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Ophthalmologica Indonesiana
Published by Perhimpunan Dokter Spesialis Mata Indonesia
ISSN : 01261193     EISSN : 2460545X     DOI : 10.35749
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Ophthalmologica Indonesiana is an open accessed online journal and comprehensive peer-reviewed ophthalmologist journal published by the Indonesian Ophthalmologist Association / Perhimpunan Dokter Spesialis Mata (PERDAMI). Our main mission is to encourage the important science in the clinical area of the ophthalmology field. We welcome authors for original articles (research), review articles, interesting case reports, special articles, clinical practices, and medical illustrations that focus on the clinical area of ophthalmology medicine.
Arjuna Subject : Kedokteran - Ophthalmology
Articles 869 Documents
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Perkembangan Terkini Optic Neuritis syntia nusanti
Majalah Oftalmologi Indonesia Vol 49 No 1 (2023): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v49i1.100775

Abstract

EFFECT OF BLOOD GLUCOSE CONTROL TOWARDS PLASMA AND VITREOUS LEVELS OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND PLACENTAL GROWTH FACTOR IN DIABETIC RATS Anggun Rama Yudantha; Nina Asrini Noor; Joedo Prihartono
Majalah Oftalmologi Indonesia Vol 49 No 1 (2023): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v49i1.100794

Abstract

Purpose: To compare plasma and vitreous level of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) in diabetic rats with poor blood glucose (BG) control, reconstitution of good BG control, and nondiabetic rats, and to investigate the effect of reconstitution of good BG control to VEGF and PlGF plasma and vitreous level. Methods: This is an experimental study using eighteen Sprague Dawley rats which were divided into intervention group (n=14) and control group (n=4). Intervention group were given Streptozotocin (STZ) injection to induce diabetes. After 4 weeks, intervention group was randomly divided into group I for termination and group II for reconstitution of good BG control with insulin for the following 4 weeks, and so was the control group. Plasma and vitreous samples were taken. VEGF and PlGF levels were evaluated with enzyme-linked immunosorbent assay (ELISA). Results: Seventeen of 18 rats survived in intervention group. BG level of intervention group II decreased dramatically to normoglycemia. ELISA at month 1 showed that VEGF vitreous level tend to be higher in intervention group I compared to control I, 196.36 ± 65.24 pg/dL and 123.64 ± 44.99, respectively (p=0.20). ELISA at month 2 showed that PlGF vitreous level of intervention group I were significantly higher compared to control I, 59.04 ± 2.48 and 51.93 ± 3.15, respectively (p=0.01). Vitreous and plasma VEGF of intervention group I and II were not different, while vitreous and plasma PlGF were significantly higher in group II. Conclusions: Vitreous levels of VEGF and PlGF were increased in diabetic rats compared to nondiabetic, and reconstitution of good BG control for 1 month were unable to reduce VEGF and PlGF levels.
COMPARISON OF SECONDARY AC-IOL IMPLANTATION ON APHAKIA PATIENTS WITHOUT CAPSULAR SUPPORT AFTER PARS PLANA VITRECTOMY VERSUS COMPLICATED CATARACT SURGERY Widya Ardhana Reswari; Prili Olda; Erin Arsianti; Elisa Manueke; Supanji Supanji
Majalah Oftalmologi Indonesia Vol 49 No 1 (2023): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v49i1.100796

Abstract

Introduction and objectiv: Capsular support is often absent in cases of aphakia secondary to ocular trauma or previous complicated intraocular surgery. This study aims to compare the short-term efficacy and safety of secondary AC IOL implantation for aphakia patients who underwent pars plana vitrectomy and complicated cataract surgery Method: Retrospective, comparative, case series of 72 aphakic eyes without capsular support after pars plana vitrectomy (Group 1 =37 eyes) and complicated cataract surgery (Group 2=35 eyes) who underwent secondary AC-IOL implantation (Iris Claw and Anterior Chamber) in Yap Eye Hospital and Air Force Central Hospital Hardjolukito. Basic characteristics such as age, sex, laterality, visual acuity, intraocular pressure (IOP), central corneal thickness, endothelial count, axial length, anterior chamber depth and keratometry were recorded Results: There were no statistically differences at baseline characteristics between the two groups. Despite the proportion difference of lens type used in both group (p=0.04), the mean visual acuity outcome at day 1 and month 3 were found similar. However, on day 7 and month 1 the difference of postoperative visual acuity showed a trend. The difference of postoperative mean IOP was also not significant at day 1, month 1 and month 3, but showed a trend in day 7 (p=0.06). The proportion of complication cases were found different in both group (p=0.01), with secondary glaucoma was found highest (18%). Conclusion: The outcomes of secondary anterior chamber IOL implantation after pars plana vitrectomy and complicated cataract surgery were found similar, although there was a significant difference in the proportion of complication in both groups
SURGICAL MANAGEMENT IN ESOTROPIA AT CIPTO MANGUNKUSUMO HOSPITAL: A 4-YEAR OBSERVATION ON CHARACTERISTIC AND RESULT Fauzia, Firdha Malisa; Bani, Anna Puspitasari
Majalah Oftalmologi Indonesia Vol 50 No 1 (2024): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/9sanvy75

