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Lantip Rujito
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Medical and Health Journal
Published by Universitas Jenderal Soedirman
ISSN : -     EISSN : 28073541     DOI : https://doi.org/10.20884/1.mhj.2023.2.2.8053
Core Subject : Health,
Medicine & Pharmacology
Medical and Health Journal (EISSN. 2807-3541) is containing various articles/ manuscripts in the forms of research article, systematic reviews, case reports in the field of medicine focusing on basic medicine, clinical medicine, biomedical sciences, medical biotechnology, and public health. This journal is published by Universitas Jenderal Soedirman, Purwokerto, Indonesia.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 124 Documents
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Pengaruh Afirmasi Positif terhadap Tingkat Kecemasan Anak saat Hospitalisasi di RSUD Dr. M.M Dunda Limboto Parawouw, Dewi Carlina; Paramata, Nanang Roswita; Antu, Mihrawaty
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.14871

Abstract

Anxiety is a response to unpleasant situations and is commonly experienced daily, particularly by children. One approach to addressing anxiety is through the use of positive affirmations. This study aims to analyze the effect of positive affirmations on children's anxiety levels during hospitalization at RSUD Dr. M.M. Dunda Limboto. This quantitative study utilized a quasi-experimental design with a non-equivalent control group approach. The sampling technique employed was incidental sampling, with a population of 177 respondents and a sample size of 38 respondents, including 19 in the intervention group and 19 in the control group. The instruments used in this research were a Standard Operating Procedure (SOP) for positive affirmations and the Visual Analog Scale for Anxiety (VAS-A) observation sheet. Non-parametric Wilcoxon testing was used for data analysis within the same group. The p-value for the intervention group was 0.000, indicating a significant change in anxiety levels before and after receiving positive affirmation intervention. In contrast, the p-value for the control group was 0.157, indicating no significant change in anxiety levels before and after the intervention. For data analysis between the two unpaired groups, an independent t-test was conducted, yielding a p-value of 0.001, indicating a significant difference in anxiety levels between the intervention group (receiving affirmations) and the control group (without affirmations) during hospitalization at RSUD Dr. M.M. Dunda Limboto. The study concludes that positive affirmations significantly affect children's anxiety levels during hospitalization at RSUD Dr. M.M. Dunda Limboto. Therefore, this study may serve as valuable information and input for RSUD Dr. M.M. Dunda Limboto to enhance the quality of hospital services and incorporate positive affirmations as an effort to reduce the impact of hospitalization on pediatric patients.
PCI Revascularization Strategies in Patients with Acute Myocardial Infarction and Multivessel Disease Laksono, Sidhi; Widyani, Wella
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.16915

Abstract

Background: The incidence of Acute Myocardial Infarction (AMI) accompanied by Multivessel Disease (MVD) has increased annually, necessitating appropriate revascularization strategies to minimize clinical risks. Objective: This study aimed to evaluate various revascularization strategies using Percutaneous Coronary Intervention (PCI) that can be applied in patients with AMI and MVD. Methods: A systematic review was conducted using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) method. The keywords used were (“Revascularization" AND "Multivessel Disease" AND "Acute Coronary Syndrome”) OR (“Revascularization" AND "Multivessel Disease" AND "Acute Myocardial Infarction”). Articles were collected based on inclusion criteria: original articles, published in English, and published between 2020 and 2025. Results: A total of 1,263 articles were found in the initial search. Of these, 169 were excluded due to duplication, 1,069 due to irrelevant PICO criteria, and 6 due to limited access. From the remaining 19 articles, it was found that revascularization strategies could be classified based on the number of vessels treated (culprit-only, incomplete, and complete revascularization) and the timing of the intervention (immediate and staged revascularization). Conclusion: No single strategy was superior in all contexts. The choice of revascularization strategy should be individualized based on each patient’s clinical status and coronary anatomy to optimize outcomes.
Iron Given, Iron Denied: Neonatal Hematologic Alterations in Obese Pregnancies Despite Universal Supplementation Santosa, Qodri; Priyanto, Edy; Muntafiah, Alfi
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17102

