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Journal of Pharmaceutical (JOP)
Published by Universitas Jenderal Achmad Yani Yogyakarta
ISSN : -     EISSN : 29877466     DOI : https://doi.org/10.30989/jop.v1i1
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Journal of Pharmaceutical (JOP) adalah Jurnal ilmiah yang memuat hasil penelitian pada ranah Farmasi. Cangkupan jurnal meliputi: 1. Pharmaceutical Technology 2. Pharmacology and Toxicology 3. Pharmaceutical Chemistry 4. Drug Discovery 5. Pharmaceutical Biology and Herbal Medicines 6. Pharmaceutical Microbiology and Biotechnology 7. Community and Clinical Pharmacy 8. Management and Sosial Pharmacy
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 45 Documents
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Uji Aktivitas Gel Ekstrak Etanol Kulit Batang Pulai (Alstonia scholaris) pada Kelinci sebagai Obat Luka Bakar Hati, Melati Permata; Pratama, Rafli Renaldy; Ittiqoa, Dzun Haryadi; Nurbaetya, Baiq; Sugara, Taufan Hadi
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2 (2024): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v2i2.1403

Abstract

Luka bakar dapat disebabkan karena terkena sumber panas seperti air panas, listrik, dan api, yang ditandai dengan rusaknya jaringan pada kulit. Penanganan luka bakar dapat dilakukan secara tradisional menggunakan bahan alam yaitu kulit batang Pulai (Alstonia scholaris). Penelitian ini bertujuan untuk mengetahui aktivitas gel ekstrak kulit batang Pulai (Alstonia scholaris) terhadap luka bakar derajat II pada kelinci. Metode yang digunakan adalah post-test-only control group design. Kulit batang Pulai diekstraksi dengan metode maserasi dengan pelarut etanol 96%. Perubahan diameter luka bakar dianalisis menggunakan metode Oneway Anova untuk mengetahui apakah terdapat perbedaan yang bermakna pada setiap perlakuan. Pengukuran diameter luka bakar pada kelinci dilakukan selama 14 hari. Terjadinya penurunan diameter tersebut didapat pada hari ke-3 sampai dengan ke-14 yang dimana, pada kontrol positif diameter awalnya yaitu 1,94 ± 0.05 cm mengalami penurunan hingga 1,5 ± 1.16 cm dengan selilsih 0,44 cm. Sedangkan pada konsentrasi ekstrak, diameter awalnya yaitu 2 ± 0.06 cm mengalami penurunan hingga 1,68 ± 0.04 cm dengan selisih 0,34 cm sehingga, hasil tersebut menunjukan bahwa gel ekstrak kulit batang pulai memiliki aktivitas dapat mempercepat penyembuhan luka bakar.
Hubungan Tingkat Pengetahuan Terhadap Perilaku Swamedikasi Maag Mahasiswa Prodi Farmasi (S-1) Universitas Jnederal Achmad Yani Yogyakarta Windi Astuti; Larasati, Niken; Rosita, Melia Eka
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 1 (2024): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v2i1.1419

Abstract

Background: Gastritis is a disease that arises due to damage or infection in the stomach and then attacks stomach acid with the characteristics of heartburn, nausea and quick satiety. Gastritis is a common disease that can be treated with self-medication or self-medication with drugs without a doctor's prescription. The level of knowledge in self-medication plays an important role in order to obtain maximum therapeutic results. Self-medication behavior is formed from external responses or stimuli carried out by a person doing self-medication in treating the disease they are experiencing. Research purposes: The purpose of this study was conducted to determine the relationship between the level of knowledge and self-medication behavior for gastric ulcer students of the Pharmacy Study Program (S-1) Jenderal Achmad Yani University, Yogyakarta. Research methods: This research method uses a type of analytic survey with a cross-sectional research design. The sampling technique used is purposive sampling technique. The sample used was 82 respondents. Research result: The results of the study show that 63 respondents (76,8%) have good knowledge and 19 respondents (23,2%) have enough knowledge. The behavior of ulcer self-medication shows that 59 respondents (72,0%) have good behavior and 23 respondents (28,0%) have enough behavior. Conclusion: Data analysis used the Chi Square correlation test and obtained a significance value of 0,000 (Asymp.Sig (2-sided) <0.05) which indicates that there is a relationship between knowledge of self-medication behavior for ulcers in Pharmacy Study Program students (S-1) General Achmad Yani University, Yogyakarta.
Uji Aktivitas Antibakteri Ekstrak Etanol Sereh Wangi (Cymbopogon nardus L. Rendle) Terhadap Pertumbuhan Bakteri Staphylococcus aureus ATCC 25923 Menggunakan Metode Sumuran Leswara, Dianita Febrina; Enggrainia, Bella; Pratama, Nofran Putra
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 1 (2024): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v2i1.1442

