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INDONESIA
Indonesian Journal of Biomedicine and Clinical Sciences
Published by Universitas Gadjah Mada
ISSN : -     EISSN : 30323134     DOI : https://doi.org/10.22146/inajbcs.v56i01.11961
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience
Indonesian Journal of Biomedicine and Clinical Sciences (InaJBCS) aims to promote the translational of basic research into clinical studies and of clinical evidence into practice. InaJBCS publishes studies that substantially enhance our standing of disease etiology and physiology; the development of prognostic and diagnostic technologies; trials that test the efficacy of specific interventions and those that compare different treatments. InaJBCS invites authors to submit articles in the fields of biomedical sciences including biomedical genetics, bioinformatics, cardiovascular medicine, endocrinology, gastroenterology, geriatrics, infectious diseases, medical oncology, physiology, pharmacology and toxicology, and phytomedicine medicine.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 15 Documents
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Search results for , issue "Vol 57 No 2 (2025)" : 15 Documents clear
Response of narrowband ultraviolet-B phototherapy combined with superoxide dismutase antioxidant cream in the management of non-segmental vitiligo Muchamad Apriyanto; Hanan Asrafi Noviandari; Niken Indrastuti; Arief Budiyanto
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.17224

Abstract

Vitiligo is a skin depigmentation disorder characterized by the loss of melanocyte function. The oxidative stress theory plays a role in the occurrence of vitiligo. Narrow band ultraviolet B (NB-UVB) phototherapy can be combined with other therapies to accelerate skin repigmentation. A 47 yo woman presented to the dermatology and venereology outpatient clinic in Dr. Sardjito General Hospital, Yogyakarta with a chief complaint of white patches on her face, neck, chest, and hands that had persisted for 11 yr. The patient had previously received NB-UVB phototherapy and a calcineurin inhibitor cream, but the symptoms persisted. Significant repigmentation of the lesion area was achieved after NB-UVB phototherapy combined with superoxide dismutase (SOD) antioxidant cream. NB-UVB phototherapy plays a role in immunomodulation, biostimulation, and reducing oxidative stress. The SOD helps clear superoxide radicals, preventing damage to melanocytes. The combination of NB-UVB phototherapy and antioxidant cream can be considered a treatment option for vitiligo.
Managing diagnostic problem of syphilis manifested as chronic colitis and enteropathic arthritis in a 29 yo male: a case report Auliya, Kamila; Nugroho, Cahyo Wibisono; Mumtaza, Hilya Itsnain
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.17895

Abstract

Syphilis is a chronic sexually transmitted infection caused by Gram-negative bacterium, Treponema pallidum, known for its ability to mimic other diseases, leading to misdiagnosis and delayed treatment. We present a case of a 29 yo male with recurrent acute diarrhea, accompanied by fever, nausea, vomiting, prolonged mouth ulcers, and weight loss for the last three months. He was hospitalized multiple times due to the same recurrent problems. He was initially suspected for immunodeficiency diseases and was screened for HIV and hepatitis B, but both results came out negative. The patient was then suspected with malignancy of the gastrointestinal tract and underwent several examinations including; hematology workup, abdominal X-ray, gastroduodenoscopy, colonoscopy and biopsy. However, the result of all abdominal X-ray, biopsy and colonoscopy ruled out malignancy. The examinations discovered intraluminal ileocecal mass that is consist of lymphocytic cells, therefore the patient was diagnosed with chronic colitis and ileitis. The patient went to the clinic as scheduled with a new chief complain of other symptoms; painful spine and hip join movement, which added to his new diagnose of enterophatic arthritis and he was hospitalized for further diagnosis. During hospitalization, the patient was screened for another venereal disease i.e. syphilis, due to the everchanging symptomatology. He was being screened with VDRL, and later TPHA test. This case encompasses the complexity and challenges of diagnostic workup in non-suggestive findings of the disease syphilis as the Great Imitator.
Biofilm detection of clinical isolates of Klebsiella pneumoniae from Pontianak, West Kalimantan Anggie, Joycely; Fajar Liana, Delima; Mardhia, Mardhia; Mahyarudin, Mahyarudin; Agustina, Risa
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/10.22146/inajbcs.v57i2.18918

