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Grimsa Journal of Science Engineering and Technology
Published by PT. Graha Primera Saintifika
ISSN : -     EISSN : 30265118     DOI : https://doi.org/10.61975/gjset
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Engineering Medicine & Pharmacology Physics
Grimsa Journal of Science Engineering and Technology aims to provide a platform for researchers, scholars, and professionals to share their innovative ideas, findings, and insights in the following areas: Science and Innovation, Engineering and Technology, Information Technology and Computer Science, Environmental Science and Sustainability, Biotechnology and Bioengineering, Materials Science and Engineering, Healthcare and Medical Technology, Interdisciplinary Studies
Arjuna Subject : Umum - Umum
Articles 45 Documents
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Surgical Management of Manifest Exotropia and Its Effect on Cosmetic Appearance in Amblyopic Patients Imelda, Eva; Mahfiza, Cut Salsabila; Fadliyani, Eka; Toshnowal, Nikhil
Grimsa Journal of Science Engineering and Technology Vol. 4 No. 1 (2026): April 2026
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v4i1.101

Abstract

Constant exotropia, defined by persistent outward deviation of the eye, can cause cosmetic concerns and disrupt binocular function if untreated. We report a case of a 26-year-old male with long-standing left-eye exotropia and amblyopia since early childhood. Preoperative assessment revealed a visual acuity of 6/30 in the left eye, 15° exotropia on Hirschberg testing, 30 prism diopters on prism alternate cover testing, alternating fixation with right-eye dominance, and left-eye suppression on the Worth Four Dot test. The patient underwent unilateral lateral rectus recession and medial rectus resection. One week postoperatively, ocular alignment was orthotropic with satisfactory cosmetic and motor outcomes, while functional binocular vision remained limited. This case demonstrates the effectiveness of surgical intervention in restoring alignment and appearance in adult sensory exotropia and emphasizes the importance of early detection and timely management to prevent irreversible sensory deficits.
Mechanistic Exploration of Moringa oleifera Leaf Bioactives in Prostate Cancer Using Network Pharmacology Tengke, Feniea Wulan Agaype; Tallei, Trina Ekawati; Turalaki, Grace Lendawati Amelia; Tendean, Lydia Estelina Naomi; Kaseke, Martha Marie; Niode, Nurdjannah Jane; Fatimawali, Fatimawali
Grimsa Journal of Science Engineering and Technology Vol. 4 No. 1 (2026): April 2026
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v4i1.105

Abstract

Prostate cancer remains one of the most prevalent malignancies in men worldwide, while current therapeutic strategies are often associated with adverse effects and the emergence of drug resistance, highlighting the need for safer and more effective alternatives. This study aimed to elucidate the multitarget molecular mechanisms of bioactive compounds derived from Moringa oleifera leaves against prostate cancer using an integrated in silico network pharmacology approach. A total of 137 bioactive compounds were collected from LC–MS/MS profiling data and phytochemical databases, of which 20 compounds with high predicted biological activity were prioritized based on Way2Drug PASS analysis. Potential protein targets were predicted and intersected with prostate cancer–associated genes to identify shared targets. Protein–protein interaction network analysis revealed 536 overlapping targets, with ten hub proteins, ESR1, AKT1, SRC, EGFR, TP53, HSP90AA1, PIK3CA, HSP90AB1, PIK3R1, and MAPK1, identified as central nodes. Pathway enrichment analysis demonstrated that these targets were predominantly involved in cancer-related signaling pathways, including pathways associated with EGFR tyrosine kinase inhibitor resistance. Pharmacokinetic and toxicity assessments indicated that several compounds, such as isorhamnetin, kaempferol, tocopherol, and afzelin, exhibited favorable drug-likeness properties and low predicted toxicity. Overall, these findings suggest that bioactive compounds from Moringa oleifera leaves exert anticancer effects through a multitarget and multi pathway mode of action rather than single-protein modulation. This study provides systematic insight into the molecular mechanisms underlying the anti–prostate cancer potential of Moringa oleifera leaves and supports their relevance as candidates for further experimental validation and drug development.
Rational Use of Proton Pump Inhibitors Among the Early Aging Population: Evidence from a Community Health Center in Indonesia Suryawati, Suryawati; Animalika, Lulu; Narisa, Maghyan; Suardi, Hijra Novia; Aini, Zahratul; Mulia, Vera Dewi; Maghfirah, Desi
Grimsa Journal of Science Engineering and Technology Vol. 4 No. 1 (2026): April 2026
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v4i1.116

