dan menggunakan rancangan cross sectional. Pengambilan sampel dilakukan secara purposive sampling dan didapatkan sampel sebanyak 40 orang. Data dianalisis menggunakan uji t-berpasangan. Hasil penelitian di Puskesmas Lerep menunjukkan kepatuhan sebelum intervensi kategori sedang 60%, kategori rendah 35% dan kategori tinggi 5%. Kepatuhan sesudah intervensi kategori sedang 20%, kategori rendah 0% dan kategori tinggi 80%. Nilai signifikansi uji t berpasangan yaitu 0,000 (<0,05). Hasil penelitian di Klinik Gracia kepatuhan pasien sebelum intervensi adalah rendah (20%), sedang (55%), dan tinggi (25%), setelah intervensi terjadi peningkatan kepatuhan yaitu rendah (5%), sedang (5%) dan tinggi (90%). Nilai signifikasi uji t-berpasangan dalam penelitian ini yaitu 0,000 < 0,05. Tingkat kepatuhan untuk uji pill count terdiri atas dua kategori yaitu patuh (kepatuhan≥80%) dan tidak patuh (kepatuhan<80%). Seluruh responden, baik pada Puskesmas Lerep maupun Klinik Gracia menunjukkan skor kepatuhan ≥80%, termasuk kategori patuh. Hasil penelitian menunjukan bahwa penyuluhan dengan media video dapat meningkatkan kepatuhan minum obat hipertensi di puskesmas Lerep dan Klinik Gracia.Kata Kunci : Hipertensi, Media Video, Kepatuhan Minum Obat, MMASHypertension is a chronic disease which is a priority health problem in Indonesia and in the world. Hypertension can cause complications such as can cause arterial occlusion, ischemic injury and stroke as long-term complications. Then there is a need to increase patient compliance by using video to provide drug information in order to increase patient’s understanding. The study was conducted prospectively with pretest-posttest design using cross sectional design. Forty sample was chosen by purposive sampling method. Data were analyzed using paired t-test. The results at Lerep Health Centre showed that the patient’s compliance before the intervention was categorized as moderate (60%), the low (35%) and high (5%). After the intervention, the moderate group was down to 20%, low was down to 0%, and the high group was increased to 80%. The significance value of paired t-test is 0,000 (<0.05). Research results at Gracia Clinic showed that patient’s compliance before intervention was low (20%), moderate (55%), and high (25%), and after intervention there was an increase in patient’s compliance that was low (5%), moderate (5%) and high (90 %). The significance value of paired t-test in this study is 0,000 <0.05. The level of adherence to the pill count test consists of two categories: adherence (80% adherence) and non-adherence (adherence <80%). All respondents, both at the Lerep Health Center and the Gracia Clinic showed a compliance score of ≥80%, including the compliance category. Counseling using video could improve compliance with taking hypertension medication at the Lerep health center and Gracia Clinic.Keywords: Hypertension, Video, Medication Compliance, MMAS
Analisis Keefektifan Biaya Pengobatan Pada Pasien Pneumonia Balita Di Instalasi Rawat Inap Rumah Sakit Paru Dr. Ario Wirawan Salatiga Tahun 2018 Nita Tanti Wulandari; Ening Listyanti; Niken Dyahariesti; Agitya Resti Erwiyani
Indonesian Journal of Pharmacy and Natural Product Vol. 2 No. 2 (2019)
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.716 KB) | DOI: 10.35473/ijpnp.v2i2.276

