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INDONESIA
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi
Published by Sekolah Tinggi Ilmu Kesehatan Kesetiakawanan Sosial Indonesia
ISSN : 30265819     EISSN : 30265800     DOI : 10.57213
Core Subject : Health,
Health Professions Public Health
Jurnal ini adalah Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) yang bersifat peer-review dan terbuka. Bidang kajian dalam jurnal ini termasuk riset Ilmu Kesehatan Umum, dan Farmasi.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 184 Documents
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Uji Efek Daun Jati dan Senggani Terhadap Penurunan Suhu Tubuh pada Tikus yang diinduksi Pepton Seriyani Wulandari; Dhini Andriani; Fhadlyatul Khusna; Mu'tia Aulia Ramadhani; A. Ilmi Alfiani; Nadia Nadia
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.807

Abstract

This study aims to examine the effect of several types of antipyretics on the immune response and body thermal homeostasis in experimental animals induced by fever. This study was conducted at the Pharmacology and Toxicology Laboratory of Muhammadiyah University of Makassar, using Rattus norvegicus mice as test animals. The study involved five treatment groups, each given a different drug or infusion, namely diclofenac sodium, ibuprofen, farmadol, teak leaf infusion (Tectona grandis), and senggani leaf infusion (Melastoma malabathricum), while NaCMC was used as a negative control. Body temperature measurements were taken at 15, 30, 45, and 60 minutes after treatment to evaluate the effect of antipyretics on body temperature in fever-induced mice. Each treatment group was given a dose according to the related literature, and temperature measurements were carried out using a well-calibrated thermometer. The data obtained were then analyzed using ANOVA to determine any significant differences in body temperature reduction between treatment groups. The results showed that sodium diclofenac provided the highest antipyretic effect, as seen from a significant decrease in body temperature at all measurement times. Ibuprofen also provided a significant antipyretic effect, although not as strong as sodium diclofenac. Meanwhile, teak leaf infusion and senggani leaf infusion showed a decrease in body temperature, but with lower effectiveness compared to synthetic drugs. The group given NaCMC as a negative control did not show a significant decrease in body temperature. These findings indicate that sodium diclofenac is very effective in restoring the body's thermal balance and can be a reference for further research on antipyretic agents, both synthetic and herbal. The implications of this study also emphasize the importance of developing alternative fever therapies, either through more efficient synthetic drugs or through the use of herbal plants that have the potential as natural antipyretics.
Kepemimpinan Technopreneur Dalam Bidang Farmasi: Studi Pengambilan Keputusan dan Integrasi Nilai - Nilai Syariat Islam Dalam Pengolahan Usaha Frya RahmanDanny; Jaira Jacquitta Putri; Rifa Husnul Khotimah; Mochammad Fadhlani Salam
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.810

Abstract

This study aims to describe the characteristics of Muslim technopreneur leadership, analyze the decision-making process, and examine the implementation of Islamic values in managing a Sharia-based pharmaceutical business. The research uses a descriptive qualitative approach with a case study of Apotek Fernanda, owned by Mrs. Yelni Erita, located in Tembilahan, Riau. The results of the study show that Muslim technopreneur leadership is reflected in the integration of Islamic values such as honesty, trust, responsibility, and blessings, which are applied as the main principles in running the business. This leadership emphasizes the importance of personal character in line with Islamic teachings, where every decision made should be based on moral and spiritual principles. The decision-making process is carried out carefully, especially with spiritual considerations. Mrs. Yelni Erita often conducts istikharah to seek guidance from Allah before making important business decisions. Additionally, consultations with the team and evaluation of maslahat (benefit) are part of the decision-making process to ensure that the steps taken bring the greatest benefit, not only for the business but also for the community at large. This approach does not only prioritize profit but also considers the social and spiritual well-being of all parties involved. In managerial practices, the implementation of Islamic values is reflected in the selection of halal products, ethical service systems, and work relationships based on fairness and transparency. Apotek Fernanda provides services while upholding these principles, ensuring that the products sold meet halal standards and offering customer-oriented services. The application of these Sharia principles not only meets the needs of an increasingly discerning and critical market but also brings positive economic and spiritual impacts to the community. The findings show that entrepreneurship in the pharmaceutical field can be developed competitively while adhering to Sharia principles, providing sustainable profits and positive impacts on the broader community.
Laporan Kasus: Perempuan 19 Tahun dengan Anastomosis Colon Relaparotomy Post Ileus Obstruktif Muhammad Afifudin Auliy; Catur Widayat
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.820

