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Sinteza
Published by Universitas Hamzanwadi
ISSN : -     EISSN : 27978133     DOI : https://doi.org/10.29408/sinteza
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Sinteza, ISSN (online) 2797-8133, is a peer-reviewed journal in pharmacy. Established 2021, the journal is an open access of published articles to support greater exposure of scientific knowledge. Sinteza published online twice a year by Faculty of Health, Universitas hamzanwadi. Sinteza accepts various fields of research in pharmacy including community and clinical pharmacy, pharmaceutics, pharmacology, toxicology, pharmacokinetics, pharmaceutical chemistry, and pharmaceutical biology. Manuscript accepted in Sinteza written in both Bahasa Indonesia and English
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 55 Documents
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Gambaran Tingkat Pengetahuan dan Perilaku Responden pada Penggunaan Sunscreen di Klinik Kecantikan Wilayah Bekasi Amirulah, Fajar; Yulianti, Yulianti; Yanti, Silfera Indra
Sinteza Vol. 4 No. 1 (2024): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i1.7926

Abstract

Sunlight contains ultraviolet rays that harm the skin, causing various kinds of skin disorders such as redness, premature aging, black spots, dryness, wrinkles, and skin cancer. Sunscreen is a skin care product that is useful for protecting the skin from the sun. This study aimed to determine the level of knowledge, attitudes, and behavior of female patients at the Beauty Clinic Region of Bekasi about the use of sunscreen. This study uses a descriptive method with a cross-sectional approach. The sample of 92 respondents at the Beauty Clinic Region of Bekasi was selected by purposive sampling by distributing questionnaires. The highest research results were obtained in the age group of 17-25 years as much as 38%, the Senior High School education group as much as 54,3%, the housewives occupation group as much as 35,9%, and private employees as much as 35,9%. The level of sufficient knowledge is 59,8%, sufficient attitude is 56,5% and sufficient behavior is 45,7%. Based on the results of this study, it can be concluded that the respondents at the Beauty Clinic Region of Bekasi have sufficient knowledge and behavior regarding the use of sunscreen.
Analisis Kandungan Piroksikam dan Deksametason pada Jamu Pegal Linu yang Beredar di Lombok Timur Hanifa, Ahdiani; Febriani, Yuyun; Gemantari, Baiq Maylinda
Sinteza Vol. 4 No. 1 (2024): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i1.17436

Abstract

In recent year 2020 and 2021 BPOM discovered aching herbs containing medicinal chemicals such as piroxicam and dexamethasone. The addition of piroxicam and dexamethasone to herbal rheumatic pain can cause dangerous side effects such as myopathy, impaired kidney function, edema, hypertension, and gastrointestinal bleeding. The aim of this study was to determine the presence and levels of piroxicam and dexamethasone in herbal aches and pains circulating in East Lombok. The qualitative and quatittaive analysis of piroxicam and dexamethasone used in this research. The qualitative analysis used test of drug class compounds to determine the presence or absence of piroxicam and dexamethasone with FeCl3 reagent to detect piroxicam and acetic anhydrous and sulfuric acid reagent to detect dexamethasone.  Therefore, using TLC (Thin Layer Chromatography) as confirmation of the presence or absence of piroxicam and dexamethasone also used in this study. Each positive sample in the TLC process has confirmed and searched for levels using UV-Visible Spectrophotometry as quantitave analysis. The data result have analyzed by   SPSS version 16 to show the signification data in each sample. The TLC analysis results showed 6 positive samples containing piroxicam and 5 positive samples containing dexamethasone. According to assay results, the piroxicam levels were 13,71 ppm, 13,74 ppm, 14, 49 ppm, 13,87 ppm, 13, 99 ppm resepectively. The results for dexamethasone levels were 25,20 ppm, 0,45 ppm, 2,20ppm respectively. So, this show that herbal rheumatic pain in east Lombok contained piroxicam and dexamethasone with diffrence level in each sample with signification value p<0,05.
Gambaran Penggunaan Multivitamin selama Pandemi COVID-19 di Apotek Kota Pekanbaru Aryani, Fina; Ningsih, Windi Sayuti; Djohari, Meiriza; Humairah, Anugrah
Sinteza Vol. 4 No. 1 (2024): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i1.21051

