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Journal of Pharmaceutical and Sciences.

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Published by Universitas Tjut Nyak Dhien

ISSN : - EISSN : 26563088 DOI : https://doi.org/10.36490/journal-jps.com

Core Subject : Health, Science, Agriculture, Engineering,

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 47 Documents

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Search results for , issue "JPS Volume 6 Nomor 1 (2023)" : 47 Documents clear

Formulasi Dan Evaluasi Sediaan Lipstik Dari Ekstrak Buah Naga Merah (Hylocereus polyrhizus) Dan Ekstrak Lidah Buaya (Aloe vera) Sebagai Pewarna Dan Pelembab Alami Athaillah Athaillah; Dwi Sundari; Aswan Pangondian; Putra Chandra
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Red dragon fruit (Hylocereus polyrhizus) contains the chemical betacyanin, which functions as a natural dye, and aloe vera (Aloe vera) also has a polysaccharide derivative lignin which functions as a binder of skin moisture. The combination of red dragon fruit extract and aloe vera can be made as a pharmaceutical preparation in the form of lipstick. This study aimed to determine the optimum concentration of red dragon fruit extract and aloe vera on the physical properties of lipstick. This research is an experimental study with the stages of making extracts by maceration method with betacyanin phytochemical test on red dragon fruit and infundation method with a phytochemical test of lignin on aloe vera before making lipstick. Making lipstick with six variations of concentration of red dragon fruit extract 30,25,20,15,10,5% (w/v) and aloe vera 5,10,15,20,25,30% (w/v) and organoleptic test, homogeneity test, pH test, smear test, melting point test, hardness test, irritation test and tested the physical stability of lipstick preparation with a stability test of 3 cycles. The result of maceration on red dragon fruit was 57 ml, and aloe vera infundation was 57 ml. The results of the phytochemical test showed that the red dragon fruit extract was positive for betacyanin and the aloe vera extract was positive for lignin. The formula (F) in this study is concentration. The results showed that the concentration of red dragon fruit extract by an organoleptic test with Formula 1 (F1) to formula 6 (F6) produced good color, smell, and shape. The pH test results of all formulas have a pH below the standard range of skin pH, namely pH 8. The smear test results show that all formulas have good smearing power. The melting point test results show that formula 4 (F4) has a melting point of 66̊ C. The hardness test results showed that Formula 6 (F6) produces a strong textural power. The results of the irritation test showed that all of the formulas did not produce an itchy or swollen effect when applied successively for three days and the results of the stability test showed that formulas 3 (F3) to formula 6 (F6) produced discoloration such as drastic fading and melting texture at the bottom of the preparation happened on day 4 of being at extreme temperatures. The optimum lipstick formulation in the standard range is formula 1 (F1) with a concentration of 30% red dragon fruit and 5% aloe vera, which is quite good and can be formulated as a lipstick preparation.

Analisa Zat Warna Rhodamin B Pada Lipstik Gloss Dan Matte Yang Dijual Dikota Banda Aceh Dengan Metode Kromatografi Lapis Tipis Azmalina Adriani; Rizki Andalia; Rinaldi Rinaldi; Nadhira Ulya
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Cosmetics are a very important need for women, one type of cosmetics that must be owned by women is lipstick. Lipstick is a lip color that has many colors. Rhodamine B is a synthetic dye that is prohibited for use in cosmetics and is declared a dangerous substance. This study aims to identify the presence or absence of Rhodamine B in gloss and matte sold in the city of Banda Aceh using the Thin Layer Chromatography (TLC) method. The population in this study was a sample of lipstick sold in the city of Banda Aceh with a sampling technique using a purposive sampling method. The criteria for lipstick taken from the gloss liquid, homogeneous, sharp smelling, red and purplish pink in color. Whereas matte has a semi-solid and smooth texture, has a purplish pink color and smells of lipstick in general and has a BPOM or not BPOM statement. Observations were made by looking at the stains under a 254 nm UV lamp. The results of this study were that of the eight samples, non-BPOM SS samples tested positive for Rhodamine B, with an Rf of 0.68 which is in line with the standard Rf value. In accordance with the requirements of the Regulation of the Food and Drug Supervisory Agency of the Republic of Indonesia Number 23 of 2019 concerning technical requirements for prohibited dyestuffs in cosmetics.

