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Grimsa Journal of Science Engineering and Technology
Published by PT. Graha Primera Saintifika
ISSN : -     EISSN : 30265118     DOI : https://doi.org/10.61975/gjset
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Engineering Medicine & Pharmacology Physics
Grimsa Journal of Science Engineering and Technology aims to provide a platform for researchers, scholars, and professionals to share their innovative ideas, findings, and insights in the following areas: Science and Innovation, Engineering and Technology, Information Technology and Computer Science, Environmental Science and Sustainability, Biotechnology and Bioengineering, Materials Science and Engineering, Healthcare and Medical Technology, Interdisciplinary Studies
Arjuna Subject : Umum - Umum
Articles 10 Documents
 1 
Search results for , issue "Vol. 1 No. 2 (2023): December 2023" : 10 Documents clear
Hippobroma longiflora L Leaves as a Natural Inhibitor of Cataract Progression: A Comprehensive Study Integrating Ethanol Extract, HPLC, and Molecular Docking Approaches Eva Imelda; Ulfa Fitria; Ulmiza Putri Mutia; Syahrul Syahrul; Masitha Dewi Sari; Sarra Mutiara Adev; Alya Mutiara Adev; Zakiaturrahmi Zakiaturrahmi; Navneet Shamsundar Toshniwal
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.10

Abstract

Cataract remains the highest preventable cause of blindness in the world. The H. longiflora plant (Hippobroma longiflora L) is a plant that has empirically been widely used to treat a variety of eye diseases including cataract. This plant has high antioxidant activity due to its high phenolic and flavonoid content. The H. longiflora plant was extracted using an ethanol solvent and its compound content was analyzed using GCMS and phytochemistry analysis. The extracts obtained were tested with TPC, TFC, antioxidants and quercetine compound with HPLC. From phytochemical and GCMS analysis, it was found that triterpenoid compounds were not found in the sample, and the compound 1-Isobutyl-2,5-dimethyl-4-phenyl-piperidin-4-ol was the most abundant (37.77%), as well as 4-Penten-1-ol, 5-phenyl-3-pperidino (1,30%) were the least abundant in the ethanol extract of the H. longiflora leaves extract. The total phenolic, flavonoid and HPLC results of quercetin were 139.21 mg GAE/g; 11.48 mg QE/G and 0.009 mg/G. Meanwhile, in an antioxidant activity test, it was found that the ethanol extract of the H. longiflora leaves has very strong antioxidants. This finding revealed the potential of ethanol extracts of H. longiflora leaves as a cataract inhibitor through its process as an antioxidant.
Theoretical Evaluation of Michelia Species’ Bioactive Compounds and Theraupetic Potential: A Literature Review Nurul Oktaviana; Nadia Isnaini; Essy Harnelly; Zulkarnain Zulkarnain; Syaifullah Muhammad; Misrahanum Misrahanum
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.12

Abstract

Michelia alba is a multifunctional plant found in Indonesia and is also called magnolia. Michelia alba is a tree known for its essential oil, which has long been used as a fragrance ingredient in perfumes and cosmetics. The potential of M. alba is immense for use in the prevention and treatment of disease as well as the management of human health and wellness. To date, there have been few publications regarding the biological activities of M. alba, focusing on tyrosinase inhibitory, antibacterial, antidiabetic, anti-inflammatory and antioxidant activities. However, M. alba may have additional undiscovered biological activities associated with its bioactive compounds. The purpose of this literature review research is to find out the bioactive compounds and therapeutic potential of the M. alba plant through literature searches that can be a reference for further research. The literature review method is carried out by searching and collecting data from literature sources obtained from several national and international journals that review bioactive compounds and the therapeutic potential of M. alba plants. Based on the literature review, it was found that M. alba has bioactive compounds namely linalool (72.8 flower oil and 80.1% leaf oil), α-terpineol (6.04% flower oil), phenylethyl alcohol (2.58% flower oil), β-pinene (2.39% flower oil) and geraniol (1, 23%) which have therapeutic activities such as mental health disorders, anticancer, anti-inflammatory, antihypertensive, antidiabetic, antihyperlipidemia, antimaagic, antidiarrheal, anti-asthma, and antihyperpigmentation. In traditional medicine it is used to treat fever, syphilis, gonorrhea and malaria, bronchitis, prostatitis, cancer, headache, sinusitis, cough, inflammation of the respiratory tract, chest fullness, flatulence, nausea, body and underarm odor, and vaginal discharge.
Benefits of Green Tea Polyphenols for Kidney Health: A Literature Review Nadia Warda Sekar Sari; Trina Ekawati Tallei; Beivy Jonathan Kolondam
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.13