Abstract

Background: Bacteria are one of the organisms that cause infectious diseases. One of the bacteria that can cause infection is Staphylococcus aureus. Treatment of bacterial infections is by using antibiotics, but using the antibiotics for a long term can cause resistance. It is necessary looking for alternative compounds that can inhibit the growth of Staphylococcus aureus. Cymbopogon nardus L. Rendle is a plant that has antibacterial compound, that compounds are flavonoids and tannins.Objective: To determine the antibacterial activity of Cymbopogon nardus ethanol extract against the growth of Staphylococcus aureus ATCC 25923 using the well method.Method: Cymbopogon nardus is extracted using the maceration method with 70% ethanol solvent. A phytochemical screening test was carried out and continued with an antibacterial activity test using the well method with concentrations of 5%, 10%, 15% and 20%.Results: Phytochemical screening show that Cymbopogon nardus ethanol extract contains saponins, flavonoids, steroids and tannins. The results of the antibacterial test showed that the average inhibitory zone value of Cymbopogon nardus ethanol extract at concentrations of 10%, 15% and 20% was 23.00; 23.77; 24.96 mm, whereas at concentration of 5% it did not show an inhibition zone for the Staphylococcus aureus ATCC 259323 bacteria.Conclusion: Cymbopogon nardus ethanol extract has antibacterial activity against the growth of Staphylococcus aureus ATCC 259323 with a minimum inhibitory concentration (MIC) which is able to inhibit the growth of Staphylococcus aureus ATCC 259323 at concentration of 10%, for concentrations of 10%, 15% and 20% it has an inhibitory power of very strong category.
Pengaruh Variasi Waktu Ekstraksi terhadap Aktivitas Peredaman Radikal Bebas DPPH Ekstrak Biji Kopi Robusta Lampung Barat Arifah, Mitsalina Fildzah; Rusydan, Azka Muhammad; Sayyidah Yahya, Fina Ummu; Pratama , Nofran Putra; Saputra, Diky Permana
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2 (2024): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v2i2.1454

Abstract

Background: Robusta Coffee (Coffea canephora) has been cultivated in Indonesia, especially in the West Lampung area. Robusta coffee contains secondary metabolites that act as antioxidants, namely chlorogenic acid and other phenolic components. These secondary metabolites of robusta coffee bean can be obtained using the extraction method. The ultrasound-assisted extraction (UAE) is a well-known method to be more effective and lower temperature than other extraction methods. Variations in time impacted by the antioxidant activity of coffee bean extract. Research objective: To determine the effect of variation in extraction time on the free radical reduction activity of DPPH from West Lampung Robusta coffee bean extract. Research method: Robusta coffee beans were extracted by the UAE method using a 70% ethanol solvent (1:100). The variation in extraction time was 10, 20, and 30 minutes. Robusta coffee bean extract was subjected to organoleptic tests, phytochemical screening, and antioxidant activity in DPPH free radical scavenging. Research results: The yield results at 10, 20, and 30 minutes of robusta coffee bean extract were 24.04%, 35.71%, and 20.15%. The results of the organoleptic test of the extract produce a thick texture, brown color, and unique aroma. The results of the phytochemical screening of the extract contain alkaloids, phenolics, tannins, and flavonoids.  The IC50 values at the time variations of 10, 20, and 30 minutes, and quercetin were 29.97 ± 2.737 ppm; 30.5 ± 1.745 ppm; 23.31 ± 4.638 ppm; and 1.42 ± 0.440 ppm respectively, which were significantly different. Conclusion: The variation in extraction time affected the free radical reduction activity of DPPH was an extraction time of 30 minutes in the most optimal DPPH free radical scavenging activity  
Analisis Kandungan Sibutramin HCl pada Jamu Pelangsing dengan Metode Spektrofotometri UV-Vis Kholif, Kholif Sholehah Indra K; Kurniawati, Endah; Komalasari, Desy
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2 (2024): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v2i2.1459

