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Patricia Wulandari
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Sriwijaya Journal of Internal Medicine
Published by Phlox Institute: Indonesian Medical Research Organization
ISSN : 29883237     EISSN : 29883237     DOI : https://doi.org/10.59345/sjim
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing
Focus Sriwijaya Journal of Internal Medicine (SJIM) focused on the development of medical sciences especially internal medicine for human well-being. Scope Sriwijaya Journal of Internal Medicine (SJIM) publishes articles which encompass all aspects of basic research/clinical studies related to the field of internal medicine and allied science fields, especially all type of original articles, case reports, review articles, narrative review, meta-analysis, systematic review, mini-reviews and book review.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 25 Documents
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Assessing the Efficacy of Cardiac Catheterization in Enhancing Blood Circulation in Patients with Coronary Heart Disease: A Systematic Literature Review Sari, Khomariyana Purnama
Sriwijaya Journal of Internal Medicine Vol. 2 No. 2 (2024): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i1.102

Abstract

Introduction: Cardiac catheterization is a highly efficient treatment for enhancing blood circulation to the heart in individuals with coronary heart disease (CHD). This operation has the potential to alleviate angina, enhance quality of life, and mitigate the likelihood of myocardial infarction. The objective of this study is to investigate the efficacy of cardiac catheterization in enhancing blood circulation among individuals suffering from CHD. Methods: We conducted a literature search on multiple databases, including PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar, to investigate the efficacy of cardiac catheterization in enhancing blood circulation among individuals diagnosed with CHD. This study adheres to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) Guidelines. Results: We identified twenty papers that satisfied the inclusion criteria in this investigation. The research articles were published between 2013 and 2023. The study analysis demonstrates that cardiac catheterization is efficacious in enhancing blood circulation in individuals with CHD. Cardiac catheterization can augment myocardial perfusion by up to 20%. Conclusion: Cardiac catheterization is more successful in individuals who have mild or moderate stenosis of the coronary arteries. The study analysis indicates that cardiac catheterization is efficacious in enhancing blood circulation in individuals with CHD.
Quality of Life of Coronary Artery Disease Patients Based on the Degree of Physical Ability Zuriati, Zuriati; Farida Moh. Said
Sriwijaya Journal of Internal Medicine Vol. 2 No. 2 (2024): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i1.107

Abstract

Introduction: Coronary artery disease (CAD) is a chronic disease that can reduce the patient's quality of life (QoL). Decreased physical ability is one of the factors that can influence the QoL of CAD patients. Methods: This study used a cross-sectional descriptive design with a sample of 125 CAD patients aged 35-64 years at Dr. M. Djamil General Hospital Padang. QoL data was collected using the WHOQOL-BREF questionnaire, and the degree of physical ability was measured using the Duke Activity Status Index (DASI) questionnaire. Data analysis used the chi-square test. Results: The results showed that 43.8% of patients had good QoL, and 56.2% had very severe physical abilities. There is a significant relationship between the degree of physical ability and QoL in CAD patients (p-value 0.000). Conclusion: The degree of physical ability is a predictor of QoL in CAD patients. Interventions to improve physical abilities can help improve QoL in CAD patients.
Analysis of Risk Prediction Models to Identify Patients at High Risk of Urinary Incontinence Amal, Rizki Jaya; Suherdy; Delfi Sanutra; Munawmarah; Jevo Rifan Sandikta
Sriwijaya Journal of Internal Medicine Vol. 2 No. 2 (2024): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i1.110

Abstract

Introduction: Urinary incontinence (UI) is a common health problem and is often undiagnosed in hospital patients. UI can cause complications such as urinary tract infections, dermatitis, and decreased quality of life. This study aims to apply a risk prediction model to identify patients at high risk of experiencing UI at Tengku Peukan General Hospital, Southwest Aceh, Indonesia. Methods: This study used a prospective cohort design. Data was collected from 100 patients hospitalized at Tengku Peukan General Hospital, Southwest Aceh. A risk prediction model was developed using logistic regression. Model performance is measured by AUC-ROC values and accuracy. Results: The risk prediction model developed had an AUC-ROC value of 0.85 (95% CI: 0.78-0.92) and an accuracy of 82%. The most significant risk factors for UI are age, gender, history of UI, and use of diuretic medications. Conclusion: This risk prediction model can help nurses and doctors identify patients who are at high risk of experiencing UI at Tengku Peukan General Hospital, Southwest Aceh. Early intervention in high-risk patients can help prevent UI complications and improve the patient's quality of life.
Impact of Smartphone Application Education on Stress in Type 2 Diabetes Mellitus Patients Bagus Santosa, Winanda Rizki; Nisha Nambiar; Erlina Abdullah
Sriwijaya Journal of Internal Medicine Vol. 2 No. 2 (2024): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i1.136

