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INDONESIA
Indonesian Journal of Science and Pharmacy
Published by Pustaka Media Publishing
ISSN : -     EISSN : 30255244     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Indonesian Journal of Science and Pharmacy (IJSP) accepts scientific articles as original research articles, short communication, reviews, and mini-reviews from anyone without any discrimination, as long as they submit articles that meet scientific principles. Indonesian Journal of Science and Pharmacy publishes various scientific articles covering Science and Pharmacy, Pharmaceutical Sciences. The following are the field within the scope of Indonesian Journal of Science and Pharmacy: Chemistry, Biology, Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceuticals, Analytical Pharmacy-Medicinal Chemistry, Natural Product Development, Management Pharmacy, Clinical-Community Pharmacy, Microbiology Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 42 Documents
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Antibacterial Activity of Ethanol Extracts of N-hexane and Ethyl Acetate Fractions from Nutmeg Leaves (Myristica fragrans) on Shigella dysenteriae and Streptococcus pyogenes Sunita, Della; Mambang, D Elysa Putri; Pulungan, Ainil Fithri; Yuniarti, Rafita
Indonesian Journal of Science and Pharmacy Vol. 2 No. 1 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i1.61

Abstract

Nutmeg leaves (Myristica fragrans) have been known as a traditional medicinal plant with properties as a pain reliever, anti-inflammatory, digestive and respiratory smoothener, and antibacterial. This study aims to determine the antibacterial activity of ethanol extract, n-hexane fraction, and ethyl acetate fraction of nutmeg leaves against Shigella dysenteriae and Streptococcus pyogenes. Ethanol extract of nutmeg leaves was made by maceration method with 96% ethanol solvent and fractionated using n-hexane and ethyl acetate solvents. Antibacterial activity test against Shigella dysenteriae and Streptococcus pyogenes was carried out using the agar diffusion method. The results showed that the ethyl acetate fraction of nutmeg leaf extract produced a larger inhibition zone diameter compared to the n-hexane fraction of nutmeg leaf extract, which was 16.6 mm at a concentration of 50% for Shigella dysenteriae bacteria and 18.1 mm at a concentration of 50% for Streptococcus pyogenes bacteria, which was classified as moderate. Based on this study, the ethyl acetate fraction of nutmeg leaf extract had the best antibacterial activity against Shigella dysenteriae and Streptococcus pyogenes.
Determination of Total Flavonoid of Ethanol Extract of Pegagan Leaves (Centella asiatica (L.) Urb) Using Maceration and Soxhletation Methods Wahyudi, Muhammad; Manik, Umi Chairani; Ridwanto, Ridwanto; Daulay, Anny Sartika; Rahmadani, Rahmadani
Indonesian Journal of Science and Pharmacy Vol. 2 No. 1 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i1.63

Abstract

A study was conducted to determine the total flavonoid content of ethanol extract of pegagan leaves (Centella asiatica (L.) Urb) using maceration and soxhletation methods. The study began with the preparation of pegagan leaf simplicia and its characterization, preparation of ethanol extract by maceration and soxhletation, phytochemical screening and determination of total flavonoid content of ethanol extract of pegagan leaves using visible spectrophotometry method. The results of phytochemical screening of ethanol extract of pegagan leaves indicated the presence of alkaloid, flavonoid, saponin, tannin, steroid/triterpenoid and glycoside compounds. The results of determining the total flavonoid content in ethanol solvent extract by maceration were 31.6416±0.1534 mgQE/g and ethanol solvent extract by soxhletation were 20.832±0.0514 mgQE/g. Extraction of pegagan leaves by maceration method was more effective than soxhletation method.
Toxicity Test Of Ethanol Extract Of Pletekan Leaves (Ruellia tuberosa L) Using The Brine Shrimp Lethality Test (BSLT) Method Fajri, Fajrilda Aqilah; ridwanto, ridwanto; Pulungan, Ainil Fithri; Rani, Zulmai
Indonesian Journal of Science and Pharmacy Vol. 2 No. 1 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i1.71

Abstract

The pletekan plant (Ruellia tuberosa L.) is a family of Acanthaceae Ruellia tuberosa L.) one of the plants used as a medicinal plant, especially the leaves, have been used empirically for therapy as a diuretic, antidiabetic, antihypertensive. Also used in the treatment of syphilis, kidney stones, cancer, heart disease, colds, hypertension and digestive problems. The purpose of this study was to determine the toxicity by determining the LC50 in the ethanol extract of pletekan leaves (Ruellia tuberosa L). The analysis carried out was a toxicity test on the ethanol extract of pletekan leaves against Artemia Salina Leach shrimp larvae using the BSLT method with various concentrations, namely 10, 15, 20, 25, 30, 35, and 40 ppm and determining the LC50 value with probit analysis. Based on the results of the toxicity test, the LC50 value was 96.4595 µg/Ml. These results show that the ethanol extract of pletekan leaves (Ruellia tuberosa L) has a toxic effect on Artemia Salina Leach shrimp larvae.
Formulation of Transparent Solid Soap Using Aloe Vera Leaf Flesh (Aloe vera (L.) Burm.f.) as Antioxidant Ritonga, Oktavia; Lubis, Minda Sari; Dalimunthe, Gabena Indrayani; Yuniarti, Rafita
Indonesian Journal of Science and Pharmacy Vol. 2 No. 2 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i2.75

