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Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Published by Asosiasi Riset Ilmu Kesehatan Indonesia
ISSN : 3031013X     EISSN : 30310148     DOI : 10.61132
Core Subject : Health,
Health Professions Nursing Public Health
Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Alam, Biokimia, Analisis Kimia, Kimia Fisika, Biologi, Mikrobiologi, Jaringan Budaya, Botani dan Hewan terkait Produk Farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Gizi dan Kesehatan Masyarakat.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 378 Documents
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Analysis of Adiponectin, TNF-α, and Biochemical Markers in Fallujah Atherosclerosis Patients Amenh Muhammed Abdulrahman
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1377

Abstract

Background: Atherosclerosis is a chronic inflammatory cardiovascular disorder strongly associated with elevated low-density lipoprotein cholesterol (LDL-C) levels and serves as a major predictor of adverse cardiovascular events. This study aimed to investigate the relationship between inflammatory markers (adiponectin and TNF-α) and key biochemical parameters in atherosclerosis patients. Methods: A case-control study was conducted on 60 participants (aged 40–65 years) recruited from private cardiac clinics in Fallujah, Iraq, between October and December 2024. Subjects were stratified into two groups: 30 atherosclerosis patients (diagnosed by specialists) and 30 age-matched healthy controls. Blood samples were collected, centrifuged, and analyzed for CRP, TNF-α, adiponectin, PAI-1, MDA, GSH, sodium (Na), and magnesium (Mg) levels using standardized biochemical assays. Statistical analysis was performed using SPSS, with significance set at *p* ≤ 0.001. Results: Atherosclerosis patients exhibited significantly elevated serum levels of CRP (2.21 ± 14.46 vs. 1.07 ± 7.76 mg/dL), TNF-α (15.14 ± 120.86 vs. 4.27 ± 65.16 pg/mL), PAI-1 (6.52 ± 0.82 vs. 2.02 ± 0.42 ng/dL), MDA (590.26 ± 29.64 vs. 155.52 ± 25.19 ng/mL), and Na (140.16 ± 1.18 vs. 125.46 ± 6.17 nmol/L) compared to controls (*p* ≤ 0.001). Conversely, adiponectin (0.18 ± 1.81 vs. 0.67 ± 4.18 mg/dL), GSH (22.79 ± 1.37 vs. 40.81 ± 3.05 μg/mL), and Mg (1.46 ± 0.175 vs. 1.84 ± 0.67 nmol/L) were markedly reduced in patients. ROC curve analysis demonstrated perfect diagnostic accuracy (AUC = 1.0) for CRP, TNF-α, and adiponectin in distinguishing patients from controls. Conclusion: The study highlights pronounced dysregulation of inflammatory, oxidative, and metabolic pathways in atherosclerosis, with CRP, TNF-α, and adiponectin serving as robust discriminative biomarkers. These findings underscore the potential of targeting these pathways for therapeutic intervention and early diagnosis.
Peran Orang Tua dengan Perilaku Pencegahan Kehamilan Usia Dini pada Siswi Merfina Alexsandra Scolastica Rori; Zainar Kasim; Silvia Dewi Mayasari Riu
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1378

Abstract

Early pregnancy is at high risk for health complications such as anemia, preeclampsia, and premature birth.In addition, social impacts such as dropping out of school, societal stigma, and economic instability also become serious consequences that can affect the future of adolescents.The objective of this study is to determine the relationship between parental roles and the prevention of early pregnancy among students at SMA Negeri 1 Touluaan.The research uses a cross-sectional design.The sample in this study consisted of 38 respondents using purposive sampling technique.Data collection on parental roles and prevention of early pregnancy was conducted using a questionnaire, analyzed using the chi-square statistical test.The results of the study on the role of parents mostly showed that the role of parents in the good category amounted to 32 respondents (66.7%), and the behavior of pregnancy prevention mostly in the good category amounted to 34 respondents (70.8%).The results of the chi-square test obtained a p-value of 0.006 where < α 0.05.Conclusion: There is a relationship between the role of parents and the prevention of early pregnancy among students of SMA Negeri 1 Touluaan.
Modification and In Vitro Biological Evaluation of Ceftriaxone-Imine Derivatives: Possible Anticancer and Antimicrobial Reem Alaulddin Jameel; Balsam Mohammed Ahmed; Raghad Haddad
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1393