KOMBINASI VIRGIN COCONUT OIL (VCO) DAN EKSTRAK ETANOL KELOPAK JANTUNG PISANG KEPOK (Musa paradisiaca L.) PADA FORMULASI SEDIAAN POMADE Siti Fatimah Hanum; Pebry Nursanti Sihombing; Evi Ekayanti Ginting; Fahma Shufyani; Jefri Naldi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Background; Pomade is an oily or waxy substance used for hairstyles. The pomade looks shiny, smooth and not dry. The properties of pomade make hairstyles look neater, while long-lasting moisturizing properties are popular with textured individuals. Method; This research was carried out experimentally, including the manufacture of ethanol extract of the banana flower petals of Kepok (Musa paradisiaca L.) using the maceration method of a combination of VCO (Virgin Coconut Oil) oil with the fishing method as a pomade preparation, with a concentration of 2%, 4%, 6%. Physical quality examination, namely organoleptic test, pH, homogeneity, stability, spreadability, irritation based on SNI 16-4955-1998, and effectiveness test using volunteers. Results; In this study, it was found that preparations that showed or showed good orgnoleptic at a concentration of 2%, 4%, 6%, fulfilled the homogeneity requirements at a concentration of 2%, 4%, 6%, good dispersion at a concentration of 4%, the irritation test did not irritate. skin, pH test has a pH value according to the pH value of pomade, good stability aimed at a concentration of 2% for 14 days. The results of the effectiveness test of pomade preparations concentrations of 2%, 4%, 6% obtained effective results at 5 hours of use compared to those on days 1, 2, 3.Use 5 hours with the category of tidy 100%, durable 66.67%, no durable 33.33%, and easy 100% of 9 volunteers. Conclusion; From this research, the ethanol extract of Kepok banana flower petals with a combination of VCO (Virgin Coconut Oil) can be formulated into pomade preparations and the stable formula is one that contains ethanol extract of Kepok banana flower petals with a 2% concentration of VCO (Virgin Coconut Oil).

Pemeriksaan Hemoglobin Pada Petugas SPBU Di Daerah Glugur Rimbun Kabupaten Deli Serdang Tahun 2021 Radina YM Ginting; Yuspita Wahyu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Gas station workers are one of the workers who have a high risk of exposure to toxic substances that are exposed to fuel because every day they work in a place related to motorized vehicles, exposure to gases which, if inhaled, enter the human body in high levels, can inhibit the formation process. hemoglobin. Hemoglobin is a protein molecule in red blood cells that functions as a medium for transporting oxygen from the lungs throughout the body and carrying carbon dioxide from the body's tissues to the lungs. When hemoglobin is reduced, the body will become tired, lethargic, drowsy, and lose concentration more quickly. Hemoglobin that is too low can cause a disease known as Anemia. The purpose of this study was to determine hemoglobin levels in gas station attendants. This research was conducted using the blood cyanmethemoglobin method using Drabkins reagent. The population of this study were gas station attendants in the Glugur Rimbun area, Deli Serdang Regency with a sample of 14. This research was conducted at the North Sumatra Regional Health Laboratory. The results of this study showed that 21% had below normal Hb values.

Uji Aktivitas Antidiabetes Fraksi Etil Asetat Daun Seledri (Apium graveolens L.) Terhadap Tikus Jantan Wistar (Rattus norvegicus) Rena Meutia; Novitaria br Sembiring; Octavian Ashido Nababan; Nerly Simanjuntak; Erida Novriani; Nurasni Nurasni
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

