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Journal of General Procedural Dermatology and Venereology Indonesia
Published by Universitas Indonesia
ISSN : -     EISSN : 24607991     DOI : https://doi.org/10.19100/jdvi.v1i1.8
Core Subject : Health,
Medicine & Pharmacology
Journal of General-Procedural Dermatology & Venereology Indonesia is an open access and peer-reviewed journal that focuses on dermatology and venereology. This journal publishes original articles, reviews, case reports, and brief communications which contain short features of medicine, current developments in diagnostic procedures, treatments, or other health issues that are relevant and important.
Arjuna Subject : Kedokteran - Dematologi
Articles 11 Documents
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Search results for , issue "Vol. 8, No. 2" : 11 Documents clear
A prospective study in the treatment of androgenic alopecia using combination of procapil, capixyl, redensyl Bansal, Garima; Bansal, Rishi
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
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Background: Androgenic alopecia is characterized by its diffuse loss and the miniaturization of the hair. The study aimed to assess the safety and efficacy of procapil, redensyl, capixyl, bicapil, and anagain in topical hair growth serum in androgenic alopecia. Methods: A prospective study was conducted on 110 healthy subjects aged 18-60 with androgenic alopecia in the Department of Dermatology, Tundla, Etmadhpur. Each subject applied 1 ml of serum on a dry scalp and was followed up on the 4th, 8th, 12th, and 16th week. Mean, median, and standard deviation were calculated. A repeated measure of the ANOVA test followed by post-hoc pairwise comparison using the Bonferroni test was applied. JAMOVI® (Sydney, Australia) software, was used for the statistical analysis. Results: Seventy subjects completed the four follow-ups. Post hoc pair-wise comparison showed that each pair differed significantly, and an increased mean score was observed between the initial and follow-up assessments for the mean Anagen:Telogen (A:T) ratio and mean hair diameter [76.84 μm vs 77.77μm, 76.84μm vs 80.03 μm, 76.84 μm vs 82.33 μm; p<0.05]. A significant difference was found in hair density between baseline and 16th week [76.84 vs 84.60; p=0.002]. No adverse effects were observed. Conclusion: This study's results suggest that after 120 days of treatment with hair serum, it is safe and effective, improving the A:T ratio, hair density, and hair thickness and hence reducing hair fall.
Telogen effluvium incidence in women wearing hijab compared to non-hijab: A cross-sectional study Sirait, Sondang Pandjaitan; Widaty, Sandra; Legiawati, Lili; Surachmiati Suseno, Lis; Krisanti, Roro Inge Ade; Budianti, Windy Keumala; Miranda, Eliza; Rihatmadja, Rahadi; Oktarina, Caroline; Pandelaki, Paulus Anung Anindita; Situmeang, Irhen
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
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Background: Hair loss is a normal experience, but if the amount of hair loss exceeds what is considered normal, it will usually cause anxiety for the patient. In Indonesia, almost every Muslim woman wears a hijab. The hijab is one of many factors believed to cause hair loss. Telogen effluvium (TE) itself is a hair cycle disorder in which the anagen phase terminates prematurely, resulting in diffuse club hair loss without scarring, and TE itself has many risk factors. The purpose of this study was to determine the relationship between the incidence of TE in women who wear hijabs and those who do not. Methods: This cross-sectional study was conducted from August 2019 to April 2021 involving 188 healthy women aged 18 years and over who had not yet reached menopause. In the hijab group, it was determined that they should wear a minimum of 8 hours a day for at least 5 years. The test was carried out on hair that had not been washed using a trichogram, to look for hair characteristics in each group (hijab-wearing and non-hijab-wearing). Analysis of the data obtained was carried out using the Chi-square test and odds ratio. Results: Telogen effluvium was higher in subjects wearing hijab (26.8%) than in subjects who did not wear hijab (18.1%), (p-value 0.040, OR 2.036). Conclusion: There was a significant relationship between TE in women who wear hijab compared to those who do not. Further studies should be conducted in other populations with a larger sample size to confirm these results.
