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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 55 Documents
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Search results for , issue "JPS Volume 8 Nomor 1 (2025)" : 55 Documents clear
Studi pemanfaatan ekstrak kulit batang jamblang (Syzygium cumini L.) sebagai alternatif pewarna rambut berbasis herbal Muzakkir , Muzakkir; Sembiring, Fanny Rizki; Indriana , Meutia; Salman, Salman
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.795

Abstract

Hair dye is a cosmetic product used to restore or alter hair colour. Research on herbal-based hair dyes has expanded with the growing interest in natural ingredients. The bark of the jamblang tree (Syzygium cumini L.), which produces a black pigment, has long been utilised in various crafts. This potential makes it a candidate for natural hair dye. This study examines the use of ethanol extract from jamblang bark in the formulation of herbal hair dye and its effectiveness in producing a black colour. The research aims to investigate the utilization of ethanol extract from jamblang bark (Syzygium cumini L.) as an herbal hair dye. The focus is on evaluating the extract's effectiveness in a formulation with pyrogallol, copper (II) sulfate, and xanthan gum, as well as determining the optimal concentration to achieve black hair colour. The method for preparing the hair dye formulation involved the use of ethanol extract from jamblang bark in varying concentrations of 5%, 7.5%, 9.5%, and 11.5%, with the addition of 2% each of pyrogallol, copper (II) sulfate, and xanthan gum. Distilled water was used as the solvent. The dyeing process was conducted by immersing 200 strands of grey hair in preparation for 4 hours, followed by visual observation of colour changes. Colour stability was tested through 15 wash cycles and exposure to sunlight for 5 hours. An irritation test was also conducted on volunteers to evaluate the safety of the hair dye preparation. The study's results indicate that increasing the concentration of ethanol extract from jamblang bark affects the effectiveness of hair dyeing. The optimal formulation was achieved at a 7.5% extract concentration with the addition of 2% pyrogallol, 2% copper (II) sulfate, and 2% xanthan gum, which resulted in black colour. Stability tests showed that the colour remained unchanged after 15 wash cycles and 5 hours of sunlight exposure. Furthermore, the irritation test on volunteers demonstrated that the preparation did not cause skin irritation reactions. Thus, the ethanol extract of jamblang bark has the potential to serve as a safe natural hair dye, offering good colour stability and effectiveness in darkening grey hair.
Penetapan kadar flavonoid total dan aktivitas antioksidan ekstrak etanol, fraksi n-heksan, etil asetat daun senggani (Melastoma candidum D.Don) secara spektrofotometri visibel Apmarja, Sarah Utami; Nasution, Muhammad Amin; Nasution , Haris Munandar; Yuniarti , Rafita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.797

Abstract

Medicinal plants are natural sources that have antioxidant activity, characterized by the content of phenolic and flavonoid components in reducing free radicals which depends on the number of hydroxyl groups in their molecular structure. One of the plants that contain flavonoid compounds which have antioxidant activity is senggani leaves (Melastoma candidum D.Don). This research aimed to determine the chemical compounds contained in the ethanol extract, to determine the total flavonoid value of the ethanol extract, the ethyl acetate fraction and the n-hexane fraction and to determine the antioxidant activity of the ethanol extract, the ethyl acetate fraction and n-hexane fraction. The stages of this research include processing plant materials, making ethanol extract, making ethyl acetate fraction and n-hexane fraction, characterization examination, phytochemical screening, and determining the total flavonoid content of ethanol extract, ethyl acetate fraction and n-hexane fraction of senggani leaves using Visible and Spectrophotometric methods. Determination of the antioxidant activity of ethanol extract, ethyl acetate fraction, and n-hexane fraction using different techniques, namely DPPH with ABTS. The results of phytochemical screening on simplicia powder and ethanol extract contained chemical compound groups such as alkaloids, flavonoids, saponins, tannins, steroids/triterpenoids, and glycosides. The results of determining the total flavonoid content in the ethanol extract of senggani leaves were 44.7805 ± 0.176606439 mgQE/g; In the ethyl acetate fraction, it was 48.421 ± 0 mgQE/g, and in the n-hexane fraction it was 31.491 ± 0.091844121 mgQE/g. The results of antioxidant activity using the DPPH method obtained an IC₅₀ value for the ethanol extract of 12.51 (μg/ml); in the ethyl acetate fraction of 9.42 (μg/ml); in the n-hexane fraction, it was 40.45 (μg/ml), and in the vitamin C standard it was 4.32 (μg/ml). Antioxidant results using the ABTS method obtained an IC₅₀ value for the ethanol extract of 8.21(μg/ml); in the ethyl acetate fraction of 5.93(μg/ml); in the n-hexane fraction, it was 23.35(μg/ml), and in the vitamin C odor it was 2.65(μg/ml).
Penetapan kadar flavonoid ekstrak metanol kulit kayu raru (Cotylelobium lanceolatum Craib) pada variasi konsentrasi pelarut menggunakan metode spektrofotometri UV-Vis Nasution, Kartika Zsaskia; Daulay, Anny Sartika; Ridwanto, Ridwanto; Nasution, Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.724