Abstract

Background: Plant, mineral, animal, extract (galenic) preparations, or a combination of various ingredients form the basis of jamu, a type of traditional herbal medicine. Herbal medicine has been applied in treatment based on experience, where its benefits and safety have been proven empirically. One type of herbal medicine popular with the public, especially women, is slimming herbal medicine. As the demand for slimming herbal medicine increases, some parties capitalize on this trend by adding medicinal chemicals (BKOs). Sibutramine HCl is a commonly added BKO in slimming herbal medicine. Objective: To qualitatively and quantitatively analyze the sibutramine HCl content in herbal slimming powders circulating in the Yogyakarta city market. Method: This type of research is non-experimental descriptive with a purposive sampling technique. The samples used in this research were 10 herbal slimming powders with various brands circulating in the Yogyakarta City market. Sample analysis was carried out qualitatively using the Thin Layer Chromatography method and wavelength scanning. Meanwhile, quantitative analysis was carried out using UV-Vis Spectrophotometry. Results: The results of qualitative and quantitative sample analysis showed that from 10 samples, 2 samples were positive for containing sibutramine HCl in samples A and B. The sibutramine HCl content in sample A was 2,4377 ± 0,0066%w/w and B was 1,0164 ± 0,0114%w/w. Conclusion: There is BKO sibutramine HCl content in the powdered slimming herbal medicine samples with respective levels of 2,4377 ± 0,0066%w/w and 1,0164 ± 0,0114%w/w.
Uji Aktivitas Antibakteri Infusa Kayu Secang (Caesalpinia Sappan L.) Terhadap Bakteri Escherichia coli ATCC 25922 dan Staphylococcus aureus ATCC 25923 Leswara, Dianita Febrina; Nurhasanah, Devika; Retno P., Maysi
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2 (2024): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v2i2.1460

Abstract

Background: Escherichia coli and Staphylococcus aureus are two common types of bacteria that can cause infections in the human body. The treatment to overcome infections caused by Escherichia coli and Staphylococcus aureus bacteria is by administering antibiotics. The use of antibiotics that are not appropriate or not according to instructions can cause resistance so that alternative antibacterial agents from herbal plants begin to be developed. One of the plants known to contain antibacterial compounds is the secang plant. The secang wood stem is known to contain flavonoid and tannin antibacterial compounds.  Objective: To determine the bacterial activity and Minimum Inhibitory Concentration (MIC) of secang wood infusa (Caesalpinia sappan L.) against Escherichia coli and Staphylococcus aureus. Method: Extraction of active compounds in secang wood was done by infundation method. The concentration of secang wood infusion that will be tested is 25%, 50%, 75% and 100%. Testing the antibacterial activity of secang wood infusion was carried out against Escherichia coli and Staphylococcus aureus using the well diffusion method. Results: Extraction of active compounds in secang wood is carried out using the infundation method. All concentrations of secang wood infusion tested 25%, 50%, 75% and 100%, showed antibacterial activity against Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923. The smallest concentration that showed inhibition of antibacterial activity was at a concentration of 25% with diameter of of inhibition zone is 20.52 mm in Escherichia coli ATCC 25922 and 20.58 mm in Staphylococcus aureus ATCC 25923 bacteria. Conclusion: Secang wood infusion has antibacterial activity with Minimum Inhibitory Concentration (MIC) at 25% concentration with strong inhibition
Evaluasi Penyimpanan Obat di Gudang Farmasi Rumah Sakit PKU Muhammadiyah Gamping Yogyakarta Andriani, Yuni; Zotie, Refary Nurizza; Wahyu D.S, Afrizal
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2 (2024): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v2i2.1461