Abstract

Proton pump inhibitors (PPIs) are among the most commonly prescribed medications worldwide and are widely used for the management of acid-related disorders, particularly among adults in their early ageing period, where concerns about inappropriate prescribing remain prevalent. This study aimed to evaluate the rational use of PPIs among adults aged ≥46 years at a primary healthcare centre in Banda Aceh, Indonesia. This study focuses on the appropriateness of indications, dosages, and durations, as well as potential drug–drug interactions. Dose appropriateness was assessed using Lexicomp standard adult dosing. Duration and appropriateness of indications were assessed according to the Indonesian Gastroenterology Consensus. A retrospective cross-sectional study was conducted, comprising 1,997 records. A sample of 107 patients who met the predefined inclusion and exclusion criteria was analysed. Most patients were aged 56–65 years and predominantly female, with dyspepsia as the main indication. Omeprazole was prescribed in all cases, commonly at 20 mg twice daily. Nearly half of prescriptions were inappropriate, and appropriate dosing was limited. While treatment duration was generally adequate, some cases were shorter than recommended. Potential drug–drug interactions were identified but were mostly of low clinical significance. Overall, the rational use of PPIs among the patients in this primary healthcare setting remains suboptimal, particularly in terms of indication and dosing. These findings highlight the need to strengthen adherence to clinical guidelines and to implement regular medication reviews to promote safer, more rational PPI use in this population.
Sustainable Plant-Assisted Production of Silver Nanoparticle Hybrids for Antimicrobial Use: Insights from Chromolaena odorata and Patchouli Oil Pebriani, Liska Nova; Kemala, Pati; Idroes, Ghazi Mauer; Fatriasari, Widya; Khairan, Khairan; Idroes, Rinaldi
Grimsa Journal of Science Engineering and Technology Vol. 4 No. 1 (2026): April 2026
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v4i1.117

Abstract

This study developed a green synthesis approach for silver nanoparticles (AgNPs) using ethanolic extracts of Chromolaena odorata leaves (LCo) collected from geothermal areas, followed by post-synthesis incorporation of patchouli oil (PO) to improve antimicrobial performance. The synthesis was optimized using Response Surface Methodology (RSM) based on AgNO₃ concentration and pH, with surface plasmon resonance (SPR) as the response indicator. Successful formation of AgNPs was confirmed by characteristic SPR absorption in the visible region. Structural and morphological analyses indicated the involvement of plant-derived functional groups in nanoparticle stabilization, with predominantly spherical particles and some aggregation observed. Antimicrobial testing against Staphylococcus aureus, Escherichia coli, and Candida albicans showed that the PO-AgNPs-LCo system exhibited a slightly higher inhibition zone compared to AgNPs-LCo alone, indicating a marginal enhancement in antimicrobial activity. These results suggest that geothermal-derived plant extracts can be effectively utilized for AgNPs synthesis, while post-synthesis incorporation of natural oils may provide additional functional modification. However, the observed enhancement remains limited, indicating the need for further optimization and mechanistic studies. Overall, this work highlights a simple and eco-friendly route for developing plant-based antimicrobial nanomaterials.
Heritage-Driven Revitalization of Indrapurwa Mosque: A Conceptual Design Study Shara, Siti; Zahriah, Zahriah; Wulandari, Elysa; Djamaluddin, Masdar; Maharani, Lisa
Grimsa Journal of Science Engineering and Technology Vol. 4 No. 1 (2026): April 2026
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v4i1.118

Abstract

The Indrapurwa Mosque, located in Lamguron Village, Aceh Besar, Indonesia, is a significant historical site dating back to the Aceh Sultanate period. However, following the 2004 earthquake and tsunami, the mosque has experienced physical degradation and diminished public recognition. As part of the historical spatial network of Aceh Lhee Sagoe, the mosque requires a systematic and context-sensitive preservation approach to safeguard its historical and cultural values. This study aims to formulate a revitalization concept for the Indrapurwa Mosque complex by using its original architectural character as the primary design foundation. This research employs a qualitative descriptive method, integrating field observations, interviews, and historical literature review. The study is conducted in two main stages. The first stage involves identifying and analyzing the architectural character of the original Indrapurwa Mosque, including its tiered (tumpang) roof typology, structural system, materiality, and spatial organization. The second stage translates these characteristics into design parameters for the revitalization of the mosque complex, adapted to contemporary functional and spatial requirements. The findings demonstrate that integrating traditional Nusantara architectural character into the design framework can effectively restore the identity of the Indrapurwa Mosque while maintaining historical continuity. The proposed revitalization concept balances preservation and development by reinterpreting architectural values into a contemporary context. This research contributes both theoretically and practically, offering a character-based revitalization approach and providing a reference for the design and preservation of historic religious architecture in Aceh that is rooted in local cultural heritage.

Page 5 of 5 | Total Record : 45

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