Articles
45 Documents
<![CDATA[Evaluasi Kesesuaian Obat Dengan Kartu Stok Di Puskesmas Gondomanan Kota Yogyakarta ]]>
<![CDATA[Titami, Arina]]>;
<![CDATA[Andriani, Yuni]]>;
<![CDATA[Saputra, Doni]]>
<![CDATA[ JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2, Special Edition (2024): Journal of Pharmaceutical (JOP) ]]>
Publisher : <![CDATA[Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.30989/jop.v2i2, Special Edition.1465
<![CDATA[Background: The proper storage and distribution of drugs is very important to ensure the effects of drugs in the body and all drugs should be stored in the right storage place. Improper drug storage can cause damage to drugs that can endanger patients and health services themselves. Objective: This study aims to evaluate drug storage, specifically the accuracy of data on the number of drugs on the stock card, at the Gondomanan Primary Health Center in Yogyakarta. Method: The research was conducted using a descriptive observational approach with a cross-sectional design. Data were collected using a checklist referring to Peraturan Menteri Kesehatan Republik Indonesia Nomor 74 Tahun 2016 and Petunjuk Teknis Standar Pelayanan Kefarmasiaan di Puskesmas Tahun 2019. Result: The accuracy of data on the number of drugs on the stock card at the Gondomanan Primary Health Center in Yogyakarta is 100%. Conclusion: The accuracy of data on the number of drugs on the stock card at the Gondomanan Primary Health Center in Yogyakarta is by standards based on Peraturan Pemerintah Kesehatan Republik Indonesia Nomor 74 Tahun 2016 and Petunjuk Teknis Standar Pelayanan Kefarmasiaan di Puskesmas Tahun 2019.]]>
<![CDATA[Laporan kasus: Tata laksana terapi sirosis hepatik pada pasien geriatri ]]>
<![CDATA[Novia Ariani Dewi]]>;
<![CDATA[Lutfi Hidiyaningtyas]]>;
<![CDATA[Shalahuddin Al Madury]]>
<![CDATA[ JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2, Special Edition (2024): Journal of Pharmaceutical (JOP) ]]>
Publisher : <![CDATA[Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.30989/jop.v2i2, Special Edition.1466
<![CDATA[Background: Cirrhosis Hepatic is a late-stage liver disease that can be caused by various causes, including metabolic disorders or ongoing hepatitis B and hepatitis C virus infections, auto-immune, alcohol consumption, fatty liver or other diseases that cause bile duct obstruction, and genetics. Cirrhosis of the liver is irreversible or cannot be cured which ends with a liver transplant, the treatment is only done to treat complications. Objective: Provides details about the patient's condition, diagnosis, treatment, and results obtained so that it can be used as a reference for providing therapy to geriatric patients diagnosed with hepatic cirrhosis. Method: This study is a case report that occurred in a hospital X in the city of Semarang. Case data were collected through various methods, such as interviews, observations, documentation, and patient visits. All patient-related data were recorded and comprehensively assessed to see the suitability of therapy for patients by comparing it with existing literature. Result: The patient received treatment, namely 25% albumin infusion 100 ml every 24 hours, ampicillin sulbactam injection 1 g/0.5 g every 12 hours, spironolactone tablets 100 mg every 24 hours, N-acetylcysteine ??200 mg every 8 hours, ursodeoxycholic acid capsules 250 mg every 12 hours, slow-release morphine tablets 10 mg every 24 hours. Conclusion: In this case, the treatment given is in accordance with the patient's condition, but there are several things that must be considered regarding the dosage of slow-release morphine tablets. In elderly patients, in addition to patient treatment, patients also need to undergo a comprehensive geriatric assessment to improve the success of therapy and the patient's quality of life.]]>
<![CDATA[Formulasi Sediaan Emulgel Minyak Bunga Cengkeh (Syzygium aromaticum L.,) Sebagai Antiinflamasi ]]>
<![CDATA[Tsalasani, Nanda]]>;
<![CDATA[Larasati, Dwi]]>
<![CDATA[ JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2, Special Edition (2024): Journal of Pharmaceutical (JOP) ]]>
Publisher : <![CDATA[Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.30989/jop.v2i2, Special Edition.1467