Abstract

Penyimpanan obat merupakan salah satu tahap penting dalam pengelolaan obat. Penyimpanan obat yang tidak sesuai dengan standar dapat menyebabkan obat menjadi rusak sehingga mutu obat tidak terjaga, akibatnya bisa berdampak pada pengobatan yang diterima pasien menjadi tidak optimal. Penelitian ini bertujuan mengetahui kesesuaian penyimpanan obat dan efisiensi penyimpanan obat di gudang farmasi Rumah Sakit PKU Muhammadiyah Gamping.  Penelitian ini merupakan penelitian deskriptif observasional yakni membandingkan kesesuaian penyimpanan obat berdasarkan pedoman Permenkes RI No. 72 tahun 2016 dan Petunjuk Teknis Standar Kefarmasian di Rumah Sakit Tahun 2019, serta menilai kesesuaian efisiensi penyimpanan obat. Data yang digunakan yakni data primer berupa data observasi ruang penyimpanan obat di gudang farmasi dan wawancara. Data sekunder berupa data obat tahun 2023 dan 2024.  Hasil kesesuaian persyaratan ruang penyimpanan obat 80%, sistem penyimpanan 75%, persentase metode penyimpanan 100%, sarana dan fasilitas penyimpanan diperoleh persentase sebesar 74%. Secara keseluruhan, hasil yang didapat yakni beberapa indikator pengelolaan penyimpanan obat di Rumah Sakit PKU Muhammadiyah Gamping yang yang belum sesuai dengan standar yakni persyaratan penyimpanan, sistem penyimpanan, kesesuaian ruang penyimpanan obat, obat kadaluwarsa, obat rusak, stok mati obat, TOR, stok akhir obat.
Potensi Antioksidan Ekstrak Metanol Fuli Pala (Myristica fragrans Houtt) Djamaluddin, Rosmiyati R; Putra Pratama, Nofran; Nurhasanah, Devika
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 1 (2024): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v2i1.1517

Abstract

Background : The mace is the part that surrounds the nutmeg seeds. Mace and nutmeg seeds are widely used as a spice in food products and in traditional medicine used as a remedy for stomach pain, analgesics, stimulants. Nutmeg mace also contains flavonoids and phenolics that have potential as antioxidants. Research Objective: Determine the antioxidant activity of methanol extract of nutmeg mace (Myristica fragrans Houtt) in reducing free radicals DPPH Research Method: Nutmeg macaques are extracted using methanol solvents through a maceration process (1:10), then the extracts obtained are tested, namely organoleptic tests, moisture content tests, phytochemical tests, KLT tests, and antioxidant tests using quercetin comparators with varying concentrations, namely 2 ppm, 4 pmm, 6 ppm, 8 ppm, and 10 ppm Research Results: The results of the organoleptis test showed that the methanol extract of nutmeg mace had a deep black color, a distinctive aroma, and a thick texture. 0.83% for moisture content test results. The results of phytochemical screening showed that nutmeg mace methanol extract was positive for flavonoids, phenolics, alkaloids, saponins, and tannins. The KLT test also showed positive results containing flavonoids. The free radical scavenging activity of DPPH from metanol extract of nutmeg mace showed an IC50 value of 13.781 ppm ±SD 0.247 and a standard IC50 value of 4.181 ppm ±SD 0.247 compared to quercetin. Based on statistical analysis, there was no significant difference because the data obtained was 0.074 > 0.05 Conclusion: Methanol extract of nutmeg mace has antioxidant activity in reducing DPPH free radicals and shows an IC50 value of 13.781 ±0,211 ppm which is included in the category of very strong.
Karakterisasi simplisia dan identifikasi senyawa fitokimia ekstrak Pakis Sayur (Diplazium escelentum Swartz) Yoga Pratama, Virgiawan; Rahayu, Putri Dwi; Putri, Selmi; Tiara; Long, Yuliana; Mentari, Ika Ayu
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 1 (2024): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v2i1.1549

