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Benzena Pharmaceutical Scientific Journal
Published by Universitas Pekalongan
ISSN : -     EISSN : 29617375     DOI : http://dx.doi.org/10.31941/benzena.v2i01.3065
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology Public Health
Benzena Pharmaceutical Scientific Journal adalah jurnal peer-review yang diterbitkan dua kali setahun (Juni dan Desember) oleh Fakultas Farmasi Universitas Pekalongan. Ini tersedia online sebagai sumber akses terbuka dan juga dalam bentuk cetak. Pernyataan ini memperjelas perilaku etis semua pihak yang terlibat dalam tindakan penerbitan artikel di jurnal ini, termasuk penulis, pemimpin redaksi, Dewan Editorial, reviewer, dan penerbit. Pernyataan ini didasarkan pada Pedoman Praktik Terbaik COPE untuk Editor Jurnal. Focus dan scope : Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutics, Pharmaceutical Microbiology and Biotechnology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 84 Documents
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UJI DISOLUSI DAN PENETAPAN KADAR TABLET AMLODIPIN 5 mg GENERIK DAN BERMEREK khasanah, kharismatul
BENZENA Pharmaceutical Scientific Journal Vol 4 No 01 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hypertension is a significant health issue with a prevalence of 34.1% in Indonesia, yet many individuals with hypertension do not consistently take medication. Amlodipine, an antihypertensive and antianginal drug belonging to the calcium channel blocker class, is widely used in both generic and branded forms. The differences between these two are often considered when choosing treatment, as generic drugs are more affordable, although their quality is frequently questioned. Generic drugs are often perceived as inferior to branded or innovator drugs. Therefore, research is needed to ensure that the quality of generic drugs is not lower than that of branded products. This study aims to compare the quality of generic and branded amlodipine tablets through weight uniformity testing, content determination, and dissolution testing. A descriptive research method was used. The weight uniformity test was performed by weighing 20 tablets from each sample. The dissolution test was conducted using a paddle-type apparatus (method 2). Content determination was performed using UV-Vis spectrophotometry at a wavelength of 237 nm to determine the amlodipine content in the tablets. Data obtained were analyzed using Microsoft Excel. The results showed that both generic and branded amlodipine tablets met the dissolution test requirements according to the Indonesian Pharmacopoeia (Edition VI), with at least 50% dissolution within 30 minutes as indicated on the label. The dissolution profiles of both generic and branded amlodipine tablets showed similar drug release patterns. However, the dissolution efficiency (DE) for both samples was relatively low, with DE values at the 5-minute mark being 9.52% for the generic tablet and 10.32% for the branded tablet. At the 30-minute mark, the dissolution efficiency for both samples reached approximately 33%.
SMART INHALER DALAM PENATALAKSANAAN ASMA: STUDI TERKINI TENTANG PENINGKATAN KEPATUHAN TERAPI DAN HASIL KLINIS Salsabela
BENZENA Pharmaceutical Scientific Journal Vol 4 No 02 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v4i02.7119

Abstract

Latar bekalang: Asma merupakan penyakit pernapasan kronis yang paling umum di dunia, dengan kepatuhan terhadap terapi pemeliharaan masih rendah, sehingga meningkatkan risiko eksaserbasi, rawat inap, dan mortalitas. Intervensi digital, termasuk perangkat pemantauan elektronik, smart inhaler, smart spacer, aplikasi mobile, dan pengingat SMS, telah muncul sebagai strategi inovatif untuk meningkatkan kepatuhan dan hasil klinis. Tujuan: Menilai efektivitas intervensi digital dalam meningkatkan kepatuhan terhadap terapi pemeliharaan pada pasien asma, mengevaluasi dampak klinis dan ekonomi. Metode: Tinjauan dilakukan terhadap delapan studi RCT dan observasional yang mengevaluasi intervensi digital pada pasien dewasa dan anak-anak dengan asma. Variabel utama meliputi kepatuhan, teknik inhaler, kontrol asma, kualitas hidup, prediksi eksaserbasi, dan cost-effectiveness. Hasil: Intervensi digital secara konsisten meningkatkan kepatuhan hingga 23% dibandingkan kontrol, memperbaiki teknik inhalasi, dan meningkatkan kontrol asma serta kualitas hidup. Algoritma pembelajaran mesin pada inhaler cerdas dapat memprediksi eksaserbasi secara akurat, memungkinkan manajemen proaktif. Studi jangka panjang menunjukkan penghematan biaya melalui pengurangan penggunaan terapi biologik tambahan. Pada anak-anak, kepatuhan dan teknik inhalasi terbukti sebagai dua aspek berbeda, sehingga memerlukan strategi edukasi yang terfokus. Kesimpulan: Intervensi digital terbukti efektif meningkatkan kepatuhan dan hasil klinis pada pasien asma. Strategi ini memiliki potensi untuk mendukung manajemen asma yang dipersonalisasi dan hemat biaya. Penelitian lebih lanjut diperlukan untuk mengevaluasi efektivitas jangka panjang dan implementasi di praktik klinis dunia nyata.
A NARRATIVE REVIEW: PEMANFAATAN TEKNOLOGI DIGITAL OLEH APOTEKER DALAM PENINGKATAN KEPATUHAN PENGOBATAN PENYAKIT KRONIS Anisya, Kharina
BENZENA Pharmaceutical Scientific Journal Vol 4 No 02 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v4i02.7146

