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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Dapagliflozin pada Gagal Jantung dengan Fraksi Ejeksi Rendah (HFrEF): Tinjauan Sistematis Mekanisme dan Efektivitas Klinis Karmawan, Zalfa Nadia Prasasti; Simorangkir, Rahel Lambok Yohana; Kalalo, Jef Gishard Kristo
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1121

Abstract

Background: Heart failure with reduced ejection fraction (HFrEF) is a serious condition associated with high morbidity and mortality. Dapagliflozin has demonstrated cardioprotective effects in patients with HFrEF. Objective: This review explores the mechanisms underlying the clinical benefits of dapagliflozin and summarizes current evidence from the DAPA-HF trial and its sub-analyses regarding its effectiveness in patients with HFrEF. Methods: Relevant literature was systematically searched in PubMed, Google Scholar, and Scopus. Eligible studies were analyzed using a narrative approach to summarize the drug’s mechanisms of action and clinical outcomes. Results: Dapagliflozin improves cardiac energy efficiency, stimulates erythropoiesis, reduces myocardial fibrosis, and lowers oxidative stress and NT-proBNP levels. Clinically, 10 mg/day therapy reduces heart failure hospitalizations and cardiovascular mortality by 26% (HR: 0.74), with recently hospitalized patients experiencing benefits up to 49% (HR: 0.51), consistent across subpopulations and providing added advantages to standard therapy. Conclusion: Dapagliflozin serves as an effective adjunct therapy for HFrEF, offering rapid and sustained benefits, reducing morbidity and mortality, and improving patients’ quality of life. Further research is warranted to expand its clinical application.
Drug Related Problems (DRPs) pada Pasien Mata Rawat Inap: Kajian Potong Lintang Retrospektif selama Dua Tahun Utaminingsih, Esthi; Oktasari, Solikhah Rosvita; Cholisoh, Zakky
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1123

Abstract

Drug-related problems (DRPs) in ophthalmic inpatients may compromise the effectiveness and safety of therapy. This study aimed to identify the characteristics of DRPs among inpatients with eye diseases at Hospital X Tangerang during September 2022–August 2024. A retrospective cross-sectional design was applied, involving 178 patients who met the inclusion criteria. DRPs were identified using the Pharmaceutical Care Network Europe (PCNE) classification version 9.1 through review of prescriptions, clinical data, and medication records. Descriptive analysis were used to determine the DRP occurrence. Results showed that most patients were aged 18–60 years (71.9%), female (55.1%), without comorbidities (82.0%), and received an average of 5 medications during hospitalization. Four DRP cases (2.2%) were identified, consisting of one case of treatment effectiveness (P1.2) 25% and three cases of drug safety problems (P2.1) 75%. The main causes were contraindicated drug use despite guideline adherence (C1.2) 50%, inappropriate drug combinations (C1.4) 25%, and patient non-adherence (C7.1) 25%. The low DRP incidence was likely related to the short hospitalization duration and the predominance of topical therapy with minimal systemic exposure. These findings highlight the important role of clinical pharmacists in therapy monitoring to prevent DRPs in ophthalmic inpatients.
Intervensi Apoteker Dalam Edukasi dan Pengelolaan Pada Obesitas Sebagai Faktor Risiko Diabetes Mellitus Tipe 2: Tinjauan Literatur Simorangkir, Rahel Lambok Yohana; Karmawan, Zalfa Nadia Prasasti; Kalalo, Jef Gishard Kristo
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1124