Abstract

Introduction: Esotropia, although have low prevalence in Indonesia, give significant impacts on its sufferer, and due to the wide range of types creates numerous options for surgery without much consensus. Success rates of the surgery also varied depends on many factors. This study aims to evaluate clinical characteristics, success rate in esotropia surgery, and factors that may influence the outcome. Methods: A retrospective descriptive study based on secondary data from medical records of child and adult esotropia patients who underwent surgery from January 2018 to December 2021. Result: Of 68 patients included in the study, 60.2% were adults. More than half of patients have an onset before 7 years of age, though amblyopia only affects 29.4% of patients. Squinted-eye was the chief complaint in most patients (76.5%). One-third of patients had basic type esotropia and 59.7% had large preoperative deviation. Unilateral procedure was done in 50% of patients. The surgery success rate reached 65% with good stability on 8 months of follow-up. Better results were seen in congenital and basic type esotropia than in other types. Although none of the believed influenced factors affecting outcome were significant statistically, duration <5 years and preoperative deviation <50 PD had a higher success rate of 75% and 84.6%. Conclusion: Esotropia surgery in Cipto Mangunkusumo hospital were performed majorly in adults with large pre-operative deviations, mostly by unilateral procedure of recession and resection. The surgeries yield good results and stability, with shorter duration and smaller preoperative deviation giving higher success rates.
EFFICACY AND SAFETY OF RHO KINASE INHIBITOR EYEDROPS FOR THE TREATMENT OF OPEN-ANGLE GLAUCOMA AND OCULAR HYPERTENSION: A LITERATURE REVIEW Sahar Salim Saleh Alatas; Astrianda Nadya Suryono
Majalah Oftalmologi Indonesia Vol 49 No 2 (2023): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v49i2.100847

Abstract

Introduction: Reduction of intraocular pressure (IOP) is the only proven method to treat glaucoma. Studies on aqueous humor dynamics have contributed to our understanding of aqueous outflow mechanisms that have led to the discovery of new drugs from Rho Kinase Inhibitors (RKI). Aims: To evaluate the efficacy and safety of RKI for treating open-angle glaucoma (OAG) and ocular hypertension (OHT). Methods: Literature searching was conducted through PubMed, ScienceDirect, Google Scholar, and Springer Link. Search terms included: “Open Angle Glaucoma”, “Ocular Hypertension”, and “Rho Kinase Inhibitors”, which provides for Netarsudil (AR-13530), Ripasudil (K-115)" or any relevant synonym. Validity was assessed using version 2 of the Cochrane risk of bias tool for randomized trials (RoB 2). Efficacy was evaluated by reported mean change IOP from baseline. Safety was assessed by adverse events experienced during the treatment course. Results: Eight randomized clinical trial studies fulfilled our inclusion criteria (four studies using Netarsudil 0.02% and four using FCNL as the primary treatment). IOP reduction from Netarsudil 0.02% was not inferior to Timolol 0.5%. Meanwhile, IOP reduction from FCNL class was statistically superior to its active component alone. The most common adverse events of Netarsudil 0.02% and FCNL were conjunctival hyperemia, cornea verticillate, and conjunctival hemorrhage. FCNL showed additional adverse events of site hyperemia and pain. Conclusion: Netarsudil 0.02% and FCNL can be reliable IOP control medications. The adverse events were tolerable.
EFFECTS OF CATARACT SURGERY ON THE CORNEAL ENDOTHEL Agustian Firmansyah Purnomo; Hidayat Sujuti
Majalah Oftalmologi Indonesia Vol 49 No 2 (2023): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v49i2.100865

