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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Interaksi Obat-Herbal dengan Agen Hormon dalam Terapi Kanker: Tinjauan Mekanisme dan Implikasi Klinis Zulqifli, Iqbal; Hikmah, Nurul; Shella, Tasya Permata; Azizah, Nabilla Faoziyyah; Apriani, Risa Dwi; Putri, Mukarromah Dita; Hilmi , Indah Laily
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1073

Abstract

Hormone therapy is the cornerstone of treatment for hormone-dependent cancers, such as breast and prostate cancer. On the other hand, the high rate of herbal medicine use as complementary treatment in cancer patients has the potential to cause herbal drug interactions (HDIs), which can affect the efficacy and safety of the primary therapy. This study aims to identify and categorize drug-herbal interactions (DHIs) in cancer hormone therapy based on pharmacokinetic mechanisms (including CYP450 enzyme and drug transporter modulation) and pharmacodynamic mechanisms (including hormone receptor and signaling pathway modulation), as well as to conclude their clinical implications. A systematic review was conducted following the PRISMA-ScR guidelines. A literature search was performed in the PubMed, Scopus, ScienceDirect, Frontiers, and Google Scholar databases for relevant in silico, in vitro, and in vivo studies published between 2015 and 2025. Analysis showed that HDI can be categorized into two main groups. First, pharmacokinetic interactions that occur through the modulation of cytochrome P450 (CYP) enzymes and drug transporters, such as the reduction in the bioavailability of tamoxifen by Hedyotis diffusa. Second, pharmacodynamic interactions at hormone receptors, such as the synergistic effect between Boswellia serrata and enzalutamide. The nature of interactions varies greatly, from antagonistic to synergistic, depending on the specific herbal-drug pair. These findings emphasize the importance of clinical vigilance, such as open communication with patients, dose adjustments, therapeutic monitoring, and interprofessional collaboration. These measures are necessary to reduce the risk of HDI and improve the efficacy of cancer therapy.
Hubungan Lama Perawatan dengan Outcome Tekanan Darah dan Proteinuria pada Preeklampsia Berat Annisadillah, Dwi; Rachmaini , Fitri; Juwita, Dian Ayu
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1076

Abstract

Severe preeclampsia is a major obstetric complication associated with maternal and perinatal morbidity and mortality. Hospitalization duration may influence clinical outcomes, including blood pressure and proteinuria, particularly in patients receiving antihypertensive therapy with nifedipine or methyldopa. This study aims to evaluate the association between the length of hospital stay and changes in systolic and diastolic blood pressure, as well as proteinuria, in patients with severe preeclampsia treated with nifedipine or methyldopa. This retrospective study reviewed medical records of patients diagnosed with severe preeclampsia and admitted to Dr. M. Djamil Central General Hospital, Padang, between January and December 2023. Patients were categorized into two groups based on hospitalization duration: <5 days and ≥5 days. All patients received monotherapy with either nifedipine or methyldopa. Data on patient demographics, clinical parameters, and hospitalization length were collected. Statistical analyses were performed using the independent t-test and the Mann–Whitney test, with a significance level of p<0.05. Of 60 patients included, 44 (73.3%) were hospitalized for ≥5 days, while 16 (26.7%) stayed <5 days. Patients with ≥5 days of hospitalization experienced a significantly greater reduction in systolic blood pressure (40.93 mmHg vs. 29.00 mmHg, p=0.025) and proteinuria (23.06 vs 33.20, p=0.031) compared to the <5-day group. No significant difference was observed in diastolic blood pressure reduction (p=0.128).
Lulur Krim Ekstrak Etanol Buah Pare (Momordica charantia L.) Sebagai Pelembap Kulit Diana , Vivi Eulis; Nabila, Nabila; Ulina , Sry; Syahputra , Arif; Rizkina , Salsabila
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1080

