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Patricia Wulandari
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Sriwijaya Journal of Internal Medicine
Published by Phlox Institute: Indonesian Medical Research Organization
ISSN : 29883237     EISSN : 29883237     DOI : https://doi.org/10.59345/sjim
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing
Focus Sriwijaya Journal of Internal Medicine (SJIM) focused on the development of medical sciences especially internal medicine for human well-being. Scope Sriwijaya Journal of Internal Medicine (SJIM) publishes articles which encompass all aspects of basic research/clinical studies related to the field of internal medicine and allied science fields, especially all type of original articles, case reports, review articles, narrative review, meta-analysis, systematic review, mini-reviews and book review.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 31 Documents
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Risk Factors of Contrast-Induced Nephropa thy in Patients Undergoing Coronary Intervention Procedures Ferdiyanti Sari; Taufik Sanjya
Sriwijaya Journal of Internal Medicine Vol. 1 No. 1 (2023): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v1i1.204

Abstract

Introduction: C oronary intervention (coronary angiography and percutaneous coronary intervention) is a medical procedure that uses significant amounts of contrast, which can lead to an increased incidence of contrast-induced nephropathy (CIN). This study aimed to determine the risk factors for contrast-induced nephrop athy in patients undergoing coronary intervention procedures at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This study is a cross-sectional analytic observational study. A total of 100 research subjects participated in this study. Univariate analysis of the frequency distribution was performed on the variable test. Bivariate analysis was performed to determine the risk factors associated with CIN in patients undergoing coronary intervention procedures, p<0.05. Results: The results of the study showed that contrast volume ≥ 100 ml was associated with the incidence of CIN, p<0.05. In addition, serum creatinine level > 1.5 mg/dL was associated with the incidence of CIN, p<0.05. Conclusion: Contrast volume ≥ 100 ml and serum creatinine level > 1.5 mg/dl increase the risk of contrast-induced nephropathy in patients undergoing coronary intervention procedures at Dr. M. Djamil General Hospital, Padang, Indonesia.
Overview of Microorganisms Causing Urinary T ract Infections at Cut Meutia General Hospital, North Aceh, Indonesia Santoso, Hidayat; Ali, Zulfikar
Sriwijaya Journal of Internal Medicine Vol. 1 No. 1 (2023): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v1i1.205

Abstract

Introduction: Urinary tract infection (UTI) is a general term that refers to the presence of microorganisms in the urine. Bacteria and fungi are the causative agents of urinary tract infections, which can be found in the urine of someone who is indicated to be suffering from a urinary tract infection. This study aimed to provide an overvie w of microorganisms that cause urinary tract infections in Cut Meutia General Hospital, North Aceh, Indonesia. Methods: This study is a descriptive observati onal study. A total of 100 research subjects participated in this study. Data analysis on the distribution of microorganisms that cause UTIs was carried out in a univariate. Results: The majority of microorganisms that cause urinary tract infections are Escherichia coli. In addition, other microorganisms as the cause of urinary tract infections are Klebsiella pneumoniae, Acinetobacter baumannii, Proteus mirabilis, Klebsiella oxytoca, and Pseudomonas aeruginosa. Conclusion: Escherichia coli is the most common microorganism that causes urinary tract infections at Cut Meutia General Hospital, North Aceh, Indonesia.
Overview of the Cardiac Conduction System: A Narrative Literature Review Hidayat, Rachmat
Sriwijaya Journal of Internal Medicine Vol. 1 No. 1 (2023): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v1i1.206

Abstract

The conduction system of the cardiac initiates and coordinates the electrical signals that cause rhythmic and synchronous contraction of the atria and ventricles. This literature review aims to describe the electrophysiology of the cardiac conducti on system. Electrical impulses usually arise in the sinoatrial (SA) node. The SA node is innervated by sympathetic and parasympathetic nerves. Each act ion potential moves rapidly from cell to cell and through the myocardium of the atria, onto the atrioventricular node (AV node), and causes both atria to contract and begin systole. The AV node, located on the right atrial wall superior to the tricuspid valve and anterior to the coronary sinus ostium, conducts action potentials into the ventricles. From the AV node, the conducting fibers converge t o form the bundle of His (atrioventricular bundle) within the posterior border of the interventricular septum.
Diagnosis and Management of Constipation : A Narrative Literature Review Ridwan, Muhammad
Sriwijaya Journal of Internal Medicine Vol. 1 No. 1 (2023): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v1i1.207