Abstract

Anastomotic leaks are one of the most feared complications after bowel surgery, given the potential for devastating consequences. Anastomotic leaks can occur early in the postoperative period and are a major concern for medical personnel, particularly surgeons. A 19-year-old female patient, referred from Bhakti Persada Hospital to the emergency room of Dr. Sayidiman Hospital, Magetan, on July 20, 2024, presented with complaints of vomiting, black stools with blood spots, and epigastric pain radiating to the back. The patient had previously been hospitalized at Bhakti Persada Hospital for 14 days and was diagnosed with obstructive ileus. She subsequently underwent a laparotomy. Postoperatively, the patient's suture site began to discharge a fecal-smelling fluid, indicating a complication of the anastomosis. A relaparotomy was performed to further evaluate the patient's condition. A follow-up examination revealed an anastomotic leak between the jejunum and sigmoid colon. After anastomotic repair, the patient was transferred back to the ward for further care. A few days later, she was discharged home. However, some time after discharge, the patient returned to the emergency room complaining of pain in the surgical wound and a foul-smelling discharge from the wound. The next step was to refer the patient to Dr. Sutomo General Hospital in Surabaya for further treatment, given the complexity of the patient's condition. This incident highlights the importance of being aware of anastomotic complications and prompt treatment to prevent more serious consequences. Complications such as anastomotic leaks require intensive postoperative attention, including careful monitoring for signs of infection or leakage at the suture site. Optimal preventive measures need to be implemented, taking into account both surgical techniques and the preparedness of medical facilities to handle potential complications.
Penerapan Terapi Benson untuk Mengurangi Nyeri pada Pasien Post Operasi Fraktur di RSUD Kajen Kabupaten Pekalongan Indah Permata Sari; Dwi Retnaningsih; Rahayu Winarti
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 4 (2025): Oktober : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i4.882

Abstract

Post-fracture surgery patients generally experience acute pain due to damage to bone, muscle, and soft tissue affected by surgical trauma. Untreated pain can cause mobility disorders, anxiety, and even slow the healing process. Pain management can be carried out pharmacologically and non-pharmacologically. One effective non-pharmacological intervention is Benson relaxation therapy, a breathing relaxation technique combined with elements of belief or positive affirmations to create a sense of calm and comfort. The purpose of this case study is to determine the application of Benson relaxation therapy in reducing pain in post-fracture surgery patients at Kajen Regional Hospital, Pekalongan Regency. The method used is a descriptive case study approach, involving four post-fracture surgery patients who experienced pain with a scale of 4–6 (moderate pain). The instruments used include the Benson relaxation SOP, a Numeric Rating Scale (NRS) pain observation sheet, and a respondent consent form (informed consent). This case study was conducted in the inpatient ward of Kajen Regional Hospital, Pekalongan Regency, from September 8–13, 2025. Results showed a decrease in the average pain scale from 4–6 to 2–4 after 15 minutes of Benson relaxation therapy. Conclusion: Benson relaxation therapy effectively reduces pain intensity in post-fracture surgery patients and can be recommended as a non-pharmacological intervention in pain management in the ward.  
Literatur Review: Strategi dan Perkembangan Computer-Aided Drug Design (Cadd) untuk Identifikasi Lead Compound Antikanker dalam Konteks Kimia Medisinal dan Farmasi Nurul Sulistia Azzahra; Saeful Amin
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 4 (2025): Oktober : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i4.875

Abstract

Cancer remains the second leading cause of death worldwide, while conventional therapies are often limited by toxicity, resistance, and high costs. Advances in bioinformatics and artificial intelligence have established Computer-Aided Drug Design (CADD) as an efficient tool for modern drug discovery. Integrating medicinal chemistry, structural biology, and computational modeling, CADD accelerates the identification and optimization of anticancer candidates through in silico approaches such as molecular docking, molecular dynamics, QSAR, and pharmacophore modeling. This review systematically analyzed literature from PubMed, ScienceDirect, ResearchGate, and Google Scholar (2015–2025) focusing on in silico studies related to anticancer drug design. Selected articles were evaluated based on molecular targets, compound types, CADD techniques, and major findings.The results reveal that CADD effectively identifies natural and synthetic compounds targeting key cancer proteins including EGFR, CDK2, PI3K/Akt/mTOR, and p53. Integration with artificial intelligence enhances screening efficiency, prediction accuracy, and ADMET assessment. Overall, CADD represents a crucial strategy to accelerate the discovery of selective and clinically promising anticancer drugs.
Kimia Medisinal dan Perjalanan Obat: Dari Desain Molekul Hingga Monitoring Klinis Syakila Syalsa Reiza Putri; Saeful Amin
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 4 (2025): Oktober : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i4.880

