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Grimsa Journal of Science Engineering and Technology
Published by PT. Graha Primera Saintifika
ISSN : -     EISSN : 30265118     DOI : https://doi.org/10.61975/gjset
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Engineering Medicine & Pharmacology Physics
Grimsa Journal of Science Engineering and Technology aims to provide a platform for researchers, scholars, and professionals to share their innovative ideas, findings, and insights in the following areas: Science and Innovation, Engineering and Technology, Information Technology and Computer Science, Environmental Science and Sustainability, Biotechnology and Bioengineering, Materials Science and Engineering, Healthcare and Medical Technology, Interdisciplinary Studies
Arjuna Subject : Umum - Umum
Articles 5 Documents
 1 
Search results for , issue "Vol. 2 No. 1 (2024): April 2024" : 5 Documents clear
From Nature to Laboratory: The Impact of Leilem Leaves’ Ethanol Extract on Pancreatic Lipase Enzyme Activity Siringo-Ringo, Aurian Fricilia; Fatimawali, Fatimawali; Bodhi, Widdhi; Manampiring, Aaltje E.; Kepel, Billy J.; Budiarso, Fone D.H.
Grimsa Journal of Science Engineering and Technology Vol. 2 No. 1 (2024): April 2024
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v2i1.23

Abstract

For many years, there have been theories on the possibility of preventing or delaying type 2 Diabetes Mellitus by altering some of its risk factors. Drugs that combat obesity have recently been researched concerning the prevention of type 2 Diabetes Mellitus. Inhibition of the digestive enzyme pancreatic lipase is a potential therapeutic strategy in treating and managing chronic diseases such as diabetes and obesity. Plants containing bioactive compounds are identified as potential sources of pancreatic lipase enzyme inhibitors. The use of natural compounds in inhibiting pancreatic lipase enzyme activity is considered to have more potential due to low toxicity and side effects. This study aims to determine the potential and activity effect of ethanol extract of leilem leaves on inhibiting pancreatic lipase enzyme. This study is a laboratory experimental study, the method of measuring lipase inhibition potential was performed using porcine lipase and PNPB with several modifications and using Orlistat as a positive control. Readings were taken using an ELISA reader at a wavelength of 405 nm. The data were then processed to obtain the IC50 value and relative potency. The results of in vitro studies have shown the potential of leilem leaf extract to inhibit pancreatic lipase enzyme activity. Qualitatively, the results showed that leilem leaf extract contains secondary metabolite compounds such as Alkaloids, Flavonoids, Tannins, Saponins, Steroids, and Terpenoids. Quantitatively, the results showed that the ethanol extract of leilem leaves had an absorbance value at the lowest concentration of 1.346 ± 0.53 and 0.709 ± 0.29 for the highest concentration. The IC50 result obtained was 137.89 μg/mL while the IC50 value of the positive control Orlistat was 77.022 μg/mL. Ethanol extract of leilem leaves (Clerodendrum minahassae Teijsm. & Binn) has a potential value of 0.558.
Analysis Of Factors Associated with The Use of IUD in Women of Childbearing Age Kristanti, Yani; Noor , Meitria Syahadatina; Arifin, Syamsul; Ringoringo , Harapan Parlindungan; Hartoyo, Edi
Grimsa Journal of Science Engineering and Technology Vol. 2 No. 1 (2024): April 2024
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v2i1.25

Abstract

The Intra-Uterine Device (IUD) stands out as one of the safest long-term contraceptives, boasting a remarkable user effectiveness rate of 99.4%. Despite this, recent data from the 2021 Indonesian health profile in South Kalimantan Province reveals suboptimal coverage of IUD usage. Specifically, the coverage stands at 1.95% with 12,011 users in the region, 1.02% (477 users) in Kotabaru District, and 1.79% (82 users) in the Serongga Health Center. These figures fall short of the targeted coverage of 12.9%. This study aims to identify factors influencing IUD usage among women of childbearing age. Employing an analytical observational method with a Case-Control design, the research was conducted within the Serongga Health Center's jurisdiction. The investigation sought to establish correlations between education, knowledge, occupation, age, parity, and husband support with the utilization of IUDs among women of childbearing age. Utilizing a cluster proportional random sampling technique, the study comprised a sample population of 110 individuals. Statistical analysis involved the application of the Chi-Square test and Logistic Regression test for multivariate analysis. The findings of the study indicate that education (p=0.554), knowledge (p=0.308), age (p=0.566), and parity (p=0.835) demonstrate no significant association with IUD usage among women of childbearing age. Conversely, occupational factors (p=0.022, Exp (B)=2.667) and husband support (p=0.035, Exp (B)=2.813) exhibit a notable association. Notably, occupation emerges as the dominant factor influencing IUD usage.
The Dynamics of Adolescent Sexuality: A Comprehensive Study Jannah, Raudhatul; Budinurdjaja, Pribakti; Febriana, Silvia Kristanti Tri; Arifin, Syamsul; Panghiyangani, Roselina
Grimsa Journal of Science Engineering and Technology Vol. 2 No. 1 (2024): April 2024
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v2i1.27

