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INDONESIA
Indonesian Journal of Science and Pharmacy
Published by Pustaka Media Publishing
ISSN : -     EISSN : 30255244     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Indonesian Journal of Science and Pharmacy (IJSP) accepts scientific articles as original research articles, short communication, reviews, and mini-reviews from anyone without any discrimination, as long as they submit articles that meet scientific principles. Indonesian Journal of Science and Pharmacy publishes various scientific articles covering Science and Pharmacy, Pharmaceutical Sciences. The following are the field within the scope of Indonesian Journal of Science and Pharmacy: Chemistry, Biology, Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceuticals, Analytical Pharmacy-Medicinal Chemistry, Natural Product Development, Management Pharmacy, Clinical-Community Pharmacy, Microbiology Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 42 Documents
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Analysis of Antioxidant Activity of Curcumin Extract from White Turmeric (Curcuma zedoria) and Yellow Turmeric (Curcuma longa) Using Soxhletation Method Vivi Shofia; Anggraeni, Adek Bela; Nurlaila, Hamida
Indonesian Journal of Science and Pharmacy Vol. 1 No. 3 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i3.49

Abstract

Turmeric has been a staple in traditional medicine and cuisine in various countries. Tumeric contains the main bioactive compound, namely curcumin. Curcumin is recognized as antioxidants that can which donate one or more electrons to free radicals, effectively neutralizing them. The commonly used turmeric varieties are white turmeric (Curcuma zedoaria) and yellow turmeric (Curcuma longa). White turmeric is characterized by its white rhizome, while yellow turmeric has a yellow rhizome. Both varieties contain curcumin, but their antioxidant activities must be fully elucidated. The Soxhlet method is a common technique employed for curcumin extraction. This study investigated the antioxidant activity of white turmeric and yellow turmeric compared to vitamin C. The DPPH method was used to assess antioxidant activity. The findings revealed that white turmeric (Curcuma zedoaria) and yellow turmeric (Curcuma longa) extracts exhibited antioxidant activity with IC50 values of 12.39 µg/mL and 44.065 µg/mL, respectively. Conversely, vitamin C showed an IC50 value of 19.95 µg/mL. These results indicate that yellow turmeric curcumin extract possesses superior antioxidant activity compared to white turmeric and vitamin C, falling within the category of solid antioxidants with IC50 values below 50 µg/mL.
Knowledge, Attitudes, and Practices Regarding Smoking Prevention Among Students of Jakarta Global University Adina, Anugerah Budipratama; Zhafira, Bilqis; Indriani, Melis; Nopratilova, Nopratilova; Nugroho, Dedy
Indonesian Journal of Science and Pharmacy Vol. 2 No. 3 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i3.73

Abstract

ABSTRACT Students need to have good knowledge, attitudes, and behaviors regarding healthy living, particularly in avoiding smoking and understanding its dangers, to serve as positive role models for the broader community and younger generations. This study aims to assess the knowledge, attitudes, and practices (KAP) of students related to smoking habits at Jakarta Global University (JGU). The research method employed is a quantitative descriptive approach using an online survey with a questionnaire. The sample consisted of 105 respondents. The results indicate that, among the 105 respondents, the majority of students are aged 18 to 22 years (86.7%), with the largest proportion coming from the pharmacy department (43.8%). Students' knowledge about the dangers of smoking is fairly good, though there are challenges in enhancing precise understanding of the serious health risks associated with smoking. Attitudes show high confidence in the effectiveness of anti-smoking campaigns, with 67.6% of respondents believing that smoking has a very detrimental impact on health. Furthermore, preventive practices against smoking are also relatively high, with 64.8% of students supporting smoking cessation programs and replacing smoking habits with healthy activities. The conclusion of this study is that the knowledge, attitudes, and behaviors related to smoking among students are categorized as good. The findings underscore the importance of further education on effective smoking prevention, especially in the context of reducing health risks associated with smoking.
Antibacterial Activity Test of Ethanol, N-Hexane, and Ethyl Acetate Extracts of Lemon Peel (Citrus x limon (L.) Burm. f.) Nisa, Uswatun; Mambang, D Elysa Putri; Yuniarti, Rafita; Ridwanto, Ridwanto
Indonesian Journal of Science and Pharmacy Vol. 2 No. 3 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i3.88