Abstract

The use of plant-based traditional medicine remains a common practice in developing countries, with more than 80% of the population relying on it for healthcare and treatment. In Indonesia, natural medicines continue to be a primary choice for public health, aligning with local traditions and cultural practices. One such medicinal plant is raru bark, which possesses various pharmacological activities, including antidiabetic, astringent, antilaxative, antibacterial, antiseptic, antidiarrheal, and blood-clotting properties. This study aims to characterize the methanol extract of raru bark and determine its flavonoid content using UV-Vis spectrophotometry. The research stages included plant material processing, methanol extraction, characterization tests, macroscopic and microscopic examinations, phytochemical screening, and flavonoid quantification. Phytochemical analysis revealed that the methanol extract of raru bark contains flavonoids, tannins, saponins, and triterpenoids. Characterization tests showed that all evaluated parameters met the required standards. Flavonoid quantification was performed by determining the maximum wavelength of quercetin using UV-Vis spectrophotometry at different solvent concentrations. The results indicated that the total flavonoid content at a 96% solvent concentration was 1.625 ± 0.153 mgQE/g, at 70% was 1.318 ± 0.003 mgQE/g, and at 50% was 1.146 ± 0.006 mgQE/g.
Analisa Waktu Tunggu Dalam Pelayanan Resep pada Pasien Rawat Jalan di Instalasi Farmasi RSUD dr. Hadrianus Sinaga Pangururan Tahun 2023 Dewi Ginting, Fitri; Manurung, Kesaktian; E Sitorus, Mido; Nababan, Donal; Lina Tarigan, Frida
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.780

Abstract

Quality of health services is one approach or effort that is fundamental in providing health services to patients. As a professional person in the field of health services, both individually and in groups, you must always try to provide good quality health services to all patients, Without exception. One of the most essential parts of a hospital is the pharmacy installation. Pharmacy installations are an inseparable part of a complete hospital health service system. The pharmacy installation is responsible for procuring and presenting drug information to all parties in the hospital and developing extensive and well-coordinated pharmaceutical services to meet and provide good service to patients. Servicing old prescriptions to outpatients in the pharmacy installation can cause patient dissatisfaction, impacting the quality of service and hospital. This makes researchers interested in analyzing the waiting time in prescription services for outpatients in the pharmacy installation at RSUD dr. Hadrianus Sinaga Pangururan in 2023. Research Focus on Waiting Times for Prescription Services for Outpatients at the Pharmacy Installation at RSUD dr. Hadrianus Sinaga Pangururan in 2023. The research subfocus is: What is the flow of patient prescription services, what causes the lengthening of waiting times for patient prescription services, and what is the impact of extending waiting times for outpatient prescription services at the pharmacy installation at RSUD Dr. Hadrianus Sinaga Pangururan? Type of Research: This research is survey research using a qualitative approach and an in-depth interview method. Research Location: This research was carried out at RSUD dr. Hadrianus Sinaga Pangururan. Based on the research results on analyzing waiting times for outpatient services at the pharmacy installation at RSU dr. Hadrianus Sinaga In 2023, the results can be taken: The lengthening of waiting times that occurs in Outpatient Pharmacy Installations due to the availability of medicines that often happen in vacancies. The extended waiting time occurs in the Outpatient Pharmacy Installation because writing labels takes a long time. The extended waiting time at the Outpatient Pharmacy Installation is due to taking one month's prescription, which must go through the verification stage. The impact of extending the waiting time in the Outpatient Pharmacy Installation is that patients' dissatisfaction is indicated by protesting and getting angry. The effect of lengthening waiting times in Outpatient Pharmacy Installations due to the unavailability of medicines causes patient management to be hampered.
Evaluasi Hubungan Kualitas Pelayanan Kesehatan Terhadap Kepuasan Pasien di Instalasi Rawat Jalan Rumah Sakit Umum Daerah Tarutung Tahun 2023 Hutabarat, Andrian; Manurung, Kesaktian; Lina Tarigan, Frida; Nababan, Donal; Sipayung, Rosetty
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.781

