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INDONESIA
SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN
Published by Universitas Islam Sultan Agung
ISSN : 20851545     EISSN : 2339093X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.
Arjuna Subject : -
Articles 6 Documents
 1 
Search results for , issue "Vol 16, No 2 (2025): December 2025" : 6 Documents clear
Bioinformatics study of the a222v substitution in sars-cov-2 spike protein Ariesaka, Kiky Martha; Nuryady, Moh Mirza; Rini, Ika Agus
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i2.39242

Abstract

COVID-19, caused by SARS-CoV-2, has infected over 200 million people and caused 4.3 million deaths globally, with over 3.7 million cases and 110,000 deaths in Indonesia. SARS-CoV-2, a single-stranded RNA virus, has a genome encoding proteins such as Spike (S), Envelope (E), Membrane (M), and Nucleocapsid (N). The S protein, comprising S1 and S2 domains, facilitates ACE2 receptor binding and membrane fusion. This study examines the phylogenetic relationship of the A222V substitution in the S protein with various global isolates. We collected 25 complete SARS-CoV-2 sequences from the GISAID database, performed multiple sequence alignments using Clustal W in MEGA-X software, and constructed phylogenetic trees using the neighbor-joining method. The urgency of this paper lies in understanding the impact of the A222V mutation on the virus's infectivity and spread, which is crucial for developing targeted treatments and vaccines. The A222V variant, first identified in Spain in summer 2020, has spread rapidly across Europe, raising concerns about its potential to increase transmissibility or affect vaccine efficacy. The A222V variant likely affects protein conformation or stability rather than receptor binding or membrane fusion. Understanding these changes is essential as it can influence the virus's behavior and efficacy of public health interventions. The study found high mutation rates in the S gene with diverse point mutations. Phylogenetic analysis revealed that A222V isolates clustered closely with D614G variants. In conclusion, not all mutations result in amino acid changes, and A222V has minimal impact on ACE2 binding but may influence protein stability.
Reconciling Contradictory Findings: In Silico Evaluation of Annonacin’s Antimalarial Efficacy and Safety Tsaqif, Anindya Zerlina; Khodijah, Khodijah; Prayogi, Fahrizal Ryuzen; Nuryady, Moh Mirza; Ariesaka, Kiky Martha
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i2.39412

Abstract

Introduction. With the increasing resistance to existing antimalarial therapies, the discovery of new drugs has become urgent. Annona muricata contains phenolic compounds with antioxidant potential and bioactive properties, including annonaceous acetogenins, which exhibit cytotoxicity, raising safety concerns. Conversely, other studies have shown significant antimalarial activity from A. muricata extracts without observed toxicity, suggesting its potential as a lead compound for malaria treatment. This inconsistency calls for further investigation, particularly through in silico analyses, to clarify the interactions between these compounds and key malaria targets. Aim. This study employs in silico methods to explore Annonacin’s binding affinity to malaria proteins, PfDHODH and PfLDH, and evaluates its toxicity and bioavailability. Methods. Molecular docking was conducted using Molegro Virtual Docker (MVD) version 6.0 to assess Annonacin’s binding interactions with PfDHODH and PfLDH. Toxicity was analyzed using ProTox-II, focusing on cytotoxicity and LD50 value. Pharmacokinetic properties, including gastrointestinal absorption and adherence to Lipinski’s rule of five, were evaluated using SwissADME. Results. Docking results revealed that Annonacin forms stable complexes with both proteins, suggesting strong inhibitory potential. However, toxicity analysis highlighted significant cytotoxic effects, with an LD50 of 400 mg/kg placing Annonacin in Toxicity Class IV, indicating ingestion risks. Pharmacokinetic analysis revealed challenges such as low gastrointestinal absorption and a violation of Lipinski’s rule due to high molecular weight. Conclusion. These findings suggest Annonacin has antimalarial potential, but its development is hindered by safety concerns and pharmacokinetic limitations. Further optimization is needed to balance efficacy with safety, providing a foundation for future research and development.
Effectivity Combination of Low Impact Aerobic Exercise and Hatha Yoga on Blood Pressure and Pulse Rate in Patients with Hypertension Priyantini, Diah; Ayatulloh, Daviq; Rofiqi, Erfan; Prabawati, chlara Yuanita; Winata, Septian Galuh; Kiptiyah, Mariyatul
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i2.39271