Abstract

Adolescent sexual behavior is all adolescent behavior that is driven by sexual desire. One of the impacts of risky sexual behavior is STIs in the form of AIDS. Banjarbaru City is one of the cities with the highest prevalence rate of AIDS sufferers aged 15-19 years, namely 28.57%. The aim of this research is to analyze the influence of knowledge, attitudes, parenting patterns and spiritual beliefs on adolescent sexual behavior through intention in Banjarbaru City. This research uses cross sectional. There are 200 samples using the Cluster Proportional Random Sampling technique. The instrument uses a questionnaire. Dependent variable: adolescent sexual behavior. Independent variables: knowledge, attitudes, parenting patterns and spiritual beliefs. Intermediary variable: intention. Analysis uses path analysis. The research results show the p-value of the direct effect on sexual behavior, knowledge variables (p=0.016), parenting patterns (p=0.004) and spiritual beliefs (p=0.005), attitudes (p=0.305). Simultaneously the p-value of all independent variables on sexual behavior (p=0.014). Taken together in the indirect effect, intention was not a significant mediating variable (p=0.159>0.05). The conclusion of this research is that there is a direct effect between knowledge, parenting patterns and spiritual beliefs and there is no direct effect between attitudes towards sexual behavior. Simultaneously, all independent variables have a direct effect on sexual behavior. The indirect effect of intention was not a significant mediation in this study.
Impact of Cocoa Seed Extract Toothpaste on Plaque Reduction in Pediatric Populations Nuraskin, Cut Aja; Salfiyadi, Teuku; Reca, Reca; Mardiah, Ainun
Grimsa Journal of Science Engineering and Technology Vol. 2 No. 1 (2024): April 2024
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v2i1.30

Abstract

Plaque is a soft deposit that forms a helical biofilm layer and attached tightly to the tooth surface, in which its presence requiring the use of specific control agents. The safest and most effective plaque control is to use a toothbrush and toothpaste. On the other hand, extract from Theobroma cacao L. seeds contains antioxidant and antibacterial secondary metabolites which could act as a toothpaste active agent. The aim of this research was to determine the impact of Theobroma cacao L. seeds-added toothpaste in reducing plaque index of among children. This is a non-blinding clinical experiment with a pre-test and post-test research design. The research subjects were 30 healthy children aged 8-10 years which were randomly divided into three arms (treatment and control). The results revealed that Theobroma cacao L. extract used as the active ingredient contained contains phenolics, tannins, flavonoids, terpenoids, saponins, and alkaloids. Significantly higher plaque index reductions were observed among children treated with toothpaste containing 1% (mean difference=2.060; p=0.06) as compared to control. In conclusion, the Theobroma cacao L. seeds-added toothpaste could significantly reduce plaque index among healthy children.
Evaluating Extraction Methods for Caffeine Content in Gayo Arabica Coffee Oil through Gas Chromatography-Mass Spectroscopy Khairan, Khairan; Musvira, Intan; Lala, Andi; Diah, Muhammad; Maulana, Aga; Idroes, Ghazi Mauer; Awang, Khalijah
Grimsa Journal of Science Engineering and Technology Vol. 2 No. 1 (2024): April 2024
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v2i1.31

Abstract

This study aims to determine physicochemical properties, and caffeine analysis of green bean coffee essential oil (GBCEO) and roasted bean coffee essential oil (RBCEO) by maceration and soxhlet extraction methods. The results indicated that RBCEO by maceration method have higher percentage of yield compared to GBCEO. By the same to soxhlet extraction method, RBCEO also showed higher percentage of yield compared to GBCEO. The refractive index of the GBCEOm and GBCEOs have a lower acid value compared to RBCEOm and RBCEOs. The specific gravity obtained for GBCEOm, RBCEOm, GBCEOs, and RBCEOs ranged from 0.87 to 0.97. The results showed that GBCEOm has the highest saponification value followed by RBCEOs. GBCEOm has the highest iodine value followed by RBCEOs, while RBCEOm and GBCEOs have a similar iodine value. The peroxide value showed that GBCEOs, and RBCEOs by soxhlet extraction method have higher peroxide value. The GC-MS analysis revealed that GBCEOm has higher caffeine followed by GBCEOs with the percentages area of 9.31% and 7.36% respectively. Meanwhile RBCEOm has lower caffeine followed by RBCEOs with the percentages area of 7.36% and 4.28% respectively. This finding showed that GBCEO shows higher caffeine compound compared with RBCEO.

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