<![CDATA[Bacground: The use of natural ingredients has been widely used in the world of health for treatment, one of which is the clove plant (Syzygium aromaticum L.,). The clove plant is a plant from the Myrtaceae family, a dried simplicia which is widely used, for example as a food ingredient and for use in the pharmaceutical sector. Emulgel consists of two phases, namely a large phase of organic molecules that penetrate water in the form of a gel and a small oil phase. The presence of an oil phase in it makes emulgel superior compared to gel preparations. Obhjective: The aim objective this research is to determine the composition of the combined emulsifier, namely Tween 80 and Span 80, to obtain a good emulgel preparation. Method: The method used was experimental with 3 formulas with different emulsifier compositions and the physical properties of the preparations were evaluated. Result: Based on the experimental results, clove flower oil emulsion was obtained with a clear brownish yellow organoleptic form, the pH value of the three formulas met SNI requirements, namely 6.0 - 6.2; Spreadability ranges from 5.67 - 8.95, viscosity meets SNI standards and minimum content > 90%. Conclusion: Based on research, a good clove flower oil emulgel formula was obtained, namely formula III with a pH value of 6.2 ± 0.3, a viscosity of 22,926 CPs and a spreadability of 8.95 ± 0.03. Formula III also shows that it meets the minimum content test requirements as required by the Indonesian Pharmacopoeia Edition VI]]>
<![CDATA[Inovasi Pemanfaatan Daun Sirsak Dalam Formulasi Masker Gel Peel-Off Sebagai Sediaan Kosmetik ]]>
<![CDATA[Larasati, Dwi]]>;
<![CDATA[Fatkhunisa , Wulan]]>;
<![CDATA[Bingar Hernowo , Bingar]]>;
<![CDATA[Tsalasani Zulfaidah , Nanda]]>
<![CDATA[ JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2, Special Edition (2024): Journal of Pharmaceutical (JOP) ]]>
Publisher : <![CDATA[Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.30989/jop.v2i2, Special Edition.1468
<![CDATA[Tanaman sirsak (Annona muricata L.) diklasifikasikan sebagai spesies botani yang kaya akan flavonoid, sehingga memiliki sifat antioksidan yang penting yang membantu mengurangi kerusakan oksidatif yang disebabkan oleh radikal bebas pada sel-sel kulit wajah. Masker gel peel-off mewakili formulasi kosmetik yang dirancang untuk perawatan wajah, dan memiliki keuntungan, yaitu mudah digunakan dan dapat dibersihkan setelah dilepaskan dari kulit wajah dalam waktu 15 hingga 30 menit. Tujuan dari penelitian ini adalah untuk menentukan apakah daun sirsak dapat digunakan untuk membuat masker gel peel-off dan untuk mengevaluasi sifat fisik masker tersebut. Proses maserasi menggunakan etanol 70% dengan perbedaan konsentrasi 1%, 2% dan 4%. Pengujian yang dilakukan terhadap sediaan masker gel peel-off yang dibuat meliputi uji organoleptik, homogenitas, pH, daya sebar, waktu mengering, daya lekat, dan uji kesukaan. Hasil penelitian menunjukkan bahwa ekstrak daun sirsak dengan perbedaan konsentrasi 1%, 2%, dan 4% dapat diformulasikan dalam sediaan masker gel peel-off. Masker gel peel-off ekstrak daun sirsak memiliki penampilan fisik, pH, homogenitas, daya sebar, waktu kering, daya lekat yang baik sesuai dengan persyaratan. Formulasi terbaik untuk ekstrak daun sirsak dalam bentuk gel peel-off berdasarkan uji kesukaan adalah pada formulasi 1 dengan konsentrasi 1%.]]>
<![CDATA[Pengaruh Metode Ekstraksi Terhadap Kadar Flavonoid Total Daun Sukun (Artocarpus altilis (Park.) Fosberg) ]]>
<![CDATA[Ulvia, Rengganis]]>;
<![CDATA[Pratama, Nofran Putra]]>;
<![CDATA[Nurjanah, Baiti]]>
<![CDATA[ JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2, Special Edition (2024): Journal of Pharmaceutical (JOP) ]]>
Publisher : <![CDATA[Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.30989/jop.v2i2, Special Edition.1470
