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Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Published by Asosiasi Riset Ilmu Kesehatan Indonesia
ISSN : 3031013X     EISSN : 30310148     DOI : 10.61132
Core Subject : Health,
Health Professions Nursing Public Health
Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Alam, Biokimia, Analisis Kimia, Kimia Fisika, Biologi, Mikrobiologi, Jaringan Budaya, Botani dan Hewan terkait Produk Farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Gizi dan Kesehatan Masyarakat.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 352 Documents
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Evaluation Antioxidant and Immunity Activities of Green Synthesized Selenium Nanoparticles by Extraction spirulina to reduces oxidative stress induced by phentermine in males rats Hawraa Ali Sultan; Ali Noory Fajer
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1543

Abstract

Abstract. Background: Slimming drugs, such as phentermine, are widely used for weight reduction but are known to induce oxidative stress, particularly affecting hepatic and renal tissues. Selenium nanoparticles (SeNPs), especially those biosynthesized using natural sources like spirulina platensis, have demonstrated promising antioxidant and protective activities in biological systems. Objective: This study aimed to assess the protective effects of selenium nanoparticles synthesized from spirulina platensis extract on renal and hepatic functions in male rats exposed to phentermine induced oxidative stress. Methods: Twenty-six adult male wistar rats were divided into five experimental groups: control group (dosed with water n=5), SeNPs group (dosed with SeNPs n=5), phentermine group (dosed with phentermine n=5), SeNPs then phentermine group (dosed with SeNPs then phentermine n=5), phentermine then SeNPs group (dosed with phentermine then SeNPs n=5). The experiment lasted for 45 days, the measurement of cytokines IL-6, IL-12, TOS and TO-AC. Results: Phentermine administration significantly increased cytokines IL-6, IL-12 indicating marked oxidative stress and immune activation. Treatment with SeNPs alone or in combination with phentermine notably improved these parameters. The group dosed with SeNPs prior to phentermine (SeNPs then phentermine) showed the most prominent protective effects with values approaching those of the control. Conclusions: Selenium nanoparticles from spirulina platensis demonstrated significant protective, antioxidant, and immunomodulatory effects against phentermine induced immune disturbances. These findings support their potential
Evaluasi Rasionalitas Tepat Pasien dan Tepat Indikasi Pasien Rawat Jalan Diabetes Melitus Tipe 2 di RSUD Tabanan I Wayan Weda Aryawan; Putu Ika Indah Indraswari; Pande Made Ayu Aprianti
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1572

Abstract

Type 2 Diabetes Mellitus (DM) is a disease caused by impaired insulin function, impaired insulin secretion, or both, resulting in a hyperglycemic condition. Patients with type 2 DM generally exhibit characteristics such as a Random Blood Glucose level exceeding 200 mg/dL and an HbA1c level exceeding 6.5%. The accuracy of medication administration to patients must also consider the rationality of antidiabetic therapy in order to influence the success rate of optimal therapy. This study aims to evaluate the rationality of patient appropriateness and indication appropriateness in outpatients with type 2 DM at Tabanan Regional Public Hospital (RSUD Tabanan). This study employed a semi-quantitative observational research design with a retrospective approach by reviewing patient medical records from the initiation of therapy. Sampling was conducted using purposive sampling, whereby samples had to meet predetermined inclusion criteria. The results indicated that the age group with the highest prevalence of DM patients at RSUD Tabanan was over 56 years old (74%), with a predominance of females (63%). The most common comorbidity among DM patients was hypertension alone (24.5%). Based on the findings, the percentage of patient appropriateness rationality among DM outpatients at RSUD Tabanan was 97.5%, while the percentage of indication appropriateness rationality in type 2 DM outpatients at RSUD Tabanan was 98.5%.
Effect of Urea Fertilizer on the Biological Nitrification Process in Soils of Different Textures and Locations Hamid Mohsin Ghyadh; Mohammed Saeed Haran
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1587

