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Journal of Food and Pharmaceutical Sciences
Published by Universitas Gadjah Mada
ISSN : 20897200     EISSN : 23390948     DOI : https://doi.org/10.22146/jfps.8237
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience
Journal of Food and Pharmaceutical Sciences offers scientists, researchers, and other professionals to share knowledge of scientific advancements. The journal will publish original research articles, review articles, short communication, and letter to editor. The area of focus should cover all aspects of food and pharmaceutical sciences. The range of topics covered in the journal include: New Horizons in Food Research; Food Chemistry; Integrated Food Science; Health, Nutrition, and Food; Food Engineering, Materials Science, and Nanotechnology; Toxicology and Chemical Food Safety; Food Microbiology and Safety; Drug Discovery; Computational Chemistry and Molecular Modeling; Pharmaceutical Biotechnology and Protein-Peptide Chemistry; Pharmaceutics, Biopharmaceutics, Drug Delivery, and Pharmaceutical Technology; Pharmaceutical Nanotechnology; Pharmacokinetics, Pharmacodynamics, and Drug Transport Metabolism; Analytical and Bioanalytical Chemistry; Pharmaceutical Chemistry; Natural Medicine and Nutraceutical; Chemical Processing of Pharmaceuticals including Crystallization, Lyophilization, and Chemical Stability of Drugs; Immunology, Biochemistry, and Cell and Molecular Biology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 154 Documents
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Emulgel Formulation of Musa paradisiaca L. Peels Kimelvina Kimelvina; Suwaldi Martodihardjo; Rina Kuswahyuning
Journal of Food and Pharmaceutical Sciences Vol 7, No 2 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.716

Abstract

Penelitian ini bertujuan memanfaatkan limbah kulit buah pisang ambon (Musa paradisiaca L.) untuk diformulasikan menjadi sediaan topikal emulgel dan mengevaluasi aktivitas antiradikal dan stabilitas fisik setelah 4 minggu penyimpanan pada suhu ruang. Kulit buah pisang ambon diolah menjadi jus yang kemudian dipekatkan melalui proses freeze drying. Hasil freeze dried jus kulit buah pisang ambon sebanyak 1% diformulasikan menjadi sediaan topikal emulgel. Freeze dried jus kulit buah pisang ambon mengandung flavonoid sebesar 52,71 μg ekuivalen kuersetin/gram kulit pisang ambon segar dan memiliki nilai aktivitas penangkapan radikal 2,2-diphenyl-1-picrylhydrazyl (DPPH) dengan IC50 65,6 μg/mL. Emulgel freeze dried jus kulit buah pisang ambon menujukkan aktivitas penangkapan radikal DPPH dan aktivitas ini stabil selama 4 minggu penyimpanan pada suhu ruang. Emulgel freeze dried jus kulit buah pisang ambon tidak mengalami pemisahan meskipun terindikasi mengalami perubahan ukuran droplet setelah penyimpanan. Viskositas emulgel mengalami peningkatan secara signifikan, sedangkan daya sebar dan daya lekat emulgel menunjukkan penurunan yang signifikan setelah penyimpanan.
α-Amilase Inhibitory Activity of Fraction of Ethanolic Extract of Lebui Seed (Cajanus cajan (L.) Millsp.) Grown in West Nusa Tenggara Dian Resti Setyaningrum; Rumiyati; Yekti Asih Purwestri; Satrijo Saloko; Agung Endro Nugroho; Yudi Pranoto; Sri Widyastuti
Journal of Food and Pharmaceutical Sciences Vol 8, No 2 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.720

Abstract

Diabetes is a metabolic syndrome characterized by high blood sugar levels or hyperglycemia.Alpha-amylase inhibitors can be used as an antidiabetic that controls postprandial hyperglycemia.Alpha-amylase inhibitors are found in plants as protein and non-protein bioactive content such as in lebuiseed. The purpose of this study was to determine the activity of alpha-amylase inhibition of the fraction ofethanol extract of lebui seed. This research was carried out by extraction of lebui seed and then fractionatedlebui extract to obtain n-hexane fraction (HF), ethyl acetate fraction (EAF), and water fraction (WF). Thefractions then tested to alpha-amylase inhibition activity in vitro by measuring the reducing sugar using3.5-dinitrosalicylic (DNS) reagent. Furthermore, the identification of the bioactive content of each fraction wascarried out using thin layer chromatography. The results of alpha-amylase inhibition activity test showed thatall fractions had the ability to inhibit alpha-amylase. The IC50 value of the n-hexane fraction, ethyl acetatefraction, and water fraction were 173.05 mg/ml, 9.98 mg/ml, and 137.19 mg/ml, respectively. Ethyl acetatefraction has the smallest IC50 value compared to other fractions. Based on the identification of the bioactivecontent, bioactive content that is only found in the ethyl acetate fraction but not in other fractions are tannins.Therefore, the chemical content in lebui seed which acts as an alpha-amylase inhibitor might be tannins.
Application Simplex Lattice Design on Optimizing Formula of Ketoprofen Matrix Patch Transdermal Eka Indra Setyawan; Akhmad Kharis Nugroho; Achmad Fudholi
Journal of Food and Pharmaceutical Sciences Vol 7, No 2 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.722