The spectrum of cutaneous manifestations in COVID-19 patients at Dr. Cipto Mangunkusumo Hospital Widaty, Sandra; Menaldi, Sri Linuwih Susetyo Wardhani; Miranda, Eliza; Marissa, Melani; Nilasari, Hanny; Melinda, Thong Felicia; Cornain, Emilina Faradila
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
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Background: Cutaneous manifestations are identified in 0.2%–20% of COVID-19 cases, both in adult and pediatric patients. They can occur before, simultaneously with, or after the systemic symptoms of COVID-19. This study aims to analyze the association between cutaneous manifestations, severity, and outcomes of patients with COVID-19. Methods: This observational study was conducted from April 2020 to April 2021 in Dr. Cipto Mangunkusumo Hospital, a referral center for COVID-19 in Jakarta, Indonesia. Medical records were used to collect demographic, clinical, and laboratory data. Results: A total of 0.61% (31/5070) of COVID-19 cases showed cutaneous manifestations, consisting of maculopapular (80.6%), vesicular (16.1%), livedoid (6.4%), pseudo-chilblain (3.2%), and urticarial (3.2%) lesions, with three patients showing more than one cutaneous manifestation. In the present study, only 2,001 out of 5,070 patients were appropriately confirmed to suffer from COVID-19 infection. Multisystem inflammatory syndrome in children (MIS-C) was identified in one out of eleven patients under 21 years old. Laboratory examinations showed an increased neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), procalcitonin, D-dimer, and creatinine alongside a decreased albumin level. Conclusion: We reported various cutaneous manifestations and diagnostic test results associated with COVID-19. More than one cutaneous manifestations are present in several COVID-19 patients in our study. Several contradictory findings relative to previous publications indicate the necessity of collecting more data regarding the cutaneous manifestation of COVID-19.
Bowen’s disease mimicking lichen simplex chronicus in a 56-year-old Filipino man: A case report Karim, Cynthia Angela; Ryan, Elisabeth; Ugalde, Reynaldo
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
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Background: Bowen's disease (BD) is a chronic skin condition presenting clinically as erythematous plaques with scales on sun-exposed areas. BD is generally regarded as a squamous cell carcinoma (SCC) in situ. In contrast, lichen simplex chronicus (LSC), also known as neurodermatitis, is a chronic skin disorder characterized by extreme pruritus. In LSC, lichenified plaques form primarily on accessible body parts due to repeated scratching or rubbing. Case Illustration: A 56-year-old male presented with a solitary chronic plaque with a central ulcer and erosions on his left upper thigh. Dermoscopy findings were glomerular vessels and a scaly surface, which are typical features of BD. A skin punch biopsy showed numerous atypical keratinocytes with mitotic figures in the epidermis, which is also typical of BD. The patient underwent carbon dioxide (CO2) laser treatment in our institution. Discussion: The natural course of LSC and BD is usually prolonged, and their similarities in clinical presentation require appropriate examination. Dermoscopy findings and histopathology results may help determine the precise diagnosis and appropriate treatment. Conclusion: BD lesions can mimic LSC; therefore, histopathology examination is the gold-standard to establish the diagnosis of BD. Careful and precise examination should be done to distinguish the similarities between LSC and BD.
Non–invasive vulvovaginal rejuvenation: A review Dhillon, Jesryn; Jusuf, Nelva Karmila
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
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Background: Non–invasive vulvovaginal rejuvenation is a promising option for women who want to restore the appearance and function of the vagina. Vaginal atrophy and vulvovaginal laxity are caused by several circumstances, including ageing, menopause, delivery, and others. Until now, non–invasive vulvovaginal rejuvenation has not been medically indicated, but it is estimated to be the focus of cosmetic dermatology in the future. Discussion: Non–invasive vulvovaginal rejuvenation can be divided into two methods: using energy-based devices and injectables. Carbon dioxide, Erbium:YAG laser and radiofrequency are the commonly used energy-based devices. Injectables most frequently used are hyaluronic acid and platelet–rich plasma. Some additional therapies, such as vaginal bleaching and vaginal tightening, are available to complement the available modalities. Several proposed combination treatments might be used to improve treatment outcomes. Side effects and complications reported are mild, but no consensus has approved its long–term effects. The legal aspect is not to be forgotten during the whole procedure. Conclusion: Further multicenter, double–randomized studies are needed to determine these procedures' safety and efficacy.