The high population of diabetic patients every year is increasing, with the number of diabetic patients increasing by 463,000 in 2019. Estimates of Idiabetic foot in 2045 the number of the diabetic patient will be 700.000.000 patients. Celery leaves are used as an anti-diabetic (Apium graveolens L.). This study aimed to determine the anti-diabetic activity of the ethyl acetate fraction in celery leaves against male Wistar rats. Celery leaf Simplicia powder was extracted with 70% ethanol solvent in the maceration method. After obtaining 70% ethanol extract, then fractionation of n-hexane, ethanol-water, and ethyl acetate was carried out. The anti-diabetic test of the ethyl acetate fraction on celery leaves used the compound alloxan at a dose of 150 mg/kg BW. This study obtained the results of the ethyl acetate fraction in celery leaves at a dose of 300 mg/kg, which had the highest anti-diabetic activity with a reduction percentage of 65% compared to the positive control with a reduction percentage of 64%. The contents of chemical compounds from the ethyl acetate fraction in celery leaves are alkaloids, flavonoids and saponins.

Review : Potensi Yoghurt Sinbiotik Kombinasi Rempah Sebagai Suplementasi Probiotik Dan Antioksidan Berbasis Nutrasetikal Bahan Alam Dari Lontar Usadha Taru Pramana Sebagai Kearifan Pengobatan Lokal Bali Ameilia Ameilia; I Gede Bayu Somantara; Aliya Nur Hasanah
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Along with the development of COVID-19 cases, health maintenance efforts to maintain and increase endurance are significant. Healthy living efforts that need to be implemented are by regulating the intake of nutritional supplementation of both macronutrients and micronutrients. One type of nutraceutical food with complex nutrients that has the potential to be used as a nutraceutical for supplementation efforts is yogurt. Traditionally, yogurt is also mentioned in the Balinese medical wisdom, namely, Usadha. In Usadha, yogurt combines ingredients found in Lontar Usadha Taru Pramana (Usadha, which contains various medicinal plants). The method used to compile this article is a systematic review literature study. Relevant information was collected from Google Scholar, Science Direct, ProQuest, Pubmed, and EBSCO. Scopus, Sinta, or Garuda-indexed articles published in the last five years were selected. Based on the literature search, it is known that the addition of each turmeric, ginger, secang, and cinnamon extract to yogurt can improve the physicochemical quality and nutritional content of the yogurt, especially antioxidants, thus contributing to health maintenance and being able to maintain the probiotic stability of yogurt. The combination of spiced yogurt with ginger, turmeric, secang wood, and cinnamon rhizomes can be used as probiotic-antioxidant supplementation to support a healthy lifestyle related to maintaining the immune system.

Pengaruh fermentasi tepung kulit kopi Oleh Aspergillus oryzae dengan penambahan dua variasi konsentrasi urea dan amonium sulfat terhadap penurunan serat kasar salman salman; Kurniawan Sinaga; Meutia Indriana; Yessi Febriani; Zulfikar Zulfikar
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

The high yield of coffee causes an increase in the amount of coffee husk waste produced, so innovations are needed to process coffee waste so that it can be helpful and not wasted. The study aimed to reduce crude fiber in fermented coffee husks using Aspergillus oryzae to become animal feed. The research was conducted using experimental and descriptive methods: coffee husk flour (Coffea sp.), Aspergillus oryzae, urea, ammonium sulfate, and minerals. Coffee husk flour was fermented in dry media and wet media at room temperature for 24 hours, 48 hours, and 72 hours. After fermentation, test the analysis of the decrease in the amount of crude fiber in the sample using the Wendee method test. The results showed that the fermentation of coffee husk flour (Coffea sp.) using Aspergillus oryzae with the addition of urea, ammonium sulfate, and minerals could reduce the amount of crude fiber. The difference in fermentation media showed that fermentation in wet media gave better crude fiber reduction results than fermentation in dry media. The crude fiber yield of dry media sample N1 is 0.25 grams (25%), and sample N2 is 0.22 grams (22%), while the crude fiber yield of wet media sample N1 is 0.13 grams (13%) and sample N2 is 0.11 grams (11%). Fermentation with Aspergillus oryzae produces ligninase, an enzyme that breaks down lignin which can degrade lignin into simpler compounds.

