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Sinteza
Published by Universitas Hamzanwadi
ISSN : -     EISSN : 27978133     DOI : https://doi.org/10.29408/sinteza
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Sinteza, ISSN (online) 2797-8133, is a peer-reviewed journal in pharmacy. Established 2021, the journal is an open access of published articles to support greater exposure of scientific knowledge. Sinteza published online twice a year by Faculty of Health, Universitas hamzanwadi. Sinteza accepts various fields of research in pharmacy including community and clinical pharmacy, pharmaceutics, pharmacology, toxicology, pharmacokinetics, pharmaceutical chemistry, and pharmaceutical biology. Manuscript accepted in Sinteza written in both Bahasa Indonesia and English
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 55 Documents
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Uji Aktivitas Ekstrak Etanol Kulit Buah Rambutan (Nephelium lappaceum L.) sebagai Penurun Kadar Asam Urat Tikus yang Diinduksi Jus Hati Ayam Sasmita, Yulinda Dinar; Oktresia, Erma Ewisa; Rafsanjani, Arief
Sinteza Vol. 1 No. 2 (2021): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v1i2.4449

Abstract

Asam urat adalah hasil akhir dari katabolisme (pemecahan) suatu zat yang bernama purin. Kadar asam urat normal pada laki-laki dewasa adalah sekitar 2-7,5 mg/dL, sementara pada wanita yang sudah dewasa adalah 2- 6,5 mg/dL. Peningkatan kadar asam urat diatas normal dapat menyebabkan penumpukan Kristal asam urat di jaringan. Xantin oksidase merupakan enzim yang berperan dalam mengkatalis oksidasi hipoxantin menjadi xantin dan menjadi asam urat. Penghambatan xantin oksidase menjadi target untuk menurunkan produksi asam urat. Penelitian ini bertujuan untuk menguji aktivitas ekstrak etanol dalam menurunkan kadar asam urat tikus yang diinduksi jus hati ayam. Penelitian ini merupakan penelitian eksperimental dengan desain kelompok pre dan posttest. Kulit rambutan diekstraksi menggunakan metode maserasi dengan menggunakan pelarut etanol 70%. Hasil penelitian menunjukkan bahwa ekstrak etanol kulit buah rambutan mampu menurunkan kadar asam urat tikus yang diinduksi jus hati ayam secara signifikan (p<0,05 Ekstrak etanol kulit buah rambutan dosis 3 memiliki kemampuan menurunkan kadar asam urat tikus yang lebih baik dibandingkan kelompok kontrol positif (Allopurinol). Ekstrak etanol kulit buah rambutan mengandung senyawa plavonoid, tanin, alkaloid, saponin dan terpenoid.
Formulasi Sabun Cair Cuci Tangan dan Uji Aktivitas Bakteri Staphylococcus aureus dari Ekstrak Daun Kelor (Moringa oleifera Lam.) Waris, Dinda Izzatul; Yanti, Silfera Indra; Okzelia, Sari Defi; Amirulah, Fajar
Sinteza Vol. 3 No. 1 (2023): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i1.7890

Abstract

Soap is what can be used to wash hands so as to avoid bacteria that can cause diseases such as acne and boils. One of the natural ingredients in making soap is Moringa leaves. Moringa leaves are one of the plants that have antibacterial properties, Staphylococcus aureus bacteria are bacteria that can cause infectious diseases such as acne and boils. The purpose of this study was to formulate hand washing liquid soap from Moringa leaf extract (Moringa oliefera Lam.), to evaluate the antibacterial activity of the preparation against Staphylococcus aureus. Moringa extract was obtained by maceration method. Furthermore, phytochemical screening was carried out, then formulated into soap preparations at concentrations of 20% (F1), 25% (F2), and 30% (F3). The preparations were evaluated and tested for activity against Staphylococcus aureus. Based on the results of the study, the yield of ethanol extract of Moringa leaves was 32.35% and contained secondary metabolites such as alkaloids, flavonoids, saponins and tannins. Moringa leaf ethanol extract soap formula met the requirements of all test parameters including pH test, irritation test, specific gravity test, and organoleptic test. The results of the antibacterial activity test gave an inhibition zone of 20.2 mm, 21.5 mm, and 23.2 mm, respectively. For F1, F2 and F3 against Staphylcoccus aureus.
Gambaran Penjualan Obat Swamedikasi di Apotek Karomah Palangka Raya saat Pandemi Covid-19 Tahun 2021 Citrariana, Shesanthi; Paramawidhita, Risqika Yuliatantri
Sinteza Vol. 3 No. 1 (2023): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i1.7843

