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Benzena Pharmaceutical Scientific Journal
Published by Universitas Pekalongan
ISSN : -     EISSN : 29617375     DOI : http://dx.doi.org/10.31941/benzena.v2i01.3065
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology Public Health
Benzena Pharmaceutical Scientific Journal adalah jurnal peer-review yang diterbitkan dua kali setahun (Juni dan Desember) oleh Fakultas Farmasi Universitas Pekalongan. Ini tersedia online sebagai sumber akses terbuka dan juga dalam bentuk cetak. Pernyataan ini memperjelas perilaku etis semua pihak yang terlibat dalam tindakan penerbitan artikel di jurnal ini, termasuk penulis, pemimpin redaksi, Dewan Editorial, reviewer, dan penerbit. Pernyataan ini didasarkan pada Pedoman Praktik Terbaik COPE untuk Editor Jurnal. Focus dan scope : Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutics, Pharmaceutical Microbiology and Biotechnology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 81 Documents
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PENETAPAN KADAR FLAVONOID REBUSAN DAN SEDUHAN DAUN TAPAK LIMAN (Elephantopus scaber) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Multi, Bryan Dwi; Saputri, Alip Desi Suyono; Sa'ad, Muhammad
BENZENA Pharmaceutical Scientific Journal Vol 3 No 01 (2024): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v3i01.4425

Abstract

Latar bekalang :  Banyak penduduk Indonesia yang menggunakan tanaman obat atau jamu baik untuk menjaga kesehatan maupun untuk pengobatan karena sakit. Salah satu tanaman obat yang sering dikonsumsi oleh masyarakat yaitu tanaman tapak liman (Elephantopus scaber). Tanaman Tapak liman (Elephantopus scaber) diketahui mempunyai kandungan flavonoid yang cukup tinggi. Masyarakat Indonesia dalam mengkonsumsi tanaman obat menggunakan cara direbus dan diseduh.Tujuan:Tujuan dari penelitian ini adalah untuk mengetahui kadar flavonoid tertinggi pada dua metode ekstraksi (rebusan dan seduhan) menggunakan Spektrofotometri UV-Vis.Metode:Metode penelitian ini berupa metode eksperimental. Uji kualitatif dilakukan dengan uji KLT dan menghasilkan bercak dibandingkan dengan standar kuersetin. Uji kuantitatif dilakukan dengan penetapan kadar flavonoid total rebusan dan seduhan simplisia daun tapak liman dengan Spektrofotometri UV-Vis.Hasil: Hasil penetapan kadar flavonoid total didapatkan sebesar 2,448 ± 0,1597 mgQE/100ml dengan %KV 0,65 pada metode rebusan. Pada seduhan simplisia daun tapak liman kadar yang diperoleh sebesar 0,531 ± 0,0096 mgQE/100ml dengan %KV 1,81. Uji statistik menunjukkan nilai signifikansi dari perbedaan kadar flavonoid (p value 0,000 < 0,05).Kesimpulan: Kesimpulan pada penelitian ini terdapat perbedaan kadar flavonoid yang signifikan antara rebusan dan seduhan daun tapak liman. Metode rebusan memiliki kandungan flavonoid lebih besar dibanding metode seduhan.
REVIEW ARTIKEL : POTENSI BAHAN ALAM UNTUK PENGOBATAN INFEKSI SALURAN PERNAPASAN AKUT (ISPA) Sari, Anna Khumaira; Desriyanti, Anisa; Saputri, Atikah Andria; Khairunnisa, Khairunnisa; Amilia, Jariyah
BENZENA Pharmaceutical Scientific Journal Vol 3 No 01 (2024): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v3i01.4451

