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Muhammad Iqhrammullah
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Narra X
Published by PT Narra Sains Indonesia
ISSN : -     EISSN : 29882990     DOI : DOI: https://doi.org/10.52225/narrax
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health
Narra X is a multidisciplinary journal, published three times in a year (April, August, and December). The journal aims to act as a platform for rapid scientific communication while upholding the highest integrity. Articles are published in a form of Original articles, Short Report, Case Reports, Methods articles, Review articles, and Letters to the Editor. All submitted articles are subjected to peer-review prior to their publication. As a multidisciplinary journal, Narra X welcomes articles from any subject field, depending on the editorial capacity. At the moment, Narra X is handled by section editors in the following fields: Health and medicine Chemistry Biology Mathematics Physics Narra X is online only journal and all articles do not have page numbers; instead, they are given a unique article number.
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Articles 90 Documents
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Essential oils for COVID-19 management: A systematic review of randomized controlled trials Duta, Teuku F.; Rizki, Diva R.; Purnama , Agnia; Rademaker, Marius; Wollina, Uwe; Acharya, Yogesh; Abdeen, Ziad; Rosa, Sandro G. V.; Nielsen, Henning B.; Subbaram, Kannan
Narra X Vol. 1 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i2.84

Abstract

Essential oils can be a beneficial adjuvant therapy in managing coronavirus disease 2019 (COVID-19). This systematic review aims to evaluate the efficacy of essential oils in ameliorative COVID-19-related symptoms. Published studies reporting the efficacy of essential oils as adjuvant therapy for COVID-19 were screened on Scillit, Scopus, SciFinder, and PubMed (December 7th, 2022). Inclusion criteria include the randomized controlled trials (RCTs) participated by those diagnosed with COVID-19 and treated with essential oils as adjuvant therapy. Quality assessment was carried out using Cochrane ‘risk-of-bias’ 2.0 tool. A total of 2112 records were retrieved from the initial screening, which was reduced to four publications (n=344 individuals). The foregoing studies reported that essential oils could improve the recovery rate, alleviate post-COVID-19 fatigue, and prevent disease progression. Regarding their potential antiviral activity, better designed studies are needed. In conclusion, essential oils as adjuvant therapy are beneficial in ameliorating mild COVID-19 symptoms.
Cancer in Indonesia: A bibliometric surveillance Iqhrammullah, Muhammad; Refin, Randa Y.; Rasmi, Rika I.; Andika, Fina F.; Hajjah, Hajjah; Marlina, Marlina; Ningsih, Ratna
Narra X Vol. 1 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i2.86

Abstract

Being archipelagic in geography and heterogenous in population contributes to the challenging comprehensive cancer surveillance in Indonesia. This present study analyzed the scientific publications on cancer epidemiology in Indonesia through bibliometric analysis aiming to complement the national survey data. The bibliometric data were retrieved from Scopus database on 9 May 2023 with pre-designed keyword combinations implying ‘cancer epidemiology in Indonesia’. The data were further presented in a table, distribution map, and visualized co-occurrence network. The visualization of co-occurring keywords was performed on VosViewer, and further analyzed qualitatively and quantitatively. We retrieved 1075 scientific records constituted of original articles (n=888, 82.6%), conference papers (n=102, 9.48%), and review articles (n=40, 3.72%) among others. The contributing affiliations are concentrated in Java Island, with Jakarta (n=603) as the province with the most publications. ‘Breast cancer’ (n=91) and ‘cervical cancer’ (n=39) emerged as the most frequently occurring keywords, and are assigned as the centers of research cluster, respectively. Keyword ‘breast cancer’ (total link strength, TLS=86) is connected with ‘colorectal cancer’, ‘metastasis’, ‘ovarian cancer’, and ‘prostate cancer’. Meanwhile, keyword ‘cervical cancer’ (TLS=35) is connected with ‘human papilloma virus’ and ‘knowledge’. The results are in line with the current epidemiological data of Indonesia, and they can provide different insights, especially on the research trend. Research and policy recommendations are presented in the last parts of this article.
Distribution and antimicrobial sensitivity pattern of multidrug-resistant Pseudomonas aeruginosa from the clinical specimen in Aceh, Indonesia Hayati, Zinatul; Ismail, Yulia S.; Suhartono, Suhartono; Zikra, Miftahul; Karmil, Teuku F.; Oktiviyari, Ade
Narra X Vol. 1 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i2.87