Abstract

Staphylococcus hominis and Pseudomonas aeruginosa bacteria are normal flora bacteria found on the surface of human skin, and in certain circumstances can cause infections in the body of a person with a weak immune system. Infection of both bacteria can cause body odor that can affect a person's social relationships. The use of natural antibacterials has minimal side effects, namely lemon peel which is waste from lemons. Lemon juice is commonly used by the public, but not many people know that lemon peel has great benefits like lemon juice. The objective of the research was to determine the chemical compounds contained in the n-hexane fraction, ethyl acetate of lemon peel and antibacterial activity in ethanol extract, n-hexane fraction, ethyl acetate of lemon peel (Citrus x limon (L.) Burm. f.) This research method was an experimental method that includes sample collection and processing, characterization of simple drugs, preparation of 96% ethanol extract, n-hexane fraction, ethyl acetate fraction, phytochemical screening, and antibacterial activity test using the agar diffusion method at concentrations of 10%, 20%, 30%, 40%, 50%. The results of phytochemical screening in the ethyl acetate fraction contain alkaloids, flavonoids, tannins, triterpenoids, and in the n-hexane fraction shows the presence of triterpenoid chemical compounds. Ethanol extract, n-hexane fraction and ethyl acetate fraction of lemon peel have antibacterial activity on Staphylococcus hominis and Pseudomonas aeruginosa bacteria. The results of the three samples tested for the greatest inhibitory power in the ethyl acetate fraction showed intermediate results, almost comparable to the inhibitory power of the positive control ciprofloxacin.
Evaluation of Butterfly Pea (Clitoria ternatea L) Extract Gel as an Antibacterial Agent Against Staphylococcus epidermidis Asia, Nur; Lubis, Minda Sari; Yuniarti, Rafita; Dalimunthe, Gabena Indrayani
Indonesian Journal of Science and Pharmacy Vol. 2 No. 3 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i3.89

Abstract

Acne vulgaris is a common dermatological condition, particularly prevalent among adolescents and young adults. This condition is influenced by several factors, including excessive sebum production, abnormal keratinization, inflammation, and colonization of microorganisms such as Staphylococcus epidermidis within the pilosebaceous follicles. This study aims to develop a gel formulation containing butterfly pea (Clitoria ternatea) extract that meets the physical quality standards of the Indonesian National Standard (SNI) and exhibits antibacterial activity against Staphylococcus epidermidis. The research involved purposive sampling of butterfly pea flowers from Medan City, followed by extraction and phytochemical screening to identify secondary metabolites. Four gel formulations were prepared using carbopol as the base: F0 (without extract), F1 (0.1% extract), F2 (3% extract), and F3 (5% extract). The formulations were evaluated for organoleptic properties, homogeneity, pH, spreadability, viscosity, physical stability through cycling tests, and antibacterial activity against Staphylococcus epidermidis. Phytochemical screening of the extract revealed the presence of alkaloids, tannins, flavonoids, saponins, triterpenoids, and glycosides, indicating the extract's potential antibacterial properties. The butterfly pea extract was successfully formulated into a gel that met acceptable quality standards using carbopol 940 as the gelling agent. Antibacterial tests demonstrated that the formulated gel exhibited inhibitory activity against Staphylococcus epidermidis.
Antibacterial Activity Test of Ethanol Extract, n-Hexane and Ethyl Acetate Fractions of Cardamom Fruit (Amomum cardamomum Soland. Ex Maton Benth) Nada, Dina Qatrun; Mambang, D Elysa Putri; Nasution, M. Amin; Ridwanto, Ridwanto
Indonesian Journal of Science and Pharmacy Vol. 2 No. 3 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i3.96

Abstract

Bacterial infection is a global health problem that requires special attention, especially due to increasing resistance to antibiotics. This study aims to determine the antibacterial activity of ethanol extract, n-hexane fraction and ethyl acetate fraction of cardamom fruit (Amomum cardamomum Soland. Ex Maton Benth) against Streptococcus pyogenes and Pseudomonas aeruginosa bacteria. The extraction was done by percolation using 96% ethanol, followed by fractionation using n-hexane and ethyl acetate solvents. Phytochemical screening tests showed the presence of alkaloid, flavonoid, tannin, and saponin compounds known to have antibacterial activity. Antibacterial activity test was conducted using disc diffusion method with five concentrations (10%-50%). The results showed that the ethyl acetate fraction had the greatest inhibition, with the highest inhibition zone against Streptococcus pyogenes of 14.1 mm and Pseudomonas aeruginosa of 16.8 mm at 50% concentration. Inhibition increased with increasing concentration. The ethyl acetate fraction proved to be the most effective because it contains semipolar compounds that are able to penetrate the bacterial cell wall. This study supports the potential of cardamom fruit as an alternative natural antibacterial agent.
Antibactery Activity of Etyl Asetate Fraction of Etanol Extract of Pala Leaf (Myristica Fragrans) and Lidah Buaya Leaf (Aloe Vera) Against Streptococcus Mutans Awanis, Safirah; Mambang, D Elysa Putri; Yuniarti, Rafita; Nasution, Muhammad Amin
Indonesian Journal of Science and Pharmacy Vol. 2 No. 3 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i3.97