Abstract

Background: Bitter melon (Momordica charantia L.) is known to contain active compounds such as flavonoids, polyphenols, and vitamin C, which act as natural antioxidants. These compounds have potential as natural moisturizing agents that protect skin cells from damage caused by free radicals. Objective: This study aimed to formulate a cream scrub preparation containing the ethanolic extract of bitter melon fruit as a skin moisturizer and to determine the optimum concentration that produces the best formulation. Methods: This experimental laboratory study was conducted using various extract concentrations: F0 (blank), F1 (2.5%), F2 (3.5%), and F3 (4.5%). The formulations were evaluated based on organoleptic properties, pH, emulsion type, skin moisture, and irritation tests. Results: All formulations met the physicochemical requirements, showing stable organoleptic characteristics, pH values of 4.9–5.8, an oil-in-water (o/w) emulsion type, and no skin irritation. The F2 (3.5%) formulation demonstrated optimum results with a water content of 61.56% (very moist) and an oil content of 27.6% (neutral), indicating the best skin hydration capability compared to other formulations. Conclusion: The cream scrub containing the ethanolic extract of bitter melon (Momordica charantia L.) at a concentration of 3.5% (F2) is the optimum formula, providing the best moisturizing effect and proven safe for use. Further research is recommended to analyze free fatty acid content and antibacterial activity.
Evaluasi Bukti dari Uji Klinis tentang Interaksi Antibiotik dan Antasida: Suatu Tinjauan Sistematis Literatur Al Qindy, Wildan Hidayah; Nurdin, Fitri Oktaviani; Khaerunisa, Aulia; Putri, Meisya Diffa Amalia; Hilmi, Indah Laily; Putri, Mukarromah Dita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1093

Abstract

Drug interactions between antibiotics and antacids represent an important clinical issue that can affect therapeutic efficacy and increase the risk of treatment failure. The concurrent use of these drug classes frequently occurs in clinical practice, particularly in patients receiving antibiotic therapy who also present with gastrointestinal complaints. This systematic literature review aims to evaluate the clinical trial evidence regarding antibiotic–antacid interactions, focusing on pharmacokinetic and pharmacodynamic mechanisms, clinical implications, and current research limitations. Relevant articles were identified through PubMed, Google Scholar, and other scientific databases using standardized keywords. Literature selection followed the PRISMA guidelines to ensure the quality and relevance of included studies. The analysis revealed that antacids and proton pump inhibitors (PPIs) can significantly reduce the bioavailability of antibiotics, especially fluoroquinolones and tetracyclines, through chelation with metal ions and by increasing gastric pH, thereby impairing drug absorption. Concomitant use of antibiotics and PPIs was also associated with a higher risk of Clostridioides difficile infection (CDI), particularly in elderly or comorbid patients. Conversely, newer acid-suppressing agents such as vonoprazan demonstrated good efficacy in Helicobacter pylori eradication regimens without compromising antibiotic activity. Despite these findings, most studies were retrospective, with limited sample sizes and specific populations. Therefore, large-scale prospective clinical trials are needed to strengthen the evidence base. A comprehensive understanding of antibiotic–antacid interactions is essential to support rational, safe, and effective prescribing practices in clinical settings.
Peningkatan Efek Antiinflamasi Multikomponen Etorikoksib terhadap Penurunan TNF-α Rahmadevi, Rahmadevi; Zaini , Erizal; Yuliandra , Yori
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1097

Abstract

Etoricoxib, a selective COX-2 inhibitor, is widely used for its anti-inflammatory effects but is associated with dose-dependent adverse events. Multicomponent formulations with coformers or solubilizing agents offer a potential strategy to improve efficacy while minimizing toxicity. This study aimed to evaluate the anti-inflammatory efficacy of pure etoricoxib and its multicomponent formulations with nicotinamide, N-methyl glucamine, and piperine using TNF-α as a coformer. A controlled laboratory experiment was conducted in Wistar rats using a carrageenan-induced granuloma pouch model. TNF-α levels were measured at baseline (0 hours) and at 6 hours post-treatment. Normality tests, two-way ANOVA, and Tukey HSD post-hoc analyses were applied to assess group differences and time effects. All treatment groups significantly reduced TNF-α levels compared to the control (p < 0.001). While pairwise comparisons between treatments were not statistically significant, the P4 formulation (etoricoxib–piperine) showed the most consistent reduction. P3 (etoricoxib–N-methyl glucamine) exhibited a near-significant difference from pure etoricoxib (P1), suggesting enhanced efficacy. The main effect of time confirmed the temporal decline of TNF-α (p = 0.0101), without significant group × time interaction. Multicomponent formulations, particularly those containing piperine and N-methyl glucamine, enhance the anti-inflammatory action of etoricoxib. These research support further development of bioenhanced etoricoxib as safer alternatives for antiinflammatory.
Strain Bakteri Asam Laktat SBM10 dari Matriks Berbasis Nabati Berupa Fermentasi Sirup Beras Merah: Evaluasi Keamanan In Vitro dan Karakterisasi Colin, Vito; Suandy, Suandy; Chiuman, Linda
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1099

