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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Hipnoterapi Dalam Manajemen Nyeri Pada Pasien Kanker: A Systematic Review Sartika, Dwi; Kariasa , I Made; Amelia, Amelia; Maria , Riri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.958

Abstract

Cancer remains one of the leading causes of mortality worldwide, with over 20 million newly diagnosed cases and nearly 10 million deaths globally, as reported by the International Agency for Research on Cancer (IARC) in 2020. In Indonesia, the incidence reached 408,661 new cases with 242,988 cancer-related deaths recorded in 2022. This growing burden has resulted in numerous clinical implications, with pain identified as the most frequently reported symptom among cancer patients, significantly impairing their quality of life. Among emerging approaches in pain management, non-pharmacological interventions such as hypnotherapy have gained attention due to their potential to reduce pain intensity without inducing serious adverse effects. This systematic review aims to evaluate the effectiveness of hypnosis therapy in managing cancer-related pain by analyzing six selected studies sourced from five international databases: ScienceDirect, EBSCO, PubMed, ProQuest, and Sage Journals. All included studies met the eligibility criteria, comprising randomized controlled trials (RCTs) and one meta-analysis, published within the last ten years. Five out of the six studies demonstrated that hypnosis interventions were effective in reducing pain intensity, while one study showed no statistically significant effect. Additionally, several studies explored integrative approaches combining hypnosis with complementary modalities such as music therapy and cognitive behavioral therapy. The findings of this review suggest that hypnotherapy serves as a promising complementary intervention to support effective pain management in oncology care. Further research employing more rigorous methodologies and larger sample sizes is recommended to strengthen the evidence base regarding its clinical utility.
Dampak Klinis Interaksi Obat antara Clopidogrel dan Inhibitor Pompa Proton : Tinjauan Naratif Aslama, Ideasha; Sinuraya , Rano Kurnia; Zakiyah , Neily; Dewi , Triwedya Indra
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1040

Abstract

Dual antiplatelet therapy (DAPT), consisting of aspirin and P2Y12 receptor antagonists such as clopidogrel, is the mainstay treatment for patients with acute coronary syndrome (ACS). However, its widespread use can increase the risk of gastrointestinal bleeding. Proton pump inhibitors (PPIs) are often used as prophylaxis to prevent bleeding. On the other hand, PPIs are suspected of reducing the effectiveness of clopidogrel due to pharmacokinetic drug interactions. Nevertheless, findings from various studies regarding the clinical impact of this interaction remain inconsistent and controversial. The aim of this narrative review is to evaluate the effectiveness and safety of using PPIs concurrently with clopidogrel. The method used was a literature review of international journal articles discussing the interaction between PPIs and clopidogrel. The review findings indicate that certain PPIs, such as omeprazole, can inhibit the CYP2C19 enzyme involved in clopidogrel activation, potentially reducing its effectiveness. Conversely, some PPIs such as pantoprazole have minimal effects on CYP2C19 and are considered safer for concomitant use with clopidogrel. Overall, the use of PPIs can reduce the risk of gastrointestinal bleeding; however, the selection of PPI type must be carefully considered to minimize drug interactions that may compromise clopidogrel’s efficacy.
Tinjauan literatur: Evaluasi Kepatuhan Terapi Obat Pada Pasien Diabetes Melitus 2 Menggunakan Media edukasi Booklet Tamimah, Diyanah Fauziyah; Putri , Mukarromah Dita; Salsabila, Elsyifa
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1154

Abstract

Type 2 diabetes mellitus is a chronic disease that requires long-term treatment and continuous management, with its prevalence increasing in Indonesia. Patient adherence to treatment is crucial for effective disease control. This article explains that the use of booklets as educational media can play an important role in improving treatment adherence among patients with type 2 diabetes. A Systematic Literature Review was conducted following the PRISMA guidelines by searching PubMed and Google Scholar for articles published between 2015 and 2025. The findings show that booklets are effective when used independently or in combination with other educational methods; however, combining them with direct education from healthcare professionals yields more optimal results in improving adherence. Factors such as age, educational level, family support, and ease of access to information influence the success of this intervention. Booklets are superior to other educational media because they can be reread, provide comprehensive information, and are affordable without requiring advanced technology. The results indicate that booklets are an effective and valuable educational tool to enhance treatment adherence among patients with type 2 diabetes mellitus. Therefore, it is recommended that they be incorporated into chronic disease management strategies in primary healthcare facilities.
Formulasi, Evaluasi dan Aktivitas Antioksidan Sabun Padat Serbuk Nano Teh Celup Bekas Siregar , Misbah; Lubis , Minda Sari; Yuniarti , Rafita; Rani, Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1055

