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INDONESIA
Jurnal Tumbuhan Obat Indonesia
Published by Universitas Tidar
ISSN : 1979897X     EISSN : 23548797     DOI : https://doi.org/10.31002/jtoi
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Public Health
Jurnal Tumbuhan Obat Indonesia is published periodically twice a year. Result or review written by researcher from university or research Institute. Journal TOI has had an ISSN print version since 2008 and has an online Volume 6 number 1 year 2013.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 84 Documents
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Pengaruh Ekstrak Jintan Hitam Terhadap Berat Badan dan Jalur NF-κB Tikus Wistar dengan Mukositis Oral Akibat Cisplatin: Studi in Vivo – in Silico ⁠Oke Kadarullah; Hasna Khalifatunnisa; ⁠Muhammad Fadhol Romdhoni; Titik Kusumawinakhyu
Jurnal Tumbuhan Obat Indonesia Vol. 19 No. 1 (2026): July 2026
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v19i1.3693

Abstract

Cisplatin-induced oral mucositis involves oxidative stress and inflammatory pathway activation thatcontribute to weight loss. Nigella sativa contains thymoquinone with antioxidant and anti-inflammatoryproperties, yet integrative evidence linking in vivo effects and in silico molecular affinity remains limited.Standard in vivo therapy commonly uses N-acetylcysteine (NAC). This study evaluated the effect of Nigellasativa extract on body weight changes and the NF-κB inflammatory pathway in Wistar rats with cisplatininducedoral mucositis using in vivo and in silico approaches.Thirty rats were divided into five groups: negativecontrol, Nigella sativa at 125, 250, and 500 mg/kgBW, and NAC 100 mg/kgBW as positive control. Body weightwas measured before and after induction and analyzed using Repeated ANOVA. Molecular docking ofthymoquinone and NAC to NF-κB was conducted for in silico analysis. A significant difference was observedbetween pre- and post-treatment body weight (F=143.399; p<0.001). Mean weight decreased from 247.30 g to216.83 g (−30.47 g). The control group showed the greatest loss (−53.84 g), while the 125 mg/kgBW doseprovided the best protection (−20.33 g). Thymoquinone demonstrated stronger binding af????inity (−5.2kcal/mol) than NAC (−4.2 kcal/mol). Nigella sativa, particularly at 125 mg/kgBW, effectively reduced weightloss and may suppress NF-κB activation. Keywords: Cisplatin, Mucositis Oral, NF-κB, Nigella Sativa, Thymoquinone.
Keanekaragaman Jenis Tumbuhan Bawah dan Potensinya sebagai Tumbuhan Obat Berdasarkan Kajian Pustaka di Hutan Dataran Rendah Agus Yadi Ismail; Sukron Aminudin; Seca Gandaseca
Jurnal Tumbuhan Obat Indonesia Vol. 19 No. 1 (2026): July 2026
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v19i1.2144

Abstract

The treatment of diseases with synthetic drugs is often regarded as suboptimal and may cause side effects.Natural medicinal sources that are easy to obtain and affordable have therefore become a preferred optionfor many communities. Among plant groups, understory plants are among those most frequently examined fortheir medicinal potential. This study aimed to identify the diversity of understory plant species in the GunungPutri Block of Mount Ciremai National Park and to review their potential as medicinal plants. Understoryvegetation was surveyed using a plotted-line (belt-transect) method, with plots arranged along an elevationgradient at 100 m intervals, and the data were analysed using the Importance Value Index and the Shannon–Wiener species diversity index (H′). Medicinal potential was assessed through a literature review ofdocumented traditional uses and previously reported bioactive compounds, rather than throughphytochemical or pharmacological testing. The survey recorded 39 understory plant species, of which 16 wereidentified as having potential medicinal uses. Across all elevation intervals, the species diversity index fellwithin the range 1 ≤ H′ ≤ 3, indicating that the diversity of understory plant species in the study area ismoderate. Leaves were the plant part most commonly used for medicinal purposes, followed by roots, tubers,latex, and flowers. Ethnobotanical and laboratory validation is recommended as a follow-up study. Keywords: diversity; identification; lowland forest; medicinal plants; understory plants
Evaluasi Kandungan Kunyit (Curcuma longa L.) pada Sediaan Jamu Herbal Menggunakan FTIR dan Analisis Kemometrik Gharsina Yumni; Nabilla Selviana Putri; Sugito Chandra
Jurnal Tumbuhan Obat Indonesia Vol. 19 No. 1 (2026): July 2026
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v19i1.3668