Abstract

Plant-based fermentation offers a route to develop nondairy probiotic candidates, yet syrup-like matrices remain underexplored compared with solid or beverage systems. This study investigated fermented red rice syrup (prepared from red rice and barley malt powder) as a source of lactic acid bacteria (LAB) and advanced one isolate, SBM10. Cultivation on MRS supplemented with CaCO₃ yielded acidogenic colonies. A stable morphotype (SBM10) was purified and exhibited a LAB consistent profile, Gram-positive rods, catalase negative, TSIA K/A without H₂S, Simmons citrate negative, gelatinase negative, CO₂ positive in Durham and γ-hemolytic on 5% sheep blood agar. Under gastrointestinal stress models (4 h, 37 °C), tolerance relative to controls was 27.14% at pH 3.0 and 35.58% in 0.3% oxgall. In disk diffusion assays, the cell-free supernatant (CFS) showed no inhibition of Escherichia coli or Staphylococcus aureus. Thus, no antibacterial activity was detected by disk diffusion under the conditions tested, whereas amoxicillin produced zones of 13.95 mm and 12.43 mm, respectively. SBM10 presents a safety-supportive, LAB-typical profile with partial tolerance to gastric-like acidity and bile. Although no disk diffusion antagonism was detected for the CFS, the results motivate taxonomic confirmation and process/formulation optimization, such as improving acid/bile robustness and re-evaluating antimicrobial potential with complementary assays, to clarify the suitability of SBM10 for plant-based functional applications.
Formulasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) dari Ekstrak Etanol Daun Pegagan (Centella asiatica) Sebagai Obat Antidiabetes Oral Melati, Rynna; Setiyadi, Gunawan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1104

Abstract

This research aims to develop a SNEDDS formulation based on the ethanolic extract of pegagan leaves (Centella asiatica). The goal is to improve the solubility and effectiveness of asiaticosida, an active compound that holds promise as a diabetes therapy. The extract is obtained through a soaking process with 96% ethanolic, resulting in a yield of 32.8%. The asiaticosida content in 200 mg of extract was analyzed using the HPLC method. To compile the SNEDDS, a combination of oils, surfactants, and cosurfactants that are most compatible with asiaticosida is selected. The selection results showed that soybean oil, Tween 20, and PEG 400 had the highest solubility levels: 375 mg/L, 115.73 mg/L, and 71.62 mg/L, respectively. This formulation used a 5:4:1 ratio of all three components, resulting in nanoemulsions with an average particle size of 127.6 nm, PDI 0.33, and a zeta potential of -45.86 mV that a best indicator of stability. Experimental results indicated that fast emulsification times and high levels of transmittance in various media (water, AGF, and AIF), approximately 47.33 s, respectively; 52.66 s; and 40.33 s, with a transmittance value above 85%. The nanoemulsion remained stable for 4 hours of observation. Further analysis showed that the asiaticosida dissolved in SNEDDS reached 12,34 ± 2,91 mg (4,11 mg/mL, n=3), slightly lower than the pure extract of dan 13,05 ± 2,62 mg (6,525%b/b, n=3). Overall, the SNEDDS of pegagan leaves show great potential as an innovation in the development of herbal medicines, especially for future clinical applications.
Pengaruh Metode Ekstraksi Terhadap Kadar Flavonoid Total dan Aktivitas Antioksidan Tanaman Kenop (Gomphrena globosa) Ramadhan, Rohan; Sari, Asti Arum
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1111