<![CDATA[Background: The breadfruit (Artocarpus altilis (Park) Fosberg.) is an Indonesian herbal plant that has long been used as a traditional medicine by the community, especially the leaves. Breadfruit leaves treat various diseases such as canker sores, hepatitis, inflammation, skin diseases, hypertension, asthma, fever, and aches and pains. Breadfruit leaves have various pharmacological properties, such as antiseptic, antibacterial, and antioxidant. This activity is related to the content of flavonoid compounds in breadfruit leaves. These flavonoid compounds can be obtained by extraction using conventional methods, namely maceration and non-conventional methods, namely Ultrasonic-Assisted Extraction (UAE). The choice of extraction method is an important factor in producing secondary metabolite compounds such as flavonoids. Objective: This study aims to determine the effect of extraction methods on total flavonoid levels in breadfruit leaves. Method: Breadfruit leaves were extracted using the maceration and UAE methods with 96% ethanol solvent at a ratio of 1:10 b/v. Qualitative tests were carried out using organoleptic tests and thin-layer chromatography (TLC) tests. Quantitative test by measuring the total flavonoid content of macerated and UAE breadfruit leaf extract using a UV-Vis spectrophotometer. The qualitative data obtained were then analyzed statistically using SPSS with Independent Samples T-Test with a confidence level of 95%. Results: The yield value of the maceration method was 11.8976% and the UAE method was 11.0854%. The results of the TLC test of breadfruit leaf extract produced an Rf value of 0.812 which was the same as the standard Rf value of quercetin, namely Rf 0.812 and the total flavonoid content produced by the UAE method was 44.689 ± 0.1764 mg QE / g extract, and the maceration method 42.3322 ± 0.3792 mg QE / g extract which was significantly different (p <0.05) Conclusion: The extraction method influences the total flavonoid content in breadfruit leaves, whereas the UAE extraction method produces higher flavonoid levels than the maceration method.]]>
<![CDATA[Laporan Kasus: Kajian Efek Samping Obat Antipsikotik pada Kejadian Gejala Ekstrapiramidal pada Pasien Skizofrenia ]]>
<![CDATA[Madury, Shalahuddin Al Madury]]>;
<![CDATA[Padmasari, Siwi]]>;
<![CDATA[Ishak, Ishak]]>
<![CDATA[ JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2, Special Edition (2024): Journal of Pharmaceutical (JOP) ]]>
Publisher : <![CDATA[Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.30989/jop.v2i2, Special Edition.1474
<![CDATA[Background: Initial treatment of acute psychosis in schizophrenia patients is recommended to start second-generation antipsychotics rather than first-generation antipsychotics which have greater side effects on movement disorders, such as akathisia, and dystonia. Extrapyramidal symptoms (EPS) are one of the most common side effects of drugs experienced by patients due to dopamine receptor blocking agents in the form of uncontrolled movements that risk disrupting patient activities. Objective: The purpose of this case report is to determine the pattern of antipsychotic drug use, and the results of a clinical pharmacist study related to the side effects of drugs causing EPS in schizophrenia patients in the inpatient installation of Soerojo Hospital. Method: This study is in the form of a case report taken from an inpatient of Soerojo Hospital in Magelang City. Case data were collected through various methods during the pharmacist's visit, all patient-related data were recorded and a comprehensive assessment was carried out to see the suitability of therapy, DRP in patients by comparing it with existing literature. Result: Patient NH (18 years old) was diagnosed with Schizophrenia for the first time. The patient received Diazepam and haloperidol injection therapy while in the ER and was programmed with haloperidol 5 mg every 12 hours, and clozapine 100 mg 2x a day, on the third day the patient could not swallow the medicine because he showed symptoms of EPS such as stiffness, mouth could not close, walking like a robot, and hypersalivation. Pharmacists through pharmaceutical care found DRP related to potential ESO from the use of haloperidol injection which increased the incidence of EPS, especially in patients who first received antipsychotics. 2 days later, signs of EPS continued to NMS marked by severe hypersalivation, rigidity, and muscle stiffness disorders, and supported by high CK examination results of 2030 U / l. The patient received Trihexyphenidyl therapy 3x2 mg, and bromocriptine 2.5 mg / 8 hours. Slowly the symptoms of NMS experienced clinical improvement. Conclusion: Early discontinuation of antipsychotic agents that cause EPS can prevent the severity of EPS in patients. Bromocriptine can be an option for NMS patients.]]>
<![CDATA[Penentuan Kadar Fenolik Total Dan Peredaman Radikal Bebas Ekstrak Metanol Daun Bayam Hijau (Amaranthus hybridus L) Dengan DPPH ]]>
