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Journal of Pharmaceutical (JOP)
Published by Universitas Jenderal Achmad Yani Yogyakarta
ISSN : -     EISSN : 29877466     DOI : https://doi.org/10.30989/jop.v1i1
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Journal of Pharmaceutical (JOP) adalah Jurnal ilmiah yang memuat hasil penelitian pada ranah Farmasi. Cangkupan jurnal meliputi: 1. Pharmaceutical Technology 2. Pharmacology and Toxicology 3. Pharmaceutical Chemistry 4. Drug Discovery 5. Pharmaceutical Biology and Herbal Medicines 6. Pharmaceutical Microbiology and Biotechnology 7. Community and Clinical Pharmacy 8. Management and Sosial Pharmacy
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 45 Documents
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Daya Hambat Fraksi n-heksan, Etil Asetat, dan Air dari Ekstrak Etanol Bunga Cengkeh (Syzygium aromaticum (L.) Merrill & Perry) Terhadap Bakteri Staphylococcus epidermidis Ratih Armay Gustari; Nofran Putra Pratama; Kurnia Rahayu Purnomo Sari
JOURNAL OF PHARMACEUTICAL (JOP) Vol 1 No 1 (2023): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v1i1.865

Abstract

Background: Clove flower plants are known as traditional plants that can be used in food, drink and medicine. Clove flower ethanol extract (Syzygium aromaticum (L.) Merrill & Perry) has antibacterial activity. Antibacterial is a substance that can interfere with the growth or kill bacteria by interfering with the metabolism of harmful microbes.Objective: This study was conducted to determine how effective the n-hexane, ethyl acetate, and water fractions from clove the ethanol extract of clove flower (Syzygium aromaticum (L.) Merrill &Perry) in inhibiting the growth of Staphylococcus epidermidis bacteria.Method: Extract were made by the maceration method with 70% ethanol as a solvent. Then proceed with the fractionation process using a liquid-liquid extraction method using three solvents, namely n-hexane solvent (non-polar), ethyl acetate solvent (semi-polar), and water solvent (polar). Identification of clove flower extract and fraction flower was carried out by organoleptic test, phytochemical screening test, and thin layer chromatography test. A Bacterial inhibition test was carried out using the Kirby-Bauer disc diffusion method using concentrations of 20%, 40%, 60%, 80% and 100% with positive control used chloramphenicol while the negative control used distilled water.Result: The results of the n-hexane and ethyl acetate fraction had bacterial inhibition at concentrations of 60%, 80%, and 100%. The water fraction had a zone of bacterial inhibition at 100% concentration.Conclusion: Based on the results of the study was found that the n-hexane, ethyl acetate, and water fractions had effectiveness in inhibiting the growth of Staphylococcus epidermidis bacteria.
Peredaman Radikal Bebas Ekstrak Etanol Daun Rosella (Hibiscus sabdariffa L) Dengan Metode Frap (Ferric Reducing Antioxidant Power) Vina Farah Fauziah; Devika Nurhasanah; Nofran Putra Pratama
JOURNAL OF PHARMACEUTICAL (JOP) Vol 1 No 1 (2023): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v1i1.866

Abstract

Background: Antioxidant are chemical compounds that can donate electrons to unpaired free radicals, thereby reducing the effects of free radical oxidation. One of the plants that have antioxidants activity is the rosella plant, for example in the leaves. Rosella leaves contain phytochemical compounds that are useful as antioxidant, namely flavonoids, alkaloids, saponins, tanin.Objective: Determine the antioxidant activity of the ethanol extract of rosella leave (Hibiscus sabdariffa L) by FRAP method.Method: Rosella leaf was macerated using 70% ethanol as solvent. Then filtered and thicken using a frying pan on an electric stove over medium heat of approximately 300 watt. Phytochemical screening was carried out, namely flavonoids, alkaloids, saponins, tanin and TLC test to indicate the presence of flavonoid compounds as antioxidants. Quantitative analysis was carried out to determine antioxidant activity with the FRAP method measured using a UV-Vis spectrophotometer.Result: The antioxidant activity test of the ethanol extract of rosella leaves has FRAP value of 1,749 mmol FeSO4/mg. Based on statistical analysis T-test, shows that there is a difference between the sample and the standard with a significant value (p<0,05) is 0,001.Conclusion: The antioxidant activity test on rosella leaves with the FRAP method proved that the ethanol extract of rosella leaves had antioxidant content with a FRAP value of 1,749 mmol FeSO4/mg.
Analisis Tartrazin dalam Minuman Kemasan di Pasar Bandar, Batang secara Spektrofotometri UV-Vis Widyasari, Diah Ayu; Khasanah , Kharismatul
JOURNAL OF PHARMACEUTICAL (JOP) Vol 1 No 1 (2023): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v1i1.918