Abstract

The development of P. aeruginosa resistance to antibiotics is increasing globally due to the inappropriate use of antibiotics. This retrospective descriptive study aimed to determine the distribution of multidrug resistant P. aeruginosa (MDRPA) and its antimicrobial sensitivity profiles. Data were taken from the bacterial identification and antibiotic sensitivity testing of clinical specimens in Aceh Provincial Referral Hospital from July 2017 to June 2019, where the VITEK® 2 Compact automatic device was used for the identification. In total, there were 307 P. aeruginosa isolates analyzed in this study. The results of this study revealed that 54.39% of P. aeruginosa isolates were multidrug resistant.  The MDRPA were mostly found in sputum and pus cultures (41.91% and 23.95%, respectively). Based on the wardroom as the source, most samples came from the internal medicine unit, intensive care unit, and surgical unit with prevalence of 27.54%, 25.74%, and 20.35%, respectively. High proportion of infected patients were male (52.09%) and aged 56–65 years (23.95%). P. aeruginosa showed the highest sensitivity rate to amikacin (77.1%), followed by meropenem (74.4%), ceftazidime (70.1%), levofloxacin (65.1%), tobramycin (64.9%), piperacillin-tazobactam (64.3%), and gentamicin (61.4%). In conclusion, our data suggest that the MDRPA infection is prevalent in Aceh Province and Amikacin is recommended as the highest standard of therapy for MDRPA.
Music therapy improves social interaction and verbal communication skill among children with autism spectrum disorder: A systematic review and meta-analysis Amirah, Shakira; Abdurrahman, Muhammad F.; Akbar, Raihan F. A.; Mulya, Intan C.
Narra X Vol. 1 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i2.90

Abstract

The incidence of Autism Spectrum Disorder (ASD) is constantly increasing, in which 6 of 1000 ASD children are from Asia. Music therapy as a developing alternative is believed to improve communication and expression skills in children with ASD. Unfortunately, no specific meta-analysis has evaluated social interaction and verbal communication skills in children with ASD. Therefore, the aim of this meta-analysis was to evaluate music therapy in children with ASD. We performed a comprehensive literature review on PubMed, Scopus, Embase, Wiley, and Proquest to study the efficacy of music therapy as an ASD management therapy until October 20th, 2022. Twenty-three randomized controlled trials involving patients with ASD, where 1129 patients were assigned in the intervention group and 759 patients – in the control group, were included in qualitative and quantitative analysis. The pooled estimates revealed that music therapy increased the social interaction score with mean difference (MD)=2.08 (95% confidence interval [CI]: 0.35–3.81; p<0.02), social interaction score based on Autism Diagnostic Observation Schedule with MD: 0.77 (95% CI: 0.03–1.51; p<0.04), verbal communication skill based on Autism Diagnostic Interview-Revised with MD=0.90 (95% CI: 0.79–1.00, p<0.01). In conclusion, music therapy has excellent efficacy and strong potency as a part of ASD management. Nevertheless, more clinical trials with similar parameters are still required to confirm these findings.
Metal oxide/chitosan composite for organic pollutants removal: A comprehensive review with bibliometric analysis Ahmad, Khairunnas; Chiari, Williams
Narra X Vol. 1 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i2.91

Abstract

Organic pollutants are now a global concern because of their rapid increase following the rapid industrial growth. In tackling this problem, researchers have used chitosan that could act as adsorbing material. However, chitosan use in wastewater treatment requires further modification owing to its drawbacks of being susceptible to acidic environment and mechanically weak. Of many modifying approaches, metal-oxide embedment is perceived as promising because not only does it improve the chemical and physical properties of chitosan, but it also adds new features to the material such as being magnetic or photocatalytic. This present review describes the modification of chitosan through metal oxide embedment aiming to its utility in organic waste removal. Firstly, the definition of chitosan and the progress of its application in wastewater treatment are presented. Types of metal oxides, namely photocatalyst and magnetic iron oxide are also discussed. Embedment of metal oxides into chitosan could be done using methods such as sol-gel, high-energy ball milling, and spray-drying, where they affect the chemical and physical properties of the produced metal oxide/chitosan composites. Reported studies suggest a high percentage of organic pollutant removal, up to 100%. In addition to its removal ability, metal oxide/chitosan is also proven to be environmentally friendly and economical.
Acceptance, safety, and impact on quality of life of exergame for elderly patients with neurodegenerative diseases: A systematic review and meta-analysis Tsurayya, Ghina; Duta, Teuku F.; Naufal, Muhammad A.; Alina, Meulu; Isitua, Chinwe C.; Ohanu, Ernest C.
Narra X Vol. 1 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i3.94