Abstract

This research investigates the modification of ceftriaxone to synthesized imine derivatives (A-C), assessing their chemical and biological efficacy. This study underscores the notable antibacterial effectiveness of synthesized derivatives against Staphylococcus aureus and Escherichia coli, exhibiting a determined dose correlation. The synthesis procedure reacts ceftriaxone with different aldehydes, such as 2-Hydroxy-4-Methoxybenzaldehyde and 4-ethoxy-2-hydroxy-benzaldehyde, and 5-Chloro-2-hydroxybenzaldehyde yielding imines analyzed by various methods, such as FT-IR and 1H-NMR. The results indicate that imines may have implications in medical therapies, especially in addressing multidrug-resistant bacteria and a human breast cancer cell line MCF-7. Imine derivative C exhibits significant antibacterial efficacy, measuring 33 mm at 0.1 ppm against Staphylococcus aureus, while 30 mm at 0.1 as anti-Escherichia coli more activity from other synthesized derivatives. The derivative C recorded a value of 29.2441 after 24 hours as an inhibition MCF-7 cell line.
Structural and Electronic Effects of Multiligand Coordination in a Single Transition Metal Complex a Study in Organic Reaction Catalysis Samar Sabah Mohammed
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1401

Abstract

The modulation of the structures and electronic properties of transition metal complexes by multi-ligands coordination has been widely exploited to enhance the catalytic efficiency in organic transformations. Here, we present synthesis, characterization, and catalytic performance of Cu(II), Ni(II) and Pd(II) complexes of multidentate ligands- EDTA, 1,10-phenanthroline and N-heterocyclic carbenes (NHCs). The Pd-NHC complex displayed the high catalytic activity for hydrogenation as well as small-molecule activation, up to 450 h⁻¹ of turnover frequency (TOF) and total conversion of styrene to ethylbenzene at room temperature, and is higher efficient than Cu-EDTA (TOF =120 h⁻¹), Ni-Phen (TOF= 85 h⁻¹). The DFT calculation with Pd-NHC system showed that the small HOMO-LUMO gap (3.2 eV) and the short Pd–C bond (1.95 Å) of Pd-NHC, which could facilitate the transfer of the growth species, contributed to the low energy of activation (28 kJ/mol). Mathematical model also discussed its high catalytic activity (TOF/Ea = 16.07 h⁻¹·kJ⁻¹·mol) due to the strong σ-donor ligands and proper geometry. These findings underscore the influence of ligand architecture to secure transition states and modulate electron density in designing efficient sustainable catalysis that is industrially relevant.
Review Artikel: Analisis Formulasi dan Evaluasi Tablet Effervescent Dewi Rahmawati; Dzakiya Zhihrotulwida; M. Fithrul Mubarak; Yani Ambari; Allyssia Salma; Siti Nur Rohmania; Siti Khoiriyah; Achmad Saichoni Arthaganda; Winda Wulandari; Salsabila Firdausi Hernila Putri; Silfi Maslicha
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1404

Abstract

The purpose of writing this review article is to analyze the formulation and evaluation of the use of various additives in effervescent tablets. The method used is a literature review taken from journals and other relevant research results regarding the formulation and evaluation of additives in various types of effervescent tablets. The purpose of this analysis is to provide a summary of relevant publications and to improve current understanding in this field. The importance of the formulation and evaluation of additives in effervescent tablets cannot be ignored, because it is a crucial aspect in product development. Decisions in the use of additives must consider the objectives to be achieved, the desired physical characteristics, product stability, and the level of consumer acceptance. With a deep understanding of this formulation and evaluation, we have the potential to produce high-quality effervescent tablets. Variations in additives can also provide different taste and texture characteristics, which of course can affect consumer acceptance.  
The Application of Benson Relaxation Therapy Technique to Reduce Pain in Post-Cesarean Section Patients in the Mawar Ward of Bengkalis Regional General Hospital Tuti Qodarsih; Fitra Mayenti; Fajar Sari Tanberika; Riski Novera Yenita
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1413

Abstract

Cesarean section (Sectio Caesarea) is a surgical procedure performed by making an incision in the anterior wall of the uterus to assist the childbirth process. This study aims to examine the application of Benson relaxation technique in reducing the intensity of pain scale in post-cesarean section mothers at Bengkalis Regional General Hospital (RSUD Bengkalis). This research is a quantitative study using a quasi-experimental design. The study was conducted from November to December 2024, involving a sample of 15 respondents. Data were analyzed using univariate and bivariate analysis, with the Chi-Square test applied. All respondents were post-cesarean section mothers. The findings showed that before the intervention, all 15 respondents (100%) experienced severe pain. After receiving the Benson relaxation intervention for 10–15 minutes, a decrease in pain scale was reported. The data indicated that the majority of respondents (86.7% or 13 respondents) experienced a reduction from severe to moderate pain. The statistical test results yielded a p-value of 0.000, indicating a significant effect of Benson relaxation therapy on pain reduction in post-cesarean section patients in the Mawar Ward of RSUD Bengkalis. It is recommended that RSUD Bengkalis consider adopting this technique as an innovation in health services, particularly in nursing care, to help reduce pain in post-cesarean section mothers.
Effect of Chronic Smoking on Plasma Antioxidant Enzyme Activity Abdulkadhim Kareem Abbood Zerjawi
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1415