Abstract

Tingginya kasus COVID-19, mengharuskan masyarakat untuk melakukan berbagai upaya preventif atau pencegahan, salah satu upaya yang dapat dilakukan adalah dengan menjaga imunitas tubuh yang dapat ditingkatkan dengan penggunaan multivitamin. Multivitamin mengandung beberapa vitamin dan mineral, kecukupan zat gizi terutama vitamin dan mineral sangat diperlukan dalam mempertahankan sistem kekebalan tubuh yang optimal. Penelitian ini bertujuan untuk mengetahui penggunaan multivitamin pada masyarakat di salah satu apotek Kota Pekanbaru selama pandemi COVID-19. Penelitian ini merupakan penelitian observasional yang bersifat deskriptif dengan teknik pengambilan data secara retrospektif. Populasi pada penelitian ini adalah data semua penjualan multivitamin selama pandemi Covid-19 dari bulan Maret 2020 hingga Juni 2021. Sampel adalah semua populasi sehingga teknik pengambilan sampel yang digunakan yaitu sampel jenuh. Data yang diambil adalah data sekunder berupa data penjualan multivitamin selama pandemi Covid-19 dari bulan Maret 2020 hingga Juni 2021. Hasil penelitian menunjukkan bahwa penjualan nama multivitamin yang paling banyak adalah Zegavit® sebanyak 10,41% dengan zat aktif Vitamin C sebesar 45,40%, bentuk sediaan multivitamin yang paling banyak terjual adalah tablet atau kaplet dengan persentase 68,16% dengan komposisi kombinasi sebesar 98,42%. Berdasarkan hasil penelitian disimpulkan multivitamin yang paling tinggi angka penjualannya yaitu multivitamin kombinasi dengan bentuk sediaan tablet.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Bintaro (Cerbera odollam) dalam Menghambat Pertumbuhan Streptococcus mutans dan Escherichia coli Mahdi, Nur; Susanti, Susi; Agustina, Ani; Mukhlis, Andi Zsazsa Rafiatul
Sinteza Vol. 4 No. 1 (2024): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i1.21431

Abstract

Tanaman bintaro (Cerbera odollam) salah satu dari banyak tanaman antimikroba yang ditemukan di Indonesia. Tanaman bintaro efektif dalam mengendalikan serangan hama, namun dalam penelitian antibakteri belum banyak diteliti. Penelitian ini bertujuan untuk menguji aktivitas antibakteri ekstrak etanol daun bintaro menghambat pertumbuhan bakteri Streptococcus mutans dan Escherichia coli. Penelitian ini menggunakan metode eksperimental untuk menguji aktivitas antibakteri menggunakan metode difusi cakram. Pengujian dilakukan dengan menggunakan konsentrasi ekstrak daun bintaro terdiri dari 25%, 50%, 75%, dan 100%, kemudian dilanjutkan dengan analisis data menggunakan uji Kruskal Wallis dan uji Chi Square. Hasil penelitian menunjukkan bahwa ekstrak etanol daun bintaro memiliki sifat antibakteri. Pada konsentrasi ekstrak 75% terhadap Streptococcus mutans diperoleh rata-rata zona hambat sebesar 6,125 mm dengan kategori daya hambat sedang dan pada Escherichia coli diperoleh rata-rata zona hambat sebesar 6,5mm. Kemudian pada pada konsentrasi 100% diperoleh pada kedua bakteri tersebut dengan zona hambat 7,5 mm dengan kategori daya hambat sedang. Uji Kruskal Wallis diperoleh nilai signifikansi sebesar 0,003 atau (p < 0,05) menunjukkan perbedaan bermakna. Uji Chi Square menunjukkan nilai signifikansi untuk Streptococcus mutans sebesar 0,433 atau (p < 0,05) dan Escherichia coli sebesar 0,433 atau (p < 0,05). Pada konsentrasi 100% diameter zona hambat 7,5 mm, hasil ekstrak etanol daun bintaro menunjukkan aktivitas antibakteri dengan kategori sedang terhadap bakteri Streptococcus mutans dan Escherichia coli.
Uji Minyak Atsiri Daun Mengkudu (Morinda citrifolia L) terhadap Diameter Zona Hambat Staphylococcus aureus Wardani, Evi; Hariadi, Puspawan; Yuliana, Tri Puspita
Sinteza Vol. 4 No. 1 (2024): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i1.25237