Abstract

Background: Ideal soap should not only cleanse the skin but also contain substances that protect it from adverse effects, including those of free radicals, which can accelerate aging and cause other skin problems. Antioxidant compounds are needed to counteract free radicals. Used tea bags are a waste product that still contains antioxidant compounds. The use of nanotechnology is expected to enhance the stability and long-term effectiveness of cosmetic formulations, including soap. Objective: This study aimed to formulate a solid soap containing used nano tea bag powder, evaluate the physical characteristics of the soap, and test its antioxidant activity. Method: This research used a True Experimental method with a Post Test Only Control Group Design. The used tea bag powder sample was processed into nano powder using a Ball Mill. Solid soap was formulated in three variations: F0 (control without powder), F1 (containing 1.4% used tea bag powder), and F2 (containing 1.4% used nano tea bag powder). The soap preparations were then evaluated for their physical characteristics (organoleptic, pH, foam stability, hardness, cleaning power) and tested for antioxidant activity using the DPPH method. Results: The used tea bag powder was successfully converted into nano powder with an average particle size of 684.35 nm. Phytochemical screening results showed that both the powder and nano powder contained alkaloids, steroids, flavonoids, saponins, and tannins. Evaluation of the solid soap showed that all formulas (F0, F1, F2) met the physical quality requirements. The antioxidant activity test yielded IC50 values for F0, F1, and F2 of 975.2861 µg/ml (very weak), 211.3533 µg/ml (very weak), and 168.3053 µg/ml (weak), respectively. Conclusion: It can be concluded that the used tea bag powder meets the characteristics of nano powder. The solid soap formulation containing used nano tea bag powder meets physical quality requirements and demonstrates antioxidant activity, albeit in the weak category. The F2 formula (nano powder) showed better antioxidant activity than F1 (coarse powder) and F0 (control).
Uji Aktivitas Antioksidan Ekstrak dan Fraksinasi Daun Tekelan (Chromolaena odorata (L.) R.M.King & H.Rob) Serta Uji Antibakteri Terhadap Staphylococcus aureus dan Escherichia coli Parapat , Anjarlit Romiyuliana Br; Ridwanto, Ridwanto; Yuniarti , Rafita; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1059

Abstract

Background: Tekelan leaf (Chromolaena odorata (L.) R.M.King & H.Rob) is one of Indonesia's natural resources rich in bioactive compounds. Its traditional use for treating wounds, sore throats, diarrhea, and various other ailments is suspected to be linked to its antioxidant and antibacterial content. Objective: This research aimed to analyze the antioxidant activity of the ethanol extract, n-hexane fraction, and ethyl acetate fraction of tekelan leaves, and to test their antibacterial activity against Staphylococcus aureus and Escherichia coli. Method: The study used an experimental method. Antioxidant activity was tested using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method with a UV-Vis spectrophotometer, and the results were expressed as IC₅₀ values. The antibacterial test against S. aureus and E. coli was conducted using the disc diffusion method, and the inhibitory power was measured based on the inhibition zone diameter (mm). Results: The antioxidant test results showed that the ethanol extract and ethyl acetate fraction had strong activity with IC₅₀ values of 98.26 ppm and 75.43 ppm, respectively, while the n-hexane fraction showed weak activity (IC₅₀ 110.54 ppm). In the antibacterial test at a 40% concentration, the ethanol extract, n-hexane fraction, and ethyl acetate fraction inhibited the growth of both bacteria with strong to very strong categories. The highest average inhibition zones against E. coli and S. aureus were 19.03 mm and 21.36 mm (ethanol extract), 10.56 mm and 12.13 mm (n-hexane fraction), and 13.60 mm and 15.40 mm (ethyl acetate fraction), respectively. This activity was still lower than the positive control chloramphenicol, which produced inhibition zones of 28.23 mm (E. coli) and 27.43 mm (S. aureus). Conclusion: It was concluded that the extract and ethyl acetate fraction of tekelan leaves have strong antioxidant activity, while the n-hexane fraction is classified as weak. All samples (extract, n-hexane fraction, and ethyl acetate fraction) showed strong antibacterial activity against E. coli and S. aureus, although they have not matched the effectiveness of chloramphenicol.
Uji Aktivitas Antioksidan dan Antibakteri Ekstrak dan Hasil Fraksinasi Daun Bandotan (Ageratum conyzoides L.) Terhadap Bakteri Escherichia coli Dan Staphylococcus aureus Harahap, Sumiyarni; Ridwanto, Ridwanto; Pulungan, Ainil Fithri; Rani, Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1060

