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INDONESIA
Indonesian Journal of Science and Pharmacy
Published by Pustaka Media Publishing
ISSN : -     EISSN : 30255244     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Indonesian Journal of Science and Pharmacy (IJSP) accepts scientific articles as original research articles, short communication, reviews, and mini-reviews from anyone without any discrimination, as long as they submit articles that meet scientific principles. Indonesian Journal of Science and Pharmacy publishes various scientific articles covering Science and Pharmacy, Pharmaceutical Sciences. The following are the field within the scope of Indonesian Journal of Science and Pharmacy: Chemistry, Biology, Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceuticals, Analytical Pharmacy-Medicinal Chemistry, Natural Product Development, Management Pharmacy, Clinical-Community Pharmacy, Microbiology Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 42 Documents
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Cytotoxicity Test of Ethanol Extract of Herb Sintrong (Crassocephalum crepidioides (Benth.) S. Moore) Against Artemia Salina Leach Shrimp Larvae Using the BSLT Method Tambupolon, Sanya Tanika; Ridwanto, Ridwanto
Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i2.33

Abstract

Cancer is a disease that arises as a result of an error in the division system at the cell level resulting in abnormal cell growth with a continuous, uncontrolled growth rate that can change shape and spread to other organs or is called metastasis. One of the plants that has the potential as an anticancer is the herb sintrong (Crassocephalum crepidiodes (Benth.) S. Moore). The purpose of this study was to determine the class of secondary metabolites contained in the powder and ethanol extract of the herb sintrong (Crassocephalum crepidioides (benth.) S. Moore) and its cytotoxicity by looking at the LC50 value using the Brine Shrimp Lethality Test (BSLT) method.Cytotoxicity testing was carried out using the BSLT method with Artemia salina Leach shrimp larvae as test animals with concentrations of 100-1000 µg/mL, with negative control without added extract. The LC50 value was analyzed using a straight line regression equation by entering data on the probit value and the logarithm of the concentration.The secondary metabolite compounds contained in sintrong herb (Crassocephalum crepidiodes (Benth.) S. Moore) using the phytochemical screening method are flavonoids, alkaloids, tannins, saponins and steroids. Based on the results of the toxicity test using the Brine Shrimp Lethality Test (BSLT) method, the LC50 value = 295.3800 µg/mL showed that the sintrong herb extract is toxic and has the potential as an anticancer. The test compound is said to be toxic if the LC50 value is ˂1000 µg/mL.
The Formulation Cream Of Black Cumin Seed Oil (Nigella sativa Linn.) Utami, Dinda Sari; Lubis, Minda Sari; Meilani, Debi
Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i2.38

Abstract

Indonesia is rich in natural resources, has done a lot of research on the utilization of natural materials. Nigella sativa Linn. or in Indonesia known black jintan has pain relieving or analgesic and anti-inflammatory properties. The aim of this study is to determine the antinyeri effect of black ginger oil on white male rats by plantar test method. Black ginger seed oil is standardized and performed test effectiveness, then black gender oil is made cream with concentrations of 5ml, 10ml, and 20ml. Observations were performed for the occurrence of muscle antinyeri every 15 minutes during the time the plantar test device stopped when the mice licked their legs and hands.The test results of the standardization of black geranium seed oil obtained type weight in black germanium oil 0.958 g/ml, water content 0.000056%, and acid count 39.97 ml/g. Physical quality test results the preparation of the cream no bruising with the oil emulsion type in water that is easily washed with water as well as pH adjusted with the skin with range 7.3-7.6 and the cream does not undergo color change, shape and rupture emulsions.
Simultaneous Solubility Analysis of Paracetamol, Propyphenazone, and Caffeine Using Principal Component and Absorbance Ratio Regression Methods Rosaldi, Hikmah; Pulungan, Ainil Fithri; Ridwanto, Ridwanto; Daulay, Anny Sartika
Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i2.39

Abstract

Medicines can cause changes in the physiology or psychology of an organism when consumed. In general, medicines consist of several mixtures of active ingredients such as paracetamol (PCT), propifenazone (PRO), and caffeine (KAF), which are often found in several types of branded medicines that are claimed to be able to cure or treat. This research aims to obtain a type of solvent that has the smallest photometric error value and can completely dissolve the active ingredient mixture of PCT, PRO, and KAF. In general, organic solvents such as ethanol and methanol are very often used to dissolve compounds that mix with each other, but these solvents cannot always dissolve other active substances. Therefore, researchers carried out an analysis of several types of solvents that could dissolve the three active ingredients. Solvents that can dissolve perfectly without any specification stage must go through a solvent optimization process. The types of solvents that will be tested are methanol, HCl 0.1N, phosphate buffer pH 7.2, and the ratio of phosphate buffer: methanol (DM) (DM 9:1 pH 7.4), (DM 7:3 pH 7.8), (DM 5:5 pH 8.3), (DM 3:7 pH 8.9), and (DM 1:9 pH 9.6). The results of this research show that the solvent that has the smallest photometric error value and can completely dissolve the three active substances is the DM 7:3 pH 7.8 solvent with a total percentage of 0.0846%, which is the smallest value compared to other solvents that have been optimized.
Characterization and Phytochemical Screening Of Tampala Bajakah Wood (Spatholobus littoralis Hassk) Extract With Methanol and Ethyl Acetate Solvents Alviana, Liya; Ridwanto, Ridwanto; Daulay, Anny Sartika; Rani, Zulmai
Indonesian Journal of Science and Pharmacy Vol. 1 No. 3 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i3.40