Abstract

Obesity is one of the major modifiable risk factors contributing to the rising prevalence of type 2 diabetes mellitus (T2DM). Pharmacists play an essential role in health promotion and preventive care through patient education and lifestyle counseling. This review aims to summarize and critically evaluate pharmacist-led interventions in obesity management as an effort to prevent T2DM. Literature searches were conducted using Google Scholar and PubMed with the keywords “pharmacist,” “obesity,” “type 2 diabetes,” and “lifestyle modification.” From the search results, ten international intervention studies published within the last ten years met the inclusion criteria and were analyzed in detail. Findings indicate that pharmacist interventions, such as structured education, medication optimization, motivational counseling, and clinical monitoring, significantly improved weight reduction, body mass index, HbA1c levels, and adherence to healthy behaviors. Pharmacists also play a key role in deprescribing, monitoring metabolic outcomes, and supporting patient self-management. Overall, pharmacist involvement in obesity prevention and T2DM control demonstrates measurable clinical benefits and has strong potential to be adapted into national healthcare systems.
Uji Aktivitas Antidiabetes Kombinasi Esktrak Daun Kelor (Moringa oleifera L.) dan Daun Jambu Biji (Psidium guajava) Pada Tikus Putih Jantan Galur Wistar Wahyuni, Arifah Sri; Haryati, Resti Dwi; Fadhilah , Arini
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1135

Abstract

Purpose: to test whether the combination of Moringa oleifera L. and guava (Psidium guajava) leaf extract has a better effect in reducing blood glucose levels compared to single extracts. Method: an experiment with a pre- and post-test with control group design. The samples were Moringa leaves, guava leaves with 30 Wistar rats divided into 6 groups. Normal control group, negative control group (Na CMC 1%), positive control group (glibenclamide 5 mg/kgBW), Moringa leaf extract group dose 100 mg/kgBW, guava leaf extract group dose 105 mg/kgBW, and a combination group of Moringa leaf extract with guava leaves. Data analysis used a computerized program using the Welch ANOVA and Post Hoc Games-Howell tests. Results: showed that all treatment groups significantly reduced blood glucose levels compared to negative controls (p<0.05), but the effect was not comparable to positive controls and was not significant with normal controls on day 21. The combination of EEDK and EEDJB did not provide a better effect than the single extract. Conclusion: This study shows that the single extract and the combination of moringa leaf and guava leaf extracts have antidiabetic activity, but the combination of moringa leaf and guava leaf extracts did not show a better effect.
Optimasi Formula Gel Fraksi Teraktif Buah Mengkudu (Morinda citrifolia L.) Sebagai Antioksidan Topikal Sari, Erlinda Novita; Purwidyaningrum, Ika; Iswandi, Iswandi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1141

Abstract

Introduction: Flavonoid compounds and vitamin C from noni fruit have the potential to be antioxidants. The unpleasant odor, soft texture, and unpleasant taste of noni fruit are minimized through a fractionation process and formulated into a gel preparation, which is expected to increase the acceptance of noni fruit in the community. Objective: to determine the optimal gel formula of the most active fraction of noni fruit with variations of HPMC, carbopol 940, and propylene glycol through critical parameters of viscosity, pH, and antioxidant activity using the Simplex Lattice Design method. Method: The extraction used is maceration and continued with a fractionation process. Physical properties tests include organoleptic, homogeneity, viscosity, adhesiveness, spreadability, and pH. Determination of the IC50 value of antioxidants with DPPH using a UV-Vis spectrophotometer. The statistical results of the data obtained were processed using ANOVA, Wilcoxon, and the T-test. Results: showed that the noni fruit fraction that had the best antioxidant activity was the ethyl acetate fraction (20.35±0.18 ppm), variations of 13 gel formula compositions with the most optimal viscosity, pH, and IC50 responses were carbopol 940:HPMC 8060-M: propylene glycol (1.491:0.509:8.000). Variations in the combination of HPMC 8060-M, carbopol 940, and propylene glycol in the gel preparation of the most active noni fruit fraction affected the critical parameters of viscosity, pH, and antioxidant activity. Conclusion: The ethyl acetate fraction has the best antioxidant activity and the optimal gel formula composition is carbopol 940:HPMC 8060-M:propylene glycol (1.491:0.509:8.000) which is predicted to have a very high desirability value (0.917) and has been validated.
Determinan Pemilihan Metode Kontrasepsi Vasektomi Pada Pria di Wilayah Kerja Puskesmas Buhit Kecamatan Pangururan Kabupaten Samosir 2024 Sihaloho , Lasmauli; Manurung, Kesaktian; Sipayung , Rosetty; Sinaga , Taruli Rohana; Hutajulu , Johansen
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1163