Abstract

Ketoprofen is a propionic acid derivative that has anti-inflammatory, analgesic, and antipyretic activity. Transdermal patch dosage form is the right choice for ketoprofen in an effort to minimize side effects, improving patient compliance and ensure the achievement of therapeutic targets. This study aimed to optimize the formulation of ketoprofen matrix patch transdermal. The optimizing process was analyzed by simplex lattice model. Determination of the level of ketoprofen released was carried out by spectrophotometer UV-Vis. Interpretation of the dissolution profile can be seen visually fit between the model constructed from the zero-order approximation, first-order, Higuchi, Korsmeyer-Peppas, Weibull, Hixson-Crowell and Baker-Lonsdale. The results provide information that a combination of MC and HPMC polymers have a significant influence on increasing the patch weight, patch thickness, loss on drying and dissolution efficiency and insignificant effect against folding endurance. The optimal formula is generated by a combination of HPMC:MC (0.1:0.9) and produces a patch matrix with weight, thickness, drying loss, and DE were 0.68 g, 0.36 mm, 12.42%, and 23.21%, respectively. The release kinetic of ketoprofen followed Korsmeyer-Peppas model through the mechanism of non-Fickian diffusion.
Potential Effect of Pegagan (Centella asiatica (L.) Urban) and Widuri (Calotropis gigantea (L.)) as Immunomodulator Tias Pramesti Griana
Journal of Food and Pharmaceutical Sciences Vol 7, No 2 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.723

Abstract

Abstract: The immune system functions to protect the body from pathogens and cure disease. Even a mild infection will have a bad effect if the host's immune system is not working properly. Modification of the immune response functions to increase and decrease the immune response to overcome disease known as immunomodulation. Immunomodulators are used either as a prevention or treatment of various diseases related to immune disorders. Immunomodulatory drugs change the immune system response by increasing (immunostimulating) or decreasing (immunosuppressive) antibody production. Immunostimulators are given to increase the immune response to infectious diseases, immunodeficiency (e.g. AIDS) and cancer. Immunosuppressive drugs are used to reduce the immune response to transplanted organs and treat autoimmune diseases. The use of medicinal plants to treat various diseases has shown minimal side effects. Natural compounds that are produced from the metabolism of medicinal plants are known to affect the immune system, both the function and production of immune cells, as well as antibody secretion. Indonesia is one of the countries that has used plants as traditional medicine since ancient times. Indonesia 7,000 species of medicinal plants that have been studied to address health problems. Among the medicinal plants that have been studied are Centella asiatica (L.) Urban and Calotropis gigantea (L.) which have been shown to cure various diseases. This review article describes the potential of native Indonesian medicinal plants, namely Centella asiatica (L.) Urban and Calotropis gigantea (L.) as immunomodulators.
Protection Effect of Self-Nanoemulsifying Drug Delivery System (SNEDDS) Piroxicam as Ulcerogenic Agent towards Malondialdehid Level and Protein Expression of Caspase-3, COX-1, COX-2 at Rat Gastric Iis Wahyuningsih; Kurnia Ambarwati; Erninda Ayu Hapsari; Afifah Fauziyyah; Azis Ikhsanudin; Deasy Vanda Pertiwi; Wahyu Widyaningsih
Journal of Food and Pharmaceutical Sciences Vol 8, No 2 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.732

