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Jurnal Riset Ilmu Kesehatan Umum dan Farmasi
Published by Sekolah Tinggi Ilmu Kesehatan Kesetiakawanan Sosial Indonesia
ISSN : 30265819     EISSN : 30265800     DOI : 10.57213
Core Subject : Health,
Health Professions Public Health
Jurnal ini adalah Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) yang bersifat peer-review dan terbuka. Bidang kajian dalam jurnal ini termasuk riset Ilmu Kesehatan Umum, dan Farmasi.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 184 Documents
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Analisis Kompaaratif Stabilitas Kimia dan Fisika Paracetamol pada Sediaan Padat dan Cair Anisa Anisa; Annisa Normiani Putri; Nor Latifah
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.773

Abstract

Paracetamol is one of the most widely used analgesic-antipyretic drugs and is available in various formulations, including solid tablets and liquid syrups, which differ significantly in long-term stability. This review analyzes data from ten journal studies (2013–2024) comparing the stability of paracetamol in different dosage forms. A literature review method was employed to assess physical and chemical stability under various storage conditions. Solid dosage forms, such as tablets, generally exhibit excellent long-term stability. When stored in sealed packaging at 30 °C/75% RH, tablets maintained potency and low impurity levels for up to five years. In contrast, liquid formulations, especially oral suspensions, degrade more rapidly once opened. For example, an opened Panadol® suspension retained acceptable quality for about five months under optimal conditions (refrigerated, protected from light) and degraded faster (around 3.5 months) under high temperatures. The main degradation product, p-aminophenol (PAP), remained below 0.005% in tablets but exceeded the 0.1% limit in most opened suspensions.Formulation factors, including pH and cosolvent use (e.g., glycerin, PEG 400), significantly affected liquid stability. Syrups with PEG 400 + glycerin maintained stable pH levels (5.6–6.8). In conclusion, solid forms are more stable than liquids, and careful formulation and adherence to storage guidelines are essential to ensure product quality.
Respon Antibiotik Salmonella typhi pada Anak dengan Demam Tifoid Febilla Naili Alfalah; Intanri Kurniati; Dian Isti Angraini; Oktadoni Saputra
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.774

Abstract

Typhoid fever is a significant health issue worldwide, especially in developing countries. The highest incidence of typhoid fever occurs in the pediatric population, particularly among school-age children. Patients often resort to self-medication with antibiotics, where chloramphenicol is the primary choice for treating typhoid fever in Indonesia. However, reports of resistance to the chloramphenicol group have been documented in some locations. A total of 8 articles are included in this literature, revealing the existence of resistant isolates in the antibiotic susceptibility test for Salmonella thypi during the primary therapy. Several cases demonstrate resistance to various antibiotics such as ceftriaxone, cefuroxime, amoxicillin, ampicillin, ciprofloxacin, augmentin, fluoroquinolones, azithromycin, and nalidixic acid. However, some drugs have proven effective, including Cefixime, ceftriaxone, chloramphenicol, ofloxacin, cefepime, quinolones, and third-generation cephalosporins, which are considered sensitive to S. Typhi.
Literature Review : Faktor - Faktor yang Berpengaruh Terhadap Kejadian Demam Tifoid di Indonesia Renitta Anggraeni; Tri Umiana Soleha; Rani Himayani
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.781

Abstract

Typhoid fever is an endemic disease in Indonesia caused by Salmonella typhi bacteria and transmitted through the fecal-oral route. It remains a major public health issue with a relatively high prevalence rate. This study aims to identify the various factors influencing the incidence of typhoid fever in Indonesia through a literature review of scientific articles published between 2015 and 2025. A total of 10 articles were selected based on predefined inclusion criteria. The analysis revealed that the most prominent contributing factors include poor environmental sanitation, inadequate personal hygiene, a history of typhoid fever, and the habit of consuming food from street vendors. Understanding these factors is expected to enhance the effectiveness of disease prevention and control strategies.
Penerapan Terapi Murottal terhadap Tingkat Kecemasan Pasien Pre-operasi Sectio Caesarea (SC) di Ruang Gladiol RSUD Dr. Tjitrowardojo Purworejo Rima Febtriani Khasanah; Despita Pramesti
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.784

