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Puspawan Hariadi
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Sinteza
Published by Universitas Hamzanwadi
ISSN : -     EISSN : 27978133     DOI : https://doi.org/10.29408/sinteza
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Sinteza, ISSN (online) 2797-8133, is a peer-reviewed journal in pharmacy. Established 2021, the journal is an open access of published articles to support greater exposure of scientific knowledge. Sinteza published online twice a year by Faculty of Health, Universitas hamzanwadi. Sinteza accepts various fields of research in pharmacy including community and clinical pharmacy, pharmaceutics, pharmacology, toxicology, pharmacokinetics, pharmaceutical chemistry, and pharmaceutical biology. Manuscript accepted in Sinteza written in both Bahasa Indonesia and English
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 63 Documents
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Formulasi Pil Kunyit (Curcuma Longa L.) Kombinasi Sari Jeruk Limau Kuit (Citrus Hystrix Dc.) Sebagai Antioksidan Citrariana, Shesanthi; Muhammad Priyadi; Anograh R, Defilia; Rahmman, Sudarman; Febrianto, Yahya; Irawan, Ahmad; June N, Franz; Elphasa H, Shavira; Adistia P, Allaya
Sinteza Vol. 6 No. 1 (2026): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v6i1.32965

Abstract

Turmeric contains the active compound curcumin, which has been studied for its various biological activities, including antioxidant, anti-inflammatory, antimicrobial, and immunomodulatory properties. Kaffir lime is a plant commonly found on the island of Borneo and is used in traditional medicine and culinary flavors. Kaffir lime fruit and leaves contain various bioactive compounds, such as flavonoids (hesperidin, naringenin), essential oils (citronellal, limonene), and vitamin C. Flavonoids are known to have antioxidant and anti-inflammatory effects that can boost the immune system. Pills are one of the oldest dosage forms in the pharmaceutical world and are still relevant, especially for herbal preparations due to their ease of manufacture and stability. This study aims to formulate pill preparations by combining turmeric and lime juice. The method used is wet granulation to make pills with varying turmeric concentrations, namely F1 0.26% and F2 0.52% using polyvinyl alcohol as a binder. Physical evaluations include water content, weight uniformity, pH, and disintegration time tests. The pills were then tested for antioxidant activity against DPPH. The results showed that the water content of F1 pills was 4.06% and F2 pills 3.75%, pill weight uniformity with RSD value criteria of F1 was 0.21% and F2 pills 3.40%, the average pH of F1 was 6.32 and F2 pills 6.22, and the disintegration time of F1 was 30 minutes and F2 pills 8.26 minutes. The results of the antioxidant activity of the pill preparations showed that the F1 IC50 was 6.36 ppm and the F2 IC50 was 5.53 ppm. From the results obtained, it can be concluded that F2 pill preparations have good physical properties and potential antioxidant activity.
What Solvent is Actually the Best for Extracting Andrographolide? – Computational Evaluation of the Atomic Behavior in Different Solvent Models Setiawansyah, Arif; Khairunnisa, Khairunnisa; Wilsya, Mayaranti
Sinteza Vol. 6 No. 1 (2026): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v6i1.33127

Abstract

Andrographolide, a bioactive diterpenoid lactone from Andrographis paniculata, exhibits significant anti-inflammatory, antimicrobial, and anticancer properties, making solvent selection critical for optimizing extraction efficiency while preserving bioactivity. This study aimed to identify the optimal solvent for andrographolide extraction through computational evaluation of solvation thermodynamics and electronic properties using density functional theory. Geometry optimization and solvation calculations were performed at the B3LYP/def2-SVP level using the Conductor-like Polarizable Continuum Model (CPCM) in ORCA version 6.0.1 across twelve solvent systems including water, alcohols, aprotic solvents, and non-polar media. Molecular properties including solvation free energy, frontier molecular orbitals, global chemical reactivity descriptors, dipole moment, atomic charge distribution, molecular electrostatic potential, and infrared spectra were systematically analyzed. Results demonstrated that water exhibited the most favorable solvation free energy at -76.64 kJ/mol, superior to all other examined solvents including acetonitrile (-75.30 kJ/mol), methanol (-75.05 kJ/mol), and significantly better than hexane (-33.52 kJ/mol). Water induces optimal dipole moment enhancement to 1.253 Debye while maintaining stable HOMO-LUMO energy gap of 5.009 eV and consistent global reactivity descriptors, confirming preservation of intrinsic chemical properties and bioactivity. Infrared spectroscopic analysis revealed complete structural integrity in aqueous environment. This computational study establishes water as the superior extraction medium for andrographolide based on exceptional thermodynamic favorability, optimal electronic stabilization, maintained molecular stability, and practical advantages including non-toxicity and environmental sustainability.
Evaluasi Tablet Effervescent Curcuma longa dan Tamarindus indica: Sifat Fisik, Analgesik, dan Toksisitas Akut Kautsari, Farah Widya; Emha, Maulida Rahmawati
Sinteza Vol. 6 No. 1 (2026): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v6i1.33296

Abstract

Dysmenorrhea was a common complaint among adolescent women and was often treated with nonsteroidal anti-inflammatory drugs (NSAIDs), although long-term NSAID use could cause adverse effects. Turmeric (Curcuma longa) and tamarind (Tamarindus indica) had traditionally been used in Indonesia as the “kunyit-asam” herbal preparation due to their anti-inflammatory and analgesic activities. However, traditional herbal drinks such as jamu godhog had several limitations, including inconsistent dosing and low stability, which supported the need for developing modern dosage forms like effervescent tablets. This study aimed to formulate and evaluate the physical quality and pharmacological activity of kunyit-asam effervescent tablets in three variations of turmeric extract concentrations, namely 250 mg, 500 mg, and 750 mg. The physical evaluations included organoleptic testing, weight uniformity, tablet hardness, and dissolution time, while pharmacological evaluations consisted of analgesic activity using the writhing test in male mice and acute toxicity testing to assess safety. The results showed that all three formulations met the required physical quality parameters. Analgesic testing indicated that doses of 2.6 mg/20 g BW and 3.9 mg/20 g BW produced analgesic effects comparable to paracetamol. Acute toxicity testing demonstrated that no mortality occurred in any treatment group. Overall, the developed kunyit-asam effervescent tablets exhibited good physical quality, were safe, and demonstrated potential as a modern herbal alternative for pain relief.

Page 7 of 7 | Total Record : 63

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