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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Optimasi Formula dan Evaluasi Stabilitas Sediaan Toner Wajah Ekstrak Daun Keji Beling (Strobilanthes crispus L.) Gobel, Alia Afrilia; Resvita Bahi, Rizky; Mappa, Moh. Rivaldi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.902

Abstract

Facial skin is prone to dryness due to UV radiation, which accelerates premature aging (photoaging) and triggers various skin problems such as atopic dermatitis. In Indonesia, the prevalence of dry skin reaches 50%–80%. Several commercial toner products still contain alcohol, which can further dry the skin when used for a long period of time. Therefore, natural ingredients with moisturizing effects are needed, one of which is Strobilanthes crispus (keji beling) leaves, containing flavonoids with antioxidant activity. This study aimed to determine the effect of varying concentrations of Tween 80 surfactant on the stability of toner formulations. The research method was experimental, formulating four formulas with surfactant concentrations of 0% (F0), 5% (FI), 7.5% (FII), and 10% (FIII), followed by stability testing using the cycling test and evaluating organoleptic properties, homogeneity, viscosity, pH, irritation, and hedonic acceptance. The organoleptic evaluation showed that FI, FII, and FIII produced clear yellowish-green liquid preparations with a characteristic odor of keji beling leaves, whereas F0 produced a dark green liquid with the same odor. All formulas were homogeneous with a pH of 5. The viscosity values were 1.72 cPs for FI, 1.82 cPs for FII, 2.37 cPs for FIII, and 1.35 cPs for F0. Irritation testing showed negative results for all formulas, indicating no signs of primary irritation. Hedonic testing revealed that FIII was the most preferred by panelists. Based on these findings, it can be concluded that the formula containing 10% polysorbate (FIII) provided the best physical stability and panelist acceptance. Thus, variation in surfactant concentration affects the physical stability of Strobilanthes crispus leaf extract toner formulations.
The Hubungan Rasionalitas Penggunaan Antibiotik Terhadap Keberhasilan Terapi Pada Pasien Anak Terdiagnosis Pneumonia di Instalasi Rawat Inap RSUD dr. R. Soedjati Purwodadi Menggunakan Metode Gyssens Hidaya, Anggi Fajriatu; Fortuna, Tista Ayu
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1050

Abstract

Pneumonia is an inflammation of the lung parenchyma that can be caused by microorganisms including fungi, viruses, bacteria, and mycobacteria. In addition, chronic inflammatory diseases of the respiratory tract can be characterized by wheezing, chest tightness, and coughing accompanied by flu. To evaluate the rational use of antibiotics, the Gyssens method was developed, which includes the appropriate selection of antibiotics based on effectiveness, toxicity, lower cost, narrower spectrum, duration of administration, dose, interval, route, and timing of administration. A patient's improvement or lack thereof can be assessed based on body temperature, white blood cell count, respiratory rate, and clinical symptoms. The study design is non-experimental (observational) with a cross-sectional study design. Data collection was conducted retrospectively using data from medical records of pediatric patients diagnosed with pneumonia at Dr. R. Soedjati Purwodadi General Hospital, with a total of 110 pediatric patients meeting the inclusion criteria. The results showed that 38 patients (34.55%) received antibiotics irrationally, with the most inaccuracies in the drug selection category (IV A, IV C, and IV D). A total of 72 users (65.45%) were rational and 38 users (34.55%) were irrational. The results of statistical analysis of the data using the Chi-Square test show that these results were obtained from the Exact Sig (2-sided) value, namely p = 0.003 (p < 0.05), so it can be interpreted that there is a rational relationship between the use of antibiotics and the success of therapy in pediatric patients.
Hubungan Pendidikan, Pengetahuan dan Paritas dengan Kemampuan Merawat Bayi Baru Lahir Sitanggang , Sarta Kami; Laia, Sastra Keis; Hardianti, Sartika Putri; Hanum, Parida
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1102