Abstract

Background: Sectio Caesarea is a surgical procedure to create an artificial birth canal by making an incision in the uterine wall, allowing the baby to be delivered safely and healthily. C-section has psychological impacts such as fear, anxiety, and stress. Physiological effects include increased blood pressure, shortness of breath, palpitations, elevated heart rate, and difficulty sleeping. Spiritually, it requires support from the husband/family, prayer, dhikr, and listening to murottal. Anxiety is an emotional response related to feelings of worry, restlessness, and fear when facing dangerous or threatening procedures. The therapy used to provide relaxation, calmness, peace, and to uplift the spirit in facing upcoming situations is murottal therapy using Surah Ar-Rahman verse 78, which means “The Most Merciful” and is believed to soothe the soul and body. Objective: To overcome anxiety levels in second-time pregnant patients undergoing pre-operative C-section with murottal therapy using Surah Ar-Rahman. Method: This research used a case study of 2 second-time pregnant patients undergoing C-section, conducted on May 16 & 17, 2025, for 1 session of 30 minutes with murottal therapy from Surah Ar-Rahman verse 78 and the APAIS questionnaire for pre- and post-test. Results: Pre-test scores showed that Mrs. Y scored 22 and Mrs. R scored 17, with a mean pre-test score of 19.5, and a median post-test result of 8. Post-test scores showed Mrs. Y scored 9 and Mrs. R scored 7, indicating a decrease in anxiety level from severe to mild according to the APAIS score. Conclusion: The application of murottal therapy for pre-operative Sectio Caesarea patients can reduce anxiety in patients undergoing surgery.
A Systematic Review: Evaluasi Terhadap Kejadian Perdarahan Pada Pasien ACS dengan Terapi Antiplatelet Tunggal Dibandingkan Terapi Antiplatelet Ganda Pasca Percutaneous Coronary Intervention (PCI) Allysia Maria Vianney Putri; Rini Noviyani
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.785

Abstract

Acute Coronary Syndrome (ACS) is a cardiovascular disorder with a high global mortality rate, including in Indonesia. Antiplatelet therapy administered either as monotherapy or as Dual Antiplatelet Therapy (DAPT) plays a crucial role in managing ACS patients after Percutaneous Coronary Intervention (PCI). However, such therapies carry a bleeding risk that requires careful evaluation. Previous studies on the pharmacological use of antiplatelet agents in post-PCI ACS patients have shown varying results. Therefore, this systematic review aims to compare the incidence of bleeding between single and dual antiplatelet therapies in ACS patients following PCI. Literature was retrieved from PubMed and Google Scholar using relevant keywords, resulting in 11 articles that met the inclusion criteria for further analysis. The reviewed studies include meta-analyses, randomized controlled trials (RCT), and cohort studies. Findings indicate that P2Y12 inhibitor monotherapy following short-term DAPT significantly reduces bleeding risk without increasing ischemic events, particularly in high-risk patients. This treatment strategy demonstrates better safety and comparable efficacy when compared to prolonged DAPT. This review is expected to serve as a reference for selecting safer and more appropriate antiplatelet therapy for ACS patients post-PCI, and as a foundation for future clinical policy development.
Penerapan Aromaterapi Lavender terhadap Kualitas Tidur Ibu Postparum Sectio Caesarea di Ruang Gladiol  RSUD Dr. Tjitrowardojo Purworejo Septie Ambarwati; Despita Pramesti
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.786

Abstract

Background: The impact of pain experienced by post-cesarean section (SC) patients can lead to several specific psychological changes, such as alterations in eating patterns, daily activities, energy levels, and sleep patterns. Individuals who are unwell generally require more sleep than usual; however, in post-surgical patients, sleep disturbances are a common issue. Sleep disorders in post-cesarean patients can be caused by various factors, including pain from the surgical wound, changes in sleep patterns due to caring for a newborn, and stress or anxiety related to childbirth. Objective: To describe the effect of lavender aromatherapy on the sleep quality of post-SC mothers at Tjitrowardojo Regional Hospital, Purworejo. Research Method: This study employed a pre-experimental approach with a one-group pretest-posttest design, aiming to determine changes in sleep quality among post-cesarean section (SC) mothers after the administration of lavender aromatherapy. Sleep quality was measured using the Sleep Quality Scale (SQS), which was administered on the first and third days of the study. Research Results: The administration of lavender aromatherapy successfully improved sleep quality in post-SC patients. Conclusion: Non-pharmacological therapy using lavender aromatherapy can have a positive effect on improving sleep quality in post-SC patients. This is evidenced by the research results showing a decrease in the Sleep Quality Scale (SQS) scores, leading to the conclusion that lavender aromatherapy is effective in enhancing sleep quality in post-operative patients.
Perbedaan Antara Tingkat Kepuasan Pasien Layanan Kefarmasian di Puskesmas Induk Natar dan Puskesmas Rajabasa Indah Lani Hartanti; Rasmi Zakiah Oktarlina; Zulpakor Oktoba; Asep Sukohar
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.787

