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INDONESIA
Jurnal Tumbuhan Obat Indonesia
Published by Universitas Tidar
ISSN : 1979897X     EISSN : 23548797     DOI : https://doi.org/10.31002/jtoi
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Public Health
Jurnal Tumbuhan Obat Indonesia is published periodically twice a year. Result or review written by researcher from university or research Institute. Journal TOI has had an ISSN print version since 2008 and has an online Volume 6 number 1 year 2013.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 70 Documents
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Potensi Tanaman Ganjan (Artemisia vulgaris) dalam Penyembuhan Luka Sayat pada Tikus (Sprague Dawley): The Potential of Ganjan (Artemisia vulgaris) in Wound Healing in Rats (Sprague Dawley) Istiqomah, Indriana Noor; Mashuri; Abdillah, Achlish; Azizah, Laili Nur
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 1 (2024): July 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i1.1159

Abstract

Recent studies have focused on exploring natural remedies to accelerate wound healing. One such herbal plant is the Ganjan plant (Artemisia vulgaris), which contains essential oils, coumarins, flavonoids, triterpenoids, and phenolic acids, which make it a good candidate for natural remedies. This study analyzed the wound-healing potential of the Ganjan plant using a true experimental research design on 16 male Sprague Dawley rats. The rats were divided into four groups and subjected to different treatments, including a negative control group without treatment (K1), a 10% Ganjan herbal extract ointment group (K2), a 30% Ganjan herbal extract ointment group (K3), and a positive control group with 10% betadine ointment (K4). The ointments were applied once daily for 21 days or until the wounds healed, and wound area measurements were taken every three days. The results showed that the 10% and 30% Ganjan ointments effectively reduced the wound area, and there was no difference in wound contraction between 10% and 30% Ganjan ointment and 10% Betadine. The study concludes that Ganjan plant extract ointment is an effective natural remedy for wound healing and that the best results are seen in the 30% Ganjan extract ointment group.
Antifungal Activity the Active Fraction of Orange Jasmine (Murraya paniculata (Linn) Jack) Leaves and Stem Bark Against Malassezia furfur: Aktivitas Antifungi Fraksi Aktif Daun dan Kulit Batang Kemuning (Murraya paniculata (Linn) Jack) terhadap Malassezia furfur Mulangsri, Dewi Andini Kunti; Rosella, Sevitia; Isna Azmut Baroroh
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 1 (2024): July 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i1.1186

Abstract

Leaves and stem bark of orange jasmine have bioactive compounds such as phenol and flavonoids, which these compounds could be extracted by organic solvent and have antifungal activity against Malassezia furfur which cause excema, dandruff and tinea versicolor in humans. Fractionation of the extract would obtain a specific compound based on the polarity of the solvent. This research aims to know the active fraction of leaves and stem bark of orange jasmine which had antifungal activity against Malassezia furfur.  The simplicia powder of leaves and stem bark orange jasmine was macerated with 96% ethanol solvent and then fractionated as gradually with n-hexane, ethyl acetate, and water solvent. The antifungal activity of ethanol extract and fractions was tested against Malassezia furfur with 80; 90; 100% concentration by disk diffusion method at 37˚C for 48 hours of incubation. The data of antifungal activity was analyzed by two-way ANOVA. The result of this research showed antifungal activity from active fraction as water fraction of leaves and stem bark of orange jasmine against Malassezia furfur. The diameter of inhibition zones for the active fraction of leaves and stem bark of orange jasmine such as 8.6 – 14 mm and 12.3 – 15.8 mm respectively.
Chemical Characterization of Moringa oleifera Lam. from Six Growth Locations in Central of Java: An Initiation of Standardization `: Karakterisasi Kimia Moringa oleifera Lam. dari Enam Lokasi Tumbuh di Jawa Tengah: Inisiasi Standardisasi Budiarti, Mery; Wijaya, Nur Rahmawati; Jokopriyambodo, Wahyu
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 1 (2024): July 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i1.1192