Abstract

Background: Neonates are children aged 0 to 28 days. Efforts to establish a healthy lifestyle should begin during the neonatal period, as this is a stage of rapid growth and development. The mother's role is crucial as the primary caregiver, supporting the baby's physical, social, and emotional development. To address various challenges in infants, mothers are required to possess good knowledge and skills in caring for their babies. Objective: To determine the correlation between knowledge, education, and parity on the ability to care for newborns at the Sunggal Primary Clinic. Methods: This study was a quantitative analytical study with a cross-sectional approach. Data were collected through questionnaires and direct interviews with 60 respondents. Data analysis employed univariate and bivariate analysis using the chi-square test, supplemented with the association measure Prevalence Ratio (PR) and 95% Confidence Interval (CI). Results: The bivariate analysis results showed that education (p = 0.000; PR = 3.58; 95% CI: 1.45-8.83), knowledge (p = 0.000), and parity (p = 0.000; PR = 2.79; 95% CI: 1.83-4.24) were significantly associated with the ability to care for newborns. The PR values indicate that mothers with higher education were 3.58 times more likely to be capable of caring for their babies, and mothers with higher parity were 2.79 times more likely. Conclusion: The variables of education, knowledge, and parity have a significant and meaningful relationship with maternal competence in caring for neonates. Education and parity demonstrate a strong influence on the ability to care for newborns.
Efektivitas Sensory play tactile terhadap Perkembangan Kognitif Bayi Usia 12 sampai 15 Bulan di Desa Mekar Sari Kecamatan Deli Tua Zendrato, Riska Liberta; Saputri , Rara Meilani; Tambunan, Rahel; Zahra, Raudha; Siregar, Debi Novita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1125

Abstract

Background: The period from birth to five years of age is known as the golden period, a crucial phase for a child’s growth and development. During this stage, developmental monitoring—particularly of cognitive aspects—is essential as a foundation for the child’s future. Tactile sensory play is one form of stimulation that contributes to infants’ cognitive development. A lack of stimulation may hinder this development. Objective: To determine the effectiveness of tactile sensory play on the cognitive development of infants aged 12–15 months in Mekar Sari Village, Deli Tua District. Method: This study employed a quantitative design using a quasi-experimental approach with a one-group pretest–posttest design. The sample consisted of 30 respondents selected through accidental sampling. The tactile sensory play intervention was administered three times. Data were collected through observation using observation sheets and analyzed using a t-test with SPSS software. Results: The t-test results showed a p-value of 0.000 (p < 0.05), indicating a significant effect of tactile sensory play on the cognitive development of infants aged 12–15 months in Mekar Sari Village, Deli Tua District. Conclusion: Tactile sensory play is effective in improving the cognitive development of infants aged 12–15 months.
Evaluasi Mutu Fisik, Uji Kelembapan dan Potensi Aktivitas Tabir Surya Pelembab Bibir Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp.) Safitri , Nurhaliza; Yuniarti , Rafita; Dalimunthe , Gabena Indrayani; Lubis , Minda Sari
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1052

Abstract

Background: Lip balm is a cosmetic preparation containing key components such as waxes, fats, and oils—derived from either natural or synthetic extracts—to prevent lip dryness by enhancing moisture and protecting against harmful environmental factors. The red shoot plant (Syzygium myrtifolium Walp.) is commonly known as an ornamental plant but also contains beneficial chemical compounds. Objective: This study aims to formulate red shoot leaf ethanol extract into a lip balm with good physical quality, sun protection capability, and moisturizing effects. Methods: This research uses an experimental method with quantitative and qualitative data collection. The stages include simplicia characterization, secondary metabolite identification, extract preparation through maceration, lip balm formulation, and evaluation of physical quality (organoleptic test, homogeneity, pH, stability, irritation, melting point, and hedonic test), moisture test, and Sun Protection Factor (SPF) value determination. Results: The red shoot leaf extract was successfully formulated into a stick lip balm at concentrations of 5%, 7%, and 10%. The formulas demonstrated good physical quality in all tests, increased lip moisture and oil content (especially at 10% concentration), and high SPF values with ultra protection at the 10% concentration. Conclusion: Red shoot leaf extract (Syzygium myrtifolium Walp.) can be used as an active ingredient in lip balm, providing optimal physical quality, moisturizing effects, and UV radiation protection.
Hubungan waktu tunggu pelayanan resep racikan pasien bpjs terhadap tingkat kepuasan pasien di farmasi rawat jalan di Rumah Sakit ‘x’ Kota Malang Siwi , Mayang Aditya Ayuning; Sari , Puspita Maya; Aprilianti , Rakhmadani Gadis
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.651