Abstract

Background : The increasing prevalence of chronic diseases such as diabetes, hypertension, and cardiovascular disorders poses a major challenge to global health systems. A key determinant of successful chronic disease therapy is patient adherence to medication, which remains low, particularly among populations with limited access to healthcare services. Pharmacists play a crucial role in supporting medication adherence through digital technology–based interventions, such as telepharmacy and mobile health applications. The digitalization of pharmacy services enables improved access, therapy monitoring, and continuous communication between pharmacists and patients. Objective : This study aims to explore the implementation of digital technology by pharmacists in enhancing medication adherence among patients with chronic diseases. Method : A narrative review was conducted through a search of the PubMed, ProQuest, and Google Scholar databases for articles published between 2015 and 2025. Inclusion criteria were applied based on the relevance to pharmacist-led interventions and adherence outcomes among patients with chronic diseases. Ten eligible articles were selected and analyzed qualitatively. Result : The review findings indicate that digital interventions by pharmacists—including telepharmacy, mobile applications, web-based systems, and short message reminders—consistently improve medication adherence and clinical outcomes among patients. Several studies reported reductions in Drug-Related Problems (DRPs), improvements in quality of life, and better control of clinical parameters such as blood pressure and glucose levels. The success of these interventions is influenced by patients’ digital literacy, the support of the healthcare system, and the frequency of communication between pharmacists and patients. Identified barriers include limited internet access, low digital literacy among elderly patients, and insufficient interprofessional collaboration. Conclusion : The utilization of digital technology in pharmaceutical interventions has proven effective in improving medication adherence and clinical outcomes among patients with chronic diseases. The role of pharmacists as digital care facilitators serves as a key factor in achieving these positive results. The integration of telepharmacy and health applications into primary care services holds great potential to expand access and support a more inclusive and sustainable health system. Keywords: telepharmacy, digital technology, medication adherence, chronic disease.
ANTIOXIDANT ACTIVITY OF 96% ETHANOL, ETHYL ACETATE AND N-HEXANE EXTRACT OF GREEN GIRL EGGPLANT (Solanum Melongena L) USING DPPH METHOD Winda Nur Rahayu; Nita Fajaryanti; Azizah, Tri Nur; Andamari Wahyu Utami, Rose Malinda; Putri, Nabilla Andasari
BENZENA Pharmaceutical Scientific Journal Vol 4 No 02 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v4i02.7194

Abstract

Terong umumnya mengandung metabolit sekunder yang merupakan sumber antioksidan termasuk karotenoid, antosianin, alkaloid, dan flavonoid, diketahui memiliki sifat antioksidan. Masyarakat Jawa sering mengonsumsi terong gelatik hijau (Solanum melongena L.) sebagai lauk. Tujuan penelitian ini adalah untuk mengetahui apakah ekstrak etanol 96%, etil asetat, dan N-heksana dari terong gelatik hijau (Solanum melongena L.) memiliki aktivitas antioksidan menggunakan metode DPPH dan ekstrak mana yang memiliki aktivitas antioksidan tertinggi. Metode ekstraksi yang digunakan adalah maserasi. Penelitian ini menggunakan tiga ekstrak: etanol 96%, etil asetat, dan N-heksana menggunakan metode DPPH. Penelitian ini menggunakan tiga pelarut hasil ekstraksi DPPH: etil asetat, N-heksana, dan etanol 96%. Berdasarkan data yang diperoleh dalam penelitian ini menunjukkan nilai IC50 rata-rata sebesar 16,85 µg/mL untuk ekstrak etanol 96%, 36,61 µg/mL untuk ekstrak etil asetat, dan 46,17 µg/mL untuk ekstrak N-heksana. Ekstrak etanol 96% dari terong gelatik hijau (Solanum melongena L.) memiliki aktivitas antioksidan tertinggi dibandingkan dengan ekstrak etil asetat dan N-heksana. Kata kunci: Antioksidan, DPPH, Ekstrak, Terong

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