Abstract

Introduction: High population growth rates impact development, necessitating restrictive policies through Long-Term Contraceptive Method (LTCM) programs. Vasectomy, as one of the LTCMs, still has very low acceptance, as seen in Pangururan District, where participation is less than 1%. Objective: This study aimed to analyze the factors associated with the selection of vasectomy as a contraceptive method among men in the working area of Buhit Public Health Center, Pangururan District, Samosir Regency. Methods: This study used a cross-sectional design with a quantitative approach. The population consisted of men with fertile-age wives, with a sample of 73 individuals selected through simple random sampling. Data were collected using a validated and reliable questionnaire. Data analysis used the Chi-Square test and logistic regression. Results: Bivariate analysis results showed significant relationships between the husband’s age (p = 0.039), number of children (p = 0.019), husband’s knowledge level (p = 0.047), attitude (p = 0.029), social norms (p = 0.016), and wife’s support (p = 0.001) with the decision to undergo vasectomy. Multivariate analysis proved that wife’s support was the most dominant variable (p=0.003; OR=23.500), meaning that husbands who received wife’s support were 23.5 times more likely to choose vasectomy. Conclusion: Wife’s support is the most dominant factor influencing the selection of vasectomy. Therefore, healthcare workers are expected to enhance their role through health education about vasectomy to the community, especially wives, to provide good support for their husbands.
Hubungan Inisiasi Menyusu Dini dengan Penurunan Perdarahan Post Partum dan Proses Involusio Uteri di PMB Supiani Pasaribu, Miraria Rosalina; Silaban, Verawaty Fitrinelda; Sitorus, Ester Rosalia Lasma; Alriyanti, Alriyanti; Siregar, Dina Adelia; Purba, Agina Timanta Br
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1098

Abstract

Background: The postpartum period is a critical time for mothers. Postpartum hemorrhage and delayed uterine involution are complications that can increase maternal morbidity and mortality. Early Breastfeeding Initiation (EBI) is hypothesized to prevent these complications by stimulating the release of oxytocin, which triggers uterine contractions. Objective: This study aimed to analyze the relationship between the implementation of EBI and the reduction of postpartum hemorrhage and the acceleration of uterine involution at PMB Supiani. Methods: This research employed a cross-sectional design with a quantitative approach. The sample consisted of 80 postpartum mothers selected using a purposive sampling technique. Data were collected using an observational questionnaire and analyzed using the Chi-Square statistical test to identify relationships between variables. Results: A total of 87.5% of respondents performed EBI. The analysis results showed a significant relationship between EBI and reduced postpartum hemorrhage (p-value = 0.001) and between EBI and accelerated uterine involution (p-value = 0.001). Mothers who performed EBI tended to experience normal bleeding and a faster uterine involution process. Conclusion: EBI has a significant relationship with the reduction of postpartum hemorrhage and the acceleration of uterine involution. Therefore, education and support to encourage the implementation of EBI in delivering mothers are essential to prevent postpartum complications.
Plasma pTau181 dan Gejala Neuropsikiatri pada Demensia Alzheimer: Sebuah Studi Cross-Sectional Fadhilah, Nailatul; Syafrita, Yuliarni; Susanti, Restu; Indra, Syarif; Susanti, Lydia; Putri, Fanny Adhy
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1143

