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Medical and Health Journal
Published by Universitas Jenderal Soedirman
ISSN : -     EISSN : 28073541     DOI : https://doi.org/10.20884/1.mhj.2023.2.2.8053
Core Subject : Health,
Medicine & Pharmacology
Medical and Health Journal (EISSN. 2807-3541) is containing various articles/ manuscripts in the forms of research article, systematic reviews, case reports in the field of medicine focusing on basic medicine, clinical medicine, biomedical sciences, medical biotechnology, and public health. This journal is published by Universitas Jenderal Soedirman, Purwokerto, Indonesia.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 124 Documents
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Association Between Prematurity and Neonatal Sepsis: A Case–Control Study at a Tertiary Referral Hospital in Indonesia Hapsari, Ariadne Tiara; Krisniawati, Nia; Syiraz, Thauriq Azfa; Pratidina, Rr. Wening Gelar
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17292

Abstract

Background: Neonatal sepsis remains a leading cause of morbidity and mortality in newborns, particularly among preterm infants whose immature organ systems and immune defenses increase their vulnerability to infection. Evidence on the association between prematurity and neonatal sepsis remains variable across settings, highlighting the need for context-specific research. Objective: To examine the association between prematurity and the occurrence of neonatal sepsis at a tertiary referral hospital in Indonesia. Methods: A hospital-based analytic observational study with an unmatched case–control design was conducted at Margono Soekarjo Regional Hospital, Central Java, Indonesia, from June to November 2024. Medical records of neonates admitted in 2023 were reviewed. Cases were neonates diagnosed with sepsis, while controls had no sepsis diagnosis. A total of 136 neonates were selected using simple random sampling, with 68 cases and 68 controls. Data were analyzed using Chi-square tests and odds ratios (OR) with 95% confidence intervals (CI). Results: Preterm birth was more frequent among cases (64.7%) compared to controls (32.4%). The majority of sepsis cases were moderate-to-late preterm (41.2%) and predominantly late-onset (86.8%). Bivariable analysis demonstrated a significant association between prematurity and neonatal sepsis (χ² = 14.248, p < 0.001), with an OR of 3.833 (95% CI: 1.883–7.805), indicating that preterm neonates had nearly four times higher risk of developing sepsis than term neonates. Conclusion: Prematurity is a significant risk factor for neonatal sepsis, particularly late-onset cases, in this tertiary care setting. These findings highlight the urgent need for targeted infection prevention strategies and enhanced clinical monitoring for preterm infants in neonatal intensive care units.
Psoriasis Vulgaris Complicated by Secondary Tinea Pedis Infection: A Case Report Sylviningrum, Thianti; Anjarwati, Dwi Utami
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17324

Abstract

Background: The coexistence of psoriasis vulgaris and tinea pedis presents significant diagnostic challenges due to similar clinical presentations. Chronic topical corticosteroid therapy may predispose psoriatic patients to secondary fungal infections through local immunosuppression. Case report: A 34-year-old female presented with a one-year history of erythematous, scaly, thickened lesions on bilateral feet extending above ankles, knees, elbows, and inguinal areas. Initial psoriasis vulgaris diagnosis led to treatment with topical desoximetasone 0.25% twice daily and oral cetirizine once 10mg daily. While other body sites improved significantly, bilateral foot lesions showed minimal response. Skin biopsy revealed characteristic psoriatic features including parakeratosis, Munro microabscesses, and epidermal acanthosis. Lactophenol cotton blue staining demonstrated septate hyphae with conidia consistent with Trichophyton species, confirming concurrent tinea pedis. Treatment was modified to fluconazole 150 mg weekly, topical ketoconazole 2% twice daily, and temporary corticosteroid discontinuation, resulting in significant improvement of foot lesions after three weeks.Summary: This case demonstrates the importance of comprehensive diagnostic evaluation when standard psoriasis treatment fails where the differential treatment response across anatomical sites served as a crucial indicator for further investigation emphasizing systematic approaches incorporating histopathological and microbiological examinations..
Platelet-to-Lymphocyte Ratio as a Prognostic Biomarker for Overall Survival in Glioma Patients: A Retrospective Cohort Study in Yogyakarta, Indonesia Ermawati, Tutik
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17532