Abstract

Caries is a progressive chronic hard tissue disease of the teeth caused by the action of microorganisms. The bacteria that causes this disease is Streptococcus mutans. Nutmeg leaves (Myristica fragrans) and aloe vera leaves (Aloe vera) can potentially overcome diseases and health problems. This study was to determine the antibacterial activity of n-hexane fraction, ethyl acetate, ethanol extract of  nutmeg leaf and aloe vera leaf in Streptococcus mutans and to determine the effect of n-hexane fraction, ethyl acetate, ethanol extract of the antibacterial of nutmeg leaf and aloe vera leaf. The method uses was an experimental method with phytochemical screening, then manufacture of ethanol extracts of nutmeg leaves and aloe vera leaves, then fractionated with ethyl acetate solvent, then testes for antibacterial activity against Streptococcus mutans by the agar diffusion method. The results of the antibacterial activity test of the ethyl acetate fraction of nutmeg leaves showed the diamete of the inhibition zones at concentrations of 50%, 40%, 30%, 20%, and 10% were obtaines with inhibition zones of 16.2 mm, 15.46 mm, 15.2 mm, 12.26 mm and 11.76 mm. The test results on aloe vera leaf ethanol extract at concentrations of 50%, 40%, 30%, 20%, and 10 % were obtained with inhibition zones of 16.53 mm, 15.13 mm, 14.3 mm, 11,5 mm, and 11.3 mm. From the results of the study, it can be concluded that simplisia, ethanol extract, ethyl acetate fraction, n-hexane nutmeg leaf and aloe vera leaf contain secondary metabolites that act as antibacterial. The antibacterial activty of ethyl acetate fraction of nutmeg leaves was highest at a concentratioan of 50% with an inhibition zone of 16.2 mm and the antibacterial activity of aloe vera leaf ethanol extract was highest at a concentration of 50% with an inhibition zone of 16.53 mm in Streptococcus mutans which can be categorized as having strong inhibitory power.
Determination of Total Flavonoid Content of Ethanol Extract and Ethyl Acetate Fraction of Avocado Seed (Persea americana Mill) by Visible Spectrofotometry Methods Natasya, Siti Adinda; Nasution, M. Pandapotan; Nasution, Haris Munandar; Yuniarti, Rafita
Indonesian Journal of Science and Pharmacy Vol. 2 No. 3 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i3.98

Abstract

Avocado (Persea americana Mill.) has long been used in traditional medicine, and its seeds are known to contain flavonoid compounds, which are natural phenolics with antioxidant properties and potential therapeutic benefits. This study aims to identify the chemical compounds present in the ethanol extract and ethyl acetate fraction of avocado seeds, and to determine their total flavonoid content using UV-Visible spectrophotometry. This experimental study included sample collection, simplicia characterization, extraction, fractionation, phytochemical screening, and flavonoid quantification. Phytochemical screening showed that the ethanol extract contains alkaloids, flavonoids, tannins, saponins, triterpenoids, and glycosides, while the ethyl acetate fraction contains alkaloids, flavonoids, tannins, steroids, and glycosides. Flavonoid content was determined using quercetin as a standard. The results showed that the total flavonoid content in the ethanol extract was 8.655 ± 0.144 mgQE/g, while the ethyl acetate fraction contained 32.828 ± 0.105 mgQE/g. It can be concluded that the ethyl acetate fraction contains a significantly higher level of flavonoids compared to the ethanol extract.
Determination of Blood Lead Levels in Drivers at Marunda Terminal, North Jakarta, Using ICP-MS Utama, Aditiya Tri; Sari, Elfira Maya; Amelia, Ria
Indonesian Journal of Science and Pharmacy Vol. 3 No. 1 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v3i1.104