Abstract

Pulau Kalimantan dikenal memiliki keanekaragaman hayati yang melimpah, salah satunya adalah tanaman pakis sayur (Diplazium esculentum Swartz), yang berpotensi sebagai obat tradisional. Penelitian ini bertujuan untuk melakukan karakterisasi simplisia dan identifikasi senyawa fitokimia dari ekstrak pakis sayur. Evaluasi dilakukan melalui pengujian organoleptik, kadar sari larut etanol, susut pengeringan, ekstraksi, fraksinasi, skrining fitokimia, dan analisis senyawa flavonoid menggunakan Kromatografi Lapis Tipis (KLT). Hasil menunjukkan bahwa simplisia pakis sayur memiliki bau khas, tanpa rasa, dan berwarna hijau kecoklatan, sedangkan ekstraknya berbau khas, memiliki rasa pahit, dan berwarna hijau kehitaman. Kadar sari larut etanol simplisia tercatat sebesar 14,34%, dengan susut pengeringan 2,16%, yang memenuhi standar kualitas. Ekstraksi dengan metode maserasi menggunakan etanol menghasilkan rendemen sebesar 7,81%. Fraksinasi menggunakan n-heksan dan akuades menghasilkan fraksi dengan ciri organoleptik yang berbeda. Skrining fitokimia mengidentifikasi keberadaan alkaloid, flavonoid, polifenol, dan saponin dalam ekstrak, yang menunjukkan potensi aktivitas biologis. Uji KLT mengungkapkan keberadaan flavonoid dengan nilai Rf 0,21. Berdasarkan temuan ini, pakis sayur berpotensi sebagai sumber senyawa bioaktif dengan prospek pengembangan untuk aplikasi farmakologis lebih lanjut.
Uji Aktivitas Antibakteri Fraksi N-Heksana Daun Pepaya (Carica papaya Linn.) Terhadap Escherichia coli dan Staphylococcus aureus Aprillia, Hananing; Utari, Nelya; Purnamaningsih, Nur’aini
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 1 (2024): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v2i1.1555

Abstract

Background: Infectious diseases are still a problem for the world of health. Infectious diseases are caused by viral, bacterial and parasitic infections. Inappropriate use of antibiotics in treating bacterial infections can cause antibiotic resistance effects. Prevention of the effects of resistance can be done by looking for natural antibiotic agents derived from plants. One of the potential medicinal plants as antibiotics is papaya leaf. Objective: The objective of study was determine the antibacterial activity of the papaya leaf n-hexane fraction against Escherichia coliand Staphylococcus aureus and to determine the diameter zone of inhibition the papaya leaf n-hexane fraction at 20%; 40%; 60%; 80%; and 100% against Escherichia coli and Staphylococcus aureus. Method: Papaya leaf were extraction by using maceration method of 70% ethanol as solvent. Separation of compounds based on the level of polarity using fractionation method with n-hexane: water (1:1 v/v) solvent then carried out phytochemical screening and separation of compounds using TLC method. The antibacterial activity testing used by agar diffusion method Kirby Bauer with the treatment group of papaya leaf n-hexane fraction with a concentration of 20%; 40%; 60%; 80%; and 100%, the positive control group used Ampicillin 10 μg and the negative control group used Aquades. Result: Diameter zone of inhibition Escherichia coli and Staphylococcus aureus was smallest at 20% was 6,57 ± 0,15 mm and 6,69 ± 0,33 mm, while the diameter zone of inhibition the largest at 100% was 7,92 ± 0,23 mm and 7,94 ± 0,16 mm. Conclusion: The papaya leaf n-hexane fraction concentration of 20%; 40%; 60%; 80%; and 100% had antibacterial activity against Escherichia coli and Staphylococcus aureus. The higher concentration then the larger diameter zone of inhibition formed.

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