Abstract

This study explores the role of medicinal chemistry in the entire drug development process, from molecular design to post-marketing monitoring. Using a literature study method with a descriptive qualitative approach, data were collected from various scientific journals published between 2020 and 2025 that are relevant to drug development and the application of medicinal chemistry. The findings indicate that medicinal chemistry plays a crucial role in designing, modifying, and optimizing the structure of bioactive compounds through approaches such as structure–activity relationship (SAR) analysis, in silico modeling, and modern biotechnology. These approaches enable the discovery of new compounds that are more selective, effective, and safe. Examples include natural compounds such as betel leaf (Piper betle), green tea, berberine, and curcumin derivatives, which show potential as anticancer, antiviral, and antimalarial drug candidates. In addition, biotechnology-based therapies such as trastuzumab highlight the success of medicinal chemistry in the development of targeted therapies. However, the translation process from laboratory research to clinical application still faces several challenges, including high research costs, preclinical data reproducibility issues, limited infrastructure, and strict regulatory frameworks. Therefore, multidisciplinary collaboration, methodological innovation, and supportive policy development are required to strengthen the translation of research outcomes. Overall, medicinal chemistry plays a strategic role in accelerating the discovery of new drugs that are safe, effective, and globally competitive. The findings also show that integrating traditional approaches with modern computational methods and multidisciplinary collaboration can further accelerate new drug discovery.
Perbandingan Aromaterapi Inhalasi Lemon dan Peppermint Terhadap Mual dan Muntah Ibu Hamil Trimester I di PMB Melinda Kabupaten Way Kanan Tahun 2024 Septiara Erfika Putri; Riona Sanjaya; Iis Tri Utami; Rini Wahyuni
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 4 (2025): Oktober : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v1i4.881

Abstract

Nausea and vomiting during pregnancy, or morning sickness, are common conditions affecting approximately 70–80% of pregnant women, typically occurring between 5 and 12 weeks of gestation. Aromatherapy using lemon and peppermint essential oils is considered a complementary therapy for reducing these symptoms. In 2023, 76 cases (52.4%) of nausea and vomiting were recorded among first-trimester pregnant women at PMB Melinda. This study aimed to compare the effects of lemon and peppermint aromatherapy inhalation on nausea and vomiting in first-trimester pregnant women. Using a quantitative quasi-experimental design with a three-group pretest-posttest approach, the study involved 36 participants divided into three groups: 12 received lemon aromatherapy, 12 received peppermint aromatherapy, and 12 received vitamin B6 supplementation. Data were collected using the PUQI observation sheet and analyzed using univariate and bivariate methods with a paired sample t-test. The results showed that the mean nausea and vomiting score before lemon aromatherapy was 8.75, which decreased to 4.67 after the intervention. In the peppermint group, the mean score decreased from 8.08 to 3.83, while in the vitamin B6 group, it reduced from 8.75 to 6.42. Statistical analysis revealed that both lemon and peppermint aromatherapy significantly reduced nausea and vomiting (p = 0.000), while no significant difference was found between the two treatments (p = 0.756). The study concludes that both lemon and peppermint aromatherapy are effective non-pharmacological alternatives for managing nausea and vomiting during early pregnancy.  
Literatur Review: Peran Analisis In Silico dalam Eksplorasi Senyawa Bioaktif Tanaman untuk Pengembangan Obat Antidiabetik Fina Fatihatul Makia; Saeful Amin
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 4 (2025): Oktober : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i4.883