Abstract

The issue of kidney health has emerged as a global public health concern. Kidneys play a vital role in eliminating toxic substances and maintaining fluid and chemical balance in the body. Preserving kidney health is tantamount to safeguarding overall bodily health, as kidney damage can adversely affect other organs and organ systems. This can give rise to various ailments and compromise one’s physical condition. Throughout ancient history, plants have been employed for medicinal purposes in treating a wide array of ailments with one such plant being tea (Camellia sinensis L). Tea is renowned for its antioxidant and anti-inflammatory properties. It contains bioactive compounds, notably polyphenols, which contribute to enhancing health. Polyphenols serve as therapeutic agents for the kidneys and can prevent the onset of other degenerative disease. Prior research has demonstrated that EGCG, a derivative of polyphenols, can safeguard the kidneys against ischemia-reperfusion injury, kidney fibrosis, and inflammation. Catechins, a subcategory of polyphenols, act as antioxidants, anti-inflammatories, and anti-apoptotic agents, thereby shielding kidney cells.
Evaluation of Antibacterial Properties from Endophytic Fungi of Chrysanthemum indicum (L.) Flowers against Escherichia coli and Staphylococcus aureus Titah Amelia Ratte; Fatimawali Fatimawali; Trina Ekawati Tallei; Elly Juliana Suoth; Irma Antasionasti; Paulina Yamlean
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.15

Abstract

Uncovering the therapeutic potential of secondary metabolites produced by plants, animals, and microbes constitutes the foundation for the development of novel medications. The objective of this investigation is to discern the classes of secondary metabolites and assess the antibacterial properties of endophytic fungal extracts obtained from Chrysanthemum indicum L. flowers. Through the isolation process, five isolates designated as JEC1, JEC2, JEC3, JEC4, and JEC5 were identified. The cultivation of endophytic fungal isolates spanned a three-week period before undergoing extraction with ethyl acetate. The phytochemical tests revealed the presence of alkaloids, flavonoids, steroids, terpenoids, saponins, and tannins in the ethyl acetate extract. Antibacterial activity was determined using the agar well diffusion method, with ciprofloxacin serving as a positive control. Notably, all ethyl acetate extracts from endophytic fungi exhibited antibacterial activity. The most substantial inhibitory diameter against Staphylococcus aureus was recorded as 19.1±0.8 mm for the JEC3 endophytic fungi, while Escherichia coli exhibited an inhibitory diameter of 16±1.1 mm for the JEC2 endophytic fungi.
Assessment of Al3+ Ion Selectivity Coefficient (Kij) in Polyurethane Membranes Derived from Castor Oil (Ricinus communis. L) via Separated Solution Method Firaihanil Jannah; Rinaldi Idroes; Nazaruddin Nazaruddin; Nasrullah Idris; Eka Safitri; Nor Diyana Md Sani
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.18