Abstract

Swamedikasi diartikan sebagai pemilihan dan pemanfaatan obat-obatan untuk mengobati gejala atau penyakit yang dikenali sendiri. Provinsi Kalimantan Tengah memiliki prevalensi swamedikasi yang tinggi yaitu 89,46%. Peningkatan minat masyarakat terhadap swamedikasi meningkat karena pandemi COVID-19. Penelitian ini bertujuan untuk melihat gambaran penjualan obat swamedikasi di Apotek Karomah saat pandemi COVID- 19 berlangsung. Pengumpulan data penjualan dilakukan dengan melihat pada SIM (Sistem Informasi Management) berbasis computer pada Juli – Agustus 2021. Hasil penelitian menunjukan bahwa tiga besar penjualan berdasarkan jenis obat di Apotek Karomah berupa Batuk&Flu sebanyak 1956 item (24,48%), Jamu&Minuman sebanyak 1482 item (18,55%), dan Alkes sebanyak 993 item (12,43%). Penjualan sepuluh besar (Top 10) berdasarkan item/ merk obat ditempati oleh komix batuk sebanyak 1236 item, madu TJ sebanyak 718 item, dan masker sebanyak 554 item. Total omzet penjualan pada Bulan Juli adalah Rp 49.068.000,- dan terlihat menurun pada Bulan Agustus Rp 43.944.000,-. Dari hasil penelitian ini dapat disimpulkan bahwa pandemi COVID-19 memberikan dampak penjualan obat swamedikasi di Apotek Karomah Kota Palangka Raya terutama obat-obat yang berkaitan dengan penurunan gejala COVID-19 dan peningkatan imunitas tubuh. 
Formulasi dan Evaluasi Sediaan Sabun Mandi Cair Ekstrak Kulit Buah Manggis (Gracinia mangostana L.) dan Uji Aktivitas terhadap Bakteri Staphylococcus aureus Shakila, Shakila; Hariadi, Puspawan; Yuliana, Tri Puspita
Sinteza Vol. 1 No. 2 (2021): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v1i2.5269

Abstract

Infeksi merupakan salah satu jenis penyakit yang sering terjadi, terutama infeksi kulit. Salah satu bakteri yang dapat menyebabkan infeksi yaitu bakteri staphylococcus aureus. Kulit manggis (Gracinia mangostana L.) memiliki kandungan senyawa kimia flavonoid, saponin, tanin, dan alkaloid yang memiliki aktivitas sebagai antibakteri.Tujuan umum dari penelitian ini adalah mengetahui aktivitas antibakteri sabun cair ekstrak kulit buah manggis (Gracinia mangostana L.) terhadap bakteri Staphylococcus aureus. Jenis penelitian yang digunakan adalah penelitian eksperimental laboratorik dengan menggunakan metode sumuran terhadap bakteri Staphylococcus aureus menggunakan tiga kelompok perlakuan. Kontrol positif sipofloxacin, kontrol negatif basis sabun, formulasi 1 (50%), formulasi 2 (60%), formulasi 3 (80%). Parameter yang diamati berupa uji organoleptis, uji homogenitas, uji pH, uji tinggi busa dan stabilitas busa dan viskositas. Hasil pengamatan menunjukkan bahwa sabun mandi cair ekstrak kulit buah manggis F1, F2 dan F3 memiliki daya hambat terhadap pertumbuhan bakteri Staphylococcus aureus. Didapatkan kesimpulan bahwa F1, F2 dan F3 sabun mandi cair ekstrak kulit buah manggis dapat menghambat pertumbuhan bakteri Staphylococcus aureus dan didapatkan uji organoleptis, uji homogenitas, uji pH, uji tinggi busa dan stabilitas busa dan viskositas memenuhi persyaratan sabun cair menurut SNI 06-4085-1996.
Gambaran Tingkat Kepuasan Pasien terhadap Pelayanan Informasi Obat di Apotek Wilayah Lombok Timur Hartono, M. Herry; Oktresia, Erma Ewisa; Sovia, Fitriwati
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.18969