Abstract

Introduction: Lack of knowledge about managing health and the duration of the disease causes stress in Diabetes Mellitus (DM) patients. Uncertainty about their future health and the ongoing burden of disease can worsen the mental health of type 2 diabetes mellitus (T2DM) patients. Smartphone application education can be a solution for T2DM patients in reducing stress regarding their health condition. This study aims to determine the impact of smartphone application education on stress in type 2 diabetes mellitus patients. Methods: The design in this research is a pre-test and post-test control group design. The research was conducted in the period October 2023 – January 2024. Respondents in this study were T2DM patients. The locations of this research were nine Public Health Centers in Kediri City, Indonesia. The sample in this study was 131 respondents. Results: The results of the research showed that the stress score for T2DM sufferers in the pre-test was 41.34, after three months of smartphone application education, post-test the mean stress decreased was 4.31, and the p-value 0.000. There is a mean difference October – November was 13.50, November – December was 10.77, December – January was 12.76 and the P-Value was 0.008. Conclusion: There was a decrease in stress during the periods of October, November, December, and January after being given smartphone application education. Smartphone applications are effective in reducing stress in T2DM patients.
Antibacterial Potential of Dewandaru Leaves (Eugenia uniflora L.) Against Escherichia coli: In Vitro Study Setiyanto, Riyan; Annisa Diyan Meitasari; Sinta Cantika Natasya; Dewi Weni Sari
Sriwijaya Journal of Internal Medicine Vol. 2 No. 2 (2024): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i1.138

Abstract

Introduction: Escherichia coli is a pathogenic Gram-negative bacteria that commonly causes digestive tract infections, including diarrhea. Continuous use of antibiotics has led to an increase in bacterial resistance. Dewandaru leaves (Eugenia uniflora L.) have been known to have antibacterial activity against several pathogenic bacteria. This study aims to evaluate the antibacterial activity of dewandaru leaf extract against E. coli in vitro. Methods: Dewandaru leaves were extracted using the maceration method with 96% ethanol. The antibacterial activity test was carried out using the Kirby-Bauer disk diffusion method with gentamicin as a positive control and sterile NaCl as a negative control. The diameter of the inhibition zone was measured and analyzed statistically. Results: Dewandaru leaf extract shows antibacterial activity against E. coli with a significant zone of inhibition. An extract concentration of 80% showed moderate antibacterial activity, while concentrations of 40% and 60% did not show antibacterial activity. Conclusion: Dewandaru leaves have the potential to be a natural antibacterial agent against E. coli. Further studies are needed to isolate and identify the active compounds and evaluate the effectiveness and safety of dewandaru leaf extract in vivo.
The Dynamics of NS1 Antigen and Platelet Levels in the Acute Phase of Dengue Hemorrhagic Fever Ismawatie, Emma; Ilyas Syafiq Darul Ridzuan; Yulia Ratna Dewi; Sunarti
Sriwijaya Journal of Internal Medicine Vol. 3 No. 1 (2025): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i2.149

Abstract

Introduction: Dengue hemorrhagic fever (DHF) is a significant global health concern, particularly in tropical and subtropical regions. The early diagnosis and effective management of DHF are crucial to reduce morbidity and mortality. The NS1 antigen and platelet count are two key laboratory parameters used in the diagnosis and monitoring of DHF. This study aimed to investigate the dynamics of NS1 antigen and platelet levels during the acute phase of DHF and their correlation with disease severity. Methods: A prospective cohort study was conducted at a tertiary care hospital in Central Java, Indonesia. Patients presenting with suspected DHF were enrolled and followed up during their hospitalization. Blood samples were collected at admission and at regular intervals to measure NS1 antigen levels and platelet counts. Clinical and laboratory data were collected to assess disease severity. Results: A total of 150 patients were included in the study. The majority of patients were adults (median age, 32 years) with a female predominance (58%). The median duration of fever at presentation was 4 days. NS1 antigen levels were significantly higher in patients with DHF compared to those with dengue fever (DF) (p < 0.001). Platelet counts were significantly lower in patients with DHF compared to those with DF (p < 0.001). NS1 antigen levels showed a negative correlation with platelet counts (r = -0.62, p < 0.001). The levels of NS1 antigen and platelet count were also significantly associated with disease severity. Conclusion: The dynamics of NS1 antigen and platelet levels during the acute phase of DHF provide valuable insights into disease pathogenesis and can aid in the early diagnosis and prediction of disease severity. The negative correlation between NS1 antigen and platelet levels suggests a potential role of NS1 in the development of thrombocytopenia in DHF. Further studies are needed to elucidate the exact mechanisms underlying these observations.
The Impact of Uncontrolled Type 2 Diabetes Mellitus on Chronic Rhinosinusitis Severity and Treatment Outcomes: A Prospective Cohort Study in Bandung, Indonesia Zainal Abidin Hasan; Aisyah Andina Rasyid; Hasrita Soleiman; Alexander Mulya; Pham Uyen; Maria Rodriguez
Sriwijaya Journal of Internal Medicine Vol. 3 No. 1 (2025): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i2.176