Studi Aktivitas Antibakteri Ekstrak Etanol Daun Stroberi (Fragaria x ananassa (Weston) Rozier) Terhadap Bakteri Propionibacterium acnes Mandike Ginting; Pricella Ginting; Sinta Apriliana Sari
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Background; Strawberry leaves (Fragaria x ananassa (Westo) Rozier) contain tannin, flavonoids; secondary metabolites which have antibacterial properties, whereby the flavonoids can disrupt the function of the bacterial cell wall, while the tannins can inhibit microbial extracellular enzymes. Method; Experimental research with the maceration method using 70% ethanol. The ethanol extract of strawberry leaves (Fragaria x ananassa (Weston) Rozier) was used in this study, and it was tested for the simple characteristic test, the phytochemical screening test, and the antibacterial activity test using the disc diffusion method with sample concentrations of 10%, 12%, and 14%. Results; The results obtained from the simplicial characteristic test showed that the simplicial met the requirements for the water content test, water-soluble essence test, ethanol-soluble extract content test, total ash content test, and acid-soluble ash content test. The phytochemical screening showed that strawberry leaves contained alkaloids, flavonoids, tannins, and saponins. The antibacterial activity test showed that the ethanol extract of strawberry leaves (Fragaria x ananassa (Weston) Rozier) had an inhibitory effect on the growth of Propionibacterium acnes bacteria with an extract concentration of 10%, 12%, and 14% showing a diameter of inhibition zone of 17.3 mm respectively, 17.78 mm and 19.08 mm. Conclusion; The results of the research on the optimal concentration of the ethanol extract of Strawberry leaves (Fragaria x ananassa (Weston) Rozier) against Propionibacterium acnes bacteria at a concentration of 14% resulted in a diameter of 19.08 mm inhibition zone, this antibacterial activity is in a strong category.

Review Artikel : Pelaksanaan Telefarmasi Pada Pelayanan Kefarmasian Di Farmasi Komunitas Firda Riska Rahayu; Iqbal Sujida Ramadhan; Rini Hendriani
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

During the 21st of century, the use of information technology and telecommunications is proliferating, including in the healthcare sector. One of the health services is telepharmacy. Telepharmacy is a relatively new concept, so research is needed to optimize the application of telepharmaceuticals. Based on that, this article explains the implementation of telepharmacy in various countries and the advantages and limitations of telepharmacy. The methods were carried out by searching electronically through Google scholar, Pubmed, ScienceDirect, and NCBI. A total of 24 journals and three regulations fulfilled the inclusion criteria. This review shows that telepharmacy has been carried out in many countries, such as in Asia, Europe, America and Africa. The form of implementation is different by each country, for example, through a platform, video conferencing, chat messenger and telephone. In addition, to the advantages, several challenges involve cooperation between patients, the government and private sectors, as well as academic institutions, which is essential for achieving appropriate results and effectively improving health services.

Review: Penggunaan Off-Label Obat Golongan Antagonis Reseptor Histamin 2 Indah Sari; Ellin Febrina
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Histamine 2 (H2) receptor antagonist drugs have been widely used for a wide range of indications, including for use as off-label drugs. Even though it can potentially increase the risk of adverse drug reactions, under certain conditions, using off-label drugs is the only option for medical personnel. This review aims to provide an overview of the widespread off-label use of H2 receptor antagonists, including ranitidine, cimetidine, famotidine, and nizatidine. The results of this review are expected to be used as evaluation material by the government, drug manufacturers, and health practitioners. The method used in this review is a study of literature obtained through several services, such as PubMed®, ScienceDirect®, and Google Scholar. The results of this review show that using off-label H2 receptor antagonist drugs is a curative and preventive effort to overcome several diseases, namely off-label in the categories of patient age, dosage, and indications.

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Home Page

OAI Link

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Journal Mail Official admin@journal-jps.com

Editorial Address Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123

Location Kota medan, Sumatera utara INDONESIA

Abstract

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Contact Name
Salman

Contact Email
salman.kimia@gmail.com

Phone
+6285277011177

Journal Mail Official
admin@journal-jps.com

Editorial Address
Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123

Location
Kota medan,

Sumatera utara

INDONESIA