Abstract

Introduction: Manual cataract surgery techniques such as SICS and ECCE are still used today but not as many as phacoemulsification. Corneal endothelium can be damaged due to various factors during surgery such as intraoperative manuver, excessive ultrasound power, pressure during irrigation, collision between lens fragments and corneal endothelium, large air bubbles, and increased temperature during surgery. Methods: Journal articles and books in this paper were searched through various available search engines, including using searches through the sites Google Scholar, Medline, Proquest. The search method uses one or a combination of keywords, namely cataract surgery, corneal endothelial damage, corneal endothelium, specular microscope. Articles in this paper are found in English and Indonesian. Results: From several studies it can be concluded that the risk factors that greatly affect the corneal endothelium include age, race, use of contact lenses, surgery, trauma, refractive errors and anatomical abnormalities on the surface of the eyeball. Conclusion: Cataract surgery technique is significantly associated with the incidence of bullous keratopathy because the maneuvers are very prone to injuring the corneal endothel. The average percentage of damage to endothelial cells reaches 15%. This is what underlies the need for further research to find new methods that can protect the corneal endothelium.
HUBUNGAN ANTARA PEMAKAIAN LENSA KONTAK DAN RISIKO BLEFAROPTOSIS DIDAPAT Putri, Febianza Mawaddah
Majalah Oftalmologi Indonesia Vol 49 No S1 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/f7cvsk87

Abstract

Objectives: Contact lenses (CL) wear has been reported to be associated with acquired blepharoptosis. This literature review aims to summarize and evaluate the risk of acquired blepharoptosis in contact lens wearers. Methods: Literature searching was conducted using three online databases including PubMed, Cochrane Library, and Embase. Search terms such as “contact lens”, “ptosis”, and “blepharoptosis” were included. Reference lists of each study were also assessed for potentially relevant sources. Results: Using relevant search terms in various databases, a total of three articles were included in this review. All studies reviewed were single-center retrospective studies. The three studies suggested that wearing contact lens was significantly associated with blepharoptosis. Long-term contact lens wear, ranging from 15 to 34 years, seemed to have a significant effect on the incidence of blepharoptosis. Hard contact lens (HCL) wear has a greater risk for ptosis to occur than soft contact lens (SCL) wear. Conclusion: There is evidence of a clear association between hard or soft contact lens wear and an increased risk of blepharoptosis. Patients wearing contact lenses should be informed of the risk of blepharoptosis, and a history of contact lens wear should be sought in all patients who have acquired blepharoptosis.
KECERDASAN BUATAN UNTUK MATA KECIL: TINJAUAN SISTEMATIS TERHADAP DEEP LEARNING DALAM MENGEVALUASI KATARAK PEDIATRIK Tjoeng, Eric; Annisa, Nur Devina
Majalah Oftalmologi Indonesia Vol 49 No S1 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/1ydhv934

Abstract

Background: Pediatric or congenital cataract (CC) is a leading cause of visual impairment and blindness in children worldwide. Deep learning (DL), a subfield of artificial intelligence, has the potential to enhance diagnosis, treatment, and outcomes in various medical fields. Research Objectives: summarize and evaluate the diagnostic and prediction capabilities of DL algorithms for CC. Methods: From 1st February to 25th March 2023, a literature search was conducted in databases such as PubMed, ScienceDirect, EMBASE, and EBSCO, as well as alternative sources such as Google Scholar. Search terms included “pediatric/congenital cataract”, “artificial intelligence", "deep learning", "convolutional neural network", “diagnosis”, "screening", "prediction" and other relevant synonyms. Quality assessment of studies were assessed based on CONSORT-AI and QUADAS-2. Outcomes extracted included accuracy, sensitivity, specificity, and area under the curve (AUC). Results: Out of 69 studies screened, five studies with different study designs, dataset sizes, and type of DL algorithms employed were included in the systematic review. Most studies employed DL to analyze slit-lamp images to diagnose CC, while one study utilized DL to predict existence of CC from several risk factors. In silico, most studies demonstrated high accuracy and validity of DL algorithms in detecting and predicting CC; however, DL algorithm is not as accurate in diagnosing CC when compared to human counterparts. These studies had limited generalizability given the homogenous population. Conclusion: DL shows potential as an adjunct tool for ophthalmologists to improve diagnosis and, therefore, treatment decisions for CC, particularly in remote and underdeveloped regions with limited medical resources.
HUBUNGAN UKURAN PUPIL DENGAN KELAINAN REFRAKSI PADA SINDROM METABOLIK MAUPUN NON SINDROM METABOLIK PADA POPULASI DI DESA KABUPATEN MALANG Aini, Kurrotul; Sulistyowati, Anny; Vierlia, Wino Vrieda
Majalah Oftalmologi Indonesia Vol 49 No S1 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/ha8fm564