Abstract

The influence of foreign ions on the response of Al3+ ISE-based polyurethane membranes from castor oil has been determined using SSM. The results showed that the presence of the foreign ions tested did not affect the sensitivity and response of Al3+ ISE. The influence of foreign ions Na+, K+, Li+, Pb2+, Ca2+, Co2+, Cu2+, Ni2+, Cr3+, and Fe3+ on the selectivity of ion-selective electrodes (Al3+ ISE) in the concentration range 1x10-9 – 1x10-4 M has been performed using separate methods. The results show that the presence of foreign ions does not affect the performance of Al3+ ISE with a Kij value < 1. The selectivity sequence of foreign ions is Fe3+ > Cr3+ > Pb2+ > Cu2+ > Ni2+ > Co2+ > Ca2+ > Li+ > Na+ > K+ respectively.
Hippobroma longiflora L Leaves as a Natural Inhibitor of Cataract Progression: A Comprehensive Study Integrating Ethanol Extract, HPLC, and Molecular Docking Approaches Imelda, Eva; Fitria, Ulfa; Mutia, Ulmiza Putri; Syahrul, Syahrul; Sari, Masitha Dewi; Adev, Sarra Mutiara; Adev, Alya Mutiara; Zakiaturrahmi, Zakiaturrahmi; Toshniwal, Navneet Shamsundar
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.10

Abstract

Cataract remains the highest preventable cause of blindness in the world. The H. longiflora plant (Hippobroma longiflora L) is a plant that has empirically been widely used to treat a variety of eye diseases including cataract. This plant has high antioxidant activity due to its high phenolic and flavonoid content. The H. longiflora plant was extracted using an ethanol solvent and its compound content was analyzed using GCMS and phytochemistry analysis. The extracts obtained were tested with TPC, TFC, antioxidants and quercetine compound with HPLC. From phytochemical and GCMS analysis, it was found that triterpenoid compounds were not found in the sample, and the compound 1-Isobutyl-2,5-dimethyl-4-phenyl-piperidin-4-ol was the most abundant (37.77%), as well as 4-Penten-1-ol, 5-phenyl-3-pperidino (1,30%) were the least abundant in the ethanol extract of the H. longiflora leaves extract. The total phenolic, flavonoid and HPLC results of quercetin were 139.21 mg GAE/g; 11.48 mg QE/G and 0.009 mg/G. Meanwhile, in an antioxidant activity test, it was found that the ethanol extract of the H. longiflora leaves has very strong antioxidants. This finding revealed the potential of ethanol extracts of H. longiflora leaves as a cataract inhibitor through its process as an antioxidant.
Theoretical Evaluation of Michelia Species’ Bioactive Compounds and Theraupetic Potential: A Literature Review Oktaviana, Nurul; Isnaini, Nadia; Harnelly, Essy; Zulkarnain, Zulkarnain; Muhammad, Syaifullah; Misrahanum, Misrahanum
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.12

Abstract

Michelia alba is a multifunctional plant found in Indonesia and is also called magnolia. Michelia alba is a tree known for its essential oil, which has long been used as a fragrance ingredient in perfumes and cosmetics. The potential of M. alba is immense for use in the prevention and treatment of disease as well as the management of human health and wellness. To date, there have been few publications regarding the biological activities of M. alba, focusing on tyrosinase inhibitory, antibacterial, antidiabetic, anti-inflammatory and antioxidant activities. However, M. alba may have additional undiscovered biological activities associated with its bioactive compounds. The purpose of this literature review research is to find out the bioactive compounds and therapeutic potential of the M. alba plant through literature searches that can be a reference for further research. The literature review method is carried out by searching and collecting data from literature sources obtained from several national and international journals that review bioactive compounds and the therapeutic potential of M. alba plants. Based on the literature review, it was found that M. alba has bioactive compounds namely linalool (72.8 flower oil and 80.1% leaf oil), α-terpineol (6.04% flower oil), phenylethyl alcohol (2.58% flower oil), β-pinene (2.39% flower oil) and geraniol (1, 23%) which have therapeutic activities such as mental health disorders, anticancer, anti-inflammatory, antihypertensive, antidiabetic, antihyperlipidemia, antimaagic, antidiarrheal, anti-asthma, and antihyperpigmentation. In traditional medicine it is used to treat fever, syphilis, gonorrhea and malaria, bronchitis, prostatitis, cancer, headache, sinusitis, cough, inflammation of the respiratory tract, chest fullness, flatulence, nausea, body and underarm odor, and vaginal discharge.
Benefits of Green Tea Polyphenols for Kidney Health: A Literature Review Sari, Nadia Warda Sekar; Tallei, Trina Ekawati; Kolondam, Beivy Jonathan
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.13