Abstract

Latar bekalang : Infeksi saluran napas akut (ISPA) merupakan salah satu penyakit yang disebabkan oleh bakteri. Meskipun penggunaan antibiotik telah menjadi pendekatan umum dalam pengobatan ISPA, resistensi antibiotik yang semakin meningkat menuntut penelitian alternatif terhadap agen antimikroba. Salah satu pendekatan yang menjanjikan adalah pemanfaatan potensi bahan alam sebagai agen pengobatan ISPA.Tujuan : Penelitian ini bertujuan untuk melihat potensi dari beberapa bahan alam yang dapat berguna untuk pengobatan infeksi saluran pernapasan akut.Metode : Jenis penelitian yang dilakukan adalah narrative review dengan menggunakan database Google Scholar dengan ketentuan kriteria inklusi meliputi jurnal yang meneliti terkait topik, publikasi artikel yang dapat diakses penuh, full text, diterbitkan antara tahun 2019 hingga 2024, artikel penelitian, dipublikasikan dalam bahasa Indonesia atau bahasa InggrisHasil : Hasil pemilihan artikel didapatkan 30 jurnal dari 2160 artikel yang relevan mengenai bahan alam yang memiliki potensi untuk terapi infeksi pernapasan saluran akut. Beberapa bahan alam seperti rimpang kunyit, daun mengkudu, daun mangga arumanis berpotensi digunakan sebagai terapi dalam pengobatan gejala infeksi saluran pernapasan akut. Senyawa aktif flavonoid, alkaloid, saponin, tanin, terpenoid, dan fenol merupakan  senyawa metabolit yang sangat berperan dalam membantu terapi infeksi saluran pernapasan akut.Kesimpulan : Tanaman dengan senyawa aktif flavonoid, alkaloid, saponin, tanin, terpenoid, dan fenol mempunyai potensi untuk pengobatan infeksi saluran pernafasan akut Kata kunci: Bahan alam, infeksi saluran pernapasan akut, potensi
REVIEW: METODE-METODE PEMERIKSAAN GLUKOSA DARAH Wulandari, Sri Rahmawati; Dewi, Astika Sari; Ruella, Nathania; Utami, Sari Wasila
BENZENA Pharmaceutical Scientific Journal Vol 3 No 01 (2024): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v3i01.4528

Abstract

Diabetes melitus (DM) adalah suatu keadaan tubuh tidak dapat menghasilkan hormon insulin sesuai kebutuhan karena terjadi lonjakan kadar gula dalam darah melebihi normal. Pemantauan kadar gula darah sangat penting karena glukosa darah adalah indikator untuk menentukan diagnosa penyakit DM. Penelitian ini bertujuan untuk mengetahui perbedaaan dari beberapa metode pemeriksaan glukosa darah sehingga dapat menjadi bahan referensi dalam penelitian serta dapat dijadikan bahan pertimbangan dalam pemeriksaan glukosa darah. Penelitian ini dilakukan dengan metode studi literatur menggunakan data-data yang berasal dari jurnal-jurnal ilmiah terpublikasi nasional dalam terbitan 10 tahun terakhir. Kata kunci pencarian melibatkan “glukosa darah”, “pemeriksaan glukosa”, “GOD – PAP”, “diabetes melitus”, “blood glucose test”, “enzymatic methods, “POCT glukosa” dan “heksokinase”. Strategi pencarian literatur dilakukan melalui pencarian di Google Scholar dan Academia Edu.  Setiap literatur dianalisis mulai dari tujuan, metode pemeriksaan serta hasil pemeriksaan glukosa darah. Beberapa metode yang digunakan diantaranya yaitu Glucose Oxidase – Peroxidase Aminoantypirin (GOD - PAP), Point off Care Test (POCT) dan Heksokinase. Kesimpulan dari review artikel ini diperoleh bahwa metode pemeriksaan glukosa darah yang paling baik dan bagus adalah metode GOD - PAP karena akurasinya yang tinggi, spesifik, relatif bebas dari gangguan serta lebih sering digunakan dalam laboratorium klinik dibanding metode pemeriksaan glukosa yang lain.
UJI AKTIFITAS ANTIPIRETIK INFUS DAUN BAMBU TALI (Gigantochloa Apus Kruz.) TERHADAP MENCIT PUTIH JANTAN (Mus Musculus) YANG DIINDUKSI PEPTON Azizah, Tri Nur; Agustin, Priya Cyntia; Wahyu Utami, Rose Malinda Andamari
BENZENA Pharmaceutical Scientific Journal Vol 3 No 01 (2024): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v3i01.4623