Abstract

An experiment was conducted to study the effect of adding different levels of urea fertilizer (ppm Urea-N0,75,150,225,300) on the effectiveness of bio-nitrification in the studied soil. The study treatments for this experiment were (4 soils of different textures and locations × 5 urea levels × 3 replicates) in an experiment in which a completely randomized design (CRD) was used. It was incubated at laboratory temperature (25°C) for 40 days, during which the amount of formed nitrates and remaining ammonium was measured every ten days, noting the replacement of lost water every two days. The highest percentage of formed nitrates (39.8%) was recorded from the ammonium added to Basrah soil after ten days of incubation, followed by Kut soil, which recorded 29.8%, and less than that in Shatra soils (24.2%) and Fajr soils (23.7%). After that, the efficiency of nitrification decreased in the subsequent incubation periods up to 40 days of incubation.The percentage of ammonium remaining from urea added to the soil was recorded after the four incubation periods at 20.0 ppm (when adding 225 ppm urea to the Qurna soil), which differed significantly from the rest of the studied soils.
The Ulul Albab Spiritual Leadership Construct and Its Impact on Psychological Well-Being : A CFA Examination among Campus Da'wah Activists Nurzahara Sihombing; M. Agung Rahmadi; Helsa Nasution; Luthfiah Mawar; Milna Sari; Wildan Izzatul Haq
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1592

Abstract

This study rigorously investigates the Ulul Albab spiritual leadership construct and its impact on psychological well-being among campus da'wah activists, employing a Confirmatory Factor Analysis (CFA) approach grounded in both theoretical integration and empirical data. The inquiry draws upon a meta-analysis of 47 quantitative studies encompassing a total of 12,847 respondents from leading universities in Indonesia, Malaysia, and Brunei Darussalam, spanning the years 2018 to 2024. This methodological scope enhances the external validity of the findings. The CFA results confirm that the Ulul Albab spiritual leadership model exhibits a robust level of model fit, as indicated by optimal statistical indices (χ²/df = 2.34; CFI = 0.956; TLI = 0.943; RMSEA = 0.047; SRMR = 0.039), suggesting strong coherence between the theoretical construct and field data. The three core dimensions conceptualized in this model are statistically validated through high factor loadings: intellectual spirituality (0.847), Islamic transformational leadership (0.823), and emotional-spiritual intelligence (0.791), each serving as integral pillars of the Ulul Albab paradigm. Furthermore, structural regression analysis reveals a significant effect of Ulul Albab spiritual leadership on the psychological well-being of da'wah activists (β = 0.673; p < 0.001; R² = 0.453), thereby affirming the model's predictive strength in fostering individual potential rooted in Islamic spiritual values. These findings reinforce the theoretical propositions advanced by Garden, M. (2004), Fry (2003), and Zohar and Marshall (2000) regarding the significance of spiritual leadership within organizational dynamics. However, this study offers a novel conceptual contribution through the epistemological synthesis of the Ulul Albab construct, integrating intellectual and spiritual intelligence within a holistic Islamic framework. Unlike Western-based models of spiritual leadership proposed by Fry and Nisiewicz (2020), the Ulul Albab construct demonstrates a notable advantage in the dimension of intellectual spirituality, as evidenced by its higher factor loading (0.847 compared to 0.634), underscoring the imperative of balancing dzikir and fikir as both ethical and cognitive foundations in contemporary Islamic leadership.
Potensi Tanaman Obat Tradisional Indonesia sebagai Agen Bio Aktif Penunjang Kesehatan Tulang Cut Massyitah Thaib; Artha Sianipar; Siti Nurbaya; Katarina Riris Teresia; Ade Irma Suryani; Eva Diansari Marbun
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1593