Abstract

The aim of this study was to determine the protection effect of SNEDDS piroxicam ulcerogenic agent against malondialdehyde (MDA) level and protein expression of caspase-3, COX-1, COX-2. The research was conducted using the test animals as much as 30 male white Sprague dawley (SD) rats aged 1-2 months with a weight of 100-200 grams divided into 5 groups. Treatment was given for 28 days orally. On the 29th day blood samples were also taken for the determination of MDA (Malondialdehid) levels by Thiobarbituric Acid Reactive Substance (TBARs) method using a visible spectrophotometer. Rats were sacrificed, then gastric organs were taken for immunohistochemical testing of caspase-3 and COX-1 expression, COX-2. The statistical analysis showed that the piroxicam SNEDDS group and the piroxicam suspension group decreased expression of the caspase-3 protein, increased COX-1 expression, decreased COX-2 and significantly decreased MDA levels. The piroxicam-containing SNEDDS (Self-Nanoemulsifying Drug Delivery System) form has protection against ulcogenic piroxicam.
Water-in-Oil-in Water (W/O/W) Double Emulsion Formulations using Variation Concentration of Carboxymethyl Cellulose Sodium Devi Tania; Marchaban; Rina Kuswahyuning
Journal of Food and Pharmaceutical Sciences Vol 8, No 2 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.739

Abstract

Makromolekul hidrokoloid dinilai mampu menstabilkan emulsi ganda. Penelitian ini bertujuan untuk membuat formulasi emulsi ganda air dalam minyak dalam air (A/M/A) dengan menggunakan natrium karboksimetil selulosa (CMC Na) sebagai emulgator fase air eksternal. Emulsi primer air dalam minyak (A/M) dibuat dengan parafin cair sebagai fase minyak dan mengevaluasi pengaruh konsentrasi emulgator span 80, yaitu 5, 10, 15, dan 20%, terhadap mikroskopi ukuran droplet, viskositas, dan stabilitas emulsi A/M setelah uji heati4ng-cooling cycle. Span 80 dengan konsentrasi 15% menghasilkan karakteristik emulsi primer A/M yang paling baik. Emulsifikasi emulsi primer A/M ke dalam fase air eksternal yang mengandung CMC Na menghasilkan emulsi ganda A/M/A. Peningkatan konsentrasi CMC Na dari 1, 2, dan 3% menghasilkan peningkatan viskositas emulsi ganda secara signifikan. Mikroskopi visual droplet minyak menunjukkan rentang ukuran droplet minyak yang relatif besar pada semua emulsi ganda A/M/A. Pelepasan model zat warna larut air (Ponceau 4R) dari semua emulsi ganda A/M/A sangat kecil (0,06-0,09%) setelah 6 jam pengujian yang mengindikasikan potensi penggunaan emulsi ganda ini sebagai sistem penghantaran lepas lambat. Emulsi ganda A/M/A pada semua konsentrasi CMC Na tidak memisah setelah uji stabilitas dengan metode heating-cooling cycle.
Optimization of Solid Soap Containing Bentonite and Combination of Palm Oil and Virgin Coconut Oil for Cleansing Najs Mughalladzah Ika Nustiana Anggraeni; Astri Desmayanti; Mufrod; Abdul Rohman
Journal of Food and Pharmaceutical Sciences Vol 7, No 2 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.740

Abstract

This research was intended to formulate solid bentonite soap using combination of palm oil andvirgin coconut oil used for cleansing najs mughalladzah (extreme najs). Five formula of soap designated with AEapplying bentonite and combination of VCO and PO with different concentrations. The assessment of soapquality was based on soap hardness, foam stability, water content, total fatty acid, free fatty acid and free alkali.Evaluation results were analyzed using simplex lattice design (SLD) to obtain optimum formula. Verification ofoptimum formula was analyzed using one sample t-test with level of significance of 0.05. The results showedthat optimum concentration of bentonite was 4.06% with percentages of VCO 89.6% and PO of 10.4%. Based onone sample t-test, there is no significant difference (pH > 0.05) from foam stability and total fatty acid betweenthe predicted optimum formula as analyzed using SLD and verified result.
Sargassum crasifolium Extract Could Prevent the Decrese in the Thyroxine Hormone and the Body Weight Loss of Javanese Randu Goats during Transportation Claude Mona Airin; Amelia Hana; Sarmin; Pudji Astuti; Amir Husni; Rusyda Nurshitaningrum
Journal of Food and Pharmaceutical Sciences Vol 8, No 3 (2020): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.850