Abstract

One of the elements that has the biggest impact of air pollution is lead. Lead can be contaminated through the air, one of which is produced by burning vehicles and releasing lead oxide in the form of dust or particles that can be inhaled into the human respiratory tract. The duration of lead exposure affects air pollution which can harm human health. The aim of this research was to determine blood lead levels in truck drivers in a section of Marunda terminal North Jakarta using the ICP-MS method. ICP-MS has multi-element analysis capabilities and high sensitivity compared to other techniques. This type of research is quantitative descriptive with a cross-sectional research design and data collection using purposive sampling, data collection was carried out in June 2023. Lead examination was carried out at the DKI Jakarta Regional Health Laboratory. The type of specimen used is human blood. Blood samples were collected using an EDTA tube and then measured using an ICP-MS device. The results showed that 17 respondents had lead levels < 2.28 µg/L. Blood lead levels in truck drivers in a section of Marunda terminal North Jakarta were not detected. This shows that there is no lead content in the blood.
Formulation and Evaluation of Hydrocarbon Ointment from 96% Ethanol Extract of Red Tender Leaves (Syzygium myrtifolium Walp.) Stiyani, Rintika Isa; Mutripah, Siti; Rahayu, Nila Rusdi; Badriyah, Lailatul; Alfiza, Ibnu Syinna
Indonesian Journal of Science and Pharmacy Vol. 3 No. 1 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v3i1.105

Abstract

Red Shoot Leaf (Syzigium myrtifolium Walp) has chemical compounds of alkaloids, steroids, triterpenoids, flavonoids, phenolics, and saponins, and has the antibacterial effect of Staphylococcus aureus. This study aims to find out whether Red Shoot leaf extract can be formulated in ointment preparations with hydrocarbon bases and determine the opimal formulation based on physical evaluation. The research was conducted using an experimental method.  Red Shoot leaf extract (Syzigium myrtifolium Walp) was obtained by maceration using 96% ethanol solvent. The extract is formulated into an ointment preparation with three different formulas, namely formula 1 with a variation in the concentration of cera alba 4%, formula 2 with a concentration of cera alba 8% and formula 3 with a concentration of cera alba 12%. The results of the ointment preparations were then evaluated organoleptically, homogeneity, pH, and dispersibility. Based on the results obtained in the spreadability test, it has decreased. The preparation that has the greatest dispersion is found in formula I where the concentration of cera alba used is 4%, while the lowest dispersion is found in formula III with a concentration of cera alba of 12%. Meanwhile, judging from the evaluation of organoleptic, homogeneity, and pH, the three formulas have met the requirements. It can be concluded that 96% ethanol extract of Red Shoot leaves (Syzigium myrtifolium Walp) can be formulated into hydrocarbon ointment preparations and meet the optimal formula requirements, namely 4% and 8% alba cera concentrations.
Formulation and Evaluation of Sustained-Release Tablets of Jatropha curcas L. Leaf Extract Using HPMC and Xanthan Gum Matrix for Antihypertensive Therapy Maghfirah, Suci; Puteri, Cut Intan Annisa; Dalimunthe, Gabena Indrayani; Lubis, Minda Sari
Indonesian Journal of Science and Pharmacy Vol. 3 No. 1 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v3i1.100

Abstract

The development of pharmaceutical technology has enabled the formulation of sustained-release tablets to improve therapeutic efficacy and patient compliance in antihypertensive therapy. This study aimed to evaluate the potential of Jatropha curcas L. leaf extract as an active ingredient in sustained-release tablets using hydroxypropyl methylcellulose (HPMC) and xanthan gum as matrix-forming polymers. The extract was obtained by maceration with 96% ethanol, and tablets were prepared using the wet granulation method. Granule flow properties and tablet physical characteristics (organoleptic properties, weight uniformity, size uniformity, hardness, friability, and disintegration time) were assessed, followed by dissolution studies in simulated gastric fluid (pH 1.2), intestinal fluid (pH 4.5), and intestinal fluid (pH 7.4). Results showed that all formulations met pharmacopeial requirements. Formula III, containing HPMC and xanthan gum in a 2:1 ratio, demonstrated the longest disintegration time (113 minutes) and the slowest drug release profile (54.80% within 480 minutes). These findings suggest that this formulation has the potential to serve as an optimal sustained-release tablet of Jatropha curcas L. extract for antihypertensive therapy.

Page 4 of 5 | Total Record : 42

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