Abstract

Tanaman Bambu Tali (Gigantochloa Apus Kruz.)  merupakan tanaman yang secara empiris dapat digunakan oleh masyarakat sebagai obat antiinflamasi, antidiabetes, dan antioksidan. Daun Bambu Tali (Gigantochloa Apus Kruz.) mengandung senyawa metabolit sekunder seperti flavonoid, alkaloid, triterpenoid, steroid, tanin dan saponin yang berpotensi untuk digunakan sebagai antipiretik. Oleh karena itu, penelitian ini bertujuan untuk mengetahui ada atau tidaknya pengaruh aktivitas antipiretik infus Daun Bambu Tali (Gigantochloa Apus Kruz.) pada mencit putih jantan (Mus Musculus) yang diinduksi pepton. Penelitian ini menggunakan metode rancangan pra eksperimen (pra eksperimental desings) berupa static group comparison yaitu sampel telah dirandomisasi baik pada kelompok eksperimen maupun kelompok kontrol, menggunakan 15 ekor mencit yang dibagi menjadi 3 kelompok perlakuan yaitu kontrol negatif (Na CMC 0,5%), kontrol positif (paracetamol), dan kelompok uji yaitu pemberian infus Daun Bambu Tali (Gigantochloa Apus Kruz.). Setiap hewan uji diinduksi larutan pepton steril 10% dengan dosis 1 ml/Kg BB secara subkutan, munculnya demam terjadi setelah 30 menit pemberian induktor, pengukuran suhu rektal dilakukan setiap interval waktu 30 menit hingga waktu ke 120 menit. Data yang diperoleh dianalisis dengan menggunakan SPSS (Statistical Product and Service Solutions). Pengujian diawali dengan uji normalitas menggunakan uji Shapiro- Wilk. Data yang sudah berdistribusi homogen dan normal kemudian diuji menggunakan uji parametrik One Way ANOVA kemudian dilanjutkan analisa LSD Post Hoc. Dari hasil uji tersebut menunjukkan bahwa Daun Bambu Tali (Gigantochloa Apus Kruz.) memiliki efektivitas antipiretik sebanding dengan kontrol positif paracetamol dengan hasil data ANOVA (p<0,05). Kesimpulannya infus Daun Bambu Tali (Gigantochloa Apus Kruz.) memiliki aktivitas antipiretik yang dapat menurunkan suhu tubuh mencit putih jantan (Mus Musculus).
EVALUATION OF HYDROGEL MASK PREPARATION OF RED MANGROVE LEAF ETHANOL EXTRACT (Sonneratia caseolaris Engl.) Sa’diyah, Aminatus; Pambudi, Dwi Bagus
BENZENA Pharmaceutical Scientific Journal Vol 3 No 01 (2024): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v3i01.4638

Abstract

Hydrogel preparations are preparations that have a fairly high water content, ranging from 80-90%. Sonneratia caseolaris Engl is a type of mangrove plant, locally this tree is often called kapidada. Ecologically, kapidada grows in the less salty parts of the mangrove forest. This study aims to find out whether the red pidada mangrove leaf extract can be formulated into a hydrogel mask preparation. The test method used is a hydrogel mask made by mixing the basic ingredients of the mask in the form of carbopol 940 and TEA. The results of the evaluation test were in the form of an organoleptic test with greenish clear color parameters, odorless, with a thick gel form. The resulting pH test was formula 1 with a pH value of 5, formula 2 with a pH value of 6 and formula 3 with a pH value of 5. Test the homogeneity of all preparations from the three homogeneous formulas. The spreadability test produced from formula 1 was 5.1 cm, formula 2 was 4.9 cm and formula 3 was 3.6 cm. The adhesion test resulting from the three formulas obtained a value of 1.16; 1.52; and 1.63 seconds. Viscosity test obtained from the three formulas, namely 3,967; 2,989; and 1,737 cps. The results showed that the hydrogel mask preparations met the evaluation requirements, namely formula 1.
PENGARUH KONSENTRASI ETANOL TERHADAP AKTIVITAS ANTIBAKTERI EKSTRAK DAUN LILI PARIS (Chlorophytum comosum) Dany Hexa Grosny Ralphsody; Lindawati, Novena Yety
BENZENA Pharmaceutical Scientific Journal Vol 4 No 01 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v4i01.6644