Systemic antibiotic selection in skin and soft tissue infections Purnawan, Shafira Anindya; Budianti, Windy Keumala; Widaty, Sandra
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
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Background: Antibiotics are used in daily practice. To properly select antibiotics, it is important to pay attention to the definitive diagnosis, class of antibiotic, dose, interval, route of administration, and exact duration of use. Discussion: The World Health Organization (WHO) categorizes antibiotics into three groups: Access, Watch, and Reserve—known as the AWaRe classification—to help guide appropriate usage and combat antibiotic resistance. The Gyssens flowchart serves as a valuable tool for clinicians to qualitatively evaluate antibiotic utilization. In skin and soft tissue infections (SSTIs), treatment strategies are tailored according to the characteristics of the infection, including purulence, necrosis, and overall severity. For mild-to-moderate non-purulent SSTIs, beta-lactam antibiotics, such as penicillin and cephalosporin, alongside lincosamides like clindamycin, are recommended as first-line therapies. In cases of moderate-to-severe non-purulent SSTIs, empirical therapy must account for methicillin-resistant Staphylococcus aureus (MRSA). Meanwhile, purulent SSTIs require an initial incision and drainage, with subsequent treatment options including topical antibiotics for mild cases and systemic antibiotics for more complicated or severe infections. Extensive purulent SSTI in adults is empirically considered MRSA. Conclusion: Control of antimicrobial resistance can be achieved by using antibiotics according to the AWaRe classification and evaluating the use of antibiotics qualitatively using the Gyssens flowchart.
Drug-induced hypersensitivity syndrome with liver injury due to phenytoin: A case report Wijaya, Lorettha; Adevita, Stella; Alvianto, Steven; Christiani, Yoseveline; Cahyadi, Alius; Yolanda, Raesa
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
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Background: Drug-induced hypersensitivity syndrome (DIHS) is a rare and severe systemic drug reaction characterized by skin involvement, internal organ complications, and hematologic disorders. Management of this condition is challenging due to its wide range of cutaneous manifestations and 10% mortality rate. Case Illustration: A 52-year-old male presented with widespread redness throughout his body with a prior history of regular phenytoin consumption. The rash continued to spread despite the patient’s abrupt discontinuation of the suspected medication. He was diagnosed with atypical DIHS according to J-SCAR criteria and was given high-dose corticosteroid. Drastic clinical improvement was observed after nine days of therapy, and complete resolution of the rash was achieved after 14 days. The steroid was stopped after four weeks, and no relapse was observed after four months of follow-up. Discussion: Discontinuing the suspected medication is the first crucial step in DIHS management. No specific pharmaceutical strategy has been established for this syndrome; however, systemic corticosteroids have been frequently prescribed as a first-line therapy. Steroids need to be tapered off slowly over 6–8 weeks, even upon clinical resolution, to prevent relapse. In the current case, the steroid was tapered off slowly over four weeks. The lack of relapse observed after steroid discontinuation could be due to the fact that the patient stopped consuming the suspected medication immediately. Conclusion: Education on the consequences of prescribing high-risk medications is important. Early detection and prompt cessation of offending medications are needed for better DIHS outcomes.