Abstract

The use of herbal medicine as an alternative treatment continues to increase, particularly for turmeric-basedproducts. However, the adulteration of turmeric raw materials remains a significant problem, compromisingproduct quality and posing health risks to consumers. Research on the authentication of turmeric incommercial herbal medicine preparations using rapid and non-destructive methods remains limited. Thisstudy aimed to authenticate turmeric content in herbal medicine preparations using Fourier TransformInfrared (FTIR) spectroscopy combined with chemometric analysis. Turmeric powder samples and fivecommercial herbal preparations were collected from different locations in Semarang city. Spectral data wereacquired using FTIR in the range of 4000-650 cm⁻¹ and analyzed using Principal Component Analysis (PCA)and Cluster Analysis (CA) with Minitab 22 software. FTIR results revealed the presence of characteristiccurcumin functional groups, including O-H phenolic, C-H, C=C aromatic, C-O-C, and C-O in all samples. PCA andCA analysis resulted in two distinct groups: Group 1 (SA, SC, SD, SE) showed high similarity to the turmericreference standard, while Group 2 (SB) exhibited significant differences, showed spectral differences from thereference sample. The combined FTIR and chemometric approach proved effective in quickly and accuratelyidentifying and authenticating turmeric content in herbal medicine preparations, thus can be recommendedas a routine quality control method for herbal medicine industry and BPOM. Keywords: Authentication, CA, chemometrics, FTIR, PCA, turmeric
Eksplorasi Efek Gastroprotektif Ekstrak Moringa oleifera L. pada Tikus Galur Wistar: Studi in Silico dan in Vivo Febriana Astuti; Dian Anggraini; Feronika Nur Afifa; Rafiatiana Capritasari; Laili Muna
Jurnal Tumbuhan Obat Indonesia Vol. 19 No. 1 (2026): July 2026
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v19i1.3746

Abstract

Gastric ulcers are characterized by gastric mucosal damage caused by an imbalance between aggressive andprotective factors. Synthetic drugs often cause side effects, necessitating natural alternatives such as Moringaoleifera L., which contains the active compound quercetin. Objective to explore the gastroprotective effectsof Moringa oleifera L. leaf extract using in silico and in vivo approaches. Methods used In silico studies wereconducted by molecular docking quercetin against COX-2 protein (PDB ID: 5IKT) and histamine receptor (PDBID: 2AOU). In vivo tests used 25 Wistar rats induced by piroxicam (30 mg/kgBW), divided into negative controlgroups (CMC-Na), positive control groups (Omeprazole), and extract groups with doses of 100 mg/kgBW and200 mg/kgBW. In silico analysis revealed that quercetin has a binding affinity (ΔG) of -6.14 kcal/molfor COX-2 and -7.84 kcal/mol for histamine, indicating stable molecular interactions. In vivo, the 200 mg/kgBWdose provided the most effective protection, with an ulcer inhibition percentage of 30% and visualimprovement of the gastric mucosa compared to the negative control. Moringa oleifera L. leafextract possesses potential as a gastroprotective agent through the inhibition of inflammatory mediators andgastric acid secretion Keywords: Moringa oleifera, quercetin, gastroprotective, molecular docking, gastric ulcer

Page 9 of 9 | Total Record : 84

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