Abstract

Background: Non-pharmacological therapy in hypertensive patients to improve blood pressure and pulse began to be selected to provide support for pharmacological treatment. This study aims to analyze the effectiveness of a combination of low impact aerobic exercise and hatha yoga on blood pressure and pulse rate in patients with hypertension.Metode: Penelitian kuantitatif pada pasien hipertensi menggunakan pendekatan desain kelompok kontrol pra-posttest eksperimental. Pasien sesuai dengan kriteria direkrut menggunakan purposive sampling dan memperoleh 39 responden masing-masing dalam kelompok kontrol dan intervensi. Variabel independen dari penelitian ini adalah kombinasi latihan aerobik berdampak rendah dan hatha yoga yang diberikan dua kali seminggu selama 4 minggu dengan durasi 40 menit pemanasan, 10 menit istirahat dan 20 menit pendinginan. Variabel dependen tekanan darah dan denyut nadi diamati melalui pengukuran. Data dianalisis menggunakan uji-t berpasangan.Hasil: Sebanyak 37 responden dari masing-masing kelompok bertahan hingga akhir penelitian, dan hasilnya menunjukkan efek signifikan dari kombinasi aerobik berdampak rendah dan hatha yoga pada tekanan darah dan denyut nadi pada pasien hipertensi (p=0,000) pada kelompok intervensi. Tekanan darah sistolik menurun dari 147,78 ± 6,014 menjadi 131,08 ± 6,576. Tekanan darah diastolik menurun dari 95,08 ± 2,278 menjadi 80,81 ± 6,032 dan denyut nadi menurun dari 87,62 ± 5,570 menjadi 79,49 ± 5,295.Kesimpulan: Kombinasi latihan aerobik berdampak rendah dan hatha yoga telah terbukti efektif dalam menurunkan tekanan darah dan denyut nadi pada pasien hipertensi, sehingga terapi dapat digunakan sebagai terapi suportif untuk mendukung terapi farmakologis pasien.
Nutritional therapy to support polycystic ovary syndrome management in preconception and pregnancy programs Heny Yuniarti; Rini Aryani; Minidian Fasitasari
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i2.38304

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with infertility,obesity, and insulin resistance. This case report describes a 21-year-old woman with PCOS,primary infertility for 3.5 years, irregular menses, and obesity (BMI 31.3 kg/m2) who was referred to a pregnancy program and received combined management including pharmacotherapy (orlistat and vitamin D3), a calorie-restricted diet, and increased physical activity. After 3 months, she lost 6 kg, with reductions in body fat and visceral fat, and improved insulin resistance; she conceived in the 4th month and later delivered a healthy, term infant. These findings suggest that integrated nutritional therapy, together with pharmacological treatment and lifestyle modification, may support weight loss, improve metabolic parameters, and enhance pregnancy outcomes in women with PCOS, though controlled studies are needed to confirm efficacy and define optimal interventions.
Immunotherapy as an alternative therapy for myasthenia gravis Meyvita Silviana; Endang Kustiowati
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i2.28256

Abstract

Myasthenia gravis is an autoimmune disorder characterised by fluctuating, progressive weakness of skeletal muscles and activity-related fatigability. It most commonly affects young women and older men. The disease results from dysfunction at the neuromuscular junction involving acetylcholine signalling and calcium ions. Autoantibodies directed against the nicotinic acetylcholine receptor (AChR) are the principal cause of muscle weakness in many patients with myasthenia gravis. Frequently affected muscles include those controlling eye movements and eyelid elevation, chewing, swallowing, coughing, and facial expression; proximal limb and neck muscles, as well as respiratory muscles, may also be involved. Clinically, patients experience variable skeletal muscle weakness that worsens with exertion and improves with rest. Typical initial symptoms include diplopia, ptosis, dysphagia with recurrent aspiration, and difficulty chewing. Diagnostic investigations commonly used to establish the diagnosis include assays for anti-acetylcholine receptor antibodies and imaging such as chest radiography and MRI. Standard treatments comprise acetylcholinesterase inhibitors, corticosteroids, other immunosuppressive agents, and thymectomy. This review focuses on the pathophysiology of myasthenia gravis and current management strategies, with particular emphasis on immunotherapies that target components of the immune system.
Musculoskeletal Disorders (MSD) among Sack Sewing Workers in Duduk Sampeyan District Gresik Regency Pitaloka, Rizka Dyah; Syamila, Ana Islamiyah; Noveyani, Adistha Eka
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i2.39027

Abstract

Musculoskeletal Disorders (MSD) a disorder that cause damage to tissues, muscles, joints, nerves, and bones due to unergonomic working attitudes. Unergonomic work attitudes are often observed among sewing workers. One of the complaints of MSD, low back pain, occupies the highest position in the Gresik Regency in 2023. Sack-sewing workers perform sewing standing; therefore, they often experience leg pain. This study aimed to describe the risk factors for MSD in sack sewing workers in the Duduk Sampeyan District in the production section using a total sampling technique of 39 workers. This type of research uses observational descriptive and descriptive analysis to determine the RR value. Data was obtained from interviews and observations of work posture. The instruments used were Nordic Body Map, Rapid Entire Body Assessment, and %CVL. The results of this study showed that the highest level of pain experienced by workers was in the left leg. The work period showed a tendency towards MSD complaints with a p-value 0.00 and RR 5.8, which means that a working period of > 5 years are 5.8 times more likely to experience MSD than workers with a working period of ≤ 5 years. Although the work posture was not significant, it was in the medium and high categories. Recommendations that can be given are to adjust the height of the sewing table to the worker's anthropometry, stretch during breaks, especially the legs, and form an Occupational Health Post in Duduk Sampeyan District.

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