Abstract

Constipation can occur as a primary or secondary condition. This literature review aimed to describe the diagnosis and management of constipation. Primary constipation is generally classified into three categories. Normal transit (functional) constipation involves a normal rate of passage of stool, but there is difficulty wit h the evacuation of the stool. Functional constipation is most common and is associated with a sedentary lifestyle, a low-residue diet (consumption of very refined foods), or low fluid intake, which decreases stool volume and bulk and can lead to constipation. Lack of access to toilet facilities, consistent su ppression of the urge to empty the bowels, and dehydration are other causes. Slow transit constipation involves impaired motor activity of the colon with infrequent bowel movements, straining to have a bowel movement, mild abdomi nal distention, and palpable stool in the sigmoid colon. Pelvic floor dysfunction (pelvic floor dyssynergia-anismus), or outlet dysfunction, is difficulty pas sing stool due to failure of the pelvic floor muscles or anal sphincter to relax with a bowel movement.
Review of Physiological Aspects of Erythropoie sis: A Narrative Literature Review Hedayanti, Noor; Wahyudi, Arif
Sriwijaya Journal of Internal Medicine Vol. 1 No. 1 (2023): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v1i1.208

Abstract

Erythropoiesis is the development of red blood cells. Within the confines of the bone marrow, erythroid progenitor cells proliferate and differentiate into large nucleated proerythroblasts, which are committed to producing cells of the erythroid series. Th is literature review aimed to describe the physiology of erythropoiesis and its application in medical science. All stages of erythroid development are ref erred to as the erythron. Proerythroblasts, which possess ribosomes and can produce proteins, differentiate through several forms between erythroblasts while synthesizing hemoglobin and progressively removing most of th e intracellular structures, including the nucleus. Thus the mature erythroblast becomes more compact and progressively takes on the shape and character istics of the erythrocyte. Hemoglobin is easily seen, and its amount increases as the size of the nucleus decreases during the basophilic and polychromatophilic stages. The orthochromatic erythroblast (normoblast) is the smallest of the nucleated erythrocyte precursors.
Dissociated Glycemic Status in Diabetes Mellitus: A Meta-Analysis of the Interaction between Acute Stress Hyperglycemia and Chronic Glycemic Control on Sepsis Outcomes Novia Wira Tungadi
Sriwijaya Journal of Internal Medicine Vol. 3 No. 2 (2026): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v3i2.243

Abstract

Introduction: Sepsis profoundly complicates diabetes mellitus, yielding disproportionately high mortality. Clinicians traditionally utilize absolute admission blood glucose for risk stratification. However, this metric is fundamentally flawed in pre-existing diabetes because chronic hyperglycemia alters the physiological baseline. The concept of dissociated glycemic status—quantified as the stress hyperglycemia ratio or glycemic gap—captures the discordance between acute stress hyperglycemia and chronic Hemoglobin A1c. This study investigated whether dissociated status serves as a superior predictor of sepsis mortality compared to absolute hyperglycemia, with a specific subgroup focus on the distinct pathophysiology of Type 1 Diabetes. Methods: A systematic review and meta-analysis of eight manuscripts, including registry data, clinical cohorts, and pre-clinical models was conducted. The human incidence cohort encompassed over 300,000 subjects; the mortality analysis included approximately 3,500 patients. The primary exposure was dissociated glycemic status. The primary outcome was sepsis-related mortality. Animal model data and glycemic variability metrics were strictly segregated from the primary quantitative synthesis. Data were synthesized using a random-effects model, assessing heterogeneity via the I-squared statistic, alongside a comprehensive risk of bias assessment. Results: Absolute hyperglycemia failed to independently predict mortality when adjusted for chronic control. A high dissociated glycemic status is strongly associated with mortality (Pooled Odds Ratio 2.14; 95 % Confidence Interval 1.65 to 2.78; I2 42 percent). Separate analysis demonstrated that glycemic variability independently increased mortality risk. Type 1 Diabetes patients exhibited a 3.7-fold increase in sepsis hospitalization compared to controls. Review of pre-clinical models suggested this vulnerability in Type 1 Diabetes is driven by an immunoparalysis phenotype rather than a classic cytokine storm. Conclusion: The interaction between acute and chronic glycemia dictates survival in diabetic sepsis. Dissociated glycemic status represents a critical vital sign indicating a failure of metabolic and immune homeostasis.
The Impact of Peer-Led Community Testing Models on Early HIV Diagnosis Among Key Populations: A Systematic Review and Meta-Analysis Wahyuni Maria Prasetyo Hutomo; Agnesia Hetriany Sorsery; Maria Wati Manseni
Sriwijaya Journal of Internal Medicine Vol. 3 No. 2 (2026): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v3i2.244