Abstract

Minuman kemasan merupakan minuman yang dikemas dengan beraneka macam kemasan yang bisa diminum secara langsung maupun harus diolah terlebih dahulu. Salah satu zat pewarna yang ditambahkan dalam minuman kemasan yaitu tartrazin yang bertujuan untuk menambah daya tarik minuman tersebut. Batas penggunaan tartrazin sebagai bahan tambahan pangan berdasarkan BPOM No 11 Tahun 2019 yaitu 70mg/kg tiap produk sajian sekali minum. Penelitian ini bertujuan untuk mengetahui kandungan tartrazin pada minuman kemasan secara kualitatif sekaligus menganalisis kadar kandungan tartrazin secara kuantitatif pada sampel minuman kemasan dengan Spektrofotometri UV-Vis yang beredar di Pasar Bandar, Kabupaten Batang. Jenis penelitian ini adalah penelitian non eksperimental. Sampel yang digunakan pada penelitian ini yaitu sampel yang diambil sesuai dengan kriteria inklusi dan eksklusi sampel. Analisis kualitatif dengan menggunakan metode uji pengendapan FeSO4. Analisis kuantitatif dilakukan dengan metode Spektrofotometri UV-Vis. Hasil analisis kualitatif pada 7 sampel, sebanyak 42,86% positif mengandung tartrazine (sebanyak 3 sampel), dari 3 sampel yang positif dilakukan uji kuantitatif, 2 sampel diantaranya kadarnya dapat dideteksi sedangkan 1 sampel tidak terdeteksi kadarnya. Kadar tartrazin yang terkandung dalam minuman kemasan beredar di Pasar Bandar Kabupaten Batang yang dianalisis secara Spektrofotometri UV-Vis adalah 7,81mg/L pada sampel 1 dan 1,77mg/L pada sampel 2. Kadar tartrazin pada minuman kemasan beredar di Pasar Bandar Kabupaten Batang masih berada di bawah ambang batas tartrazin yang ditetapkan oleh pemerintah, yaitu 70mg/L atau 70mg/kg.
Formulasi Sediaan Krim Dari Ekstrak Daun Ketapang (Terminalia catappa L.) Ningsih , Roma Fiyati; Anjasmara , Bayu; Yunita , Erma
JOURNAL OF PHARMACEUTICAL (JOP) Vol 1 No 1 (2023): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v1i1.919

