cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Dikki Miswanda
Contact Email
editorial.ijsp@gmail.com
Phone
+6281361821460
Journal Mail Official
editorial.ijsp@gmail.com
Editorial Address
Jl. Balai Desa No.10-16G, Kota Medan, Sumatera Utara 20148
Location
Kota medan,
Sumatera utara
INDONESIA
Indonesian Journal of Science and Pharmacy
Published by Pustaka Media Publishing
ISSN : -     EISSN : 30255244     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Indonesian Journal of Science and Pharmacy (IJSP) accepts scientific articles as original research articles, short communication, reviews, and mini-reviews from anyone without any discrimination, as long as they submit articles that meet scientific principles. Indonesian Journal of Science and Pharmacy publishes various scientific articles covering Science and Pharmacy, Pharmaceutical Sciences. The following are the field within the scope of Indonesian Journal of Science and Pharmacy: Chemistry, Biology, Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceuticals, Analytical Pharmacy-Medicinal Chemistry, Natural Product Development, Management Pharmacy, Clinical-Community Pharmacy, Microbiology Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 42 Documents
 1   2   3   4   5 
Green Synthesis of Copper Nanoparticles Using Syzygium polyanthum Extract and Their Antioxidant Potential via DPPH Assay Nasution, Shamila Sufi Aulia; Miswanda, Dikki; Ridwanto, Ridwanto; Dalimunthe, Gabena Indrayani
Indonesian Journal of Science and Pharmacy Vol. 3 No. 1 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v3i1.117

Abstract

Copper nanoparticles (CuNPs) have gained attention for their cost-effective synthesis and potent antioxidant properties, offering a promising approach to address the bioavailability challenges of herbal medicines. This study investigates the green synthesis of CuNPs using bay leaf (Syzygium polyanthum (Wight.) Walp.) extract as a bioreductor and evaluates their antioxidant activity via the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Bay leaf extract, rich in flavonoids and phenolic compounds, was prepared through heating extraction and mixed with copper nitrate (CuNO₃) at varying ratios (1:1, 1:2, 1:3, 1:4). The formation of CuNPs was confirmed by a color change from yellow to greenish-brown after 24 hours, with particle sizes ranging from 527.48 nm to 3256.81 nm, as determined by Particle Size Analysis (PSA). UV-Vis spectrophotometry verified the reduction of Cu⁺ ions, with Cu concentrations decreasing post-synthesis. The antioxidant activity of CuNPs exhibited an IC₅₀ value of 15.49 ppm, classified as very strong, compared to 72.09 ppm for the bay leaf extract alone (strong) and 13.82 ppm for vitamin C (very strong). These results demonstrate that bay leaf extract-mediated CuNPs possess enhanced antioxidant potential, highlighting the efficacy of green synthesis in producing bioactive nanoparticles for potential therapeutic applications.
Formulation and Evaluation of Pharmaceutical Suspensions Using Hemicellulose Extracted from Oil Palm Empty Fruit Bunches Savika, Anggraini; Miswanda, Dikki; Lubis, Minda Sari; Dalimunthe, Gabena Indrayani
Indonesian Journal of Science and Pharmacy Vol. 3 No. 1 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v3i1.113

Abstract

Oil palm empty fruit bunches (OPEFB), a major solid waste from palm oil processing, represent a rich source of lignocellulosic biomass that can be valorized into high-value bioproducts. This study aimed to isolate hemicellulose from OPEFB and evaluate its potential as a natural suspending agent in pharmaceutical suspension formulations, either alone or in combination with sodium carboxymethyl cellulose (CMC-Na). A series of formulations (F0–F5) were prepared and characterized for organoleptic properties, pH, density, viscosity, sedimentation volume, and redispersibility over seven days of storage. The results showed that suspensions containing OPEFB hemicellulose exhibited acceptable sensory characteristics, stable pH values (5–7), and densities above 1.00 g/mL. The addition of hemicellulose and CMC-Na significantly increased viscosity (up to 683.5 cP) and improved sedimentation stability, with sedimentation volumes reaching 0.22 and redispersibility up to 90% in formulations F2 and F3. These findings indicate a synergistic effect between hemicellulose and CMC-Na, enhancing suspension uniformity and preventing particle aggregation without compromising flowability. In conclusion, OPEFB-derived hemicellulose demonstrates excellent potential as a biodegradable and eco-friendly suspending agent for pharmaceutical suspensions. Its use not only improves formulation stability but also promotes the sustainable utilization of palm oil industry waste in green pharmaceutical product development. Oil palm empty fruit bunches (OPEFB), a major solid waste from palm oil processing, represent a rich source of lignocellulosic biomass that can be valorized into high-value bioproducts. This study aimed to isolate hemicellulose from OPEFB and evaluate its potential as a natural suspending agent in pharmaceutical suspension formulations, either alone or in combination with sodium carboxymethyl cellulose (CMC-Na). A series of formulations (F0–F5) were prepared and characterized for organoleptic properties, pH, density, viscosity, sedimentation volume, and redispersibility over seven days of storage. The results showed that suspensions containing OPEFB hemicellulose exhibited acceptable sensory characteristics, stable pH values (5–7), and densities above 1.00 g/mL. The addition of hemicellulose and CMC-Na significantly increased viscosity (up to 683.5 cP) and improved sedimentation stability, with sedimentation volumes reaching 0.22 and redispersibility up to 90% in formulations F2 and F3. These findings indicate a synergistic effect between hemicellulose and CMC-Na, enhancing suspension uniformity and preventing particle aggregation without compromising flowability. In conclusion, OPEFB-derived hemicellulose demonstrates excellent potential as a biodegradable and eco-friendly suspending agent for pharmaceutical suspensions. Its use not only improves formulation stability but also promotes the sustainable utilization of palm oil industry waste in green pharmaceutical product development.

Page 5 of 5 | Total Record : 42

 1   2   3   4   5 

Filter by Year

2023 2025


Reset
Filter By Issues
All Issue Vol. 3 No. 1 (2025): Indonesian Journal of Science and Pharmacy Vol. 2 No. 3 (2025): Indonesian Journal of Science and Pharmacy Vol. 2 No. 2 (2024): Indonesian Journal of Science and Pharmacy Vol. 2 No. 1 (2024): Indonesian Journal of Science and Pharmacy Vol. 1 No. 3 (2024): Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy Vol. 1 No. 1 (2023): Indonesian Journal of Science and Pharmacy