Abstract

Introduction: Chronic rhinosinusitis (CRS) is a prevalent inflammatory condition, and type 2 diabetes mellitus (T2DM) is a known comorbidity that can exacerbate inflammatory processes. This study aimed to investigate the impact of uncontrolled T2DM on CRS severity and treatment outcomes in a cohort of patients in Bandung, Indonesia. Methods: A prospective cohort study was conducted at a private hospital in Bandung, Indonesia, from January 2020 to December 2022. Adult patients diagnosed with CRS (with or without nasal polyps) were enrolled and categorized into two groups: controlled T2DM (HbA1c ≤ 7%) and uncontrolled T2DM (HbA1c > 7%). CRS severity was assessed using the Sino-Nasal Outcome Test-22 (SNOT-22) and Lund-Mackay CT scoring. Treatment outcomes were evaluated at 3, 6, and 12 months post-initial treatment (medical and/or surgical) based on SNOT-22 scores, endoscopic findings, and the need for revision surgery. Results: A total of 240 patients were included (120 with controlled T2DM, 120 with uncontrolled T2DM). At baseline, the uncontrolled T2DM group had significantly higher mean SNOT-22 scores (58.5 ± 12.3 vs. 45.2 ± 10.1, p < 0.001) and Lund-Mackay CT scores (11.8 ± 3.5 vs. 8.2 ± 2.8, p < 0.001) compared to the controlled T2DM group. At 12 months, the uncontrolled T2DM group showed significantly less improvement in SNOT-22 scores (mean change: -15.4 ± 8.7 vs. -28.3 ± 9.2, p < 0.001) and a higher rate of revision surgery (18.3% vs. 5.8%, p = 0.002). Multivariate analysis revealed that uncontrolled T2DM (HbA1c > 7%) was an independent predictor of poorer treatment outcomes (OR: 3.45, 95% CI: 1.98-6.01, p < 0.001). Conclusion: Uncontrolled T2DM is associated with increased CRS severity and significantly poorer treatment outcomes in patients in Bandung, Indonesia. Effective glycemic control should be a crucial component of CRS management in patients with T2DM.
Cardiovascular Risk Stratification in Pregnant Women with Gestational Diabetes: A Comparative Analysis of Predictive Models in Padang, Indonesia Cinthya Callathea; Vania Delma; Muhammad Rusli; Bjorka Alma; Rinna Azrida
Sriwijaya Journal of Internal Medicine Vol. 3 No. 1 (2025): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i2.177