Abstract

Abstrak. Osteoporosis is a degenerative bone disease characterized by a decrease in bone mass and strength, particularly in postmenopausal women. Traditional plant-based therapy presents an attractive alternative given the rich local bioactive potential and limited access to pharmacological treatments. One important biochemical indicator in bone regeneration is the level of alkaline phosphatase (ALP). The aim of this study is to evaluate the potential of various Indonesian traditional medicinal plants as bioactive agents in the prevention of osteoporosis, with an emphasis on increasing ALP levels. This method employed a literature search by collecting several scientific articles discussing the anti-osteoporosis activity of traditional medicinal plants through in vitro, in vivo, and clinical observation studies. The results obtained show that traditional medicinal plants such as Turmeric (Curcuma longa), Black pepper (Piper nigrum), Bromelain (Ananas comosus), Papaya (Carica papaya), Japanese knotweed (Reynoutria japonica Houtt.), Veratrum nigrum, Sickle senna (Cassia tora), Red ginger (Zingiber officinale var. rubrum), Clove (Syzygium aromaticum L.), White turmeric (Curcuma zeadoaria), and Celery (Apium graveolens) are capable of reducing the number of osteoclasts and promoting bone formation. These findings consistently demonstrate a positive role in bone health through increased ALP levels. Indonesian traditional medicinal plants hold great potential as evidence-based anti-osteoporosis agents, particularly through enhancing ALP levels and osteoblast activity. This literature review supports the development of local herbal therapy as a promotive and preventive alternative against osteoporosis.
Hubungan Pengetahuan, Sikap dan Budaya Akseptor KB Memilih AKDR di Desa Bebesen Kecamatan Bebesen Kabupaten Aceh Tengah 2025 Rahmah Rahmah; Dede Dessy Listyana; Raodah Raodah
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1601

Abstract

The new paradigm in the National Family Planning program has changed its vision, which was originally aimed at realizing the norm of a Small Happy Prosperous Family (NKKBS), to a vision of achieving Quality Families. One of the efforts in the family planning program is the regulation of pregnancy spacing through the use of contraceptive devices, which are tools used to prevent pregnancy. This study aims to determine the relationship between the knowledge, attitudes, and culture of family planning acceptors and the selection of Intrauterine Contraceptive Devices (IUCD) in Bebesen Village, Bebesen District, Central Aceh Regency in 2025. This research is descriptive-analytic with a cross-sectional approach and uses purposive sampling method with 59 respondents. The study was conducted from January 12 to February 25, 2025. Statistical analysis using the chi-square test shows a P-value of 0.016, indicating a relationship between knowledge and the selection of IUCD. Further analysis using the chi-square test shows a P-value of 0.013, indicating a relationship between the attitudes of family planning acceptors and the selection of IUCD, and the statistical analysis with the chi-square test shows a P-value of 0.030, indicating a relationship between the culture of family planning acceptors and not selecting IUCD.
Hubungan Status Gizi, Asupan Lemak dan Zat Besi terhadap Kejadian Dismenorea pada Mahasiswi Gizi Universitas Negeri Surabaya R. Aj. Nabila Nur Syahlah Zhafirah; Choirul Anna Nur Afifah
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1604

Abstract

Dysmenorrhea is one of the most common menstrual disorders, but it often receives little attention. The purpose of this study was to determine the relationship between nutritional status, fat intake, and iron intake with the incidence of dysmenorrhea in female Nutrition students at Surabaya State University. The method in this study was quantitative with a cross-sectional study design. The sample consisted of 92 female Nutrition students at Surabaya State University using a purposive sampling technique. The instruments used were the NRS questionnaire to measure the level of dysmenorrhea pain and the SQ-FFQ form to measure fat and iron intake. Data analysis used the Spearman Rank correlation test which showed that there was a significant relationship between excess nutritional status of 33.7% with the incidence of dysmenorrhea (p = 0.000, r = 0.832), there was a significant relationship between excess fat intake of 58.7% with the incidence of dysmenorrhea (p = 0.000, r = 0.793), and there was a significant relationship between insufficient iron intake of 94.6% with the incidence of dysmenorrhea (p = 0.000, r = 0.610).
Tinjauan Persiapan Sertifikasi Halal di Industri Farmasi : Studi Kasus Analisis Titik Kritis Kehalalan Bahan Aktif dan Eksipien Priskila Margaretha; Nyi Mekar Saptarini
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1619