<![CDATA[Nurhasanah, Devika]]>;
<![CDATA[Mafa , Sutri Hud]]>;
<![CDATA[Pratama, Nofran]]>
<![CDATA[ JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2, Special Edition (2024): Journal of Pharmaceutical (JOP) ]]>
Publisher : <![CDATA[Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.30989/jop.v2i2, Special Edition.1477
<![CDATA[Background: Free radicals are molecules that have one or more free or unpaired electrons, so that free radicals are unstable. Free radicals can be inhibited in the presence of antioxidant compounds. The compound antioxidant can be obtained from various sources, one of which is from the green spinach plant. Amaranthus hybridus L. is a herbaceous plant from the Amaranthaceae family that contains natural antioxidant compounds, namely phenolic compounds. Objective: This study aimed to determine the total phenolic levels contained in methanol extract of Amaranthus hybridus L. and what is the value of IC50 methanol extract of Amaranthus hybridus L. which is able to reduce DPPH free radicals. Method: Amaranthus hybridus L. were extracted with methanol solvent by maceration method in a ratio (1:10). Then a qualitative analysis was carried out in the form of phytochemical screening, identification of phenolic compounds by Thin Layer Chromatography (TLC) method using the methanol mobile phase: chloroform: n-hexane (1:9:1 v/v/v) and the stationary phase of silica gel GF254. Quantitative analysis of the total phenolic content test, and free radical suppression activity test by DPPH method which was measured using a UV-Vis spectrophotometer to calculate IC50. Result: Methanol extract of Amaranthus hybridus L. positively contains alkaloid compounds, phenolics, flavonoids, saponins, and tannins. The TLC Rf quercetin value is 0.475, and the Rf extract is two spots namely 0.35 and 0.837. Total phenolic content of 1.150 ± 0.025% and a free radical suppression activity of IC50 value of 14.786 ppm. Conclusion: Methanol extract of Amaranthus hybridus L. could be categorized as very strong.]]>
<![CDATA[Direct FTIR and Chemometrics for Authentication of Kratom Powder and Other Alkaloids-containing Plant Matters ]]>
<![CDATA[Rusydan, Azka Muhammad]]>;
<![CDATA[Firdausia, Rizqa Salsabila]]>
<![CDATA[ JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2, Special Edition (2024): Journal of Pharmaceutical (JOP) ]]>
Publisher : <![CDATA[Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.30989/jop.v2i2, Special Edition.1482
<![CDATA[Kratom (Mitragyna speciosa), has gained attention for its use as stimulant and opioid-like analgesic effects. In Indonesia, its legal status remains uncertain in many regions, and concerns about its safety have led to increasing regulation. Even with uncertainty with its legal status, kratom remains easily accessed via online market. However with Indonesia’s Ministry of Trade is set to regulate its export regulation, a method to quickly distinguish kratom venations is needed. This study explores the potential of Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy, combined with chemometric techniques like Principal Component Analysis (PCA), to differentiate between kratom venations and other alkaloid-containing plants. Direct ATR-FTIR analysis of ground kratom, tea, and coffee leaves revealed characteristic functional groups, with distinct spectral variations observed across the plant samples. Cluster variable analysis reduced the dimensionality of the spectral data by 98.6%, while maintaining 98% similarity level. PCA highlighting key principal components (PC1 and PC2) responsible for 93.9% of the variance. The model successfully grouped the samples into five clusters with a similarity level of 88.3% and a cluster distance ratio > 1, confirming the method's ability to distinguish kratom venations and other plant materials. This study demonstrates that FTIR-PCA is an effective, rapid, and non-destructive tool for profiling plant materials, although further research with a larger and more diverse sample set is needed for more robust predictive modeling.]]>
<![CDATA[Pengaruh Jenis Pelarut Terhadap Kadar Total Fenolik dan Flavonoid Daun Kayu Bulan ]]>
<![CDATA[Anni Satul Qodariyah]]>;
<![CDATA[Anggun Saputri]]>;
<![CDATA[Rizqa Salsabila Firdausia]]>;