Abstract

Pneumonia adalah infeksi akut yang menyerang jaringan paru-paru yang disebabkan oleh bakteri, virus maupun jamur. Pengobatan pneumonia yang diterapi dengan antibiotik secara efektif dapat meningkatkan efek terapeutik klinis, meminimalkan toksisitas obat mengurangi angka kejadian resistensi dan lebih ekonomis. CEA merupakan suatu metode evaluasi ekonomi yang dapat digunakan dalam mengambil keputusan pemilihan alternatif terbaik pada pemilihan biaya pengobatan pneumonia. Penelitian ini bertujuan  untuk menganalisis keefektifan biaya pengobatan pada pasien pneumonia balita di rawat inap Rumah Sakit Paru dr. Ario Wirawan Salatiga   tahun 2018. Penelitian ini menggunakan merupakan penelitian non eksperimental (observasional) menggunakan pendekatan retrospektif dan dianalisis secara deskriptif. Sampel yang digunakan sebanyak 30 pasien. Sampel dianalisis sesuai dengan metode ACER dan ICER. Efektivitas terapi dilihat dari LOS. Nilai ACER: kelas VIP: Ceftriaxon + Cefixime Rp. 615.177, Cefotaxime + Gentamisin Rp.810.773.  Kelas I: Cefotaxime + Gentamisin Rp. 536.880. Kelas II: Cefotaxime Rp. 408.493, Cefotaxime + Cefixime Rp. 357.397, Cefotaxime + Gentamisin Rp. 385.488 dan Ceftriaxon + Cefixime  Rp. 325.355. Kelas III: Cefotaxime Rp. 278.740, Ceftriaxon Rp. 186.250, Cefotaxime + Gentamisin Rp. 312.734, Cefotaxime + Cefixime Rp.286.128 dan Ceftriaxon + Cefixime Rp.295.100. Nilai ICER pada kelas VIP : Ceftriaxon + Cefixime dan Cefotaxime + Gentamisin Rp. -356.967 dan pada kelas III adalah Ceftriaxon dan Cefotaxime Rp.-91.219. Pada pengobatan bronkopneumonia balita terapi antibiotik yang paling cost-effective di ruang kelas VIP adalah penggunaan antibiotik kombinasi Ceftriaxon + Cefixime, ruang kelas I adalah Cefotaxime + Gentamisin, ruang kelas II adalah Cefotaxime, dan ruang kelas III adalah Cefotaxime.Kata Kunci           : Analisis Keefektifan Biaya, Terapi Antibiotik, PneumoniaPneumonia is an acute infection that attacks lung tissue caused by bacteria, viruses and fungi. Treatment of pneumonia is effectively treated with antibiotics because it can increase clinical therapeutic effects, minimizing drug toxicity reduces the incidence of resistance and more economical. CEA is an economic evaluation method that can be used in making the best decision on the selection of alternatives in the selection of pneumonia treatment costs. To analyze the effectiveness of medical expenses in pneumonia patients under five inpatient hospitalized Dr. Ario Wirawan Salatiga in 2018. This study used a non-experimental (observational) method using a retrospective approach and analyzed descriptively. The sample used was 30 patients. The samples were analyzed according to the ACER and ICER methods. The effectiveness of therapy was seen from LOS. ACER Value: VIP class: Ceftriaxon + Cefixime Rp. 615,177, Cefotaxime + Gentamisin Rp.810,773. Class I: Cefotaxime + Gentamisin Rp. 536,880. Class II: Cefotaxime Rp. 408,493, Cefotaxime + Cefixime Rp. 357,397, Cefotaxime + Gentamisin Rp. 385,488 and Ceftriaxon + Cefixime Rp. 325,355. Class III: Cefotaxime Rp.278,740, Ceftriaxon Rp.186,250, Cefotaxime + Gentamisin Rp. 312,734, Cefotaxime + Cefixime Rp.286,128 and Ceftriaxon + Cefixime Rp.295.100. ICER scores at VIP class: Ceftriaxon + Cefixime and Cefotaxime + Gentamisin Rp. -356,967 and in class III Ceftriaxon and Cefotaxime Rp.-91,219. In bronchopneumonia treatment toddlers the most cost-effective antibiotic therapy in VIP classrooms is the use of a combination antibiotic Ceftriaxon + Cefixime, class I is Cefotaxime + Gentamisin, Class II is Cefotaxime, and Class III is Cefotaxime.Keywords : Cost Effectiveness Analysis, Antibiotic Therapy, Pneumonia

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