Abstract

One of the plants that contains secondary metabolite compounds is Bajakah Tampala wood (Spatholobus littoralis Hassk). The aim of this research is to determine the chemical compounds contained in methanol and ethyl acetate extracts. The stages of this research include processing plant materials, making methanol and ethyl acetate extracts, characterization examinations, and phytochemical screening. Bajakah Tampala wood extract was made using the maceration method using methanol and ethyl acetate. The extract obtained was concentrated using a rotary evaporator. The characterization of Bajakah Tampala sawdust showed that the water content test was 2%, the water soluble juice content test was 7.1%, the ethanol soluble juice content test was 12.05%, the total ash content test was 3.65%. , and testing the ash content that is insoluble in acid was 0.1%. Meanwhile, the results of the phytochemical screening of Bajakah Tampala wood showed that it contained chemical compounds such as alkaloids, flavonoids, saponins, tannins, and steroids and triterpenoids.
Isolation of Chitosan from Lake Toba Freshwater Lobster Shells (Cherax quadricarinatus) Sinaga, Novita Yulianti; Ridwanto, Ridwanto; Daulay, Anny Sartika; Nasution, Haris Munandar
Indonesian Journal of Science and Pharmacy Vol. 1 No. 3 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i3.41

Abstract

Chitosan is an amine polysaccharide that is formed after chitin undergoes a deacetylation process. This compound has a significant role as a natural biopolymer which is polycationic. This research aims to make chitosan from freshwater lobster shells obtained from Lake Toba. The research method is experimental. Includes making chitosan from freshwater lobster shells. The process of making chitosan includes demineralization, deproteination and deacetylation stages. Chitosan was characterized by measuring water content, ash content, yield, solubility, and analysis using an FTIR spectrophotometer. Based on the results of research that has been carried out, it was found that the characteristics of chitosan have a yield value of 50.88%, water content 5.9%, ash content 0.67% and chitosan dissolves in glacial acetic acid. The results of the research show that chitosan has similar functional groups to standard chitosan and the degree of deacetylation is 80.25%. This research has met the chitosan standard (SNI 7949:2013) with a percentage of the degree of deacetylation of chitosan that meets the standard (>60%).
Antibacterial Activity Of Freshwater Lobster Shells (Cherax quadricarinatus) Against Escherichia coli Hafizha, Putri; Ridwanto, Ridwanto; Daulay, Anny Sartika; Nasution, Haris Munandar
Indonesian Journal of Science and Pharmacy Vol. 1 No. 3 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i3.42

Abstract

People still do not utilize freshwater lobster (Cherax quadricarinatus) shells optimally, even though the chitin compound contained in this waste can be modified into chitosan through chemical reactions. Chitosan obtained from freshwater lobster shells can be used as an antibacterial. This study aims to test the antibacterial activity of chitosan from freshwater lobster shell waste against Escherichia coli bacteria. Making chitosan is carried out through three processes, namely, demineralization, deproteination, and deacetylation stages. Then, characterization of the chitosan is carried out, which includes water content, ash content, yield, and solubility. The research results showed that the chitosan obtained in this study was 43.96%, and the degree of deacetylation value of freshwater lobster shell chitosan was 75.11%. Chitosan with a concentration of 0.3, 0.5, 0.7, and 0.9% provides an inhibition zone of 13.5, 15.9, 16.8, and 17.2 mm, respectively, against Escherichia coli. Thus, a concentration of 0.9% chitosan from freshwater lobster shells has better antibacterial activity and is categorized as having strong inhibitory power.
Isolation and Characterization of Chitosan from Kepah Shell Waste (Polymesoda erosa) Percut Sei Tuan, North Sumatera Sitorus, Dara Indah; Ridwanto, Ridwanto
Indonesian Journal of Science and Pharmacy Vol. 1 No. 3 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i3.43