Abstract

Background: Maternal obesity, a pro-inflammatory state now highly prevalent among women of reproductive age in Indonesia, may undermine the effectiveness of antenatal iron supplementation. Neonatal iron deficiency remains a public health concern, with maternal inflammation potentially disrupting fetal iron transfer. Objective: To investigate the association between maternal third-trimester Body Mass Index (BMI) and neonatal hematologic and iron parameters, within the context of standardized antenatal iron supplementation. Methods: This hospital-based cross-sectional study in Central Java, Indonesia, enrolled84 full-term neonates whose mothers received iron supplementation. Subjects were stratified by maternal BMI into non-obese (<25 kg/m²) and obese (≥25 kg/m²) groups. Cord blood was analyzed for hematologic indices (hemoglobin, Mean Corpuscular Volume [MCV], Mentzer Index) and iron biomarkers (ferritin and hepcidin). Results: Neonates from obese pregnancies exhibited significantly higher MCV (103.4 ± 5.1 fL vs. 100.1 ± 4.9 fL, p=0.004) and Mentzer Index (21.8 ± 4.7 vs. 21.3 ± 2.9, p=0.040) compared to the non-obese group. These findings suggest macrocytic shifts and possible ineffective erythropoiesis. No significantdifferences were observed in hemoglobin, ferritin, or hepcidin levels between groups. Conclusion: Maternal obesity during late pregnancy is associated with altered neonatal hematologic profiles, despite standardized iron supplementation. These results underscore a potential inflammation-mediated disruption in placental iron transfer and erythropoiesis, reinforcing the need for tailored antenatal strategies that incorporate maternal metabolic screening and functional hematologic monitoring for atrisk infants.
The Effectiveness of FAST Method Education in Early Stroke Detection Efforts for Hypertensive Patients at Pa’betengang Community Health Center, Bantaeng Arafah, Salmah; Dewiyanti, Dewiyanti; Ernawati, Ernawati; Kamriana, Kamriana; Oktaviana, Dina; Alwi, Alwi
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17151

Abstract

Stroke is a major complication of hypertension that leads to disability and death; however, knowledge among hypertensive patients regarding the early signs of stroke remains low. This study aimed to evaluate theeffectiveness of the FAST (Face, Arm, Speech, Time) educational method in improving early stroke detection skills among hypertensive patients. A one-group pre-experimental pre-post design was used involving 60 hypertensive patients at the Pa’betengang Community Health Center, Bantaeng Regency. The education was delivered in two sessions using visual media and interactive simulations. Knowledge was measured using a questionnaire administered before and after the intervention. The results showed an increase in the average knowledge score from 10.63 (SD ±2.85) to 17.18 (SD ±1.96) after the intervention, with a statistically significant difference (p < 0.001). The FAST method of education was proven effective in enhancing early stroke detection abilities among hypertensive patients. This intervention is recommended as an educational strategy in promotive programs within primary healthcare services.
The Correlation Between Physical Activity Levels With Salivary Cortisol Levels on Medical Students, at Jenderal Soedirman University Nugraha, Raffy Ave; Mustofa, Mustofa; Candrawati, Susiana; Sinensis, Rizki Amelia; Wulansari, Rahmawati
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17175

Abstract

Medical students generally have low levels of physical activity. Medical students also experience more severe stressors than students in other study programs. Salivary cortisol levels can reflect a person's stress level. This study aims to determine the correlation between physical activity levels and salivary cortisol levels in medical students at Jenderal Soedirman University. This study was conducted on 50 medical students at Jenderal Soedirman University aged 18–25 years. The study subjects were selected using purposive sampling. Physical activity levels were measured using the International Physical Activity Questionnaire-Long Form (IPAQ-LF), and saliva cortisol levels were measured using the Enzyme-Linked Immunosorbent Assay (ELISA) method. The correlation test used was Pearson's correlation test with a significance level of p<0.05. The results showed that the average physical activity level and saliva cortisol levels of the respondents were 1334.31±552.10 MET-minutes/week and 9.76±2.97 ng/mL. Bivariate analysis showed a p-value of 0.507, indicating that there was no correlation between physical activity levels and saliva cortisol levels among medical students at Jenderal Soedirman University.
Relationship Between Diabetes Distress and Self Management on Type 2 Diabetes Mellitus Patients in Sumbang District Banyumas Fadillah, Aulia Nur; Wulansari, Rahmawati; Kuncoro, Prasetyo Tri; Isnaya, Purwa Riana; Oktavilia, Ernasiwi Astri; Anamani, Teguh
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17204