Abstract

Alzheimer’s disease is the leading cause of dementia, marked by progressive cognitive decline and neuropsychiatric disturbances collectively known as behavioral and psychological symptoms of dementia (BPSD). Plasma phosphorylated tau at threonine-181 (pTau181) has emerged as a minimally invasive biomarker of tau-related neurodegeneration, but its association with BPSD remains uncertain. This study investigated the relationship between plasma pTau181 levels and BPSD in Alzheimer’s dementia. An analytical observational study with a cross-sectional design was conducted in patients clinically diagnosed with predefined eligibility criteria. Plasma pTau181 concentrations were measured using enzyme-linked immunosorbent assay (ELISA), while BPSD was assessed using the Neuropsychiatric Inventory Questionnaire (NPI-Q). Statistical analyses were performed to examine associations between plasma pTau181 and BPSD status. Plasma pTau181 levels ranged from 4.32 to 97.23 pg/mL, with a median plasma pTau181 level of 19.29 pg/mL (IQR: 11.81-25.05) in patients without BPSD and 20.67 pg/mL (IQR: 11.81-43.41) in those with BPSD. No significant differences in pTau181 levels were observed between patients with and without BPSD (p = 0.310). These findings suggest that plasma pTau181 may not be directly related to the presence of BPSD in Alzheimer’s dementia. While plasma pTau181 remains a promising biomarker of tau pathology, its predictive value for neuropsychiatric symptoms appears limited. Longitudinal studies are needed to explore its role in BPSD pathophysiology further.
Uji Efektivitas Ekstrak Etanol Daun Jambu Air (Syzygium aqueum) Terhadap Penyembuhan Luka Sayat Pada Kelinci Putih (Oryctolagus cuniculus) Fauziah , Fani Nur; Samodra, Galih; Rahmawati, Nur
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1144

Abstract

Cut wounds, physical damage to the skin often caused by sharp instruments, require alternative treatments. This study aims to evaluate the effectiveness and determine the optimal concentration of water apple leaf (Syzygium aqueum) ethanol extract in accelerating the healing of cut wounds. Rose apple leaves are known to be rich in bioactive compounds such as flavonoids, alkaloids, and tannins, which have the potential to be wound healing agents. Extraction was carried out using the remaceration method with 96% ethanol for three days, and the extract was then formulated into concentrations of 5%, 10%, and 20%. Effectiveness tests were carried out on incision wounds on the backs of rabbits. The results showed that the healing time was inversely proportional to the extract concentration. The treatment group with a concentration of 5% healed on the 13th day, the concentration of 10% on the 12th day, while the concentration of 20% showed the highest effectiveness among all extract groups, with healing on the 10th day. Statistical analysis using the One Way ANOVA test (p=0.000; p<0.05) showed a significant difference between treatment groups. The higher the concentration of rose apple leaf ethanol extract, the faster the healing process of the incision wound, but the effectiveness of the 20% extract was still lower than the positive control (Bionet Cream), which healed the wound faster (10 days vs. 10 days) through a different mechanism, so further research is needed to compare their effectiveness statistically.
Gambaran Pengobatan Bronkitis di RSUD Hasri Ainun Habibie Ramadhani , Fika Nuzul; Suleman , Ahmad Rifly; Mamu , Siti Nur Octavia Ramadhani R.; Machmud, Fidyahtul Sayifah; Alifa , Intan Nur; Abay , Verawaty Fajrin H.; Umar, Abdul Malik
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.888

Abstract

Chronic bronchitis, a subtype of chronic obstructive pulmonary disease (COPD), is characterized by persistent inflammation of the bronchial tubes and chronic cough accompanied by mucus production. This condition is commonly caused by prolonged exposure to irritants such as cigarette smoke, air pollution, or occupational dust. Acute exacerbation of chronic bronchitis (AECB) can significantly impair a patient’s quality of life and often requires hospitalization. This study aims to evaluate the management of bronchitis at Hasri Ainun Habibie Regional General Hospital, Gorontalo Regency. The research is descriptive in nature, using a retrospective method by analyzing patient medical records dated February 25, 2025, utilizing the SOAP method (Subjective, Objective, Assessment, Plan) and supported by literature review. The treatment regimen included a combination of antibiotics (ceftriaxone and azithromycin), nebulized bronchodilators (Meprovent and Budesma), mucolytics (Resfar), neuroprotective agents (citicoline), and electrolyte replacement therapy (NaCl 0.9%, KAEN 3B). Overall, this case study concludes that the management of chronic bronchitis in patients at Hasri Ainun Habibie Regional General Hospital includes a combination of medical and non-medical therapies that are in accordance with the management guidelines and treatment algorithms for chronic bronchitis.

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