Abstract

Kepah clams (Polymesoda erosa) are one of the few aquatic animals that have a body and are protected by two cupped shells. Many people consume this shellfish meat, but many of the shells are thrown away by local people so that they only become waste. It is this shell waste that needs to be processed properly because it is known that shells are one of the fishery ingredients that contain chitin. One way to make kepah clams have a higher economic value is by isolating kepah clams into chitosan. The purpose of this study was to isolate and characterize chitosan from mussel shells and to determine functional groups using Fourier infrared (FTIR). The isolation methods used were deproteination, demineralization, depigmentation, deacetylation, and chitosan characterization. The results showed that the yield of the transformation of chitin into chitosan in cockles was 85.77% and had a brownish-white powder texture and no odor. The water content in the chitosan of the clam shells obtained was 1.53%, the ash content was 0.50%, and the degree of deacetylation obtained was 75%.
Antibacterial Activity of Kaffir Lime Leaf (Citrus hystrix DC) Ethanol Extract against Staphylococcus aureus and Escherichia coli Azhar, Gustika; Ridwanto, Ridwanto; Nasution, Haris Munandar; Pulungan, Ainil Fithri; Rani, Zulmai
Indonesian Journal of Science and Pharmacy Vol. 2 No. 1 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i1.48

Abstract

The use of herbal medicine has been increasing, which encourages researchers to use herbal materials as an alternative antibacterial, one of which is the kaffir lime leaf plant. This study was to identify the group of secondary metabolite compounds and examine the antibacterial properties of ethanol extract of kaffir lime leaves (Citrus hystrix DC) against Staphylococcus aureus and Escherichia coli bacteria. This study began with the preparation of simplisia powder, extracting kaffir lime leaf with ethanol, and the antibacterial activity test of extracts. The results of the study showed that the secondary metabolites contained in kaffir lime leaves are alkaloids, flavonoids, saponins, tannins, steroids and glycosides. Antibacterial activity test on Staphylococcus aureus bacteria showed that the ethanol extract of kaffir lime leaves with the best concentration inhibited the bacterial inhibition zone at a concentration of 10% with an inhibition diameter of 22.21 mm with a very strong category dan the best concentration is 10% with an inhibition diameter of 20.48 mm with a very strong category for Escherichia coli bacteria. Ethanol extract of Kaffir Lime leaves has been proven to inhibit Staphylococcus aureus and Escherichia coli bacteria.
The Effect of Adding Ethanol Extract of Pomegranate Peel (Punica Granatum L.) on the Sun Protection Factor (SPF) Value of Sunscreen Cream Combination of Avobenzone and Octyl Methoxycinnamate Julianty, Siti Muliani; Ginting, Ernawaty; Sudewi, Sudewi; Rizki, Fanny; Nadia, Syarifah; Saputri, Muharni
Indonesian Journal of Science and Pharmacy Vol. 2 No. 1 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i1.57

Abstract

The compounds contained in pomegranate skin are phenolic acids, flavonoids, and tannins, including anthocyanidin, gallic acid, ellagic acid, ellagitannin, gallotanin, catechin, quercetin, which have antioxidant properties. The benefits of pomegranate peels are that they treat health problems and maintain beautiful skin. This research aimed to see the effect of adding pomegranate peel (Punica granatum L.) ethanol extract on the Sun Protection Factor (SPF) value of a combination of avobenzone and octyl methoxycinnamate sunscreen cream. This research was carried out using experimental methods. The formulation of sunscreen cream preparations uses pomegranate peel ethanol extract in various concentrations. The cream was evaluated to determine its Sun Protection Factor (SPF) value, organoleptic test, homogeneity, pH, emulsion type, and irritation test. The organoleptic test results showed that the cream produced in the blank had no odor and was white, while the cream with the addition of pomegranate peel ethanol extract had a distinctive smell and was brown. The emulsion type test shows the oil in the water type.  The addition of pomegranate peel ethanol extract to each formula increased the sun protection factor (SPF) value of sunscreen preparations. The average SPF value of each formula was FI 12.5956, FII 13.9673, FIII 16 .8205, FIV 17.9187, and FV 18.8437.
Formulation and Evaluation of Solid Dispersion Griseofulvin Tablets Karima, Nurul
Indonesian Journal of Science and Pharmacy Vol. 2 No. 1 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i1.60

Abstract

Griseofulvin is one of the systemic treatments for the treatment of dermatophytes found on the skin, scalp and nails. Griseofulvin is a BCS class II group that has low solubility and high permeability. Increasing solubility is one of them by using a solid dispersion system. In this study, the solid dispersion obtained was formulated in tablet form. The purpose of this study was to increase the solubility of griseofulvin. The method used was experimental, solid dispersion using PEG 6000 as a carrier, with XRD, SEM, and FTIR test parameters. Furthermore, the solid dispersion obtained was formulated in tablet form and tablet characteristics were tested, namely: preformulation test, hardness test, friability test, disintegration time test, and dissolution test. The results of the test of the characteristics of solid dispersion griseofulvin tablets met the requirements. The results of the dissolution test showed that griseofulvin tablets showed a higher cumulative percentage compared to conventional tablets, namely at 90 minutes the cumulative percentage was 88.81%.

Page 2 of 5 | Total Record : 42

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