Abstract

Moringa oleifera Lam. is in high demand as a raw material for pharmaceutical constituents and dietary supplements, particularly for producing stunting supplements. However, recommendations regarding M. oleifera quality standards have not supported this claim as scientific evidence of its safety and effectiveness. This research intends to expand knowledge regarding the quality standards of M. oleifera leaves, particularly their chemical properties. Height-variant samples of M. oleifera were collected from six locations in the Central Java, Indonesia. A hierarchical cluster analysis (HCA) was performed to group the most each parameter's values. The parameters included water-soluble extract, ethanol-soluble extract, total ash content, acid-insoluble ash, total flavonoid content was quantified as quercetin, and thin-layer chromatography (TLC) fingerprint. The suggestion of specific value for each parameter as a future reference for M. oleifera, including water- and ethanol-soluble extract content of at least 41% and 19%, and a total- and acid-insoluble ash content of a maximum of 11% and 4%, respectively. The minimal quercetin contains as the chemical marker compound of M. oleifera was a minimum of 1.285%. The chromatogram profile of TLC suggested 7 (254 nm) and 8 (366 nm) spots.
Sublingual Film Formulation of Tempuyung Leaf Extract (Sonchus Arvensis L.) as Anthyperuricemic Agent Subagja, Seina Lathifa; Nurdianti, Lusi; Agustiani, Dika Tri; Jayanty, Rizka Sri; Khaelani, Eka; Dwi Lestari, Oktaviana
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.1406

Abstract

Tempuyung leaves (Sonchus arvensis L.) are known to contain flavonoid compounds with potential antihyperuricemic activity. This study aimed to prepare Sonchus arvensis leaf extract and formulate it into a sublingual thin film dosage form to develop a therapeutic formulation for the treatment of hyperuricemia. The study employed a Completely Randomized Design using 24 rats (Rattus norvegicus), divided into six groups: positive control (Allopurinol), negative control, blank, and three treatment groups receiving Sonchus arvensis extract at doses of 50 mg/70 kg BW, 100 mg/70 kg BW, and 200 mg/70 kg BW. The sublingual film formulation was prepared using the solvent casting method. Data were analyzed using ANOVA and LSD tests. The results indicated that Formula 3, with a dose of 200 mg, produced the most significant reduction in uric acid levels. Standardization parameters of the extract, including moisture content, ash content, water-soluble extract, ethanolsoluble extract, and loss on drying, complied with the applicable standards. Evaluation of the sublingual film demonstrated that the formulation met the required characteristics and quality standards for sublingual films. In conclusion, the sublingual film of Sonchus arvensis leaf extract shows potential as an effective antihyperuricemic agent. Keywords: Tempuyung Leaves, Antihyperuricemia, Thin Film
Studi Etnofarmakognosi Dan Etnomedisin Masyarakat Lereng Selatan Gunung Slamet Kabupaten Banyumas Jawa Tengah Rachmani, Eka Prasasti Nur; Suhesti, Tuti Sri
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.1681

Abstract

Salah satu pemanfaatan tanaman yaitu untuk tujuan pengobatan. Pemanfaatan tanaman untuk pengobatan berdasarkan pengalaman turun-temurun yang bersifat lisan, rentan terjadi kesalahan informasi. Penelitian ini bertujuan untuk mendokumentasikan pemanfaatan tanaman obat berdasarkan pengetahuan dan kearifan lokal masyarakat di lereng selatan Gunung Slamet yang meliputi Kecamatan Baturraden, Kedungbanteng, Sumbang dan Purwokerto Utara. Penelitian dilakukan dengan menggunakan pendekatan kualitatif dan kuantitatif. Metode penelitian dilakukan dengan wawancara dan observasi yang melibatkan informan yang memiliki kriteria pelaku dan pengobat tradisional. Data profil informan dianalisis secara deskriptif. Analisis kuantitatif meliputi penetapan nilai dan pentingnya tanaman bagi masyarakat dilakukan secara kuantitatif dengan menghitung nilai guna tanaman untuk pengobatan (Use Value/UV), nilai guna famili (Family Use Value/FUV), frekuensi kutipan relatif (Relative Frekuensi Citation/RFC), tingkat fidelitas (Fidelity Level/FL) serta data mengenai bagian tanaman, cara penyiapan, dan cara penggunaan tanaman. Hasil penelitian menunjukkan bahwa 12 responden menyebutkan 56 jenis tumbuhan yang termasuk dalam 27 famili. Famili yang paling banyak digunakan berdasarkan nilai FUV adalah zingiberaceae, terdapat 9 spesies yang memiliki 17 kegunaan (khasiat). Tanaman yang paling penting untuk pengobatan berdasarkan nilai RFC tertinggi berturut-turut yaitu kunyit (1,00), jahe (0,92), dan temulawak (0,92). Terdapat 13 jenis tanaman yang memiliki nilai FL 100% yang terdapat dalam famili acanthaceae, araliaceae, asteraceae, campanuiaceae, cupresaceae, euphorbiaceae, fabaceae, liliaceae, myrtaceae, dan zingiberaceae. Hal ini menunjukkan bahwa tanaman tersebut sangat dipercaya untuk tujuan pengobatan tertentu. Bagian tanaman yang paling sering digunakan adalah daun (39%), cara penyiapan bahan tanaman untuk obat yang paling sering dilakukan adalah direbus (56%), cara penggunaan yang sering dilakukan adalah secara per oral (69%) dan sebagian besar bahan tanaman yang digunakan adalah bahan segar (91%). Temuan ini menguatkan data bahwa tanaman pada famili zingiberaceae merupakan tanaman utama yang banyak digunakan untuk pengobatan pada masyarakat lereng selatan Gunung Slamet.
Total Phenolics and Flavonoids Content of Pemphis acidula Leaves Extract, In Vitro Antioxidant and Antidiabetic Activity, and Characterization of The Extract Towards Standardized Antidiabetic Herbal Medicine Mardianawati, Nurlita; Sulastri, Lilik; sinaga, ernawati
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.1852