Abstract

Indonesia, as the country with the largest Muslim population in the world, has a significant demand for halal products, including pharmaceuticals. Halal certification serves not only as a regulatory compliance requirement but also as a strategic tool to build consumer trust, ensuring that products meet both religious and quality standards. This article aims to descriptively examine the process and challenges of preparing for halal certification in the pharmaceutical industry, focusing on the evaluation of active pharmaceutical ingredients (APIs) and excipients. The study is based on firsthand experience during a pharmacist professional practice (PKPA) at a national pharmaceutical company. Key areas of focus include material flowchart analysis, identification of critical non-halal points, and the implementation of the Halal Product Assurance System SJPH, in line with Indonesian halal regulatory frameworks. The findings highlight the importance of systematically identifying critical points, especially in evaluating the origin and status of materials such as alcohol, enzymes, and activated carbon, which frequently raise concerns in halal compliance. Furthermore, successful implementation requires comprehensive documentation, revision of standard operating procedures (SOPs), and staff training to ensure traceability and consistency throughout the supply chain. Collaboration with the Indonesian Ulema Council (MUI) and the Halal Product Assurance Organizing Agency (BPJPH) is also vital for technical guidance and certification processes. The study concludes that a structured and integrated approach to halal assurance not only facilitates certification but also enhances operational quality and market competitiveness. This study is expected to provide practical insights for pharmaceutical industries in effectively and sustainably implementing halal regulations, contributing to broader consumer protection and industry accountability.
Profesionalisme Apoteker dalam Perspektif Nilai Obat sebagai Amanah pada Teori Konstitusi Kesehatan Nusantara Melsi Emilia
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1617

Abstract

Pharmacist professionalism is a key component in ensuring the quality of pharmaceutical services, encompassing not only compliance with technical and scientific standards but also a deep commitment to moral and ethical principles. In the Indonesian cultural context, the concept of "medicine as a trust" (obat sebagai amanah) reflects a profound sense of responsibility, where medicine is viewed not merely as a commodity, but as a mandate that must be preserved with integrity and accountability in health care practices. This article conceptually explores the relationship between pharmacist professionalism and the moral value of trust within the framework of the Nusantara constitutional theory. This theory emphasizes the integration of legal, cultural, and moral dimensions in shaping professional conduct in Indonesia. Using a descriptive-critical approach through literature review, this study investigates how trust functions as both a legal expectation and a cultural imperative in the practice of pharmacy. The findings highlight that trust must be internalized as a core value in pharmaceutical services—manifested through ethical decision-making, transparency in drug management, and a commitment to prioritizing patient welfare. Pharmacists are not only required to uphold professional standards, but also to carry out their duties as custodians of public trust. To realize this vision, the integration of the value of trust into pharmacy education, legal regulations, and clinical practice is essential. Educational institutions, professional organizations, and regulatory bodies must work collaboratively to instill this value as part of a pharmacist’s identity. In doing so, the profession can contribute more effectively to building a health care system that is just, culturally grounded, and centered on the well-being of the people.
Formulasi dan Evaluasi Lipstik Berbasis Parafin Solid serta Lanolin sebagai Emolien dan Penstabil Citra Bunga Lestari; Amraini Amelia
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 5 (2025): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i5.1631

Abstract

This study aims to design and evaluate lipstick preparations by utilizing solid paraffin as the base ingredient and lanolin as an emollient and stabilizer. Solid paraffin was chosen because of its dense properties at room temperature and having the ability to form a stable lipstick structure. In addition, paraffin can provide a smooth, durable surface, and provide good smearing power. On the other hand, lanolin is known as a natural emollient ingredient that functions to moisturize and protect the lips from dryness. Lanolin also has water-retaining properties (occlusive) so that lip moisture is maintained even if the lipstick is used for a long time. The process of making lipstick is carried out by the melting method using indirect heating to maintain the stability of the material and prevent color and aroma degradation. All materials are accurately weighed, then put into beaker glass and heated over three legs using a Bunsen lamp. During heating, the ingredients are gently stirred so that all the components, including solid paraffin and lanolin, melt and mix homogeneously. Once the mixture reaches the desired consistency, the formula is poured into the lipstick mold and allowed to set at room temperature until ready for use. The results of the evaluation test showed that the combination of solid paraffin and lanolin was able to create lipstick with an optimal solid texture, even color, not easy to crack, and had a smooth application power on the surface of the lips. Lanolin plays a big role in providing a soft, moisturizing effect and adding a natural shine to the lips. Meanwhile, solid paraffin helps maintain the shape of the lipstick so that it doesn't break easily when applied. This study also highlights the importance of comparing the composition of ingredients to produce lipsticks that have a stable melting point, good application power, and appropriate adhesion.  

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