Abstract

Staphylococcus aureus is a pathogenic bacterium that frequently causes serious infections, such as skin infections, pneumonia, and sepsis. The increasing resistance to conventional antibiotics has prompted the search for alternative therapies derived from natural sources. Spider plant (Chlorophytum comosum) leaves are known to contain bioactive compounds such as flavonoids, saponins, and terpenoids, which have potential antibacterial properties. This study aims to determine the effect of varying ethanol concentrations (40%, 70%, and 96%) on the antibacterial activity of spider plant leaf extracts against Staphylococcus aureus. Extraction was carried out using the maceration method with ethanol solvents at concentrations of 40%, 70%, and 96%. Each extract underwent phytochemical screening. Antibacterial activity was tested using the well diffusion method against Staphylococcus aureus ATCC 25923. The inhibition zones were measured using a caliper. Data were analyzed using normality and homogeneity tests, one-way ANOVA, and Tukey’s post hoc test. Phytochemical screening results showed that the 40% ethanol extract contained only flavonoids and tannins, while the 70% and 96% ethanol extracts contained flavonoids, terpenoids, tannins, and saponins. Antibacterial testing showed that the 70% ethanol extract produced the largest inhibition zone (9.75 mm), followed by the 96% ethanol extract (7.25 mm), and the 40% ethanol extract (6.3 mm). ANOVA results indicated significant differences between groups (p < 0.05), and the post hoc test showed that the 70% ethanol extract differed significantly from the other two groups. Ethanol 70% was the most effective solvent for extracting antibacterial compounds from spider plant leaves, as it produced the highest antibacterial activity against Staphylococcus aureus. These results support the potential use of spider plant leaf extract as a natural antibacterial candidate.
POTENSI ANTIOKSIDAN REBUSAN DAN SEDUHAN TEMU MANGGA (Curcuma mangga) DENGAN METODE DPPH Halimah, Nur; Sa'ad, Muhammad
BENZENA Pharmaceutical Scientific Journal Vol 4 No 01 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v4i01.6697

Abstract

Background : Free radicals are unstable molecules that cause oxidative stress and various chronic diseases. Antioxidant compounds can play a role in neutralizing free radicals. Plants as natural ingredients of traditional medicine contain secondary metabolite compounds that act as antioxidants. One of the plants used as an antioxidant is temu mangga (Curcuma mangga). The use of natural ingredients as medicine by the people in Indonesia mostly uses the boiling and steeping methods. Objective : This study aims to determine the antioxidant activity of boiled and brewed temu mangga rhizome (Curcuma mangga) compared to quercetin. And to determine the content of secondary metabolites that are responsible for antioxidant activity. Method : Phytochemical screening using color reagents to determine the content of secondary metabolites including: alkaloids, tannins, saponins, and flavonoids. Antioxidant activity was measured using the DPPH method using the parameter of the Inhibitory Concentration 50% (IC50) value with quercetin as a positive control. Result : The results showed that both methods have secondary metabolite compounds that are responsible for antioxidant activity, namely: alkaloids, tannins, saponins, and flavonoids. Both methods showed very strong antioxidant activity, with IC50 quercetin, boiling and brewing method respectively of 5.62 ppm; 5.75 ppm; and 5.53 ppm. The brewing method was slightly more effective, possibly because the temperature used was lower, thus maintaining the stability of thermolabile antioxidant compounds such as flavonoids. Conclusion : Extraction method has significant effect on antioxidant activity. The brewing method can be a more optimal traditional method to maintain antioxidant properties of Curcuma mangga.
ANALISIS FISIKO-KIMIA SIMPLISIA DAN PROFIL KROMATOGRAFI LAPIS TIPIS HERBA BANDOTAN (Ageratum conyzoides L.) Pratimasari, Diah; Disa Andriani
BENZENA Pharmaceutical Scientific Journal Vol 4 No 01 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v4i01.6707