Abstract

One of the minimum standards of hospital pharmacy services is waiting time. Waiting time is one of the potential components that can affect the level of patient satisfaction and also the quality of the hospital. Another indicator of the success of health services is patient satisfaction. Patient satisfaction is a reflection of the quality of health services they receive. The purpose of this study was to determine the relationship between waiting time for BPJS patient prescription services and the level of patient satisfaction at the outpatient pharmacy of Hospital 'X' in Malang City. This study design is quantitative descriptive with a Cross Sectional approach. The data collection method is Prospective, sampling using Random Sampling techniques during the period December 2023 - January 2024. The data analysis used is bivariate analysis of the Chi Square test to see the relationship between waiting time and patient satisfaction. The number of samples taken was 84 respondents. The results showed that the waiting time for compounded prescription services at the outpatient pharmacy of Hospital 'X' in Malang City was obtained as much as (51.2%) not according to standards with an average time of 81.25 minutes. The level of patient satisfaction as many as (46.4%) felt satisfied with the service at the outpatient pharmacy of Hospital 'X' in Malang City and the p-value was 0.04 (˂ 0.05). Based on the results of this study, it can be concluded that the waiting time for BPJS compounded prescription services is related to the level of patient satisfaction at Hospital 'X' in Malang City. 
Literature Review : Perbandingan Aktivitas Senyawa Kimia Yang Berpotensi Sebagai Kandidat Obat Kanker Payudara Oral Menggunakan Metode In Silico Akifah, Muthia Nur; Damara , Dandy Satria; Putri , Indah Syah; Utami , Marshah Rahmawati
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.679

Abstract

Breast cancer is a type of cancer with a high prevalence rate, especially in women, which contributes significantly to the global death rate from cancer. This disease is characterized by abnormal cell growth that attacks body tissues and is often difficult to treat due to the limitations of effective treatment and minimal side effects. Although treatments such as chemotherapy, surgery, and radiation therapy are available, significant side effects, including impaired patients' quality of life, remain a major challenge. Therefore, a new approach is needed to find drug candidates with high efficacy and lower side effects.  This study aims to compare the activity of chemical compounds that have the potential to be used as a breast cancer drug using the in silico method. The method involves computer simulations to evaluate molecular interactions with cancer receptors, such as ER-α and HER-2, as well as verify their pharmacokinetic feasibility through compliance with Lipinski's rules. This review literature draws on eight relevant recent studies, showing that some compounds have significant activity against cancer receptors and meet pharmacokinetic criteria for oral administration. The results of the analysis revealed that Longipinocarvone compounds had the best affinity for ER-α receptors (-8.20 kcal/mol), while Galagin showed the best affinity for HER-2 (-7.79 kcal/mol). Both also meet Lipinski's rule, indicating the potential to be developed into an oral drug. This in silico simulation provides efficient and cost-effective initial insight into the drug discovery process. The study concluded that both compounds have the potential to be promising breast cancer drug candidates, although further validation through in vitro and in vivo trials is needed to support these results.
Potensi Aktivitas Antioksidan dan Antibakteri Ekstrak Etanol Daun Kari (Murraya koenigii) terhadap Propionibacterium acnes Nasri, Nasri; Kaban, Vera Estefania; Rani, Zulmai; Suci, Nurul; Ferendina, Imelda; Tania, Chyntia Glori
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.881

Abstract

Indonesia is renowned for its rich natural resources, particularly medicinal plants with significant therapeutic potential. This study examined how the ethanolic extract of curry leaves (Murraya koenigii) can act as an antioxidant and antibacterial agent against Propionibacterium acnes, the primary cause of acne vulgaris. This study used phytochemical screening to identify secondary metabolites, such as alkaloids, flavonoids, tannins, saponins, and glycosides, which are associated with biological activities such as killing bacteria and protecting cells from damage. The DPPH method for testing antioxidants showed that the extract had an IC50 value of 45.88 mg/L, which is not significantly different from quercetin as a reference, at 23.7 mg/L. This result is still significant for the strong antioxidant category. We assessed antibacterial efficiency using a disc diffusion technique, which showed a zone of inhibition corresponding to the extract concentration. The widest zone of inhibition, measuring 17.77 ± 0.15 mm, was recorded at a concentration of 250 mg/mL, classifying its activity as strong by existing standards. These findings underscore the extract's promise as a natural acne therapy, addressing bacterial growth and oxidative stress. Furthermore, these results support the development of safe and efficacious pharmaceutical or cosmetic products derived from natural components. Future investigations should examine synergistic formulations and enhance bioavailability to optimize therapeutic outcomes.
Analisis Efek Samping Obat Anti Tuberkulosis Menggunakan K-Means Clustering di RSUD Prof. Dr. H. Aloei Saboe Kota Gorontalo Hipmi , Ahmad Fahrian; Wijaya , Made Hariadi; Abas , Siti Nur Rahmatiya; Darmawan , Endang; Lolita , Lolita; Irham , Lalu Muhammad; Surono , Sugiyarto
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1041

