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Iyan Hardiana
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Jurnal Farmasi Kryonaut
Published by SEKOLAH TINGGI ILMU KESEHATAN BULELENG
ISSN : -     EISSN : 28281624     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology
Focus And Scope Pharmacology And Toxicology Clinical Pharmacy Community Pharmacy Social Pharmacy Pharmaceutical Chemistry Pharmaceutical Biology Pharmacognosy Phytochemistry Microbiology Pharmacoepidemiology Pharmacoeconomics Biopharmaceutics Management And Pharmacy Practice Pharmaceutical Marketing Pharmacy Ocean Alternative Medicines
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 83 Documents
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EXPLORING THE ANTIBACTERIAL POTENTIAL OF HALOPHILIC FUNGI AND THEIR SECONDARY METABOLITES: AN EVIDENCE-BASED PERSPECTIVE ON NOVEL ANTIBIOTIC CANDIDATE DEVELOPMENT Mahadewi, Ni Kadek Wiwik; Nursid, Muhammad; Dewi, Luh Putu Mirah Kusuma; Samirana, Putu Oka
Jurnal Farmasi Kryonaut Vol 5 No 1 (2026): JFK
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59969/jfk.v5i1.223

Abstract

Antibiotic resistance has emerged as a major global health threat, creating an urgent need for alternative antibacterial sources. Halophilic fungi, which inhabit hypersaline environments, are known to produce unique secondary metabolites with potential antibacterial activity. This review aimed to evaluate the antibacterial potential of halophilic fungi and their secondary metabolites through a structured literature review approach. Relevant articles published between 2015 and 2025 were collected from the Scopus and Google Scholar databases using the keywords “halophilic fungi” and “antibacterial”. Article selection was conducted based on predefined inclusion and exclusion criteria following the PRISMA guidelines. A total of 10 eligible original research articles were analyzed descriptively. The findings show that halophilic fungi produce diverse antibacterial metabolites, including alkaloids, gramicidin S, bisvertinolone, epicoracine, alterperylenol, and (Z)-18-octadec-9-enolide, which exhibit inhibitory activity against both Gram-positive and Gram-negative bacteria. Several metabolites demonstrate antibacterial activity comparable to or higher than standard antibiotics, while low Minimum Inhibitory Concentration (MIC) values indicate strong therapeutic potential. Overall, halophilic fungi represent an underexplored biological resource with significant potential for the development of novel antibacterial agents against bacterial resistance.
PEMANFAATAN EKSTRAK ANGGUR LAUT (Caulerpa sp.) SEBAGAI BAHAN AKTIF ALAMI SEDIAAN KOSMETIK ANTI-AGING: NARRATIVE REVIEW Dian Martines, Luh Ade; Chabib, Lutfi
Jurnal Farmasi Kryonaut Vol 5 No 1 (2026): JFK
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59969/jfk.v5i1.207

Abstract

Radiasi paparan ultraviolet (UV) yang berlebihan dapat memicu stres oksidatif dan penuaan dini ( photoaging ). Anggur laut (Caulerpa sp.) merupakan makroalga hijau Indonesia yang kaya senyawa bioaktif dan berpotensi sebagai bahan aktif kosmetik alami.  Kajian literatur ini bertujuan untuk mengeluarkan kandungan senyawa bioaktif, aktivitas antioksidan, serta potensi formulasi sediaan kosmetik antiaging dari anggur laut ( Caulerpa sp.). Penelitian ini menggunakan metode Narrative Review dengan pendekatan sistematis yang mengadaptasi panduan PRISMA. Pencarian artikel dilakukan pada bulan Desember 2024 melalui database Google Scholar dan ScienceDirect dengan kriteria inklusi artikel ilmiah terbitan tahun 2014–2024 yang membahas aktivitas biologi dan formulasi kosmetik Caulerpa sp. skrining fitokimia konfirmasi bahwa Caulerpa sp. mengandung polifenol, flavonoid, vitamin C, B1, steroid, terpenoid, saponin, dan alkaloid yang berfungsi sinergis sebagai antioksidan, antibakteri, dan antiinflamasi. Aktivitas antioksidan dipengaruhi oleh spesies dan polaritas pelarut. Ekstrak etil asetat Caulerpa lentillifera menunjukkan aktivitas antioksidan terkuat dengan nilai IC50 sebesar 41,756 μg/mL (kategori kuat) dibandingkan dengan Caulerpa racemosa . Dalam aplikasinya, ekstrak anggur laut berhasil diformulasikan ke dalam sediaan topikal seperti hand cream dan krim antioksidan yang memenuhi uji kualitas fisik dan stabilitas. Bahkan formulasi krim dengan konsentrasi ekstrak 1,5% mampu menghasilkan aktivitas antioksidan yang sangat kuat dengan nilai IC50 sebesar 4,86 ppm. Anggur laut ( Caulerpa sp.) memiliki potensi yang sangat besar sebagai bahan aktif alami dalam industri kosmetik dan nanokosmetik penangkal penuaan ( antiaging ) yang aman dan efektif.
BIOACTIVE POTENTIAL OF RED AND GREEN ALGAE AS ANTIOXIDANT AND PHOTOPROTECTIVE SOURCES AGAINST OXIDATIVE STRESS AND ULTRAVIOLET RADIATION Cahyani, Ni Kadek Angga Rusnita; Puspawati, Ni Made; Dewi, Luh Putu Mirah Kusuma; Samirana, Putu Oka
Jurnal Farmasi Kryonaut Vol 5 No 1 (2026): JFK
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59969/jfk.v5i1.227

Abstract

Excessive exposure to ultraviolet (UV) radiation promotes the formation of reactive oxygen species (ROS), contributing to photoaging, hyperpigmentation, and skin cancer. Therefore, natural alternatives to synthetic sunscreens are increasingly explored due to potential health and environmental concerns. Seaweeds are promising sources of natural photoprotective agents because they produce bioactive compounds to survive high UV exposure. Among them, Eucheuma cottonii (red algae) and Ulva sp. (green algae) contain phenolics, carotenoids, and mycosporine-like amino acids (MAAs) with antioxidant and UV-protective properties. This narrative review aimed to compare the antioxidant and UV-protective activities of E. cottonii and Ulva sp. by analyzing original research articles published between 2015 and 2025. Quantitative data, including IC50 values for antioxidant activity and SPF or UV transmittance for photoprotection, were extracted and evaluated. The results show that extraction methods, solvent polarity, and formulation concentration significantly affect the observed bioactivities. Overall, E. cottonii consistently demonstrated stronger antioxidant capacity and higher UV-protection potential than Ulva sp., likely due to differences in phytochemical composition. These findings highlight the potential of red and green seaweeds as natural active ingredients for safer, eco-friendly, and sustainable sunscreen formulations.

Page 9 of 9 | Total Record : 83

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