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Nofran Putra Pratama
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Journal of Pharmaceutical (JOP)
Published by Universitas Jenderal Achmad Yani Yogyakarta
ISSN : -     EISSN : 29877466     DOI : https://doi.org/10.30989/jop.v1i1
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Journal of Pharmaceutical (JOP) adalah Jurnal ilmiah yang memuat hasil penelitian pada ranah Farmasi. Cangkupan jurnal meliputi: 1. Pharmaceutical Technology 2. Pharmacology and Toxicology 3. Pharmaceutical Chemistry 4. Drug Discovery 5. Pharmaceutical Biology and Herbal Medicines 6. Pharmaceutical Microbiology and Biotechnology 7. Community and Clinical Pharmacy 8. Management and Sosial Pharmacy
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 45 Documents
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UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN MIMBA (Azadirachta Indica A. Juss) TERHADAP BAKTERI Stapylococus aureus Dan Escherichia coli ST.NURJANAH, MUHAMMAD FAISAL; Hendriyani , Irmatika; Azemi , Nuruluni; Suryani, Ade Irma
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 3 No. 1 (2025): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v3i1.1591

Abstract

Background: Infectious diseases remain a health problem in developing countries, including Indonesia. Antibacterials are needed to inhibit or kill bacteria that cause infections. Neem leaves (Azadirachta indica A. Juss) are traditionally known to contain active compounds such as flavonoids, alkaloids, and tannins that have antibacterial potential. Several studies have shown that ethanol extracts of neem leaves are effective against bacteria such as Staphylococcus aureus and Escherichia coli. Objective:  The purpose of this study was to conduct phytochemical screening to determine the secondary metabolite content in mimba leaf extract and to test the antibacterial activity of 5%; 10%; 20%; 40%, and 80% ethanol extracts of mimba leaves against Staphylococcus aureus and Escherichia coli bacteria. Method:  Mimba leaves were extracted using the maceration method with 96% ethanol solvent. Antibacterial activity was tested using the well diffusion method with treatments of 5%; 10%; 20%; 40%, and 80% groups and a negative control group using DMSO. Results:  The inhibition zone diameters of Staphylococcus aureus and Escherichia coli at a concentration of 5% were 1,2 mm and 2 mm respectively, while the inhibition zone diameters at a concentration of 80% were 17,4 mm and 16 mm respectively. Cunclusion:  Concentrations of mimba leaf extract of 5%; 10%; 20%; 40%; and 80% showed antibacterial activity against Staphylococcus aureus and Escherichia coli. The higher the concentration, the larger the diameter of the inhibition zone formed
Hubungan kepatuhan menjalani terapi hemodialisis dengan kualitas hidup pasien gagal ginjal kronik di RSUD Provinsi NTB: Hubungan kepatuhan menjalani terapi hemodialisis dengan kualitas hidup pasien gagal ginjal kronik di RSUD Provinsi NTB Sintha Puspitasari; Baiq Leny Nopitasari; Adea Rana Honsa
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 3 No. 1 (2025): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v3i1.1594

Abstract

Chronic Kidney Disease (CKD) represents a global health challenge characterized by progressive and irreversible decline in kidney function, affecting bodily homeostasis and patients' quality of life. Epidemiological data shows a significant increase in prevalence, with four out of every thousand Indonesian residents suffering from CKD. This study aims to analyze the relationship between adherence to hemodialysis therapy and quality of life among chronic kidney disease patients at NTB Provincial Hospital. Using a quantitative research design with a cross-sectional approach, the study was conducted on 70 respondents selected through purposive sampling technique. Data collection utilized the ESRD-AQ questionnaire to measure adherence and KDQOL-SF to assess quality of life, with data analysis using the Gamma correlation test. Results showed the majority of respondents were male (55.7%) with an average age of 46-55 years (34.3%). Patient adherence levels were predominantly high (51.4%) and moderate (45.7%), with the highest adherence domain in hemodialysis attendance (300±0) and lowest in dietary behavior (154.28±65.79). The majority of patients' quality of life was in the good category (50%) with an average score of 68.18. Statistical analysis revealed no significant relationship between hemodialysis adherence and quality of life (p=0.718, r=0.071). This study concludes that the quality of life of hemodialysis patients is influenced by complex factors beyond therapy adherence. It is recommended for healthcare institutions to develop comprehensive educational programs involving psychosocial aspects and family support, as well as improved monitoring in adherence domains that remain low.
A In-VITRO ANTIBACTERIAL ACTIVITY OF NEEM LEAF ETHANOL EXTRACT (Azadirachta Indica A. Juss) AGAINST THE FUNGI Candida albicans: In-VITRO AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN MIMBA (Azadirachta Indica A. Juss) TERHADAP JAMUR Candida albicans Khairi, Widayatul; Hendriyani, Irmatika; Safwana, Safwan
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 3 No. 1 (2025): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v3i1.1597