Abstract

Diabetes mellitus is a prevalent metabolic disorder that still remains a threat to public health all over the world. Oxidative stress is a critical factor in the pathogenesis and progression of diabetes mellitus and its associated complications. Plants contain many antioxidant compounds that can provide protection against free radical-related diseases. The present study aims to evaluate the potential of ethanol extract of Pemphis acidula leaves as antidiabetic agent by measuring its total phenolics and flavonoids content, and its antioxidant and α-amylase inhibitor activity as well. The total phenols content was determined using Follin-Ciocalteu method and total flavonoids content was determined using the AlCl3 colorimetric method, while in vitro antioxidant activity was evaluated using DPPH method. Results of the study showed that ethanol extract of Pemphis acidula leaves contains total phenolics and total flavonoids equivalent to 5390mg GAE/100 grams of extract and 581.66mg QE/100 grams of extract respectively, and it had also been proven that the extract has strong antioxidant and α-amylase inhibitor activity with IC50 of 57.71 ppm and IC50 of 70.05 ppm respectively. From these results, it can be concluded that ethanol extract of Pemphis acidula leaves has the potential as an anti-diabetic agent.
Crude Drugs Standardization, Total Flavonoid and Phenolic Content Profile, and Antimicrobial Activity of Red Ginger and Lemongrass Combination Puspitasari, Adinda; Hamad, Alwani; Hartanti, Dwi
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2008

Abstract

Baturraden people use a combination of red ginger rhizomes and lemongrass leaves for the treatment of masuk angin. This study aims to evaluate the quality profile of red ginger and lemongrass crude drug, total flavonoid content (TPC), total phenolic content (TFC), and the antimicrobial activities of their combination water extracts. The quality of both crude drugs was standardized to Indonesian Herbal Pharmacopeia (IHP). The TPC and TFC of red ginger and lemongrass combination in five different ratios were determined by standard UV-Vis spectrophotometry methods. The antimicrobial activity was evaluated using the microdilution method against patient-isolated multidrug-resistant (MDR) Staphylococcus aureus and Candida albicans. Lemongrass crude drugs were of good quality, while red ginger did not meet the acid-insoluble ash and volatile matter content requirements. The combination showed the highest TFC in a 75:25% ratio, while that of TPC was 50:50%. All combinations of lemongrass and red ginger extracts inhibited MDR Staphylococcus aureus and Candida albicans with a minimum inhibitory concentration (MIC) of 0.16 mg/ml. Candida albicans were more susceptible to the combination extracts. Red ginger rhizomes and lemongrass leaves 75:25% and 50:50% ratios showing comparable effects to the respective components. Hence, the combination of red ginger and lemongrass in 75:25 and 50:50% ratios potentially developed further for their masuk angin efficacy.
Antikeloid Activity and Irritation Test of Combination Extract of Tithonia diversifolia A. Gray and Nerium indicum Mill in vivo Yuliani, Fara Silvia; Wahyuningsih , Mae Sri Hartati
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2046