Abstract

This study aims to evaluate the relationship between the quality of healthcare services and patient satisfaction at the Outpatient Installation of Tarutung Regional General Hospital in 2023. The research employed a cross-sectional design, focusing on five dimensions of service quality: tangible (facilities), reliability, responsiveness, assurance (quality assurance), and empathy. Data were collected through questionnaires administered to 96 outpatients from September 2023 to February 2024. The results indicate excellent overall service quality at the Outpatient Installation of Tarutung Regional General Hospital. However, certain dimensions require improvement, such as responsiveness (10.5% rated as poor), assurance (6.10%), tangible (6.30%), empathy (5.20%), and reliability (9.40%). While 72.9% of patients expressed satisfaction, 27.1% reported dissatisfaction. Statistical analysis revealed a significant relationship between healthcare service quality and patient satisfaction (p < 0.05). These findings underscore the importance of enhancing service quality, particularly in the underperforming dimensions, to improve patient satisfaction. This study provides practical contributions for hospital management in designing strategies to improve the quality of service.
Konsentrasi hambat minimum dan konsentrasi bunuh minimum ekstrak etanol dan nanopartikel ekstrak etanol daun matoa (Pometia pinnata) terhadap Cutibacterium acnes Safira , Liyuza; Rahayu, Yayuk Putri; Nasution , Haris Munandar; Miswanda, Dikki
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.786

Abstract

Infectious diseases are caused by the entry and proliferation of microorganisms, including bacteria, fungi, parasites, and viruses. These diseases occur when microbial interactions lead to host tissue damage, resulting in various clinical symptoms and signs. This study aimed to formulate nanoparticles of ethanol extract from matoa leaves and compare the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values, as well as evaluate the antibacterial activity of both the extract and its nanoparticles against Cutibacterium acnes. This research was conducted experimentally. The independent variables were the concentrations of matoa leaf extract (6.25%, 12.5%, 25%, and 50%) and matoa leaf extract nanoparticles (0.625%, 1.25%, 2.5%, and 5%). The dependent variable was the antibacterial activity of both formulations against Escherichia coli and Cutibacterium acnes. Nanoparticle size characterization was performed using a Particle Size Analyzer (PSA), yielding an average size of 528.95 nm. The MIC values for C. acnes were 12.5% for the extract and 1.25% for the nanoparticles, while the MBC values were 50% and 5%, respectively. The highest antibacterial activity of matoa leaf ethanol extract against C. acnes was observed at a concentration of 50% (inhibition zone: 27.86 mm), whereas the nanoparticles exhibited a maximum inhibition zone of 26.53 mm at a 5% concentration. These findings indicate that matoa leaf extract nanoparticles exhibit strong antibacterial activity against C. acnes at lower concentrations compared to the crude extract, suggesting their potential as an effective antibacterial agent. 
Uji aktivitas antioksidan dan toksisitas dari ekstrak kayu kuning (Arcangelisia flava (L.Merr)) Shilvia, Fatin; Daulay, Anny Sartika; Ridwanto, Ridwanto; Rahayu, Yayuk Putri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.776

Abstract

Currently, people are beginning to shift towards traditional medicine using natural ingredients. One of the medicinal plants is Yellow Wood (Arcangelisia flava (L.) Merr). Yellow wood has been proven to have antioxidant, antimalarial, antidepressant, antidiabetic, and anticancer activities. The purpose of this study is to determine the antioxidant activity of yellow wood by analyzing its IC50 value and to evaluate the toxicity of yellow wood extract by determining its LC50 value. In this study, the antioxidant activity of the extract was tested using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method, while the toxicity of yellow wood extract was assessed using the brine shrimp lethality test (BSLT) method with several concentration variants. The analysis of antioxidant activity in yellow wood using the 1,1-diphenyl-2-picrylhydrazyl method resulted in an IC50 value of 9.65 µg/ml, while vitamin C had an IC50 value of 3.96 µg/ml. Based on these results, both yellow wood and vitamin C fall into the category of very strong antioxidant activity. The probit analysis of the toxicity test of yellow wood extract using the brine shrimp lethality test method showed an LC50 value of 287.872 µg/ml, which is categorized as toxic.
Analisis Kepatuhan Pengguanaan Obat Tuberkulosis Pada Penderita TB Paru Di UPT RS Paru Sumatera Utara Tahun 2023 Tinambunan, Sarma; Manurung, Kesaktian; Sipayung, Rosetty; Nababan, Donal; Gultom, Rumondang
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.782