Abstract

Diabetes mellitus (DM) is a major global health problem with a steadily increasing prevalence, posing significant impacts on both public health and the world economy. Conventional antidiabetic drugs such as metformin, sulfonylureas, and thiazolidinediones are effective in lowering blood glucose levels but have several limitations, including adverse effects and reduced efficacy with long-term use. Advances in medicinal chemistry and computational approaches such as molecular docking, quantitative structure activity relationship (QSAR), and virtual screening have opened new opportunities for discovering safer, more selective, and efficient antidiabetic agents. This literature review aims to explore the role of the in silico approach in identifying bioactive plant compounds as potential antidiabetic drug candidates. Based on the analysis of ten research articles, in silico methods have proven essential in predicting the affinity and stability of interactions between natural bioactive compounds and key protein targets involved in type 2 diabetes mellitus, including α-glucosidase, DPP-IV, PPAR-γ, PTP1B, Aldose Reductase, and SGLT-2. Compounds derived from plants such as Tinospora crispa (brotowali), Moringa oleifera (moringa), Syzygium polyanthum (bay leaf), mangosteen peel, Orthosiphon stamineus (cat’s whiskers), and Smallanthus sonchifolius (yacon) exhibited stronger binding affinities compared to synthetic reference drugs such as acarbose and alogliptin. Thus, the in silico approach based on medicinal chemistry serves as a crucial strategy to accelerate the discovery and development of multi-target antidiabetic phytopharmaceuticals derived from natural products. Despite the promising results, further in vitro, in vivo, and clinical studies are required to confirm the effectiveness, safety, and bioavailability of the identified compounds.
Asuhan Kebidanan Postpartum pada Ny. M P2A0 di TPMB Hj. Siti Saidah, S.Keb., Bdn Kota Banjarmasin Jahratul Muna; Merlin Karinda; Syahrida Wahyu Utami
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 4 (2025): Oktober : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i4.884

Abstract

According to the World Health Organization (WHO), in 2023 more than 700 women died every day from preventable causes related to pregnancy and childbirth, with 92% of these deaths occurring in low- and middle-income countries, including Indonesia. In South Kalimantan, the maternal mortality rate (MMR) in 2023 reached 145 per 100,000 live births, an increase from 136 in 2022, with the main causes being hemorrhage and hypertensive complications. This study aims to provide postpartum midwifery care for Mrs. M, P2A0, from the first postpartum visit (KF1) to the fourth (KF4) at TPMB Hj. Siti Saidah, S.Keb., Bdn, in Banjarmasin City. The method used is descriptive with a case study approach using the SOAP format. The care was conducted from May 14 to June 26, 2025, at the TPMB and the client’s home. Data were collected through interviews, observations, medical records, physical examinations, supporting tests, and documents from related institutions. The results showed that the client was in good general condition, conscious (compos mentis), with blood pressure of 110/90 mmHg, respiratory rate of 22 breaths/minute, pulse rate of 82 beats/minute, temperature of 37°C, good uterine contractions, lochia rubra, and a first-degree perineal tear. The care provided was in accordance with midwifery standards, proceeded smoothly, and revealed no discrepancies between theory and practice.
Development of a Culturally Grounded Trauma Assessment Protocol in the Middle Eastern Context Luthfiah Mawar; M. Agung Rahmadi; Luthfiyah Aqilah Siagian; Sasa Maghfirah Siregar; Andieni Pratiwi; Helsa Nasution; Nurzahara Sihombing; Annisa Ardianti Br Tarigan
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 4 (2025): Oktober : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i4.885

Abstract

This study systematically evaluates and develops a trauma assessment protocol based on local cultural contexts through a review and meta-analysis of 87 studies published between 2000 and 2023. Using JASP 0.16.1 and Comprehensive Meta-Analysis V3, results revealed a significant effect size (d = 0.78, 95% CI [0.65, 0.91], p < 0.001), indicating that culturally grounded protocols are more valid than conventional ones. Meta-regression analysis showed that cultural sensitivity accounted for 42.3% of improvements in diagnostic accuracy (β = 0.423, SE = 0.089, p < 0.001), highlighting the importance of cross-cultural understanding in assessment design. Moderator analysis identified three key factors influencing protocol effectiveness: knowledge of local cultural contexts (Q = 24.31, df = 3, p < 0.001), use of culturally appropriate language (Q = 18.76, df = 2, p < 0.001), and involvement of community leaders (Q = 15.92, df = 2, p < 0.001). The study’s heterogeneity was moderate (I² = 68.5%, τ² = 0.142), reflecting variations in implementation. These findings build on prior work by Alarcón et al. (2009) and Jackson et al. (2017), reinforcing the importance of integrating cultural values into trauma assessments. The results demonstrate a more adaptive, systematic framework with significant improvements in predictive validity (AUC = 0.89 compared to 0.76 in non-cultural protocols). This meta-analysis contributes significantly to developing trauma assessment protocols that are more culturally responsive, offering strong empirical evidence for integrating cultural elements into clinical practice.

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