Abstract

Keloids, marked by overgrowth of fibrous tissue beyond wound boundaries, present therapeutic challenges due to recurrence and the side effects of current treatments. Conventional methods, including surgery and radiotherapy are often costly and carry risks such as recurrence, pain, and infection. This has led to increasing interest in natural alternatives. This study investigates the antikeloid potential of a combination extract from Nerium indicum Mill (N. indicum) and Tithonia diversifolia A. Gray (T. diversifolia) in an in vivo rabbit ear hypertrophic scar model. The efficacy of the extract was evaluated using the Scar Elevation Index (SEI), while irritation tests assessed its potential for localized skin reactions. Five groups were tested: three groups receiving different doses of the combination extract, a negative control (aquadest), and a positive control (triamcinolone acetonide). The results showed that SEI values in all treatment groups were significantly reduced compared to the negative control (p<0.05), indicating reduced scar prominence. The Draize test further classified the extract as a minimal irritant, supporting its safety for topical application. These findings suggest that the combination extract of N. indicum and T. diversifolia is a promising, safer, and natural alternative for keloid treatment, particularly in managing hypertrophic scars.  
Ekstrak Akar Purwoceng sebagai neuroprotektan Terhadap Model Stroke pada Tikus: Memori Spasial, Jumlah Sel Piramidal, Ekspresi SOD1 dan SOD2 Munawaroh, Fauziyatul; Efiyanti, Christy; Utami, Putri; Dewi, Trisni; Batubara, Irmanida
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2236

Abstract

Stroke due to cerebral ischemia is one of the leading causes of disability worldwide. Animal models of cerebral ischemia that is often used is Global Cerebral Ischemia (GCI). In GCI, the hippocampus is the most susceptible to neuronal cell death. Complications that occur after ischemia are due to increased oxidative stress. Some compounds in purwoceng are reported to have antioxidant activity which oxidative stress have not been studied in the GCI model stroke. This study aims to examine the effect of purwoceng extract on a stroke model (GCI) as a neuroprotective agent in the prevention of stroke complications that have not been previously studied. 25 rats with a stroke model were given purwoceng root extract with 3 doses (20, 30, and 40mg/kg BW) orally for three days. The mice were then tested for memory with the Morriz Water Maze (MWM) test; then histopathological analysis of pyramidal cells in the hippocampus and the expression of SOD1 and SOD2 genes was analyzed using RT-PCR. The MWM test showed that the memory results at the dose of 20mg/kg BW were better than that of the GCI group (p=0.0384), and the PCR of SOD2 showed improvement at the dose of 20mg/kg BW (p=0.0171). No significant difference in histopathological analysis and SOD1 mRNA expression across group. The administration of purwoceng root extract at a dose of 20 mg/kg BW had the effect of improving memory and SOD2 expression in GCI model rats
Potential of Secondary Metabolites from Acriopsis liliifolia Leaves as a Tyrosinase Inhibitor: Docking Study Khoeriyah, Ni'matul; Wannawijaya, Nashwa Maheswari; Apsari, Cintya Nurul; Nuraini, Latifa
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2246

Abstract

The demand of natural chemicals with high effectiveness and low side effects increases plant exploration, including in the cosmetic and pharmaceutical fields. Trend of skin-lightening products is in great demand, causing its development to overgrow. Acriopsis liliifolia is an orchid species commonly found in Java and its leaves contain many secondary metabolites, thus attracting attention to be studied its potential as a tyrosinase inhibitor to overcome hyperpigmentation. This study explores potential of secondary metabolites in A. liliifolia leaves as tyrosinase inhibitors through microchemical tests, secondary metabolite profiling with LC-HRMS, and docking study using MOE. The results of the microchemical test showed that this orchid contains flavonoid, phenolic, terpenoid, and alkaloid compounds. Secondary metabolite profiling with LC-HRMS produced 130 compounds, then 15 of the most potential compounds were selected. The docking study showed that prolylleucine had lowest S score of -8,738 kJ/mol, lower than native ligand, kojic acid. This indicates that prolylleucine has a significant binding affinity to tyrosinase enzyme receptor through twelve bonds on the active site of enzyme. Prolylleucine can be used as a lead compound for further testing. Keywords: Acriopsis liliifolia, secondary metabolites, leaves, tyrosinase inhibitor, molecular docking.

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