Abstract

Background: Bandotan plant (Ageratum conyzoides L.) is a plant of the Aceraceae family that grows wild. Bandotan is empirically used as an antiseptic and wound healer. In addition, bandotan plants are also reported to have activities as antipyretic, anti-inflammatory, and antioxidant. These various pharmacological activities make the bandotan plant potential to be developed as a medicinal and cosmetic raw material. So far, research related to bandotan standardization has been carried out on the leaves, even though all parts of the bandotan plant including the roots have the potential to be developed. In addition, the use of all parts of the plant supports green chemistry, namely minimizing residual production waste. Objective: This study aims to conduct chemical physicochemical characterization of simplisia of all parts of bandotan herb and its Thin Layer Chromatography (TLC) profile. Methods: This research begins with making simplisia from all parts of the bandotan plant. The obtained simplisia was then observed for its physicochemical aspects including drying shrinkage, total ash content, water soluble juice content, ethanol soluble juice content and TLC identification. In addition to making simplisia, all parts of bandotan were also extracted with 70% ethanol, to be analyzed KLT compared with simplisia and kaemferol standards. Conclusion: The use of all parts of the bandotan herb plant meets the quality standards of simplisia. In addition, the use of all parts of the plant shows a diversity of spots on KLT that have the potential to be developed as medicinal and cosmetic raw materials
HUBUNGAN TINGKAT PENGETAHUAN MAHASISWA TERHADAP RASIONALITAS PENGGUNAAN OBAT ANTIBIOTIK Andre; Irda Rizky Wiharti; Erin Efrilia
BENZENA Pharmaceutical Scientific Journal Vol 4 No 01 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v4i01.6762

Abstract

Antibiotics are among the most commonly used drugs to treat infections. However, their use is often accompanied by misunderstandings and a lack of knowledge regarding proper usage. Pharmacy students, as health science students who study medicines, are expected to have a good understanding in order to provide accurate information about drugs within their community. The purpose of this study is to determine the level of knowledge about antibiotics among pharmacy students at the University of Pekalongan. The method used in this study was a questionnaire distributed using random sampling, involving 108 student respondents. Based on the results, the level of respondents' knowledge was categorized as good in 77.6% of the participants. Keywords: Knowledge, Pharmacy Students, Medication Use, Antibiotic
PENGARUH VARIASI SUHU PENGERINGAN TERHADAP KADAR FLAVONOID TOTAL EKSTRAK UMBI BIT (Beta vulgaris L.) DENGAN METODE SPEKTROFOTOMETRI UV VISIBEL Susilowati
BENZENA Pharmaceutical Scientific Journal Vol 4 No 01 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Beetroot (Beta vulgaris L.) is one of the plants in Indonesia that is often utilized by the community in a traditional way. Several studies have shown that consuming red beet can improve cardiovascular health and lower daily systolic blood pressure. One of the secondary metabolites that actively plays a role in beetroot is flavonoids. This study aims to determine the highest total flavonoid content in beetroot extract dried using an oven with different drying temperature variations of 60°C, 70°C, and 80°C. The extraction method in this study is maceration using 96% ethanol as the solvent. Qualitative testing was performed with a flavonoid color test using the Taubeck method and Thin Layer Chromatography (TLC) with ammonia vapor. The determination of flavonoid content was done using UV-Visible spectrophotometry. The results showed that beetroot contains flavonoid compounds. The flavonoid content obtained at a temperature of 60°C was 371,11 ± 0 μgQE/g sample, at 70°C it was 357,77 ± 0.0128 μgQE/g sample, and at 80°C it was 241,48 ± 0.0127 mgQE/g sample. It can be concluded that drying temperature affects the total flavonoid content found in beet tubers and the highest flavonoid content obtained is at a temperature of 60°C, which is 371,11 ± 0 μgQE/g sample.

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