Abstract

Pulmonary tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a pressing global health issue, with high incidence and mortality rates. Treatment adherence is a key factor in the success of TB therapy. This study analyzes the factors influencing adherence to TB medication among pulmonary TB patients at UPT Lung Hospital of North Sumatra. The study employed a cross-sectional design with an analytical survey approach. The research sample consisted of 120 pulmonary TB patients undergoing treatment. Data were collected through questionnaires, medical records, and secondary sources and analyzed using the Chi-Square test and logistic regression. The results showed that education level (p-value = 0.03), employment status (p-value = 0.03), knowledge level (p-value = 0.00), and family support (p-value = 0.05) had a significant relationship with adherence to TB medication. Meanwhile, age (p-value = 0.91) and gender (p-value = 0.59) did not show a meaningful relationship. Multivariate analysis identified knowledge and family support as the dominant factors influencing adherence. These findings suggest that education-based interventions and enhanced family support can improve TB treatment adherence. This study recommends developing public health programs to empower patients and their families in TB control efforts.
Determinan Kepatuhan Minum Obat Tuberkulosis Di UPT Puskesmas Garoga Kecamatan Garoga Kabupaten Tapanuli Utara Tahun 2023 Hutauruk, Ricardo; Manurung, Kesaktian; Hutajulu, Johansen; Nababan, Donal; E Sitorus, Mido
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.783

Abstract

Tuberculosis (TB) is a highly infectious disease caused by Mycobacterium tuberculosis, primarily affecting the lungs and transmitted through airborne droplets. As a global health concern, TB requires long-term treatment adherence to ensure successful outcomes. This study aimed to identify determinants of medication compliance among TB patients at the UPT Garoga Community Health Center, North Tapanuli Regency, in 2023. Using a cross-sectional design, data were collected from 42 patients through interviews and medical records. Variables analyzed included age, gender, education, occupation, knowledge, the role of health workers, and medication supervisors (PMO). Univariate, bivariate, and multivariate analyses were conducted to assess relationships between these factors and medication compliance. Results indicated significant associations between compliance and age (p = 0.001), gender (p = 0.006), education (p = 0.001), knowledge (p = 0.002), the role of health workers (p = 0.001), and PMO support (p = 0.002). However, no significant relationship was found between occupation and compliance (p = 0.036). These findings highlight the importance of patient education, health worker involvement, and family support in improving TB treatment adherence. The study underscores the need for targeted interventions to address these determinants and enhance treatment outcomes in TB patients.
Faktor-Faktor Yang Mempengaruhi Kejadian Stunting Di Upt Puskesmas Lumban Sinaga Kecamatan Pangaribuan Kabupaten Tapanuli Utara Tahun 2023 Pakpahan, Leonardo; Manurung, Kesaktian; E Sitorus, Mido; Ketaren, Otniel; Lina Tarigan, Frida
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.784

Abstract

Stunting is one of the chronic nutritional problems that remains a global concern, especially in developing countries such as Indonesia. This study aims to identify factors associated with the incidence of stunting in the Puskesmas Lumban Sinaga Pangaribuan District, North Tapanuli Regency. This study is an onservational analytic study with a Case Control approach. This research was conducted from October 2023 to February 2024. The sample in this study were all mothers who had stunting toddlers as many as 75 cases(total population) control samples as many as 75 toddlers who did not suffer from stunting. Data collection using questionnaires and analyzed using logistic regression tests. The results showed that exclusive breastfeeding history (p 0.000), family income (p 0.013), maternal education (p 0.007), parity (0.000) and maternal height (p 0.000) had a significant relationship with the incidence of stunting. It is concluded that the factors associated with the incidence of stunting at the Lumban Sinaga Health Center are exclusive breastfeeding history, family income, maternal education, parity and maternal height with the dominant factor being maternal height. It is recommended for mothers to provide exclusive breastfeeding to babies for the first 6 months of life and continue breastfeeding with complementary foods until the age of 2 years to meet nutritional and immunity needs that are important for optimal growth.

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