Abstract

Daun ketapang (Terminalia catappa L.) dapat dimanfaatkan sebagai antimikroba. Pemanfaatan bahan alam sebagai bahan obat akan menjadi lebih efektif bila dibuat dalam bentuk sediaan farmasi, salah satunya adalah sediaan krim yang dapat digunakan pada kulit. Penelitian ini bertujuan untuk melakukan formulasi dan uji fisik sediaan krim ekstrak daun ketapang menggunakan basis vaselin album dan cera. Daun ketapang dimaserasi menggunakan etanol 96%. Krim dibuat dalam 6 formula yaitu F1 (vaselin album 10%); F2 (vaselin album 15%); F3 (vaselin album 20%); F4 (vaselin album 10% + cera alba 5%); F5 (vaselin album 15% + cera alba 5%); dan F6 (vaselin album 20% + cera alba 5%). Uji sifat fisik krim dilakukan selama 4 minggu, meliputi uji organoleptis, pH, homogenitas, dan sebaran. Hasil menunjukkan ekstrak daun ketapang dapat dibuat sediaan krim berwarna hijau pucat serta bau khas sediaan krim. Sediaan yang dihasilkan homogen dengan nilai sebaran pada rentang 5-7 cm, serta pH pada rentang 7-8. Sediaan krim menggunakan basis vaselin album dan cera alba memiliki dengan sifat fisik yang baik pada uji organoleptis, homogenitas, daya sebaran, namun belum memenuhi persyaratan pH sediaan krim.
Aktivitas Antioksidan Infusa Biji Kopi Robusta (Coffea canephora Pierre ex. A Froehner) Sangrai Dan Green Bean di Kota Pagaralam Dengan Metode DPPH Wenben, Desi Sagita; Wulandari, Septi
JOURNAL OF PHARMACEUTICAL (JOP) Vol 1 No 1 (2023): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v1i1.920

Abstract

Radikal bebas adalah molekul yang dapat menyebabkan berbagai kerusakan molekular pada tubuh, sehingga dapat menimbulkan berbagai macam penyakit. Oleh karena itu banyak dialkukan penelitian mengenai radikal bebas dan antioksidan. Biji kopi robusta (Caffea canephora) diduga memiliki aktivitas antioksdian yang kuat sehingga mampu meredam aktivitas radikal bebas pada tubuh. Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan dari infusa kopi robusta dengan metode DPPH (1.1-dipheny1-2-picrylhydrazyl). Cara infusa dengan pelarut etanol digunakan untuk membuat infusa. Konsetrasi yang digunakan pada uji aktivitas antioksidan infusa kopi robusta dimulai dari 200 ppm, 400 ppm, 600 ppm, 800 ppm. Infusa kopi robusta dicampurkan dengan DPPH. Vitamin C dipilih sebagai kontrol positif. Spektrofotometer digunakan untuk pengukur absorbansi dengan panjang gelombang 510-520 nm. Hasil penelitian ini menunjukan perubahan warna secara kualitatif pada infusa biji kopi robusta dan vitamin C. Nilai IC50 infusa biji kopi robusta senilai 2, 4, 6, 8, dan10 ppm dan termasuk aktivitas antioksidan sedang berdasarkan klasifikasi Blois.
Aktivitas Peredaman Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius) dengan Metode DPPH (2,2-difenil-1-pikrilhidrazil) Nurhasanah, Devika; Nofran Putra Pratama; Sri Purwa Pujihastuti
JOURNAL OF PHARMACEUTICAL (JOP) Vol 1 No 2 (2023): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v1i2.1223

