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Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Published by Asosiasi Riset Ilmu Kesehatan Indonesia
ISSN : 3031013X     EISSN : 30310148     DOI : 10.61132
Core Subject : Health,
Health Professions Nursing Public Health
Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Alam, Biokimia, Analisis Kimia, Kimia Fisika, Biologi, Mikrobiologi, Jaringan Budaya, Botani dan Hewan terkait Produk Farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Gizi dan Kesehatan Masyarakat.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 378 Documents
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Faktor Asupan terhadap Status Gizi Balita Wasting di Wilayah Kerja Puskesmas Sidotopo Wetan Surabaya Ryka Novitasari; Veni Indrawati
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 4 (2025): July: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i4.1553

Abstract

Wasting affects health and threatens children potential. Direct factors such as food intake need to be maximized to improve nutritional status. This study aims to determine the differences in energy and macronutrient intake, food parenting, and exclusive breastfeeding history in wasting and non-wasting toddlers in the working area of Sidotopo Wetan Health Center Surabaya. This study is a case control study. Total respondents were 88 toddlers aged 7-60 months, consist 44 wasting toddlers taken with total sampling technique and 44 non-wasting toddlers taken with purposive sampling technique with age and gender matching. Energy intake and macronutrients were obtained by 3x24 hour food recall questionnaire, food parenting patterns obtained from filling out FPSQ (Feeding Practices and Structure Questionnaire) and FPSQ-M (Milk Version) questionnaires, exclusive breastfeeding history obtained through interviews with questionnaires, anthropometric data measured using digital scales and microtoas. Data analysis used independent t-test and Mann Whitney test. The results of this study showed there were significant differences in energy intake (p=0.000), carbohydrates (p=0.023), protein (p=0.000), fat (p=0.000), and exclusive breastfeeding history (p=0.003) and there was no significant difference in food parenting (p=0.632) between wasting and non-wasting toddlers. Parents are expected to pay attention to food intake and provide exclusive breastfeeding.
Studi Stabilitas Sediaan Suspensi Obat dalam Kondisi Suhu yang Berbeda Muhammad Fadhli; M. Chaidir Hafidz; Nor Latifah
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 4 (2025): July: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i4.1557

Abstract

Stability testing is an important step in the development of pharmaceutical products. This testing must be conducted before the product is manufactured, whether on an industrial or non-industrial scale. Currently, liquid formulations are experiencing rapid development, one of which is suspension. Suspension itself is a liquid formulation that contains undissolved solid particles dispersed in the liquid phase. To assess the stability of suspension, various evaluations are performed such as organoleptic tests, sedimentation volume, redispersion, density, viscosity, particle size distribution, and pH measurement. Based on several studies, temperature is known to affect the stability of drugs, especially in suspension formulations. A study related to diclofenac suspension showed that at a temperature of 4°C, its stability reaches 96.3%, while at temperatures of 40°C and 60°C, there is a significant reduction in content, amounting to 89.58% and 85.17% respectively. Meanwhile, research on folic acid suspension revealed that the drug remains stable at temperatures of 4°C and 25°C, although on day 90 there was an increase in pH. Another study on cefuroxime axetil suspension showed that at a temperature of 20°C, its concentration was 87.68%, while at 5°C, it was higher at 92.35%. This research underscores the importance of considering temperature in the storage and formulation of pharmaceutical suspensions to maintain their effectiveness and stability.
Optimasi Jumlah Karbopol 1,5%, Triethanolamine, dan Air terhadap Sifat Fisik Emulgel Astaxanthin dan Ekstrak Wortel Kadek Adinda Suryadewi S.P.
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 4 (2025): July: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i4.1558