Abstract

The issue of kidney health has emerged as a global public health concern. Kidneys play a vital role in eliminating toxic substances and maintaining fluid and chemical balance in the body. Preserving kidney health is tantamount to safeguarding overall bodily health, as kidney damage can adversely affect other organs and organ systems. This can give rise to various ailments and compromise one’s physical condition. Throughout ancient history, plants have been employed for medicinal purposes in treating a wide array of ailments with one such plant being tea (Camellia sinensis L). Tea is renowned for its antioxidant and anti-inflammatory properties. It contains bioactive compounds, notably polyphenols, which contribute to enhancing health. Polyphenols serve as therapeutic agents for the kidneys and can prevent the onset of other degenerative disease. Prior research has demonstrated that EGCG, a derivative of polyphenols, can safeguard the kidneys against ischemia-reperfusion injury, kidney fibrosis, and inflammation. Catechins, a subcategory of polyphenols, act as antioxidants, anti-inflammatories, and anti-apoptotic agents, thereby shielding kidney cells.
Evaluation of Antibacterial Properties from Endophytic Fungi of Chrysanthemum indicum (L.) Flowers against Escherichia coli and Staphylococcus aureus Ratte, Titah Amelia; Fatimawali, Fatimawali; Tallei, Trina Ekawati; Suoth, Elly Juliana; Antasionasti, Irma; Yamlean, Paulina
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.15

Abstract

Uncovering the therapeutic potential of secondary metabolites produced by plants, animals, and microbes constitutes the foundation for the development of novel medications. The objective of this investigation is to discern the classes of secondary metabolites and assess the antibacterial properties of endophytic fungal extracts obtained from Chrysanthemum indicum L. flowers. Through the isolation process, five isolates designated as JEC1, JEC2, JEC3, JEC4, and JEC5 were identified. The cultivation of endophytic fungal isolates spanned a three-week period before undergoing extraction with ethyl acetate. The phytochemical tests revealed the presence of alkaloids, flavonoids, steroids, terpenoids, saponins, and tannins in the ethyl acetate extract. Antibacterial activity was determined using the agar well diffusion method, with ciprofloxacin serving as a positive control. Notably, all ethyl acetate extracts from endophytic fungi exhibited antibacterial activity. The most substantial inhibitory diameter against Staphylococcus aureus was recorded as 19.1±0.8 mm for the JEC3 endophytic fungi, while Escherichia coli exhibited an inhibitory diameter of 16±1.1 mm for the JEC2 endophytic fungi.
Assessment of Al3+ Ion Selectivity Coefficient (Kij) in Polyurethane Membranes Derived from Castor Oil (Ricinus communis. L) via Separated Solution Method Jannah, Firaihanil; Idroes, Rinaldi; Nazaruddin, Nazaruddin; Idris, Nasrullah; Safitri, Eka; Md Sani, Nor Diyana
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.18

Abstract

The influence of foreign ions on the response of Al3+ ISE-based polyurethane membranes from castor oil has been determined using SSM. The results showed that the presence of the foreign ions tested did not affect the sensitivity and response of Al3+ ISE. The influence of foreign ions Na+, K+, Li+, Pb2+, Ca2+, Co2+, Cu2+, Ni2+, Cr3+, and Fe3+ on the selectivity of ion-selective electrodes (Al3+ ISE) in the concentration range 1x10-9 – 1x10-4 M has been performed using separate methods. The results show that the presence of foreign ions does not affect the performance of Al3+ ISE with a Kij value < 1. The selectivity sequence of foreign ions is Fe3+ > Cr3+ > Pb2+ > Cu2+ > Ni2+ > Co2+ > Ca2+ > Li+ > Na+ > K+ respectively.

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