Abstract

Background: Glioma is the most common primary brain tumor in adults, with a generally poor prognosis despite advances in treatment. Inflammation plays a role in tumor initiation, progression, and invasion. The platelet-to-lymphocyte ratio (PLR) is a minimally invasive, cost-effective biomarker that may predict overall survival (OS) in glioma patients. Objective: This Study aims to evaluate the association between pre-treatment PLR and overall survival in patients with glioma. Methods: This retrospective cohort study included glioma patients treated at Dr. Sardjito General Hospital and affiliated hospitals in Yogyakarta between 2017–2022. PLR was calculated from pre-treatment complete blood counts. The optimal cut-off value was determined via ROC curve analysis. Kaplan–Meier survival analysis and Cox proportional hazards regression were performed to evaluate associations between PLR and OS, adjusting for age, sex, tumor grade, size, location, surgery type, and Karnofsky Performance Status (KPS). Results: A total of 149 patients were included (median age: 48 years; 57.7% male; 69.1% high-grade glioma). The optimal PLR cut-off was 236.77 (AUC = 0.591; sensitivity = 42.9%; specificity = 77.8%). Median OS was 14.1 months for PLR < 236.77 versus 5.8 months for PLR ≥ 236.77. High PLR was associated with increased mortality risk (HR = 2.18; 95% CI: 1.37–3.45).nConclusion: Elevated pre-treatment PLR is independently associated with shorter OS in glioma patients. PLR may serve as a simple, inexpensive prognostic biomarker in clinical practice, particularly in resource-limited settings.
Microrna Profile of Plasma Exosomes by Nanostrings in Early Onset Compared Late Onset Preeclampsia: Preliminary Study Sumawan, Herman; Pradjatmo, Heru; Hadiati, Diah Rumekti; Mubarika, Sofia; Giantari, Ifrinda
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17598

Abstract

Research on miRNA biomarkers in preeclampsia as part of screening, diagnosis, and prognosis has been widely conducted, but the results show contradictory results and vary based on the type of preeclampsia. This study aims to compare the profile of plasma exosome miRNA in early onset compared late onset as a preliminary study to identify the miRNA profile of preeclampsia patients in Indonesia. The study was conducted at Margono Hospital,Indonesia using plasma exosomes samples of three patients with early-onset preeclampsia and three patients with late-onset preeclampsia and processed with NanoStrings. KEGG was used to identify preeclampsia pathophysiological pathways by bioinformatic analysis of DIANA-miRPath v3.0 and microT-CDS v5.0. The results showed that the characteristics of parity, hemoglobin, systolic and diastolic blood pressure, proteinuria and BMI did not differ between EOPE and LOPE. Significantly different variables were the age of the EOPE (28 ± 5.29) vs LOPE (38.67 ± 2.06 mmHg), pregnancy weight gain (10.0 vs 15.33), and fetal weight in EOPE (1550 ± 132 g) vs LOPE (2693 ± 716 g). The results showed that the 24 miRNAs differed significantly. The three highest expression miRNAs in the EOPE group were miR-196b-5p, miR-190a-5p, and miR-515-3p. In contrast, the three lowest expression miRNAs are miR-3179, miR-181a-5p, and miR-15b-5p. Pathway analysis of the upregulated miRNA involved the ErbB signalling pathway, Proteoglycan in cancer, and Lysin degradation. Downregulated miRNA targets involved in the HIPPO signalling pathway, fatty acid biosynthesis, and TGF-β signalling pathway. Conclusions: The preliminary study results indicated significant differences in miRNA expression, suggesting that EOPE is influenced by aggressive cellular signaling and metabolic dysregulation, while LOPE is more linked to the disruption of growth-inhibiting pathways and fatty acid metabolism. These unique miRNAs establish a robust foundation for subsequent validation studies utilizing bigger samples as a prospective biomarker panel.

Page 13 of 13 | Total Record : 124

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