Abstract

Background: Infections are common diseases in tropical regions, including Indonesia. One of the most frequently encountered causes of infection is fungal infection by the Candida albicans species. Infections caused by Candida albicans are known as candidiasis, which is an acute or subacute fungal disease that can affect various areas such as the mouth, vagina, skin, nails, lungs, and digestive tract. Objective: This study aims to examine whether the ethanol extract of neem leaves (Azadirachta indica A. Juss) has antifungal properties that effectively inhibit the growth or kill Candida albicans, as indicated by the diameter of the inhibition zone. Method: The study utilized the well diffusion method, and the concentrations used were 80%, 40%, 20%, 10%, and 5%, with each concentration tested in triplicate. Results: The research findings showed that the inhibition zone diameters for each concentration were as follows 5%: 2.33±1.26 mm; 10%: 4.85±0.30 mm; 20%: 4.66±0.58 mm; 40%: 6.06±0.03 mm; dan 80%: 12.88±9.87 mm. Additionally, phytochemical screening confirmed that the ethanol extract of neem leaves (Azadirachta indica A. Juss) contained alkaloids, flavonoids, tannins, saponins, and steroids. Conclusion: The study concluded that the highest inhibition zone diameter against Candida albicans was observed at the 80% concentration, measuring 12.88±9.87 mm.
ANALISIS ANALISIS HUBUNGAN TERAPI POLIFARMASI DENGAN POTENSI DAN TINGKAT KEPARAHAN INTERAKSI OBAT PADA PASIEN DIABETES MELITUS TIPE 2: ANALISIS HUBUNGAN TERAPI POLIFARMASI DENGAN POTENSI DAN TINGKAT KEPARAHAN INTERAKSI OBAT PADA PASIEN DIABETES MELITUS TIPE 2 Hijriani, Nursela; Nopitasari, Baiq Leny; Furqani, Nur; Natasari, Indri
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 3 No. 1 (2025): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v3i1.1617

Abstract

Latar Belakang : Pasien Diabetes Melitus (DM) berpotensi mengalami polifarmasi karena munculnya komplikasi yang dapat meningkatkan morbiditas. Polifarmasi berkaitan erat dengan jumlah penyakit atau multimorbiditas. Semakin banyak penggunaan obat, semakin besar kemungkinan terjadi efek samping atau interaksi obat yang tidak dikehendaki. Tujuan : Penelitian ini bertujuan untuk menganalisis hubungan terapi polifarmasi dengan potensi dan tingkat keparahan interaksi obat pada pasien diabetes melitus tipe 2. Metode : Penelitian ini menggunakan desain penelitian cross sectional dan menggunakan data retrospektif, yang diambil dari data rekam medis pasien DM tipe 2 rawat jalan dan didapatkan dari ruang rekam medis dan SIRS  (Sistem Informasi Rumah Sakit) RSUD (Rumah Sakit Umum Daerah) Provinsi Nusa Tenggara Barat dengan metode pengambilan sampel secara Purposive Sampling serta dilakukan pada November 2023. Hasil : Sebanyak 33 rekam medis dengan 132 potensi kejadian interaksi, selanjutnya dianalisis secara deskriptif menggunakan Drug Interaction Checker (Medscape) dan analisis secara statistik menggunakan uji Chi-Square dan Rank Spearman. Hasil penelitian menunjukkan bahwa tidak terdapat hubungan yang signifikan antara terapi polifarmasi dengan potensi interaksi obat dengan nilai p-value sebesar 0,596 (p-value > 0,05) dan odds ratio (OR) 0,477 serta tidak terdapat hubungan yang signifikan antara terapi polifarmasi dengan tingkat keparahan interaksi obat dengan nilai p-value sebesar 0,344 (p-value > 0,05) dan nilai korelasi sebesar -0,083 yang menunjukkan tingkat hubungannya sangat rendah. Kesimpulan : Hubungan antara polifarmasi dengan potensi interaksi obat menunjukkan hubungan yang tidak signifikan, dan juga hubungan antara polifarmasi dengan tingkat keparahan menunjukkan hubungan yang tidak signifikan.
Formulasi Sabun Padat Berbasis Ekstrak Etanol Daun Pegagan (Centella asiatica (L.) Urban) dan Evaluasi Karakteristik Fisik Harahap , Fini Hamdiatunnimah; Larasati, Dwi; Kautsari, Farah Widya
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 3 No. 1 (2025): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v3i1.1641

Abstract

Background: Infections caused by Staphylococcus aureus remain prevalent in Asia, with reported rates ranging from 18% to 30%. These bacteria commonly colonize the skin, respiratory, and gastrointestinal tracts. Centella asiatica is a medicinal plant recognized for its antibacterial activity, primarily due to its bioactive constituents, including flavonoids, tannins, saponins, triterpenoids, and alkaloids. Topical applications of C. asiatica may be enhanced through formulation into solid soap.Objective: This study aimed to identify the optimal concentration of Centella asiatica ethanol extract in solid soap formulations to achieve desirable physicochemical properties and cleansing efficacy.Method: Ethanol extracts of C. asiatica leaves were obtained by maceration using 70% ethanol. Solid soap was formulated with extract concentrations of 2%, 2.5%, and 3%. The formulations were evaluated for organoleptic characteristics, homogeneity, pH, foam height, and cleansing performance. Descriptive analysis was used to interpret the findings.Results: All soap formulations met acceptable physical quality standards, including uniform texture, stable pH, and adequate foam production. The 2.5% and 3% extract concentrations exhibited superior cleansing ability compared to the 2% formulation.Conclusion: The concentration of Centella asiatica extract significantly influences the quality and functionality of solid soap. Extract levels of 2.5% and 3% yielded formulations with optimal physical properties and effective cleansing performance.

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