Abstract

Infeksi merupakan salah satu masalah kesehatan yang banyak disebabkan oleh virus, jamur, bakteri atau parasit. Bakteri Staphylococcus aureus merupakan bakteri penyebab infeksi pada manusia. Penggunaaan obat antibiotik dalam terapi infeksi yang tidak terkontrol dapat meningkatkan jumlah resistensi bakteri terhadap antibiotik, oleh karena itu perlu adanya terapi alternatif dari bahan alam yang memiliki potensi dalam menghambat pertumbuhan bakteri. Daun mengkudu (Morinda citrifolia L) merupakan salah satu tanaman yang dapat digunakan sebagai antibakteri dengan kandungan metabolit sekunder seperti flavonoid, alkaloid, saponin, steroid dan terpenoid. Tujuan penelitian ini untuk mengetahui pengaruh uji aktivitas minyak atsiri daun mengkudu terhadap pertumbuhan bakteri Staphylococcus aureus dan mengetahui konsentrasi optimum minyak atsiri daun mengkudu yang efektif dapat menghambat pertumbuhan bakteri Staphylococcus aureus. Daun mengkudu diekstraksi secara destilasi dengan pelarut aquades. Destilat minyak atsiri daun mengkudu lalu diuji aktivitas antibakteri dengan menggunakan metode difusi kertas cakram dengan konsentrasi 15%, 25%, dan 35% (b/v). Kontrol positif yang digunakan yaitu ciprofloxacin dengan kontrol negatif DMSO. Hasil penelitian menunjukkan bahwa minyak atsiri daun mengkudu memiliki aktivitas antibakteri pada bakteri Staphylococcus aureus dibuktikan dengan adanya zona bening disekitar kertas cakram. Aktivitas antbakteri tertinggi yaitu pada konsentrasi 35%. Diketahui bahwa semakin tinggi konsentrasi yang digunakan hasil diameter zona hambat bakteri yang dihasilkan juga akan semakin besar.
Pengaruh Konsentrasi Ekstrak Kayu Secang (Caesalpinia sappan) terhadap Karakteristik Fisik Sediaan Sabun Cair Jumadiyah, Cholidatul; Ismiyati, Ismiyati; Eltivitasari, Andita
Sinteza Vol. 4 No. 1 (2024): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i1.25258

Abstract

Tanaman kayu secang (Caesalpinia sappan L) banyak ditemukan di Indonesia. Kayu secang mempunyai berbagai senyawa bioaktif, termasuk brazilin, brazilein, sappan chalcone, dan protosappanin A. Brazilin adalah pigmen yang memberikan warna merah pada tanaman kayu secang.  Sabun cair mempunyai manfaat untuk membersihkan tubuh sebagai antiseptik dan antibakteri, serta membantu untuk membuat kulit menjadi sehat. Tujuan penelitian ini adalah untuk mengetahui pengaruh konsentrasi ekstrak kayu secang (C. sappan) terhadap uji karakteristik fisik sabun cair. Penelitian ini merupakan penelitian eksperimental. Teknik ekstraksi yang digunakan adalah maserasi dengan menggunakan pelarut etanol 96%.  Variasi konsentrasi ekstrak 0,25%, 0,5%, dan 1%. Uji karakteristik yang dilakukan adalah uji organoleptik, uji pH, uji homogenitas, uji stabilitas busa, uji tinggi busa, uji iritasi dan uji kesukaan.  Pada sediaan sabun cair dari ekstrak kayu secang pada formula I (0,25%)  formula II (0,5%) dan formula III (1%) telah memenuhi syarat uji organoleptis, homogenitas, uji pH, uji tinggi busa, stabilitas tinggi busa, uji iritasi dan uji kesukaan. Konsentrasi  formula terbaik sabun cair ekstrak kayu secang (C. sappan L) yang disukai responden dari segi organoleptisnya yakni pada formula I (0,25%). Pada konsentrasi ini terlihat dihasilkan  karakteristik  sediaan  sabun  cair  paling  baik  dari  semua uji yang dilakukan. Perbedaan konsentrasi pada formulasi sabun cair ekstrak kayu secang memberikan pengaruh pada karakteristik fisik sediaannya.
Pengaruh Swamedikasi Penyakit Kulit terhadap Tingkat Pengetahuan Siswa di Panti Asuhan Yatim Muhammadiyah Kabupaten Pekalongan Ningrum, Wulan Agustin; Awaludin, Muhammad Mahruj; Suryani, Irma
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.20309

Abstract

Skin disease is one of the many diseases that is still a problem in the world, including Indonesia. This fungal skin disease is not fatal, however, because it is chronic and residual, and many people are resistant to the use of antifungal drugs. In this day and age, accessing information related to medicines is easier, so many people choose to take self-medication even though the implementation can cause errors. The number of cases of self-medication for skin diseases carried out by respondents in Muhammadiyah Orphanages throughout Pekalongan Regency. The aim of this research is to determine the level of students' knowledge of self-medication among respondents in Muhammadiyah Orphanages throughout Pekalongan Regency, consisting of Pekajangan, Kedungwuni, Wuled orphanages. , Wonopringgo, and Kajen. The method used in this research is an analytical survey with a cross sectional design. The sampling technique uses total sampling. The sample for this study was 75 respondents, namely respondents who had a history of skin disease and had done self-medication. The research results showed that 86,7% of respondents had a level of knowledge in the very good category. It can be concluded from the research that students at the Pekalongan Regency Muhammadiyah Orphanage have very good knowledge in self-treatment of skin diseases. More in-depth research needs to be done so that we can find out the relationship.
Formulasi Sediaan Sabun Cair Ekstrak Daun Ramania (Bouea macrophylla Griffith) sebagai Antiseptik Mahdi, Nur; Rezekiah, Rezekiah; Ani, Agustina
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.25475