Abstract

Background: Antioxidants are compounds that prevent an oxidation reaction from free radical compounds and important role in capturing free radicals in the human body. Excessive free radicals in the body can cause tissue damage and degenerative diseases. Pandanus amarillyfolius are known to act as natural antioxidant that have the potential to capture free radical compounds, because of their presence of flavonoid compounds. Objective: This study aims to determine the free radical scavenging activity of DPPH against the leaf extract of Pandanus amaryllifolius. Method: Pandanus amaryllifolius extraction was carried out using the maceration method with methanol as solvent (1:10). Concentration was carried out using a rotary evaporator to obtain a thick extract. Phytochemical screening and TLC test were carried out qualitatively using the mobile phase n-butanol: acetic acid: water (6:2:2) and phytochemical testing including flavonoids, alkaloids, saponins, tannins, steroids or terpenoids to determine the presence of flavonoid compounds as antioxidants. Free radical scavenging activity was tested using DPPH free radical scavenger with concentrations of vitamin C 2, 4, 5, 6, 8 ppm and pandanus fragrance extract concentrations of 10, 15, 20, 25 ppm and measured using a UV-Vis spectrophotometer to calculate the IC50 value. Result: The results of the phytochemical screening test of fragrant pandan indicate the presence of flavonoid compounds. The Rf value of the TLC test obtained 0.765 quarcetin and 0.787 extract and the resulting yellow spots, the Rf value of pandan extract which was almost the same as the Rf value of quercetin indicated that the pandan extract may contain the same compounds as quercetin, namely flavonoid compounds. The results of the free radical scavenging activity of methanol extract of pandan leaves were 86,861 g/ml and for comparison, vitamin C was 39,103 g/ml. Based on the statistical analysis of the T-Test, it is known that there is a difference between the sample and the standard with a significant value (p <0.05), namely 0.001 and 0.023. Conclusion: The Pandanus amaryllifolius extract test using the DPPH method is in the strong category (IC50 <50 -100 g/ml) and the comparison of Vitamin C is in the very strong category (IC50 <50 g/ml).
Pengaruh Perbedaan Pelarut Dalam Ekstraksi Herba Seledri (Apium graveolens L.) Terhadap Aktivitas Peredaman Radikal Bebas DPPH Luluk, Luluk nurjanah; Pratama, Nofran Putra; Sari, Kurnia Rahayu Purnomo
JOURNAL OF PHARMACEUTICAL (JOP) Vol 1 No 2 (2023): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v1i2.1225

Abstract

Background: The decreased physiological function is influenced by age and degenerative diseases. Degenerative diseases can be caused by free radicals. Neutralization of free radicals can be done by giving antioxidants. However, synthetic antioxidants cause many side effects so that natural antioxidants are needed from natural ingredients. Celery (Apium graveolens L.) is a natural antioxidant that can be used as antioxidant because celery contains flavonoid compounds. Objective: This study aims to determine the effect of different solvents of ethanol 96%, ethyl acetate, and n-hexane in the extraction of celery herbs on the free radical scavenging activity of 1,1-diphenyl-2-picrylhydrazyl (DPPH). Method: Celery herbs were extracted using the maceration method to obtain ethanol 96%, ethyl acetate, and n-hexane extracts. The extract was then tested for its free radical scavenging activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method using UV-Vis spectrophotometry. The principle of the DPPH method is that a hydrogen atom binds to a free radical, causing the free radical to become a non-radical. Result: The results showed that 96% ethanol extract of celery had the highest antioxidant activity with an IC50 value of 4.084 g/mL, followed by ethyl acetate 15.250 g/mL, and n-hexane 28.206 g/mL. Conclusion: which the three solvents could be categorized as very active.
Uji Aktivitas Antibakteri Fraksi N-Heksana Daun Pepaya (Carica papaya Linn.) Terhadap Escherichia coli dan Staphylococcus aureus Aprillia, Hananing; Putra Pratama, Nofran; Nur'Aini Purnamaningsih
JOURNAL OF PHARMACEUTICAL (JOP) Vol 1 No 2 (2023): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Infectious diseases are still a problem for the world of health. Infectious diseases are caused by viral, bacterial and parasitic infections. Inappropriate use of antibiotics in treating bacterial infections can cause antibiotic resistance effects. Prevention of the effects of resistance can be done by looking for natural antibiotic agents derived from plants. One of the potential medicinal plants as antibiotics is papaya leaf. Objective: The objective of study was determine the antibacterial activity of the papaya leaf n-hexane fraction against Escherichia coli and Staphylococcus aureus and to determine the diameter zone of inhibition the papaya leaf n-hexane fraction at 20%; 40%; 60%; 80%; and 100% against Escherichia coli and Staphylococcus aureus. Method: Papaya leaf were extraction by using maceration method of 70% ethanol as solvent. Separation of compounds based on the level of polarity using fractionation method with n-hexane: water (1:1 v/v) solvent then carried out phytochemical screening and separation of compounds using TLC method. The antibacterial activity testing used by agar diffusion method Kirby Bauer with the treatment group of papaya leaf n-hexane fraction with a concentration of 20%; 40%; 60%; 80%; and 100%, the positive control group used Ampicillin 10 μg and the negative control group used Aquades. Result: Diameter zone of inhibition Escherichia coli and Staphylococcus aureus was smallest at 20% was 6,57 ± 0,15 mm and 6,69 ± 0,33 mm, while the diameter zone of inhibition the largest at 100% was 7,92 ± 0,23 mm and 7,94 ± 0,16 mm. Conclusion: The papaya leaf n-hexane fraction concentration of 20%; 40%; 60%; 80%; and 100% had antibacterial activity against Escherichia coli and Staphylococcus aureus. The higher concentration then the larger diameter zone of inhibition formed.
-Perbandingan Kadar Total Flavonoid Fraksi Air, Etil, Asetat, n-Heksana pada Daun Tanaman Apu-Apu (Pistia stratiotes L.) Menggunakan Spektrofotometri UV-Vis ika, irmatika; Widodo, Ageng Ary; Aini, Sri Rodiatul
JOURNAL OF PHARMACEUTICAL (JOP) Vol 1 No 2 (2023): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v1i2.1233