Abstract

Gomphrena globosa is a medicinal plant with attractive pigments and therapeutic properties, including antihypertensive, anticancer, and antioxidant effects. These activities are mainly attributed to phenolic compounds such as flavonoids. Previous studies have shown that ethanolic extracts of G. globosa flowers and leaves obtained by maceration have potent antioxidant activity. However, no study has yet reported Soxhlet extraction of G. globosa leaves. Therefore, this study aimed to compare Soxhlet extraction and maceration extraction methods to evaluate their efficiency in extracting flavonoids and antioxidant activity. Flavonoid levels were determined using the aluminium chloride colourimetric method with quercetin as a standard, and antioxidant activity was evaluated using the DPPH radical scavenging assay. The results showed that maceration produced a higher flavonoid content (78.33 ± 2.14 mg QE/g extract) than Soxhlet extraction (57.43 ± 1.53 mg QE/g extract). Consistently, antioxidant activity was more potent in the macerated extract (IC₅₀ = 53.93 ± 1.78 μg/mL) compared to the Soxhlet extraction (IC₅₀ = 62.50 ± 0.39 μg/mL). Evaluation using the t-test showed that the antioxidant activities of these methods were significantly different (p < 0.05). These findings indicate that maceration is more effective in extracting flavonoids from G. globosa leaves, resulting in high antioxidant activity. Moreover, G. globosa leaves emerged as a promising natural antioxidant source for pharmaceutical and functional food applications.
Pasien Kanker Payudara yang Menerima Terapi Tamoxifen di Dua Rumah Sakit Swasta di Jawa Tengah: Profil Sosiodemografi, Klinis, dan Pengobatan Setiawardani, Maria Fitri; Cholisoh, Zakky; Hapsari, Pramudita Mila
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1114

Abstract

Breast cancer is one of the most common types of cancer, including in Central Java Province, Indonesia, which reports a high incidence. The number of cases continues to increase, likely due to low public awareness of breast self-examination (BSE), limited health education, and a lack of motivation to undergo regular check-ups. One of the main treatment options is hormonal therapy, with Tamoxifen being the most widely used drug. To date, there is limited data on the sociodemographic and clinical characteristics among breast cancer patients who use Tamoxifen in Central Java. This information is essential for improving patient care and treatment strategies. This study aimed to describe the sociodemographic and clinical characteristics of breast cancer patients who received Tamoxifen at two private hospitals in Central Java. The results showed that most patients were under 50 years old (66%), had a low level of education (65.2%), and were employed (34.8%). Clinically, most patients were in advanced stages (56.5%), had no comorbidities (89.7%), and were not taking other medications (85%). These findings provide an initial overview of the profile of breast cancer patients using tamoxifen at two private hospitals in Central Java. However, these results cannot be generalized to the entire Central Java region due to the limitations of the study locations. Further studies with a broader scope are needed to obtain more representative data.
Hubungan Pengetahuan Ibu Tentang Penerapan Pijatan Stimulus Touch Dengan Peningkatan Kualitas Tidur Pada Bayi Afriza , Nurul; Syahadah, Nurul Fatehah; Azkiah, Novi; Zega, Ningsisari; Sondang, Mega; Paninsari, Debora
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1118

Abstract

Background: Baby massage is a non-pharmacological stimulation technique believed to improve infant sleep quality through gentle touch that stimulates the nervous system and circulation. A mother's knowledge of massage techniques plays a vital role in its effectiveness. Objective: To determine the relationship between maternal knowledge of stimulus touch massage application and the improvement of infant sleep quality at Siti Hajar Clinic. Methods: This study used an analytical survey design with a cross-sectional approach. A total of 30 mothers with infants aged 0–12 months who visited Siti Hajar Clinic in April 2025 were selected using total sampling. Data were collected using a questionnaire and analyzed using the Chi-Square test. Results: Based on the results obtained, out of the total respondents, the majority—27 mothers with good knowledge—had babies whose sleep quality improved, representing 90%. Two respondents with moderate knowledge also experienced improved sleep quality in their babies (6.7%), while one respondent with poor knowledge showed no improvement in the baby's sleep quality (0%). Statistical analysis revealed a significant result (p = 0.000 < 0.05), indicating a relationship between maternal knowledge and improved infant sleep quality. Conclusion: There is a significant relationship between maternal knowledge of stimulus touch massage and the improvement of infant sleep quality.

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