Abstract

Bandotan (Ageratum conyzoides L.) is a plant distributed worldwide, especially in tropical and subtropical regions. Bandotan can be used as a traditional medicine because it contains beneficial phytochemical compounds such as terpenoids, alkaloids, essential oils, saponins, and phenolics that play a role in inhibiting bacterial growth and serving as natural antioxidants. The objective of this research was to determine the antioxidant and antibacterial activity of the extract, n-hexane fraction, and ethyl acetate fraction from bandotan leaves. This research used an experimental method. It included antioxidant testing of the ethanol extract fractions of bandotan leaves (Ageratum conyzoides L.) using the DPPH method and antibacterial testing using Escherichia coli and Staphylococcus aureus bacteria. The phytochemical screening results showed that bandotan leaves contain alkaloids, saponins, tannins, flavonoids, and glycosides. The antioxidant testing for DPPH radical scavenging revealed that the bandotan leaf extract had an IC50 value of 499.3633 μg/ml, the n-hexane fraction had an IC50 value of 945.7837 μg/ml, and the ethyl acetate fraction had an IC50 value of 382.9216 μg/ml, all categorized as very weak antioxidants. Antibacterial testing indicated that the extract, n-hexane fraction, and ethyl acetate fraction of bandotan (Ageratum conyzoides L.) exhibited antibacterial activity, inhibiting the growth of Escherichia coli and Staphylococcus aureus, with strong activity at the highest concentration of 40% and moderate activity at the lowest concentration of 10%. In conclusion, bandotan leaves have very weak antioxidant activity due to the low content of flavonoids and strong antibacterial activity at 40% concentration and weak activity at 10% concentration.
Analisis Faktor yang Mempengaruhi Terjadinya Gizi Berlebih Pada Bayi Harahap, Anggita Putri; Sigalingging, Aldora Sri Oktovia; Fajarani , Annisa; Alfia , Assyari; Prasetio, Cilsilia Avindi; Nababan, Tiarnida
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1094

Abstract

Background: Overnutrition in infants aged 6-12 months is an increasingly prevalent health issue. The main factors suspected to play a role are maternal knowledge about nutrition and inappropriate feeding practices. Based on initial observations in Mekar Sari Village, Deli Serdang, 30 infants were found to be overnourished, indicating the need to identify the influencing factors. Objective: This study aimed to analyze the factors influencing the occurrence of overnutrition in infants aged 6-12 months, with a focus on maternal knowledge and feeding practices. Methods: The study used a cross-sectional design with a quantitative approach. Data were collected through interviews using questionnaires and anthropometric measurements. Infant nutritional status was determined based on Weight-for-Height (WHZ) measurements referring to WHO Growth Standards (2006), where infants were categorized as overnourished if the WHZ Z-score > +2 SD. The sample consisted of 30 infants who met the inclusion criteria. Results: WHZ measurements showed that 17 infants (56.7%) were overnourished. A total of 19 mothers (63.3%) had poor nutritional knowledge and 17 mothers (56.7%) implemented inappropriate feeding practices. Bivariate analysis showed significant relationships between overnutrition and maternal knowledge (p-value = 0.000; OR = 22.713) and feeding practices (p-value = 0.000). Conclusion: Maternal knowledge and feeding practices are factors that significantly influence the occurrence of overnutrition in infants at the research location. Public health interventions focusing on improving maternal nutritional literacy and promoting appropriate feeding practices are essential for preventing this problem.
Pengembangan Model Edukasi Partisipatif Berbasis Evidence-Based Practice dalam Penerapan PHBS di Pondok Pesantren Handayani, Sri; Sirait , Reni Aprinawaty; Susanti, Dewi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1110