Abstract

Introduction: Gestational diabetes mellitus (GDM) significantly increases the risk of both short-term and long-term cardiovascular disease (CVD) in women. Effective risk stratification during pregnancy is crucial for targeted interventions. This study aimed to compare the performance of established cardiovascular risk prediction models in a cohort of pregnant women with GDM in Padang, Indonesia. Methods: A prospective cohort study was conducted involving 350 pregnant women diagnosed with GDM at two major hospitals in Padang, Indonesia, between January 2022 and June 2023. Baseline demographic, clinical, and laboratory data were collected. Three established CVD risk prediction models – the Framingham Risk Score (FRS), the American College of Cardiology/American Heart Association (ACC/AHA) Pooled Cohort Equations (PCE), and a modified version of the PCE adapted for GDM (PCE-GDM) – were applied to calculate individual 10-year CVD risk scores. The primary outcome was the development of any major adverse cardiovascular event (MACE), defined as myocardial infarction, stroke, or cardiovascular death, or new-onset hypertension requiring medication, within one year postpartum. Model performance was assessed using discrimination (c-statistic) and calibration (Hosmer-Lemeshow goodness-of-fit test). Results: The mean age of participants was 32.4 ± 5.1 years. The prevalence of pre-existing hypertension was 8.6%, and the mean pre-pregnancy BMI was 28.5 ± 4.7 kg/m². During the one-year follow-up, 25 (7.1%) women experienced a MACE. The PCE-GDM model demonstrated the best discrimination (c-statistic = 0.82, 95% CI 0.76-0.88), followed by the PCE (c-statistic = 0.75, 95% CI 0.68-0.82), and the FRS (c-statistic = 0.68, 95% CI 0.60-0.76). The PCE-GDM also showed good calibration (χ² = 8.3, p = 0.41), while the FRS and PCE tended to underestimate risk (χ² = 18.5, p = 0.02 and χ² = 15.2, p = 0.06, respectively). Conclusion: The PCE-GDM model, specifically adapted for GDM, showed superior performance in predicting short-term cardiovascular risk compared to traditional models in this Indonesian cohort. These findings highlight the need for GDM-specific risk stratification tools to improve cardiovascular risk management in this vulnerable population.
Glycated Hemoglobin (HbA1c) as a Predictor of Periodontal Disease Progression in Patients with Type 2 Diabetes: A Longitudinal Study in Surabaya, Indonesia Alexander Mulya; Muhammad Ashraf; Muhammad Yoshandi; Ayesh Mahmood; Daphne Marshall
Sriwijaya Journal of Internal Medicine Vol. 3 No. 1 (2025): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i2.178

Abstract

Introduction: Periodontal disease is a prevalent complication of type 2 diabetes mellitus (T2DM), and poor glycemic control is a known risk factor. This longitudinal study aimed to investigate the predictive value of glycated hemoglobin (HbA1c) for periodontal disease progression in a cohort of T2DM patients in Surabaya, Indonesia. Methods: A prospective cohort study was conducted at private hospital, Surabaya, Indonesia, from January 2021 to January 2023. 180 patients with T2DM and pre-existing chronic periodontitis were enrolled. Periodontal parameters, including probing pocket depth (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), and plaque index (PI), were assessed at baseline, 12 months, and 24 months. HbA1c was measured at each visit. Multivariate linear regression and mixed-effects models were used to analyze the association between HbA1c and changes in periodontal parameters over time, adjusting for potential confounders. Results: The mean age of participants was 58.5 ± 8.2 years, and 55% were female. Baseline mean HbA1c was 8.2 ± 1.5%. After adjusting for age, gender, smoking status, diabetes duration, and baseline periodontal parameters, higher baseline HbA1c was significantly associated with greater increases in PPD (β = 0.15 mm per 1% HbA1c increase, 95% CI: 0.08-0.22, p < 0.001) and CAL (β = 0.18 mm per 1% HbA1c increase, 95% CI: 0.10-0.26, p < 0.001) over 24 months. Furthermore, sustained elevation of HbA1c (average HbA1c over 24 months) was a stronger predictor of periodontal disease progression than baseline HbA1c alone. A significant interaction between HbA1c and time was observed (p < 0.001), indicating that the effect of HbA1c on periodontal parameters increased over time. Conclusion: HbA1c is a significant independent predictor of periodontal disease progression in patients with T2DM. Sustained glycemic control is crucial for preventing and managing periodontal complications in this population. These findings highlight the importance of interdisciplinary collaboration between internists and dentists in the comprehensive care of T2DM patients.
Activated Growth Factor (AGF): An Advanced Modality of Platelet-Rich Plasma as a New Biological Agent for the Treatment of Degenerative and Traumatic Conditions Hidayat, Rachmat; Kemas Abdul Mutholib Luthfi; Maria Margareth Wilson; Shina Abdulkadir
Sriwijaya Journal of Internal Medicine Vol. 3 No. 1 (2025): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i2.168

Abstract

Platelet-rich plasma (PRP) has emerged as a promising therapeutic modality for various medical applications, particularly in regenerative medicine and wound healing. This is largely attributed to its rich concentration of growth factors (GFs) that play pivotal roles in tissue repair and regeneration. However, the inherent limitations of PRP, such as the variable GF concentrations and short-lived release kinetics, have spurred the development of advanced modalities to enhance its therapeutic efficacy. Activated growth factor (AGF) represents one such advancement, aiming to optimize the release and bioavailability of GFs from platelets. This comprehensive review delves into the biological mechanisms underlying AGF, its preparation methodologies, preclinical and clinical evidence supporting its use, and its potential applications in treating degenerative and traumatic conditions. Furthermore, it explores the advantages of AGF over conventional PRP and discusses future directions for research and clinical translation.

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