Abstract

Skin damage can adversely affect a person's health and physical appearance. One of the factors causing is exposure to free radicals that can trigger various skin problems such as premature aging, hyperpigmentation, to skin cancer. The combination of astaxanthin and carrot extract (Daucus carota L.) can be a natural approach that is promising for skin care because it contains antioxidant carotenoids. Astaxanthin and carrot extract are formulated in the form of emulgel preparations to optimize their effectiveness when used on the surface of the skin. The success of an emulgel preparation is not only determined by its active ingredient, but also by the physical characteristics of the preparation. This study aims to determine the optimum formulation of the combination of carbopol 940, triethanolamine, and aquadest in making emulgel preparations with active substances Astaxanthin and carrot extract in order to obtain physical properties that meet the standards. Optimization is carried out using the D-Optimal Mixture Design method through the Design Expert® software version 13.0.0. The evaluated parameters include pH, viscosity, scattering power, and adhesion. This study produced an optimum formulation of emulgel with a composition of 940 1.5% carbopol as much as 40.697 grams, TEA as much as 0.5 grams, and aquadest amounted to 15,188 grams. This formula shows a pH of 5,783 ± 0.0249, viscosity 24,856.7 ± 2,829.61 cps, 5,113 ± 0.4216 cm spread power, as well as the adhesion of 1,873 ± 0.1641 seconds. Based on the analysis using the D-optimal method, Tea is known as the most influential component of the physical characteristics of the Astaxanthin combination emulgel and carrot extract.
Hubungan Antara Koordinasi Mata Tangan dengan Kualitas Pukulan pada Atlet Woodball Provinsi Bali Ketut Juliati; M. Widnyana; Govinda Vittala; Ni Luh Putu Gita Karunia Saraswati
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 4 (2025): July: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i4.1560

Abstract

Woodball was first introduced in 2006 and has since grown rapidly across the country. In addition, many woodball clubs and communities have emerged, and woodball has become an officially recognized competitive sport since 2016. In 2016, woodball even became part of the national sports week (PON) in West Java. Woodball is a sport that combines elements of golf and croquet, emphasizing the accuracy of shots to pass through the goal with a wooden ball. Hand-eye coordination is one of the key factors that can influence the quality of an athlete's shots. Objective: To determine the relationship between hand-eye coordination and shot quality in woodball athletes in Bali Province. An observational analytical study with a cross-sectional approach involving 42 woodball athletes in Bali Province. Hand-eye coordination was measured using a 30-second ball catch-and-throw test, while shot quality was assessed using a skill test based on the number of balls successfully passing through the gate. Analysis was performed using Spearman's rho correlation test. The analysis revealed a significant relationship between eye-hand coordination and swing quality in woodball athletes (P < 0.05). The positive correlation coefficient indicates that better eye-hand coordination leads to higher swing quality. There is a significant relationship between eye-hand coordination and shot quality. Improving visual-motor coordination skills can contribute to the performance of woodball athletes.
Peran Inovasi Kemasan dalam Menjaga Stabilitas dan Keamanan Produk Farmasi: Sebuah Literature Review Nabilah Nabilah; Ratna Habibah; Nor Latifah
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 4 (2025): July: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i4.1562

Abstract

Pharmaceutical packaging plays an important role in maintaining the stability, safety, and effectiveness of drug products during storage and distribution. Drug stability can be affected by various environmental factors such as temperature, humidity, oxygen, and light. Therefore, packaging innovation is a crucial strategy to extend the shelf life of drugs and maintain product quality, especially for sensitive preparations such as injections, transdermal patches, and biologics. This study is a literature review that aims to evaluate the impact of packaging innovation on the physical and chemical stability of pharmaceutical products. This study confirms that packaging selection is not just a technical aspect, but a vital strategy in ensuring pharmaceutical quality. Further research is needed to integrate smart packaging and advanced barrier technologies into modern pharmaceutical distribution systems.
Studi Deskriptif Kenakalan Remaja pada Siswa SMAN X Lengayang di Pesisir Selatan Yuliandri Yuliandri; Mario Pratama
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 4 (2025): July: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i4.1567

Abstract

The purpose of the study was to determine the description of juvenile delinquency behavior that occurs in students. The study used a descriptive research method in which the author tried to reveal and describe how Juvenile Delinquency in Students of SMAN X Lengayang in Pesisir Selatan. Descriptive research is one type of research that aims to describe systematically, factually, and accurately about the facts and characteristics of a particular population. From the tests that have been carried out, the results obtained are that the level of juvenile delinquency is included in the moderate category. In the gender category, 27 male students have a moderate level of delinquency and 36 female students have a moderate level of delinquency. As for the class category, class 10 has 22 people, class XI 17 people and class XII 24 people with a moderate level of delinquency. The highest level of delinquency is in class XII, this is due to the feeling of being the most senior in school.
Studi Fenomenologis: Psychological Burden Remaja Laki-Laki dengan Ibu yang Mengalami Skizofrenia Lifsha Zulvia; Yolivia Irna Aviani
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 4 (2025): July: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i4.1569