Abstract

Thyroxine hormone (T4) was one of the hormones related to metabolism rate. Animal transportation could be stressor interfering metabolism. Sargassum crasifoium was one of brown algae species that contained some important nutrients and also flavonoids. The study aimed at finding out the effect of the Sargassum on the decrase in thyroxine hormone and body weight loss. It used 9 Javanese Randu goats that were classified into 3 treatment groups. Group I served as control, Group II was treated with 450 mg/kg BW of Sargassum estract and Group III was treated with vitamin B1. All of the goats were transported for 12 hours using pickup truck at the speed of 60 km/hour. Blood samples were drawn before the transportation, during loading, 6 hours after the transportation and at the end of the transportation, while the body weight of the goats was weighed before and after the transportation. The results of the study showed that the T4 hormone decreased in the Group I and increased in the Group III during the transportation, while it was stable in the Group II. The biggest percentage of the body weight loss took place to the Group III (0.13%), while the smallest percentage took place to the Group II (0.063%). Statistical analysis showed that the Sargassum extract did not have any significant effect (p>0.05) on both the thyroxine hormone and the body weight loss during the transportation. Based on the results of the study it could be concluded that the Sargassum extract could stabilize the thyroxine hormone during the transportation so that it could prevent the body weight loss
Application of Ultrasonic-Assisted Fractionation with Full-Factorial Design for the Production of Alkaloid-Rich Fraction from Ficus septica Leaves Muhammad Hafizh Ridho; Andayana Puspitasari Gani; Subagus Wahyuono; Nanang Fakhrudin
Journal of Food and Pharmaceutical Sciences Vol 8, No 3 (2020): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.852

Abstract

Ficus septica Burm. F (Awar-awar) in Indonesian herbal medicine traditionally used for the treatment of various disease. Previous studies indicated that the F. septica leaves contained phenantroindolizidine alkaloids with anticancer activity. Fractionation of the ethanol extract of F. septica leaves using n-hexane was able to separate chlorophylls and other inert non–polar constituents from the extract. This fractionation process can be optimized using ultrasonic-assisted fractionation to yield n-hexane insoluble fraction (HIF) that is rich in alkaloids. This study aimed to produce HIF from the ethanol extract of F. septica leaves by using optimized ultrasonic-assisted fractionation with n-hexane as a solvent and full factorial as experimental design. Ficus septica leaves were macerated in ethanol (60%) and the extract was used for the ultrasonic-assisted fractionation process. The duration of fractionation (5-30 minutes), the extract : n-hexane ratios (1:0.1 - 1:1.66 ml/ml), and the ultrasonic power (21-106 Wrms) were optimized to determine the optimal condition for each variable. These optimal variables were used for the production of HIF from the extract by using full factorial design in the ultrasonic-assisted fractionation process. The total alkaloid content was measured using spectrophotometry and was used as parameter for the optimization process. We found that the optimal condition for the fractionation process based on each single variable optimization were 5 minutes of the fractionation duration, 66-70Wrms of the ultrasonic power, and 1:0.7 - 1:0.8 of the extract : n-hexane ratio. By using these optimized variables, the ultrasonic-assisted fractionation using full factorial design yielded up to 0.035% total alkaloid content which is almost double from those in the extract (0.019%). This study provided a basic experimental model for the production of alkaloid-enriched HIF from F. septica leaves in the industrial or pilot scale, and might contribute to the development of Indonesian herbal medicine products from natural resources.
A Simple Liquid-Liquid Fractionation (LLF) Method for Isolating Deoxyandrographolide dan Andrographolide from Herbs of Andrographis paniculata (Burm., F) Ness and Its Cytotoxic Activity on 3T3-L1 Preadipocyte Cells Putri Rachma Novitasari; Novia Tri Astuti; Suwijiyo Pramono; Raymond Tjandrawinata; Agung Endro Nugroho
Journal of Food and Pharmaceutical Sciences Vol 8, No 3 (2020): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.875

Abstract

The main bitter constituents of sambiloto (Androgaphis paniculata (Burm., F) Ness) are diterpene lactones, namely andrographolide and deoxyandrographolide which have been reported to have antidiabetic, cytotoxic, antiatherosclerosis, anti-inflammatory, and antimicrobial activity. There are many studies that performed the isolation of deoxyandrographolide and andrographolide from A. paniculata herbs, but most of them included several steps that make them not efficient. This research was conducted to do an isolation of deoxyandrographolide and andrographolide through liquid-liquid fractionation (LLF) due to its simplicity, low cost, and time efficient. The extraction of deoxyandrographolide and andrographolide from the herbs was carried out using chloroform as the solvent by using Soxhlet apparatus, and LLF was performed to isolate the compounds. The identities of the compounds were confirmed by TLC scanner compared to its standard references. Hence, these present methods were successfully isolated and determined deoxyandrographolide and andrographolide of A. paniculata. The compounds were also showed relatively moderate cytotoxicity on 3T3-L1 cell lines using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) assay, with LC50 of deoxyandrographolide and andrographolide; 29.3173 µg/mL and 37.7011 µg/mL, respectively.

Page 3 of 16 | Total Record : 154

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