Abstract

Klebsiella pneumoniae (K. pneumoniae) belongs to the Enterobacteriaceae family, which is known as Gram-negative, encapsulated, and non-motile bacteria. One of its most important virulence factors of K. pneumoniae is the ability to form biofilms. A high percentage of K. pneumoniae as biofilm formation is associated with a high incidence of antibiotic resistance, leading to higher morbidity and mortality. This study aimed to evaluate biofilm formation of clinical isolates of K. pneumonia from Pontianak, West Kalimantan. A total of 24 K. pneumoniae clinical isolates from various specimens were subjected to biofilm formation detection. The biofilm formation was detected by crystal violet formation at wavelength of 570 nm as indicator using microtiter plate assay. As control of biofilm formation was Staphylococcus aureus ATCC 25923, and as control of non-biofilm formation was Staphylococcus epidermidis ATCC 12228. Data on biofilm formation of the isolates from various specimens were analyzed using Fisher’s exact test with SPSS Ver. 26. All the K. pneumoniae clinical isolates were biofilm producer consisting of 19 isolates were strong biofilm producer, four were moderate biofilm producer, and one isolates was weak biofilm producer. No association between biofilm formation and specimen type was observed (p=0.541). In conclusion, all K. pneumoniae clinical isolates from Pontianak, West Kalimantan are identified as biofilm producer.
Secondhand smoke exposure and its role in the pathogenesis of preeclampsia: a narrative review of molecular and epidemiological perspectives Yenny Febriany; Irfannuddin; Mohammad Zulkarnain; Yusuf Effendi
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.19209

Abstract

Preeclampsia (PE) is a pregnancy complication characterized by hypertension after 20 wk of gestation, often accompanied by proteinuria or organ dysfunction. This condition is linked to genetic, environmental factors, and exposure to secondhand smoke (SHS). This study explores the relationship between SHS exposure and PE risk through a narrative literature review. Epidemiological and molecular studies data demonstrate that SHS exposure increases PE risk via oxidative stress, inflammation, and angiogenic disruptions. The analysis reveals that SHS exposure enhances reactive oxygen species (ROS) production, triggers systemic inflammation through the NF-κB pathway, and impairs angiogenic function by lowering the PlGF/sFlt-1 ratio. The risk significantly increases with exposures ≥2 hr/d or weekly frequencies ≥4 d, particularly in poorly ventilated domestic and occupational settings. Biomarkers such as cotinine and carbon monoxide (CO) are employed to assess exposure levels, providing robust evidence that duration and intensity of exposure are pivotal in PE pathogenesis. These findings highlight the importance of preventive strategies, including smoking bans, public health education, and integration of biomarker-based assessments into prenatal care. Future research should aim to clarify the molecular and epigenetic mechanisms involved and explore therapeutic interventions to mitigate SHS-induced damage.
Association between undernutrition and language delay in children under 5 years old: a systematic review Lulus Hardiyanti; Anindya Khairunnisa Zahra; Fara Azmiarrizqi; Amelia Nur Khasanah; Sheila Agustina; Ardiyuga Pratitapraya; Puguh Oktavian
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.19291

Abstract

In 2022, global statistics of the WHO (World Health Organization) reported 148.1 million children under 5 y.o. were too short for their age (stunting), 45.0 million were too thin for their height (wasting), and 37.0 million were too heavy for their height (overweight). Solving the problem of undernutrition is included in the second goal of the Sustainable Development Goals. Language skills are one of the important aspects of development in children. This study aimed to assess the association between undernutrition and language delay in children under 5 y.o. We searched PubMed, Scopus, and Web of Science for relevant studies published in 2014-2024. We identified studies that analyzed children under 5 y.o. with undernutrition and screenings for language delay, full-text, Indonesia, and English language studies, used cross-sectional study, case-control study, cohort study, and RCT study designs. The risk of bias was assessed using the ROBINS-E tool. There were 4,865 articles of search results in 3 databases consisting of PubMed, Web of Science, and Scopus. A total of 16 articles, including 11 cross-sectional studies and 5 cohorts, were analyzed. An association was observed between undernutrition and language delay. Other factors that significantly influenced language delay were paternal education, maternal education, and stimulation. Most studies report that the more severe the conditions of wasting, stunting and underweight will cause more severe conditions of language delay.

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