Abstract

Adolescents living in families where a parent has schizophrenia are at risk of experiencing significant psychological distress. This study aims to gain an in-depth understanding of the subjective experiences of a teenage boy in dealing with the psychological burden of having a mother with schizophrenia. The research employed a qualitative approach with a phenomenological method and utilized Interpretative Phenomenological Analysis (IPA) for data analysis. The participant in this study was a 16-year-old male adolescent who lives with his mother diagnosed with a chronic mental illness. The findings reveal that the subject experienced psychological burden in both objective forms, such as caregiving duties and domestic responsibilities, and subjective forms, including feelings of shame, anxiety, limited social interaction, and emotional conflict. Despite these challenges, the subject developed adaptive coping strategies through social engagement, sports activities, and support from peers and the surrounding environment. These findings highlight the psychological dynamics faced by adolescents in families affected by mental disorders and emphasize the importance of experience-based approaches in psychological intervention efforts.
Hubungan Dukungan Suami terhadap Sikap Ibu untuk Imunisasi Bayi di Desa Denai Sarang Burung Kecamatan Pantai Labu Tahun 2023 Siti Anum Ginting; Plora Novita Febrina Sinaga
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 4 (2025): July: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i4.1570

Abstract

Immunity to one disease in a child does not mean immunity to other diseases. Immunization is a way to increase a person's immunity, such as when a child is actively fighting a disease in his body. The aim of this study was to determine the relationship between husband's support and mothers' attitudes towards immunization of newborns in Denai Sarang Burung Pantai Labu Village in 2023. In this study a cross-sectional technique was used. Cross sectional techniques are used to study the dynamics of the relationship between risk and impact variables by accessing, viewing or collecting data at once. Total population 45. Results of research on the relationship between husband's support and mother's attitude. Implementation of infant immunization in Denai Sarang Burung Village.
The Effect of High Doses of Dextromethorphan on The Human Nervous System Marwa Jewi; Shaban, Fatimah Nameer
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1518

Abstract

Dextromethorphan (DXM) is a commonly used nonprescription cough suppressant that has gained field of science attention with its growing complex pharmacological effects and increased incidences of nonmedical use. This review is focused on pharmacokinetic, pharmacodynamics and CNS effects of DXM, especially on its action mechanism and the interaction with neural circuits and neurotransmitter systems. Although DXM has retained clinical utility as an antitussive, and has demonstrated potential as an off-label agent for neuropsychiatric disease, the recreational use of high doses can have harmful effects on the nervous system. At high doses DXM is capable of dissociation and hallucination similar to those induced by some opioids and NMDA antagonists, altering both mental status and cognition while being associated with neurotoxic effects. In this article, review and compare the similarities and differences between DXM and classic opioids in terms of their potential for abuse and their neurological effects. By case examples and existing epidemiological data, it also highlights the mounting abuse of DXM, most notably by children and young adults, posing a pressing public health challenge. Legislation on DXM is also described and differences in legislative response worldwide are highlighted. Finally, the article finishes by emphasizing the requirement for further studies involving other disciplines to detail the long-term neurological consequences of DXM abuse and to promote integrated public health interventions targeting education, prevention, and clinical treatment.
Synthesis and Estimate of Antimicrobial Efficacy of New Benzoic Acid Hydrazide Derivatives Substituted by Piperidine Hussam Z.Naji; Ghosoun Lafta Mohsen
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1532

Abstract

Several of the best-selling small-molecule medications and natural alkaloids contain piperidine, a crucial saturated heterocyclic scaffold with a wide variety of biological functions. The hydrazide-hydrazone moiety's exceptional use in the pharmacological and biological domains made it particularly appealing. Objective: Designing and synthesizing a novel set of 4-Piperidin-1-yl-benzoic acid substituted hydrazides, Ac1-c3 and Bc1-c5, as potentially antimicrobial agents and characterizing them using IR, 1H-NMR, and mass spectroscopy. Methods: By esterifying 4- Piperidin-1-yl-benzoic acid Ac1 and then treating with hydrazine hydrate it to produce Ac3 in a good yield. The hydrazide Ac3 was condensed with the proper aldehydes or ketone to synthesis the hydrazones Bc1–c5. The in vitro bacterial activity was evaluated anti two Gram-negative bacteria, Pseudomonas aeruginosa, and Candida albicans, as well as two Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis. Results: The majority of tested compounds demonstrated significant efficacy anti Pseudomonas aeruginosa, Candida albicans. Notably, compound Bc3 emerged as the most effective derivative within the series. Conclusions: The Compounds (Bc1–c4) that were synthesized demonstrated moderate to good antimicrobial activity against a number of bacterias species and Candida albicans.

Page 30 of 38 | Total Record : 378

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