Onycholysis in an elderly woman: Proposal for treatment with Coix seed extract administration Horiuchi, Yasuhiro
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
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Background: The exact etiology of onycholysis, which is characterized by the painless separation of the nail from the nail bed, remains unclear. Currently, there are no established effective treatments for this condition. Coix seed extract (C-S extract), a traditional Chinese medicine, is recognized for its various biological properties. Case Illustration: This report describes a case of onycholysis affecting the left index finger of a 62-year-old female patient, with initial symptoms appearing three months prior. Despite ongoing internal administration of C-S extract, the patient experienced a recurrence of onycholysis on both the index finger and pinky finger of the left hand a few months later. Notably, both the initial occurrence and the relapse were resolved with the use of oral C-S extract. Discussion: C-S extract is commonly utilized in both medicinal and cosmetic application; however, its underlying biological mechanism remain largely unexplored. It has been suggested that the extract may serve as an effective anti-aging agent for the skin. Nonetheless, it is perceived that the potency of C-S extract is relatively limited. Conclusion: Therefore, further scientific evaluation of the biological function of C-S extract is warranted. While it shows promise as an anti-aging agent and has a favorable safety profile, its overall efficacy appears to be moderate.
Comparison of quality of life, anxiety, and depression levels based on acne vulgaris severity Husna, Annisaul; Yenny, Satya Wydya; Desmawati, Desmawati; Akhyar, Gardenia; Masrul, Masrul; Yulistini, Yulistini
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
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Background: Acne vulgaris is a chronic inflammation of the pilosebaceous unit. Although acne vulgaris is not fatal, it can cause psychological effects. This study aimed to compare the quality of life, anxiety, and depression levels based on the severity of acne vulgaris among medical students at Andalas University. Methods: This was an observational-analytic study with a cross-sectional design. It was conducted from May to June 2023. The population included the third-grade students of the Medical Study Program of the Faculty of Medicine, Andalas University, who had acne vulgaris. The respondents were 70 people, recruited with consecutive sampling techniques. This research used Lehmann classifications to classify acne severity, the Cardiff Acne Disability Index (CADI) to assess quality of life, and the Depression Anxiety Stress Scale (DASS-21) to assess anxiety and depression. The statistical analysis used the Kolmogorov-Smirnov test. Results: Most female respondents, aged 20 years old, experienced mild acne vulgaris (84.3%). Additionally, the respondents predominantly had mild quality of life disorders (80%), normal anxiety level (32.9%), and normal depression level (52.9%). The Kolmogorov-Smirnov test found no relationship between the severity of acne vulgaris with quality of life (p = 0.076), anxiety level (p = 0.623), and depression level (p = 0.751). Conclusion: The results showed that most respondents had mild acne vulgaris, mild impairment in quality of life, normal anxiety level, and normal depression level. Statistical tests revealed no significant association between the severity of acne vulgaris and these variables.
Dermoscopy and 30% potassium hydroxide direct examination as diagnostic tools for distal lateral subungual onychomycosis Gaol, Evangelina Lumban; Miranda, Eliza; Sirait, Sondang Pandjaitan
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
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Background: Culture and histopathological examination are gold standards for diagnosing onychomycosis. However, these examinations are subject to several limitations. Dermoscopy has the potential to become a promising diagnostic tool for onychomycosis. Direct examination of potassium hydroxide (KOH) also has advantages similar to dermoscopy. Knowing the accuracy of both examinations can help clinical decision-making. Our objectives are to assess the diagnostic value of dermoscopy, KOH examination, and their combination for distal lateral subungual onychomycosis compared to culture or histopathology. Methods: This was a cross-sectional diagnostic study of nails with suspected distal lateral subungual onychomycosis. Sixty nails were included in this study. Results: The sensitivity and specificity of the KOH examination were 89.6% and 66.7%, respectively. On dermoscopy, the sensitivity of jagged-edge-with-spikes, longitudinal striation, and discoloration were 89.6%, 93.8%, and 97.9%, respectively. Only the aurora borealis dermoscopic feature provided good specificity (91.7%). The positive predictive values of these four dermoscopic features were 75.0%–79.7%. Combination with KOH examination increased the positive predictive value of dermoscopy (90.9%–92.7%). Conclusion: Since they were superior in terms of sensitivity, dermoscopy and KOH examinations are good screening tools to determine which suspected onychomycosis cases need further examination. Additionally, an increased positive predictive value was observed when the two examinations were combined. Hence, these procedures can help establish a diagnosis in settings where mycologic examinations are unavailable.

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