Abstract

Ramania leaves (Bouea macrophylla Griffith) are natural ingredients that have activity as an antiseptic. Ramania leaves contain flavonoids, alkaloids, steroids and tannins. This study aims to make antiseptic liquid soap from ramania leaf extract with a concentration of 5%, 10%, 15%. This study used experimental methods in the laboratory. three formulations were made (FI, FII, FIII with a concentration of 5%, 10%, 15%). Evaluation includes organoleptic, homogeneity, pH, specific gravity, foam height. Antiseptic test was carried out using the zigzag method. he antiseptic test was carried out using the replica method. The statistical test for evaluating preparations is One Way Anova, for antiseptic testing using Paired sample t-test. The results of several evaluations have met the requirements, except that the specific gravity does not meet the SNI criteria. The antiseptic test is indicated by the percentage of bacterial reduction. The percentage of bacterial reduction in FI, II, and III respectively was 40.5; 48.5; and 57.5%. It can be seen that increasing the extract concentration can reduce the number of bacterial colonies. The results of the One Way Anova statistical test (a = 0.05) showed that there was no difference in the results of the preparation evaluation, the results of the paired sample test (a = 0.05) showed a significant difference in the antiseptic test. Based on the results of research on the specific gravity test however all formulas do not meet the criteria. In the antiseptic test, all formulas were effective in inhibiting bacterial growth.
Telaah Potensi Antivirus Mitraginin terhadap Protease 3CLpro SARS-CoV-2 dengan Pendekatan Molecular Docking Setiawansyah, Arif; Susanti, Gita; Hidayati, Nurul; Gemantari, Baiq Maylinda; Alrayan, Reza; Hadi, Ismanurrahman; Luthfiana, Dewi; Hasanah, Nurul
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.25634

Abstract

SARS-CoV-2 is a novel coronavirus identified as a major caused of COVID-19. COVID-19 can be prevented and managed by preventing the SARS-CoV-2 infection through inhibition of SARS-CoV-2 main protease. Mitragynine is one of the major compounds found in Mitragyna speciosa leaves that has the potential to be developed as an anti-COVID-19 agent. This research was implemented to evaluate that potential by observing the molecular interaction of mitragynine with the essential amino acid residues of SARS-CoV-2 3CLpro. The study was undertaken by in silico method via molecular docking approach using Autodock 4.2. The potential of mitragynine in inhibiting the SARS-CoV-2 main protease was justified based on its free binding energy and Ki. The result revealed that mitragynine exhibited a lower free binding energy and Ki than remdesivir with the free binding energy and Ki value of -7.80 kcal/mol dan 1.92 µM dan -7.41 kcal/mol dan 3.72 µM, respectively. This concluded that mitragynine has the potential as a SARS-CoV-2 main protease inhibitor with the affinity was better than remdesivir. However, further in vitro research must be carried out to prove this potential. 
Formulasi dan Evaluasi Sifat Fisik Sediaan Lulur Ekstrak Etanol Kulit Pisang Kepok (Musa paradisiaca L) Yuliana, Tri Puspita; Zulda, Nurul Fitri Erlinda
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.26049

Abstract

Banana peel is the part of the banana that has not been used. A body scrub is a semi-solid preparation that functions to clean dirt on the face and dead skin cells. Banana peel one of any plants can be used as the basic of formulated cream cosmetics has flavonoid and tanin compound content, in acts as an moisturizer skin. This research aims to determine the formulation and evaluation of the physical preparation of kepok banana peel (Musa Paradisiaca L) ethanol extract scrub. The research method used was the laboratory experimental method. Evaluation of the scrub preparation includes organoleptic testing, homogeneity, spreadability testing, adhesion testing, pH testing and skin moisturizing power testing. The results showed that the preparation of the ethanol extract of kepok banana peel from both formulas had organoleptic results of F1 (semi-solid cream form, light brown color, typical aroma of kepok banana peel extract), F2 (semi-solid cream form, dark brown color, typical aroma of peel extract banana kepok), the homogeneity test of the preparation produces an even preparation when smeared on the surface of a glass object in all formulas, testing acidity or pH F1: 5.45 and F2 = 6.42. The spreading ability test results were at F1: 5.80 cm and F2: 5.44 cm. Testing ability of sticking time F1: 2.44 seconds and F2: 2.57 seconds. The skin moisturizing ability test before application showed an average of 23.6%, on day 5 an average of 36.5% and on day 10 an average of 48.5%. The conclusion is that the Kapok banana peel scrub formulation has physical properties that meet standards and is able to significantly moisturize the skin after 10 days of use. Statistical data shows that there is no significant difference in each formula with significance values ​​of 0.327, 0.265 and 0.294 (P<0.05).

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