Abstract

Background: Diabetes distress is a form of anxiety, worry, fear, and perceived threat related to the struggles experienced by individuals living with diabetes mellitus. The presence of diabetes distress is associated with reduced self-care (self-management). Diabetes mellitus self-management refers to a series of actions taken by individuals to manage their medical condition, including dietary regulation, physical activity management, regular and consistent intake of diabetes medication, blood glucose monitoring, and routine foot care. Objective: This study aims to determine the relationship between diabetes distress and self- management in patients with type 2 diabetes mellitus in Sumbang District, Banyumas. Method: This research uses an analytical observational study with a cross sectional approach. The sampling technique used was a total sampling of 55 people. Data analysis using the chi-square test. Research Results: The results of the research showed that self-management of type 2 DM patients was mostly in the sufficient category, namely 25 people (45.5%) and diabetes distress of type 2 DM patients is in the mild category, namely 35 people (63.6%). There is a relationship between diabetes distress and self-management in type 2 diabetes mellitus patients in Sumbang District, Banyumas (p = 0.000). Conclusion: Diabetes distress is related to self-management in type 2 diabetes mellitus patients.
Evaluation of Medication Planning Management Using ABC-VEN Analysis at Hospital X Purwokerto Mayasari, Nurina; Fitriana, Syefi Nuraeni; Pratiwi, Hening
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17216

Abstract

Background: Pharmaceutical expenditures represent a significant portion of hospital budgets, underscoring the need for efficient inventory management to ensure medicine availability and avoid financial losses. Objective: This study aimed to evaluate the medication planning and procurement process at Hospital X using the ABC-VEN matrix to classify drugs by cost and clinical importance. Methods: A retrospective, descriptive study was conducted using procurement and planning records from January to December 2024. Results: ABC analysis revealed that 10.9% of drugs (category A) accounted for 70.13% of total spending, while 21.8% (category B) contributed 20.15%, and 67.18% (category C) represented only 9.72%. VEN classification identified 15.6% of drugs as vital, 74.22% as essential, and 10.16% as non-essential. The integrated ABC-VEN analysis categorized 20 items as Priority (P), 95 as Main (U), and 13 as Supplementary (T). Conclusion: The ABC-VEN approach effectively identified priority medicines, enhanced planning efficiency, and supported rational resource utilization in hospital pharmaceutical management.
Mortality Analysis in Neonates with Gastroschisis: A Retrospective Study at Dr. Sardjito General Hospital, Yogyakarta (2007–2012) Herowati, Novita; Agustriani, Nunik; Makhmudi, Akhmad
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17231

Abstract

Background: Gastroschisis is a congenital abdominal wall defect that poses a significant risk of morbidity and mortality in neonates, particularly in low- and middle-income settings. Despite advances in neonatal care and surgical techniques, survival outcomes remain variable and influenced by multiple clinical factors. Objective: To analyze the clinical and laboratory factors associated with mortality among neonates with gastroschisis treated at Dr. Sardjito General Hospital, Yogyakarta, Indonesia, between 2007 and 2012. Methods: This was a retrospective observational study involving 35 neonates diagnosed with gastroschisis. Data were collected from medical records, including birth weight, gestational age, timing of surgery, hemoglobin and platelet levels, albumin status, bowel necrosis, sepsis status, and anatomical characteristics of the abdominal wall defect. Univariate and multivariate logistic regression analyses were performed to identify significant predictors of mortality. Results: The overall mortality rate was high. Sepsis was found to be the only independent predictor of mortality (p = 0.037; OR 14.29; 95% CI: 1.179–173.261). Other factors significantly associated with mortality in univariate analysis included low birth weight (p = 0.043), small defect-to-bowel disproportion (p = 0.020), and postoperative hemoglobin <13 g/dL (p = 0.019). Postoperative thrombocytopenia and bowel necrosis showed a strong trend toward higher mortality but did not reach statistical significance. Gestational age, albumin levels, and timing of surgery were not significantly associated with mortality. Conclusion: Sepsis remains the most critical factor associated with mortality in neonates with gastroschisis. Early infection control, optimal perioperative hematologic management, and timely surgical intervention are essential to improve survival outcomes. These findings highlight the need for standardized protocols and further prospective studies to reduce mortality in this vulnerable population.
Biopotency of Ethanol Extract of Rasamala (Altingia excelsa) Leaves as a Botanical Insecticide Against Aedes aegypti Mosquitoes Sari, Octavia Permata; Ihtiaringyas, Suci; Susiawan, Lieza Dwianasari; Firinda, Rizma Haidif; Wahyudin, Wahyudin; Wijaya, Faza Nur
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17251