Abstract

Pharmaceutical services are a direct and responsible service to patients. One of the pharmaceutical service activities that align with the concept of pharmaceutical care is found in the quality of Drug Information Services (PIO) in pharmacies. The aim of this research is to determine the implementation of DIS based on the Indonesian Minister of Health Regulation No.73 of 2016 in pharmacies in the East Lombok region. This study is observational descriptive using quantitative analysis in the form of calculating the percentage of Respondent Achievement Level (TCR). Data was collected using a questionnaire covering eight activities that pharmacists should undertake when providing drug information, which were subsequently used as indicators. Sample selection was done through purposive sampling with a minimum of 96 samples. Based on the research results, the TCR percentage values for the indicators were as follows: information on drug efficacy at 78% with a good category; dosage form at 78% with a good category; usage instructions at 75% with a good category; drug dosage at 74% with a good category; side effects at 74% with a good category; drug storage at 74% with a good category; safety for pregnant and nursing mothers at 46% with a fair category; information on drug prices obtained a score of 90% with a very good category. The average TCR score for the 8 indicators was 73.3% with a good category in providing drug information services in accordance with the Indonesian Minister of Health Regulation No.73 of 2016 in pharmacies in the East Lombok region.
Validasi Metode dan Penetapan Kadar Sirup Kering Cefadroxil dengan Metode FTIR-ATR Rahmasari, Khusna Santika; Alfarizi, Muhammad Bahtiar
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.19812

Abstract

Cefadroxil is a broad-spectrum bactericidal antibiotic belonging to the first group of cephalosporins produced by the fungus Cephalosporium acremonium. This study aims to validate the method and determine the concentration of cefadroxil dry syrup using FTIR-ATR. The method used is FTIR-ATR with aquabides as a solvent. Parameter Validation of the analysis method carried out includes linearity, accuracy, precision, Limit of Detection (LOD) and Limit of Quantification (LOQ). The results of the linearity test show a value of r = 0.999 which indicates linear. The accuracy obtained is 97 - 105.5%. Precision with an Relative Standard Deviation (RSD) value of 0.54%, LOD of 469.72 µg/mL and LOQ of 1423.6 µg/mL. The results of determining the levels of cefadroxil dry syrup with three samples, namely sample A 100.2%; sample B 100.5%; sample C 100.1%. Based on the research results, it can be concluded that the FTIR-ATR method is valid and the sample concentration complies with the provisions of the Indonesian Pharmacopoeia Edition VI, namely the concentration of cefadroxil in dry syrup preparations is not less than 90% and not more than 120%.
Formulasi dan Evaluasi Krim Pelembab Kulit Ekstrak Mahkota Bunga Sepatu (Hibiscus rosa-sinensis L.) Nopita, Rati Astuti Dewi; Ihsan, Ersi Arviana; Hariadi, Puspawan
Sinteza Vol. 2 No. 1 (2022): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v2i1.4391

Abstract

Bunga sepatu merupakan tanaman yang memiliki kandungan flavonoid yang  berfungsi sebagai antioksidan dan sebagai pelembab. Pelembab merupakan sediaan yang digunakan untuk memperbaiki kulit kering, sediaan ini dapat menurunkan Trans Evidermal Water Loss (TEWL) dengan membentuk lapisan lemak tipis di permukaan  kulit. Penelitian bertujuan untuk mengetahui formulasi dan evaluasi sifat fisik sedian krim ekstrak etanol mahkota bunga sepatu (Hibiscus rosa-sinensis L.) sebagai pelembab kulit. Metode yang digunakan pada penelitian ini eksperimental labolatorium. Evaluasi sifat fisik sediaan krim meliputi uji organoleptis, homogenitas, pH, viskositas, daya sebar, daya lekat. Hasil penelitian menunjukkan bahwa formulasi sediaan krim ekstrak etanol mahkota bunga sepatu dari ketiga formula uji organoleptis pada F1 (semi padat, abu muda, kakao), F2 (semi padat, drak sea green, kakao), kontrol (semi padat, putih, kakao), uji homogenitas dari ketiga formula menunjukkan hasil yang homogen, uji pH pada ketiga formula F1 6,22, F2 6,23, kontrol 5,91, uji viskositas F1 318, F2 1138, kontrol 992, hasil uji daya sebar memiliki diameter pada F1 5,59 cm; F2 5,9 cm; kontrol 5,2 cm  dan uji daya lekat pada F1 2,72 detik; F2 278 detik; dan kontrol 2,65 detik. Hasil uji pelembab menunjukkan bahwa ada perbedaan yang signifikan (p<0,05) antara formula 2 dengan kelompok kontrol negatif. Sediaan krim ekstrak mahkota bunga sepatu F2 dengan sebelum pengolesan 22,64 % pada hari ke 10 rata-rata 52, 48%.
Bahan Tambahan dalam Sediaan Tablet: Review Pratiwi, Puspa Dwi; Citrariana, Shesanthi; Gemantari, Baiq Maylinda
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.17472