Abstract

Purpose: This study aims to assess the relationships between pupil size and refractive errors in both metabolic syndrome and non-metabolic syndrome populations residing in rural areas of Malang. Methods: A descriptive study was carried out in 2019 across three villages in Malang districts. All attending participants underwent a comprehensive ocular examination, including pupil size assessment. Pupil abnormalities were defined as deviations from the normal diameter of 2-4 mm in bright light. Clinically relevant refractive errors included hyperopia (SphEq value ? 0.25 D), myopia (SphEq value ? -0.25 D), and astigmatism (cylinder ? 0.25 D). Blood samples gauged serum fasting glucose, high-density lipoprotein cholesterol, and triglyceride levels. Waist circumference, systolic, and diastolic blood pressure were measured. Metabolic Syndrome diagnosis followed the 2006 International Diabetes Foundation criteria. Participants were categorized into metabolic syndrome and non-metabolic syndrome groups. Results: The examination involved 953 participants, encompassing 944 right eyes and 942 left eyes. For the right eye, 434 eyes showed emmetropia, 252 exhibited myopia, 141 had hyperopia, and 117 presented astigmatism. Pupillary abnormalities were linked to astigmatism, but lacked significance (p = 0.893). The left eye results indicated 444 eyes with emmetropia, 244 with myopia, 138 with hyperopia, and 116 with astigmatism. Correlation with pupillary abnormalities yielded a non-significant p-value of 0.864. Pupil size outcomes in metabolic syndrome (499 eyes) and non-metabolic syndrome (454 eyes) were not significant (p = 0.649). Conclusion: Refractive error does not correlate with pupil size in metabolic syndrome and nonmetabolic syndrome.
INTRAVENOUS METHYLPREDNISOLONE EFFECTS ON RECTUS MUSCLES IN THYROID EYE DISEASE Murtadha, Milzan; Supartoto, Agus; Utomo, Purjanto Tepo; Dibyasakti, Banu Aji; Darajati, Irene Titin
Majalah Oftalmologi Indonesia Vol 49 No S1 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/7nrw4309

Abstract

Introduction & Objective: Intravenous methylprednisolone has been used in management of Thyroid Eye Diseases (TED) which was an autoimmune inflammatory disease of the orbital tissues and the eyes. Previous study has shown benefits of intravenous methylprednisolone therapy on TED but there was need of quantitative measure to assess the effect of intravenous methylprednisolone therapy on extraocular rectus muscles. This study aimed to report the effect of high-dose intravenous methylprednisolone pulse therapy on inferior, medial, superior, and lateral rectus muscles and providing data distribution of active TED before and after therapy. Methods: Retrospective analyses were used in the data collection of patients with active Thyroid Eye Disease (TED) underwent high-dose intravenous methylprednisolone pulse therapy regiment 500mg every week for six consecutive weeks at Sardjito Eye Centre between January 2022 and December 2022. Ophthalmological investigation and quantitative computed tomography (CT) scan of the orbit were performed before and after methylprednisolone pulse therapy and demographics data were presented in tables and graphs. Results: This study included 62 eyes of 31 patients (61,3% female) with mean age of 37.8±13.47 years old. The mean thickness of Superior Rectus (SR) muscle before therapy were 4.12±2.20 mm and significantly decreased to 3.70±1.54 mm post therapy. There was no significant difference in delta mean Inferior Rectus (?IR) -0.18±1.69 (p=0.381), Medial Rectus (?MR) -0.34±1.68 (p=0.116), and Lateral Rectus (?LR) -0.33±1.94 (p=0.188) Conclusion: The treatment of Thyroid Eye Disease (TED) with high dose intravenous corticosteroid is safe and effective in reducing extraocular muscle tissue thickness with minimal side effects. Keywords: Thyroid Eye Disease, Extraocular Muscle, Intravenous Methylprednisolone Therapy.

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