Abstract

Background: Pharmaceutical services at primary health centers (puskesmas) play a vital role in supporting the quality of primary healthcare services. However, patient satisfaction with these services varies, influenced by factors such as service quality and demographic characteristics of the patients. In Lampung Province, the Induk Natar and Rajabasa Indah primary health care centers have different regional characteristics, which may influence patients perceptions and satisfaction with pharmaceutical services. Methods: This study employed an analytical observational method with a cross-sectional design. Samples were selected using systematic accidental sampling, with 100 respondents from each primary health care centers. Quantitative data were collected using the Servqual questionnaire and patient sociodemographic characteristics. Data were analyzed using the Mann-Whitney test and the Chi-Square test. Result: The reliability dimension showed the highest satisfaction level in both Induk Natar primary health care centers (90.10%) and Rajabasa Indah primary health care centers (94.05%). Conversely, the tangible dimension had the lowest satisfaction levels, with 88.60% in Induk Natar primary health care centers and 92.08% in Rajabasa Indah primary health care centers. A significant difference in patient satisfaction levels was found between the two health centers. However, no significant correlation was found between patient characteristics (age, gender, education, and occupation) and satisfaction levels (p-value > 0.05). Conclusion: Rajabasa Indah primary health care centers demonstrated a higher level of patient satisfaction compared to Induk Natar primary health care centers. A significant difference in satisfaction levels between the two centers was confirmed by the Mann-Whitney test.
Aktivitas Antidiabetes Ektrak Etanol Pelepeh Nipah (Nypa fruticans. Wurmb) Terhadap Tikus Model Diabetes Danang Raharjo; M. Adam Firdausi; Bangkit Riska P
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.789

Abstract

Diabetes Mellitus remains a global health challenge. In Indonesia, diabetes ranks as the third leading cause of death, after heart disease and cancer. Flavonoids, as natural antioxidants, have proven effective in mitigating the pathogenesis and complications of diabetes. Nypa fruticans is a plant with potential as an antidiabetic agent due to its high flavonoid content.This study aimed to measure the total flavonoid content and explore the potential of ethanol extract of nipa fronds as an antidiabetic, specifically in reducing blood glucose levels. Flavonoid content was determined using the AlCl₃ complex method. Antidiabetic testing was conducted in-vivo using STZ-induced diabetic rat model. Ethanol extracts of nipa fronds at doses of 125, 250, and 500 mg/kg were administered to STZ (65 mg/kg)-induced diabetic rats for 21 days, with glibenclamide (0.45 mg/kg) serving as a positive control.The study results show that the ethanol extract of nipa fronds has a total flavonoid content of 48.247 ± 0.260 mgQE/g. In the antidiabetic testing, the ethanol extract of nipa fronds at a dose of 500 mg/kg BW significantly reduced the blood glucose levels of diabetic rats compared to the negative control (p<0.05) and was comparable to the positive control. Therefore, it can be concluded that the ethanol extract of nipa fronds can be utilized for managing Type 2 Diabetes Mellitus.
Peran Pterostilbene Stilbene Sebagai Agen Anti Kanker Laily Septia Andini
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.791

Abstract

Cancer is a group of diseases characterized by uncontrolled cell growth, invasion of surrounding tissue, and potential spread to other parts of the body through a process called metastasis. Cancer can occur in almost any organ or body tissue, such as the lungs, skin, colon, pancreas, and others. The cause of cancer is multifactorial, involving genetic factors, the environment, lifestyle and certain infections. Pterostilbene is a phytochemical compound belonging to the stilbenoid group, found mainly in blueberries and grapes. These phytochemicals have demonstrated significant therapeutic potential in the context of cancer prevention and treatment. Various preclinical and clinical studies have identified pterostilbene's broad anti-cancer activities, including induction of apoptosis (programmed cell death), inhibition of cancer cell proliferation, and inhibition of metastasis (the spread of cancer cells to other parts of the body).Pterostilbene's mechanism of action involves the modulation of various molecular pathways. , such as the NF-κB, PI3K/Akt, and p53 pathways, which play important roles in cell cycle regulation, apoptosis, and cellular stress responses. Additionally, pterostilbene also has strong antioxidant properties, which can protect cells from oxidative damage that often contributes to the development of cancer
Kajian Komprehensif Perkembangan Penelitian Nanoteknologi melalui Pendekatan Bibliometrik Ni Putu Tiara Kusumadewi
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.805

Abstract

Nanotechnology is a nanoscale technological innovation (1–1000 nm) that has been widely used in the pharmaceutical and medical fields, especially as a more effective and specific drug delivery system. This technology is able to increase the bioavailability of drugs, reduce side effects, and increase the efficacy of therapy. This study aims to explore the development and thematic focus of studies on nanotechnology published in PubMed during the period 2015–2025, using bibliometric methods and data visualization through the VOSviewer software. Data is collected through the Publish or Perish application with the keywords "nanotechnology", "analysis", and "data", and then visualized in the form of network visualization, overlay visualization, and density visualization to see the relationship between keywords and publication trends. The results of the analysis show that there are 198 relevant articles, with the most significant increase in the number of publications occurring in 2024. The visualization of the topic revealed four main clusters with dominant keywords such as nanotechnology, drug delivery, application, and cancer. In addition, research trends show a shift in focus from basic development towards clinical and therapeutic applications, which marks significant progress in the translation of basic science into health practice. The author's analysis shows that there are research groups that have significant contributions and close collaborations, especially from institutions and countries with high research capacity such as the United States, China, and India. This study provides a comprehensive overview of trends, directions, and patterns of collaboration in nanotechnology studies, and is expected to be a strategic reference for the development of research policies and scientific cooperation in the future, especially in the field of nanotechnology-based biomedicine and pharmaceuticals.

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