Abstract

Introduction: HIV testing remains a critical entry point to the care cascade. Peer-led community testing models have emerged as promising approaches to improve early diagnosis among key populations, yet evidence synthesis regarding their effectiveness remains limited. This study aimed to systematically review and meta-analyse the effectiveness of peer-led community testing interventions on HIV testing uptake among key populations. Methods: Systematic search of PubMed, Embase, Global Health, CINAHL, and Web of Science (2014-2024) for randomized controlled trials and quasi-experimental studies. Screening, quality assessment (Cochrane Risk of Bias tool), and meta-analysis using Hedges' g as the pooled effect measure. GRADE methodology applied to assess certainty of evidence. Sensitivity analysis excluding systematic reviews conducted. Results: Seven studies (52,698 participants; 31,381 intervention, 21,317 control) met inclusion criteria. Pooled standardized mean difference was 0.4834 (95% CI: 0.3671 to 0.5997; p < 0.001), indicating a moderate effect of peer-led testing on uptake. Heterogeneity was moderate (I² = 55.23%, τ² = 0.0111). GRADE analysis indicated moderate certainty of evidence, downgraded for study design heterogeneity but upgraded for large absolute effect and consistency. The 95% prediction interval ranged from −0.05 to 1.02, suggesting that while most future settings would benefit, some may show minimal effects. Sensitivity analysis excluding two systematic reviews (5 primary studies: g = 0.58) remained statistically significant. Subgroup analysis demonstrated differential effectiveness by setting and intervention modality. Conclusion: Peer-led community testing models yield moderate improvements in HIV testing uptake among key populations. Translation to policy implies approximately 9,600 additional individuals tested per 100,000 reached, potentially yielding 288-480 additional diagnoses at 3-5% prevalence. However, sustainability, linkage to care, and integration within health systems remain critical implementation challenges. Further research addressing long-term retention, cost-effectiveness, and contextualization to specific key population and geographic settings is warranted.
Cold Agglutinin Disease Presenting with Acute Encephalopathy in an Elderly Patient with Multiple Comorbidities: A Case Report and Laboratory Diagnostic Perspective Desak Agung Indah Praharsini Dewi; I Gusti Ayu Wiradari Tedja; Made Ayu Vita Prianggandanni
Sriwijaya Journal of Internal Medicine Vol. 3 No. 2 (2026): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v3i2.246

Abstract

Introduction: Cold agglutinin disease (CAD) is a rare form of autoimmune hemolytic anemia caused by monoclonal immunoglobulin M autoantibodies that bind to red blood cells at temperatures below 37 degrees Celsius. CAD typically manifests with chronic hemolytic anemia in elderly patients, but presentations with acute, severe complications remain infrequent. Case presentation: We report a 70-year-old male patient who presented with acute decreased consciousness lasting 2 hours, preceded by one week of cough and fever. Initial clinical evaluation suggested sepsis-associated encephalopathy. However, a comprehensive laboratory investigation, including peripheral blood smear and direct Coombs test, revealed CAD as the underlying diagnosis. Critical laboratory finding was marked mean corpuscular hemoglobin concentration elevation to 43 g/dL, exceeding physiologic maximum and indicating erythrocyte agglutination interference. Positive Coombs test with immunoglobulin G sensitization and positive cold agglutinin titer confirmed the diagnosis. The patient had significant comorbidities, including chronic kidney disease Stage V, type 2 diabetes mellitus, and heart failure with coronary artery disease. The patient subsequently underwent supportive care with cooling precautions, and clinical improvement was noted. Conclusion: This case exemplifies how careful attention to laboratory pattern recognition, particularly supraphysiologic mean corpuscular hemoglobin concentration values, can facilitate the diagnosis of CAD in elderly patients presenting with acute multisystem complications. The role of clinical pathology in the diagnostic identification of rare hematologic disorders deserves emphasis in medical education and clinical practice.
Kimura Lymphadenitis of the Retroauricular Region in a 48-Year-Old Indonesian Male: A Rare Case Report with Long-Standing Disease Duration Kadek Susi Setyawati; Ketut Suardamana; Dekta Filantropi Esa
Sriwijaya Journal of Internal Medicine Vol. 3 No. 2 (2026): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v3i2.250