Abstract

Aedes aegypti is the primary vector of dengue hemorrhagic fever (DHF), which remains a major public health concern in Indonesia. Continuous use of synthetic insecticides has led to the emergence of resistance andadverse environmental impacts. This study aimed to evaluate the biopotential of ethanol extract from Altingia excelsa (rasamala) leaves as a botanical insecticide against Aedes aegypti mosquitoes. The experiment was conducted by exposing female Aedes aegypti mosquitoes aged 3–5 days to vapor from rasamala leaf extract at threeconcentrations (25%, 50%, and 75%) using an electric liquid vaporizer device. Mortality percentages were recorded at 8, 16, and 24 hours and subsequently analyzed using statistical and probit methods. The results demonstrated that rasamala leaf extract possesses insecticidal activity. However, the LC₅₀ value of 182% indicated low efficacy, as it exceeded the highest concentration tested. Moreover, the LT₅₀ value could not be reliably determined within the observed time frame. These findings suggest that while Altingia excelsa extract exhibits insecticidal potential, further optimization of its formulation or an increase in concentration is required to achieve greater effectiveness.
Effectiveness of Pneumococcal Conjugate Vaccine in Reducing Childhood Pneumonia: A Comprehensive Literature Review Praditina, Rr. Wening Gelar; Aprilia, Asti; Yulyanti, Desi
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17291

Abstract

Background: Pneumonia remains the leading cause of morbidity and mortality among children under five worldwide, with Streptococcus pneumoniae and Haemophilus influenzae identified as the most common etiological agents. The high disease burden, particularly in low- and middle-income countries, underscores the urgent need for effective prevention strategies. The Pneumococcal Conjugate Vaccine (PCV) has demonstrated substantial impact in reducing pneumonia incidence and invasive pneumococcal disease globally, and has been included in Indonesia’s national routine immunization program since 2022. Objective: This literature review aims to synthesize current evidence on the effectiveness of PCV in reducing childhood pneumonia morbidity and mortality, evaluate its safety profile, and discuss implications for immunization policy and program implementation in Indonesia and globally. Methods: A narrative literature review was conducted using data from peer-reviewed journals, WHO reports, and national health surveys published between 2010 and 2025. Databases searched included PubMed, Scopus, and Google Scholar, using keywords “pneumococcal conjugate vaccine,” “effectiveness,” “childhood pneumonia,” and “immunization program.” Studies meeting inclusion criteria—randomized controlled trials, cohort studies, case-control studies, and meta-analyses—were analyzed and synthesized. Results: Evidence from multiple countries, including the United States, France, Israel, South Africa, Argentina, and Indonesia, consistently demonstrates significant reductions in pneumonia hospitalizations, invasive pneumococcal disease incidence, and mortality among children following PCV introduction. PCV-13 and PCV-15 have shown broad serotype coverage and sustained impact. Co-administration of PCV with other routine vaccines has been proven safe, with no increase in adverse events following immunization (AEFI). Conclusion: PCV is an effective and safe intervention for reducing the burden of childhood pneumonia and invasive pneumococcal disease. Nationwide implementation in Indonesia has the potential to substantially decrease pneumonia-related mortality in children under five. Continuous surveillance, serotype monitoring, and program evaluation are essential to maximize vaccine benefits and inform future immunization policies.

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