Abstract

Oxidative stress is caused by regular smoking. If oxidative stress is higher than the level of antioxidants, there is said to be oxidative stress. SOD, CAT and GPx enzymes in the plasma help to reduce the harm caused by oxidative stress. This study aimed to discover if smoking regularly had any impact on the enzymes found in adults. A total of 120 people, with 60 chronic smokers and 60 nonsmokers, took part in the study and each group of 60 had equal numbers of men and women. All donors of blood and plasma had their levels of SOD, CAT and GPx checked using regular spectrophotometric procedures. I carried out the analysis using SPSS software version 26.0. The levels of SOD (1.82 ± 0.29 U/mL), CAT (31.5 ± 4.8 IU/mL) and GPx (3.21 ± 0.52 IU/mL) were lower in smokers compared to non-smokers. The gender levels showed the same effect on the study results as the smoking levels and did not interact with one another. Generally, regular smoking can decrease the amount of this enzyme working in plasma, so the body becomes less able to protect itself from oxidation for both men and women. It indicates that smoking leads to a health issue and advises taking actions to decrease risks for smokers.  
Amino Acids: Metabolism, Functions, and Their Role in Health and Disease Management Rand Thair Abdul-kader
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 4 (2025): July: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i4.1432

Abstract

Abstract. Amino acids are indispensable components of human metabolism, playing essential roles in proteinsynthesis, energy production, and cellular regulation. Branched-chain amino acids (BCAAs)-leucine, isoleucine,and valine—are particularly significant due to their involvement in muscle repair, metabolic signaling, andinsulin sensitivity. While BCAAs are vital under normal physiological conditions, multiple studies have shownthat elevated plasma BCAA levels are linked to insulin resistance, obesity, and type 2 diabetes. This associationhas led researchers to investigate whether these elevations are a cause or consequence of metabolicdysfunction. Recent findings have revealed that impaired BCAA catabolism in tissues such as adipose and livercontributes to their accumulation in circulation. If skeletal muscle becomes insulin resistant, it may shift BCAAmetabolism further, exacerbating the imbalance. Moreover, the modulation of specific enzymes and transportershas been proposed as a therapeutic avenue to mimic the beneficial effects of dietary protein restriction.Although several mechanisms have been proposed, including mTOR activation, fatty acid oxidationinterference, and altered neurotransmitter synthesis, no single pathway fully explains BCAA-induced metabolicdisturbances. Therefore, a comprehensive understanding of amino acid metabolism is crucial, particularly ifdietary and pharmacological interventions are to be optimized for preventing or treating age-related andmetabolic diseases.
Artikel Review : Penyebab Cacat pada Sediaan Kemasan Obat di Perusahaan Farmasi Nabila Sativa; Nailia Nur Isma Sumarno; Nor Latifah
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 3 (2025): May: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i3.1433

Abstract

Pharmaceutical packaging serves not only as a means of protecting the product but also as a source of information and quality assurance for consumers. However, various studies indicate that packaging defects remain a significant issue in the pharmaceutical industry. This article is a literature review that examines several studies related to the analysis of the causes of packaging defects in pharmaceutical preparations. Based on the review of multiple scientific journals, it was found that packaging defects are generally caused by a combination of technical and non-technical factors, such as machine failure, operator error, inappropriate raw material specifications, and insufficient quality control.
The Impact of Laboratory Staff Training on Reducing Error Rates in Clinical Laboratories Zainab Kamil Chassab Abd Alhuseen; Noor Hamza Hussein Kazim; Ayat Mohammed Nahi Brih; Ola Shaheed Abed Arkan
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 4 (2025): July: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i4.1435

Abstract

Laboratories play a crucial role in ensuring patient safety, with approximately 80–90% of clinical diagnoses relying on laboratory test results. Despite their importance, laboratory errors are reported to occur in about 0.012% to 0.6% of all tests conducted. Patient safety is fundamentally a managerial responsibility that can be improved through the implementation of robust systems aimed at detecting and addressing quality deficiencies. A reactive approach to this involves incident reporting followed by root cause analysis, which helps uncover and rectify weaknesses in existing policies and procedures. Alternatively, a proactive strategy such as Failure Mode and Effects Analysis (FMEA) focuses on evaluating the entire testing process, anticipating potential adverse events, and taking preventive measures before such issues arise. This method is particularly effective for prospective risk assessment in high-risk procedures, thereby minimizing the likelihood of errors within laboratories and other areas of patient care.

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