<![CDATA[Kholif Sholehah Indra Kurniasih]]>
<![CDATA[ JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2, Special Edition (2024): Journal of Pharmaceutical (JOP) ]]>
Publisher : <![CDATA[Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.30989/jop.v2i2, Special Edition.1522
<![CDATA[Kayu bulan leaves (Pisonia alba Span.) is one of the ornamental plants that contains secondary metabolites in the form of phenolic and flavonoids compounds, that contains secondary metabolites in the form of phenolic and flavonoids compounds. The extraction of phenolic and flavonoid compounds was carried out by ultrasonic wave-assisted method (UAE). Phenolic and flavonoid compounds have polar and non-polar properties that can be extracted using solvents such as 70% ethanol, methanol and ethyl acetate. This study aims to determine the effect of solvent type (70% ethanol, methanol and ethyl acetate) on total phenolic and flavonoids content in kayu bulan leaves extract extracted using the UAE method. This research was conducted by analyzing qualitatively using Thin Layer Chromatography method and quantitative using UV-Vis Spectrophotometry. test results, it shows that the kayu bulan leaves extract positively contains flavonoids and phenolics. Quantitative results showed that the total phenolic content was respectively; 70 % ethanol extract (16.2085 ± 0.7359) mg GAE/gram, extract methanol extract (24.3005 ± 0.7305) mg GAE/gram and ethyl acetate extract (28.5957 ± 0.7305) mg GAE/gram. Meanwhile, the total flavonoid content in 70% ethanol extract was 21.28 ± 0.473 mg QE/g, methanol extract was 58.68 ± 1.767 mg QE/g, and ethyl acetate extract was 118.152 ± 2.146 mg QE/g. It can be concluded that the highest total flavonoid and phenolic content was obtained in the ethyl acetate extract.]]>
<![CDATA[Kajian Tingkat Pengetahuan Dagusibu Antibiotik Pada Siswa Farmasi SMK YPKK 1 Sleman ]]>
<![CDATA[Anggeraini , Via Gusti]]>;
<![CDATA[Sugiyono, Sugiyono]]>;
<![CDATA[Larasati, Niken]]>
<![CDATA[ JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2, Special Edition (2024): Journal of Pharmaceutical (JOP) ]]>
Publisher : <![CDATA[Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.30989/jop.v2i2, Special Edition.1531
<![CDATA[Background: Antibiotics are effective in stopping the growth of bacteria and eliminating infections. However, improper use of antibiotics can lead to bacterial resistance, highlighting the importance of proper management. This management includes the appropriate ways to obtain, use, store, and dispose of antibiotics, commonly referred to as DAGUSIBU. Pharmacy students, who will later undergo internships in pharmacies and hospitals, need comprehensive knowledge about DAGUSIBU for antibiotics to effectively educate the public. Objective: This study aims to examine the relationship between specific characteristics age, gender, and learning level and the level of knowledge regarding DAGUSIBU for antibiotics among pharmacy students at SMK YPKK 1 Sleman. Method: This research employed a descriptive observational design with a cross-sectional approach. Data collection was conducted using a printed questionnaire. The study involved 41 students selected through total sampling. Data analysis was performed using univariate and bivariate methods. Univariate analysis was used to describe students' characteristics and their level of knowledge, while bivariate analysis utilized the Chi-square test to determine relationships between the students' characteristics and their knowledge levels. Results: The results showed that the majority of pharmacy students at SMK YPKK 1 Sleman were over 17 years old (63.4%), predominantly female (73.2%), and most commonly at the lowest learning level, grade X (34.1%). In terms of knowledge about DAGUSIBU for antibiotics, 29.2% of students had good knowledge, while 70.8% had poor knowledge. The Chi-square test revealed significant relationships between age (p-value: 0.000) and learning level (p-value: 0.001) with knowledge levels, while no significant relationship was found for gender (p-value: 0.524). Conclusion: There is a significant relationship between students' age and learning level and their knowledge of DAGUSIBU for antibiotics. However, gender does not show a significant correlation with their level of knowledge regarding DAGUSIBU for antibiotics.]]>