Abstract

Clean and Healthy Living Behavior (CHLB) is a crucial preventive measure to improve health status in Islamic boarding schools (pesantren). This study aimed to develop an evidence-based education model for CHLB in a pesantren in West Sumatra. The research applied a Research and Development (R&D) design through the stages of analysis, design, development, implementation, and evaluation. Data were collected through observation, in-depth interviews, and pre- and post-test questionnaires. The findings revealed that unhealthy behaviors among students remained high, with 93.47% not practicing handwashing with soap, 50% littering, 65.22% spitting in public areas, and 76.08% not engaging in mosquito larvae control. Interviews with caregivers and administrators indicated the absence of nutritionists in meal planning, lack of educational media, and limited health education, which was only provided once during the Covid-19 pandemic. The developed educational model proved effective, demonstrated by significant improvements in knowledge (increase of 43 points) and attitudes (increase of 25 points) after the intervention. Respondents considered the model practical, easy to understand, and culturally appropriate within the pesantren context. Therefore, the participatory, evidence-based education model is feasible to be implemented more widely to strengthen CHLB practices and prevent behavior-related diseases in Islamic boarding schools.
Formulasi Ekstrak Siwak (Salvadora persica) Sebagai Mouth Spray dan Uji Efektivitas Terhadap Bakteri Staphylococcus aureus Nugraha, Nasywa Fatihah Bintang; Fauzi, Ahmad; Dwi Astuti, Elsa
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1133

Abstract

Mouth-related problems often occur in human life, one of which is bad breath. Mouth spray is a health product that contains a combination of active ingredients and additional ingredients such as antibacterial, freshener, or moisturizer that work to support dental and oral health. Miswak (Salvadora persica) contains large amounts of chloride, fluorine, trimethylamine and resin, silica sulfur and vitamin C, where these chemical ingredients have great benefits for dental and oral health. This study aims to formulate miswak extract in the form of a mouth spray preparation and test its effectiveness against Staphylococcus aureus bacteria and use Simple Lattice Design as an optimization method. Extraction was carried out by the maceration method using 96% ethanol, then the extract was formulated in the form of a mouth spray preparation. The physical properties of the mouth spray were evaluated through organoleptic tests, pH, clarity and viscosity, while the antibacterial activity test was carried out by the well diffusion method. The results of the organoleptic test showed that all formulas had a dark brown color and a distinctive odor. The results of the clarity test for the five formulas looked clear and there were no visible particles. The pH test showed that all formulas had pH results within the safe range. The viscosity test did not meet the requirements, with an average result of 11.43 ± 0.52 cP. The antibacterial test showed that the miswak extract had antibacterial activity with an inhibition zone diameter of 16.25 mm against Staphylococcus aureus bacteria.
Formulasi Sediaan Denture Cleanser Dengan Ekstrak Siwak (Salvadora persica) Dan Uji Efektivitas Terhadap Bakteri Staphylococcus aureus Dwi Astuti, Elsa; Fauzi, Ahmad; Fatihah Bintang Nugraha , Naywa
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1134

Abstract

Plaque buildup and bacterial accumulation on the surface of dentures are common problems faced by denture users. One alternative that can be used to clean dentures is miswak (Salvadora persica). Miswak contains many natural ingredients, including sodium chloride, potassium chloride, salvadourea, oleic acid, linoleic acid, trimethylamine, thiocyanate, benzyl isothiocyanate, and nitrate, silica, vitamin C, resin, tannin, saponin, N-benzyl-2 phenylacetamide, lignan, flavonoid, fluoride, calcium, sodium bicarbonate, and salvadorin. The purpose of this study was to formulate an effective denture cleanser from miswak extract using the Simplex Lattice Design (SLD) optimization method and to test its effectiveness against Staphylococcus aureus bacteria. The method used for the extraction process was the maceration method using 96% alcohol. For the antibacterial test of the denture cleanser preparation, the time kill assay method was used. The physical properties of the denture cleanser preparations were tested including organoleptic tests, clarity tests, pH tests, and viscosity tests. The results of the physical properties of the preparations in the organoleptic test for formulas 1 to 5 showed the characteristics of mint odor, brown color, and liquid form. The clarity test for all five formulas showed clear results and also no foreign particles and was declared to have met the requirements. The pH test results for the five formulas ranged from 6.28 ± 0.01 to 6.43 ± 0.01 and had met the requirements. The viscosity test did not meet the requirements because the results ranged from 10 ± 2 to 12.67 ± 1.15. The antibacterial test showed that there was no significant difference between all test groups regarding antibacterial activity.

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