Abstract

Tablets are solid pharmaceutical dosage form without or with suitable excipients by press or compression manufacturing process. The excipient chosen can influence the product performance (physical properties and stability) and bioavailability. All excipients must be optimally selected to get the optimal formula of tablet dosage form. This article review aims to overview of excipient in tablet dosage form and their role in formulating tablet dosage form. this review article was written based on literature studies from electronic databases such as PubMed, ScienceDirect, and Google Scholar which contain related information using keyword in Indonesian or English use article published in 2013-2023. excipients in tablet dosage form are fillers or diluents, disintegrants, lubricants, preservatives, flavors, sweeteners, coloring, and coating agents. These excipients added to tablet dosage form to facilitating the process of manufacture tablet dosage form, increasing stability and effectiveness of active pharmaceutical ingredients in tablet. The conclusion of this review, there are many classification of tablet excipients which is different function to get compendial requirements of tablet dosage form.
Pengaruh Perbedaan Konsentrasi Propilenglikol terhadap Karakteristik Fisik Hair Tonic Ekstrak Daun Katuk (Sauropus androgynus (L). Merr) Daradasih, Elline; Devi, Sisca
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.16825

Abstract

Katuk leaf extract contains flavonoids which can stimulate hair growth by relaxing the muscles in the blood vessels around the hair follicles. One dosage form that is suitable for hair growth application is hair tonic preparations. An important component in the formulation of hair tonic is a thickener which can maintain the stability of the preparation. Propylene glycol is a thickening agent that can determine the physical characteristics of hair tonic preparations which are related to the stability of the resulting preparations. The purpose of this study was to determine the effect of different concentrations of propylene glycol on the physical characteristics of hair tonic katuk leaf extract (Sauropus androgynus (L.) Merr). This type of experimental research uses a completely randomized design (CRD) one factorial. The independent variables in this study were the concentration of propylene glycol 5%, 15% and 25%. Testing the physical characteristics of hair tonic preparations included organoleptic, clarity, pH, viscosity, and specific gravity. Data analysis used the ANOVA test with a 95% level of confidence then continued with the Post hoc test. The results of the physical characteristic test showed that the difference in the concentration of propylene glycol in hair tonic katuk leaf extract had an effect on the physical characteristics of viscosity (p<0.05).
Fraksinasi Sari Kulit Buah Pisang Kepok (Musa acuminata) Mentah Tua dan Evaluasi Aktivitas Antibakteri terhadap Pertumbuhan Bakteri Propionibacterium acnes Azhari, Yusron; Azim, Muhlisun; Gemantari, Baiq Maylinda
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.11953

Abstract

Acne vulgaris is a skin condition performed the acne due to bacterial activity that infects the skin. Acne problems are often the cause of a person that decrease in self-confidence. One of the most common acne-causing bacteria is Propionibacterium acnes. P.acnes is a gram-positive bacterium with its morphological, shape, properties and composition classified in the group of corynebacteria, but this type of bacteria is not toxigenic or bacteria that does not produce toxic substances (toxic). One of the materials that can be used for acne medication is banana peel. Banana peels are residual waste products from domestic industrial production. The waste of Banana peels have potential as an antibacterial. They contain secondary metabolites such as phenolics, quinones and flavonoids which can act as antibacterials. The purpose of this study was to examine the antibacterial activity of raw kepok banana (Musa acuminata) peel extract against Propionibacterium acne bacteria as a cause of acne. Antibacterial activity test in this study was carried out using the well diffusion method to see how the antibacterial effect of raw kepok banana peel (Musa acuminata) had on the growth of Propionibacterium acnes bacteria. Kepok banana peel extracts were fractionated with hexane, ethyl acetate and water. The results of the antibacterial activity test for the three fractions showed that the water fraction of kepok banana peel extract represented the best inhibition zone of 10.02 ± 0.05 mm, 11.28 ± 0.13 mm, 12.38 ± 0.02 mm and 16.97 ± 0.36 with a strong category at successive concentrations of 20%, 40%, 60% and 80%.

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