Abstract

Background: The side effects of anti-tuberculosis drugs (OAT) experienced by patients often interfere with their daily activities and affect their compliance in completing relatively long-term treatment. This is one of the reasons patients discontinue OAT therapy unilaterally, which can lead to treatment failure for tuberculosis (TB). Objective: To analyse the side effects of OAT in patients at Prof. Dr. H. Aloei Saboe General Hospital in Gorontalo City using k-means clustering. Methods: Data including gender, age, OAT regimen, laboratory results, comorbidities, and types of OAT side effects were analyzed using the k-means method to determine patient clustering patterns. Research Results: The analysis yielded three clusters. Cluster 1 (25 patients) was predominantly male (80%), aged 45–54 years, received first-line OAT (88%), experienced elevated SGPT/SGOT levels (88%), had hypertension as the most common comorbidity (28%), and primarily experienced liver dysfunction as the main side effect (96%). Cluster 2 (348 patients) was predominantly male (58%), aged 35–44 years, receiving OAT line 1 (96.1%), no increase in SGPT and SGOT levels (0%), almost no increase in urea and creatinine levels (0.2%), the most common comorbidity being diabetes mellitus (22.1%). The main side effect being gastrointestinal disorders (58.9%). Cluster 3 (40 patients) was predominantly male (70%), aged 45–54 years, received OAT line 1 (97.5%), experienced an increase in urea and creatinine levels (97.5%), and the most common comorbidity was diabetes mellitus (47.5%). The main side effect was renal dysfunction (95%). Conclusion: The k-means algorithm is effective in generating clusters of patient characteristics. This clustering supports specific interventions such as comorbidity therapy management and monitoring of side effect risks, thereby optimising individualised tuberculosis (TB) treatment.
Uji Aktivitas Antioksidan Teh Herbal Biji Durian (Durio zibethinus Murr.) dengan Tambahan Daun stevia (Stevia rebaudiana Bertoni) sebagai Pemanis Alami dengan Metode DPPH Andry, Muhammad; Ramadaini, Tiara; Marseli, Cindy; Nurfitriyana, Nurfitriyana; Azzahra, Rafifah; Syahputra, Hafid; Shiyan, Shaum
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1070

Abstract

Free radicals are an important health concern due to their role in the development of various diseases. Antioxidants, capable of neutralizing free radicals, are abundant in plants such as durian seeds (Durio zibethinus Murr.) and stevia leaves (Stevia rebaudiana Bertoni). Herbal tea formulated from these materials has potential as an alternative functional drink because both contain phenolic compounds with antioxidant activity. This study aimed to evaluate the potential of durian seeds and stevia leaves as herbal tea with antioxidant properties. The research involved sample collection, identification, preparation of simplicia, characterization, formulation of herbal tea, quality testing, and determination of antioxidant activity. The simplicia characteristics of durian seeds and stevia leaves showed water content of 6.16% each, water-soluble extract of 35% and 15.8%, ethanol-soluble extract of 25.5% and 14.6%, total ash of 0.73% and 0.3%, and acid-insoluble ash of 0.5% and 0.26%. Quality testing of the herbal tea showed water content of 2.18%, total ash of 3.90%, water-soluble ash of 73.85%, and acid-insoluble ash of 3.80%. Antioxidant activity based on IC50 values was 68.45 ± 1.32 ppm for durian seed tea, 61.6 ± 1.05 ppm for stevia tea, 39.28 ± 0.98 ppm (1:1), 44.64 ± 1.11 ppm (1:2), and 42.32 ppm ± 1.07 (2:1). These results indicate that combining durian seeds and stevia leaves can enhance antioxidant activity compared to individual extracts. Overall, durian seeds and stevia leaves can be developed into herbal tea formulations with very strong antioxidant activity, as reflected in their ability to reduce DPPH radicals. Radikal

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