Abstract

Introduction: Kimura disease is a rare chronic inflammatory disorder of unknown etiology predominantly affecting young Asian males, characterized by painless subcutaneous masses in the head and neck region, peripheral eosinophilia, and elevated serum immunoglobulin E levels. This condition remains underreported in Southeast Asian countries, particularly Indonesia, leading to significant diagnostic delays. Case presentation: We present the case of a 48-year-old Indonesian male from Bali who presented with a retroauricular mass persisting for 10 years prior to definitive diagnosis. The patient had undergone surgical excision one month prior and was subsequently referred for further evaluation. Laboratory investigations demonstrated leukocytosis with a white blood cell count of 13.82 × 103/µL, peripheral eosinophilia of 8.60%, absolute eosinophil count of 1.19 × 103/µL, and elevated total serum immunoglobulin E of 168.16 KUI/L. Renal function was preserved without proteinuria despite prolonged disease duration. Histopathological examination confirmed Kimura lymphadenitis with reactive follicular hyperplasia, dense eosinophilic microabscesses, vascular hyalinization, and multinucleated Warthin-Finkeldey giant cells. The patient was managed with surgical excision followed by oral methylprednisolone 8 mg daily with planned tapering. Conclusion: This case highlights diagnostic challenges of Kimura disease in Indonesian clinical settings and the importance of histopathological confirmation.
Serum Ferritin as a Prognostic Biomarker for Severe Dengue Infection: A Systematic Review and Meta-Analysis Putu Ari Paramitha Widiani; Si Ngurah Oka Putrawan; I Nyoman Windiana
Sriwijaya Journal of Internal Medicine Vol. 3 No. 2 (2026): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v3i2.259

Abstract

Introduction: Severe dengue drives mortality and poses critical triage challenges in adult internal medicine. Because standard WHO warning signs often manifest late in the disease course, early and inexpensive laboratory markers for risk stratification are urgently needed. Methods: Following PRISMA 2020 guidelines, we conducted a systematic review and random-effects meta-analysis of adult observational studies comparing serum ferritin between severe and non-severe dengue. Standardised mean differences were pooled as Hedges' g utilizing the DerSimonian-Laird estimator with Hartung-Knapp-Sidik-Jonkman correction. Heterogeneity was quantified using Cochran's Q, I², τ², and 95% prediction intervals. Results: Twelve studies (n=1,479) were qualitatively synthesized; five adult cohorts (n=495) provided continuous data for quantitative meta-analysis. Serum ferritin was significantly elevated in severe dengue, yielding a large pooled effect size (Hedges' g = 1.022; 95% CI 0.494–1.551; p=0.006). Despite substantial between-study heterogeneity (I²=78.1%; 95% PI -0.12 to 2.17), the effect direction remained consistently positive across geographic subgroups (Asia, Latin America) and demonstrated robust stability in leave-one-out sensitivity analyses. Conclusion: Adults with severe dengue demonstrate substantially higher serum ferritin levels than those with non-severe disease. Characterized by a robust effect size across diverse regions, serum ferritin serves as a promising, widely accessible adjunct to existing WHO warning signs, optimizing early risk stratification and clinical triage in resource-constrained tropical settings.

Page 3 of 4 | Total Record : 31

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