Abstract

The aim of this study was to evaluate the efficacy, safety, adherence, and acceptance of exergame in improving the quality of life (QoL) among elderly patients with neurodegenerative diseases. A systematic search was conducted in PubMed, Embase and Scopus for relevant studies up to 16 March 2023. Quality of the included studies were assessed using Cochrane’s Risk of Bias tool version 2.0. Meta-analysis using a random effect was conducted on outcomes reported at least by two studies to calculate the standard mean difference (SMD) and its 95% confidence interval (CI). The difference of influence between exergame and conventional therapy was judged based on Z- and p-values. Heterogeneity was determined by I2 score. As many as 15 studies were included (n=466 participants) published between 2013–2023. Nine studies had ‘high quality’ five studies had ‘some concerns’, and one had ‘high risk’. Results from meta-analyses suggests that the exergame does significantly not improve the QoL among patients with Parkinson’s diseases. Similarly, no statistically significant difference (p>0.05) of QoL improvement among Alzheimer’s disease patients receiving exergame intervention. No adverse effects were reported to be associated with the intervention, and in fact, the patients experienced reduced fatigue and fear of falling. Patients in intervention group showed high acceptance and adherence to the therapy, which could be attributed to exergame being enjoyable, easy-to-use, and motivational. In conclusion, despite exergame being highly acceptable and relatively safe, the intervention does not improve the QoL of the elderly patients.
Biochemical and Fe-resistant characteristics of indigene bacteria from a high iron concentration landfill in Indonesia Saputri, Purwati; Harahap, Diannita; Lubis , Syafrina S; Ilhami, Syarifa
Narra X Vol. 1 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i3.95

Abstract

Bacteria isolated from leachate with high heavy metal concentration mostly have potential for bioremediation. The aim of this study was to isolate bacteria from leachate of a landfill containing high concentration of Fe. The leachate sample was collected from Gampong Jawa Landfill, Aceh, Indonesia and used to isolate the bacteria by spread method. The purification of the isolates was carried out through four quadrant plate method. Pure isolates were characterized based on the microscopic or macroscopic appearance and biochemical tests. Fe-resistance was tested by disc diffusion method and constructing the growth curve based on the optical density of broth culture media. A total of 27 pure isolates were obtained and identified, representing eight different genera: Pseudomonas, Bacillus, Neisseria, Micrococcus, Staphylococcus, Proteus, Acinetobacter, and Escherichia. Of eight isolates (each genus was represented by a single isolate), Pseudomonas sp. and Bacillus sp. were considered resistant to Fe exposure (15 ppm) with inhibition zones of 1.00 and 0.81 mm, respectively. At Fe concentration of 20 ppm the inhibition zones exceeded 1 mm, but Bacillus sp. had smaller inhibition zone than that of Pseudomonas sp. (1.15 mm versus 2.86 mm). Growth inhibition of Bacillus sp. was concentration-dependent on Fe exposure but could survive at Fe exposure up to 20 ppm. In conclusion, Bacillus sp. had a resistance against Fe exposure and its bioremediation potential is subjected for future studies.
Vitamin D supplementation improves foot ulcers among diabetic patients: Pooled analysis of randomized controlled trials Putra, Muhammad IA.; Gusti , Naufal; Duta, Teuku F.; Alina, Meulu; Qanita, Intan; Naufal, Muhammad A.; Henira, Najlaika; Tsurayya, Ghina; Amirah, Shakira
Narra X Vol. 1 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i3.104