Abstract

Apu-apu (Pistia stratiotes L) merupakan tanaman yang tumbuh didaerah tropis dan tumbuh diatas permukaan air yang tenang ataupun mengalir relatif lambat contohnya seperti area pertanian. Umumnya para petani menganggap tanaman apu-apu (Pistia stratiotes L) sebagai hama atau gulma yang menyerap kandungan nutrisi tanaman disekitarnya. Tanaman apu-apu (Pistia stratotes L) dapat tumbuh liar didaerah rawa, sungai, danau atau genangan air, sehingga dianggap dapat menyebabkan kerusakan lingkungan. Hasil skrining fitokimia Ekstrak etanol daun tanaman apu-apu (Pistia stratiotes L.) pada fraksi air dan etil asetat mengandung senyawa flavonoid dilihat dari perubahan warna, sedangkan untuk fraksi n-Heksan tidak mengandung senyawa flavonoid, hal ini dibuktikan dengan uji sinoda perubahan warnayang dilihat. Pada perhitungan Kadar Total Flavonoid yakni fraksi air mengandung senyawa Flavonoid sebesar 0,914 mgQE dalam 10 mg ekstrak sampel, pada fraksi Etil asetat mengandung 1,205 mgQE dalam 10 mg ekstrak sampel.
Penetapan kadar total flavonoid ekstrak etanol daun ketapang (Terminalia catappa L.) secara spektrofotometri UV-Vis Valentine, Firnanda Sixca Putri; Erma Yunita
JOURNAL OF PHARMACEUTICAL (JOP) Vol 1 No 2 (2023): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v1i2.1257

Abstract

Daun ketapang diketahui mengandung senyawa kimia berupa alkaloid, flavonoid, saponin dan kuinon. Daun ketapang memiliki manfaat sebagai antioksidan. Potensi ekstrak daun ketapang sebagai antioksidan dapat meningkat apabila kadar total flavonoid juga meningkat. Tujuan penelitian ini adalah untuk mengetahui kadar total flavonoid ekstrak etanol daun ketapang secara spektrofotometri UV-Vis. Daun ketapang diekstrasi dengan metode maserasi selama 3x24 jam menggunakan pelarut etanol 96%. Metode penetapan kadar menggunakan uji kualitatif dan uji kuantitatif. Penetapan kadar dilakukan secara kuantitatif dengan alat spektrofotometer UV-Vis menggunakan reagen AlCl3 dan kuersetin sebagai larutan baku. Analisa data yang digunakan dalam penetapan kadar total ekstrak etanol daun ketapang menggunakan persamaan regresi linear y = 0,0056x+0,0063. Uji kualitatif pada ekstrak etanol daun ketapang menunjukkan hasil positif senyawa flavonoid. Kadar total flavonoid yang terkandung dalam ekstrak etanol daun ketapang yang diuji secara spektrofotometri UV-Vis diperoleh sebesar 57,86±1,49 mgEQ/g ekstrak.

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