Abstract

Serum vitamin D level is associated with the development of diabetic foot ulcer (DFU), and it is intriguing to determine if the vitamin supplementation could reverse the diabetic complication. The aim of this study was to investigate the efficacy of vitamin D supplementation in DFU management through qualitative and quantitative systematic review. A systematic search was conducted to screen the records identified in PubMed, Scopus, Embase, Scillit, Sci-Finder, LILACS, EuropePMC, medRxiv, bioRvix, Google Scholar, Semantic Scholar, and Garuda databases as of 10 March 2023. Studies investigating the efficacy of a single dose supplementation of vitamin D in DFU management were included. Quality of the included studies was appraised by Cochrane ‘Risk of Bias’ 2.0. Random-effects-based pooled analysis using Cohen’s d was performed on the wound healing progress as the primary outcome. A sensitivity test with leave-one-out method and meta-regression were also conducted to analyze the effect of heterogenous data. Five studies with a total of 245 patients (123 versus 122 for experimental and control groups, respectively) were finally included in the qualitative and quantitative analysis. The pooled estimate suggested that administering vitamin D to DFU patients could reduce the wound area or depth significantly as compared to control group (p<0.001; Cohen’s d: 2.72; 95% CI: 1.02 to 4.42). The value remained positive throughout the leave-one-out analysis. Vitamin D supplementation significantly contributed to the increased level of serum vitamin D (p=0.026, Cohen’s d: -0.719; 95% CI: -1.35 to -0.09). Elevation of high-density lipoprotein was observed in pooled estimate with p=0.016 and Cohen’d: 1.34 (95% CI: 0.25 to 2.44). Qualitatively, significant reduction of HbA1C, total cholesterol, and C-reactive protein were reported in at least two trials. Significantly improved quantitative insulin sensitivity check index (QUICKI) and decreased malondialdehyde, fructosamine, and fasting blood glucose were reported in at least one trial each. There were conflicting results on the change of low-density lipoprotein level. This study highlights that vitamin D supplementation promotes wound healing process among DFU patients; however, it is too premature to draw solid conclusions as the efficacy could be affected by multiple factors. Therefore, clinical trials from various demographics and ethnicities by using a high- versus low-dose model are needed.
Willingness-to-pay for urban green space: A meta-analysis of surveys across China Wikurendra, Edza A.; Aulia, Aulia; Fauzi, Muhammad L.; Fahmi, Iqbal; Amri, Ikhwan
Narra X Vol. 1 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i3.105

Abstract

Sustainable ecosystem services are increasingly recognized amid rapid regional transformation. While the rate of urbanization in China continues to rise, there is an urgent need to evaluate public preferences and their associated economic values concerning urban green space (UGS). The aim of this study was to calculate the overall willingness-to-pay (WTP) for UGS across China. Literature search was performed systematically on Scopus, Scilit, PubMed, and Google Scholar databases on 11 November 2023. Studies reporting the WTP in China were included in the analysis. Quality of the included studies were appraised by using Q-SSP tool consisting of 20-item quality of survey studies in psychology. To calculate the overall willing to pay rate and WTP, a meta-analysis was performed using restricted maximum-likelihood model on raw proportions. A total of nine studies were included comprised of 9381 valid responses with high quality according to Q-SSP (score: 70–90%). Findings from the meta-analysis indicated that the rate of willing to pay for UGS was 70.8% (95%CI: 60%, 82%; p-Het<0.001, I2= 99.37%). The rate was not affected by sample size, age, gender, and education (p>0.05). Among mainland Chinese population alone, the average minimum WTP was 2.97 USD/month, and increased to 3.36 USD/month if combined with Hong Kong population. A majority of over 70% Chinese population were willing to pay for UGS. Nevertheless, high heterogeneity in the pooled estimates suggest the importance of addressing contextual variables and presence of regional disparities.
Trends in publication and collaboration of health-themed systematic reviews before and during the COVID-19 pandemic: A bibliometric study Chiari, Williams; Amirah, Shakira; Lemu, Yohannes K.; Subbaram, Kannan; Edwards, Robert J.; Kretchy, James-Paul; Vento, Sandro; Khader, Yousef; Rademaker, Marius
Narra X Vol. 2 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i1.106

Abstract

The presence of global threats such as coronavirus disease 2019 (COVID-19) pandemic could potentially affect the research landscape, particularly that of systematic reviews. The aim of this study was to examine disparities between countries and the role of funding availability in the publication of health-themed systematic reviews. Metadata of published literature was collected from the Scopus database as of June 30, 2023. The dataset was divided into ‘pre-COVID-19 (2017–2019)’ and ‘during COVID-19 (2020–2022)’ by utilizing filter feature of the Scopus search engine. Network visualization of co-authorship was carried out on VoSviewer to identify collaborative patterns between countries. Our results suggest that most of the systematic reviews were published by authors from the United States of America (USA), both in pre-COVID-19 (n=29,463; Total link strength, TLS=32,832) and during COVID-19 (n=35,520; TLS=45,616). During COVID-19, the trend was not much different with the USA (14.6%), the UK (8.8%), and Australia (5%) in the top position among high-income countries. China (12.3%) and Iran (2.4%) topped the upper-middle-income and low-income countries groups. Publications by those who were from low-income countries were in a concerning low number; Ethiopia ranked first in this group only occupied 0.4% of the total publications (n=1,047). Furthermore, the number of publications was proportional to the number of funded studies (as observed in the top countries). However, during COVID-19 pandemic, the proportionality between funded publications and total publications was observed less. Taken altogether, our findings stress the importance of capacity building and providing more funds for on-desk research to close the disparity among countries.

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