Abstract

Aloe vera is a plant whose components have many benefits, aloe vera also functions as an antioxidant that can ward off free radicals. The purpose of this study was to determine transparent soap with variations in aloe vera concentration that meet the physical quality of transparent soap and to determine antioxidant activity after formulation. This research uses an experimental method. In this study, aloe vera was formulated in the form of transparent soap. The physical evaluation carried out includes organoleptic test, water content test, pH test, foam height test and antioxidant activity test. Based on the results of the study it is known that. Antioxidant activity test of aloe vera leaf meat has antioxidant activity classified as moderate with IC50 108 µg/ml, while the activity of transparent soap using aloe vera has antioxidant activity classified as very weak with IC50 obtained for F0 of 980.2290, F1: 482.3775, F2: 464.7310, F3: 407.5596 µg/ml. The conclusion of this study is that transparent soap using aloe vera meets the requirements of visual quality evaluation according to SNI and has antioxidant activity with a very weak category.
Transparent Soap Formulation from Soursop Fruit Juice (Annona muricata L.) as a Skin Moisturizer Maysarah, Aulya; Yuniarti, Rafita
Indonesian Journal of Science and Pharmacy Vol. 2 No. 2 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i2.78

Abstract

Transparent soap preparation formulation from soursop fruit juice (Annona muricata L.) as a skin moisturizer has been carried out. Soursop fruit juice is known to have a high polyphenol compound content and contains a lot of vitamin C which has antioxidant activity. Transparent soap formulation uses soursop fruit juice with concentrations of 20, 30, and 40. Evaluation of transparent soap formulation includes organoleptic tests, water content, foam height, irritation, humidity and preference or hedonic. The results of the moisture test on the blank obtained a difference of 0.66%, while in formula I there was a difference of 4.33%, in formula II there was a difference of 5%, and in formula III there was a difference of 8.66%. The results of the moisture test on the skin showed that the highest humidity was obtained in the formula with a concentration of 40% there was a difference of 8.66%. Transparent soap from soursop fruit juice in the water content test, foam height, and pH test had results that met the requirements according to SNI (Indonesian National Standard). The conclusion of this study is that soursop juice can be formulated into transparent soap and meets SNI requirements.
Antioxidant Activity Evaluation of Carrot (Daucus carota L.) Extract-Enriched Lip Balm: A Natural Approach for Lip Protection Hilmia Lukman; Vivi Shofia; Salsabila, Shinta Nova; Maysaroh, Titis
Indonesian Journal of Science and Pharmacy Vol. 2 No. 2 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i2.79

Abstract

Lips are a part of the body that is vulnerable to free radicals and UV radiation, thus requiring special protection. One effort to protect the lips is through the use of lip balm containing antioxidants. However, synthetic antioxidants in cosmetics can pose health risks, necessitating natural alternatives. This study aims to develop and evaluate lip balm based on carrot extract (Daucus carota L.) as a source of natural antioxidants. The methods used include carrot extraction using the reflux method with 96% ethanol, lip balm formulation with varying concentrations of extract (10%, 15%, and 20%), and antioxidant activity testing using the DPPH method with UV-Vis spectrophotometry. The results showed that lip balm containing carrot extract exhibited good physical characteristics, including homogeneity, color variation depending on the extract concentration, and pH within the suitable range for lip cosmetics (4.5–6.5). Antioxidant testing revealed that the higher the concentration of carrot extract, the greater the antioxidant activity, as indicated by IC50 values of 5.9214 ppm (F1), 3.5381 ppm (F2), and 1.9427 ppm (F3), which are classified as very strong antioxidants. The conclusion of this study is that carrot extract has potential as a source of natural antioxidants in lip balm, with effectiveness increasing with higher extract concentrations. This product can serve as a safe and beneficial natural cosmetic alternative for protecting lips from free radical damage.
Effect of Addition of Oleic Acid Volume on Magnetite-Oleic Acid Synthesis: FT-IR Analysis Sani, Sulwiyatul Kamariyah
Indonesian Journal of Science and Pharmacy Vol. 2 No. 2 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i2.80

Abstract

Synthesis of magnetite modified with oleic acid has been carried out and then characterization was carried out using the FT-IR instrument. This study aims to characterize the effect of variations in the addition of oleic acid volume on the synthesis of magnetite modified with oleic acid using the FT-IR instrument. Synthesis of magnetite modified with oleic acid was carried out using coprecipitation where 50 mL of 25% NH4OH was added to a mixture of 0.046 mol Fe3+ and 0.023 mol Fe2+ in 150 mL of aquabidest until pH 11 was reached, then 3, 6, 9, 12, and 15 mL of oleic acid were added. Characterization of the synthesized material was carried out using the FTIR instrument. The results showed that the addition of oleic acid volume could affect the characteristics of magnetite.
Foot Gel Mask from Aloe Vera Leaf Flesh (Aloe vera (L.) Burm.f.): Formulation and Evaluation Nurfadilla, Kiki; Lubis, Minda Sari; Dalimunthe, Gabena Indrayani; Yuniarti, Rafita
Indonesian Journal of Science and Pharmacy Vol. 2 No. 2 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i2.81

Abstract

Formulation and evaluation of a gel foot mask preparation from aloe vera leaf flesh (Aloe vera (L.) Burm.f.) have been carried out. The secondary metabolite content of aloe vera leaf flesh was identified through phytochemical screening. The formulation of the gel foot mask was carried out by varying the concentration of aloe vera leaf flesh by 2.5%, 5%, and 10%. Evaluation of the physical quality of the gel mask preparation included organoleptic, homogeneity, pH of the preparation, spreadability, adhesiveness, drying time of the preparation, viscosity, and exfoliation test. The results of phytochemical screening showed that aloe vera leaf flesh contains flavonoids, glycosides, tannins, saponins, and steroids. Evaluation of physical quality showed that the gel mask has characteristics and meets the standards of a good gel mask preparation. The exfoliation test of the gel mask showed a good effect on the skin, namely increased skin moisture and good skin elasticity after using a gel foot mask from aloe vera leaf flesh with an effective increase in the 10% formulation. The higher the concentration of the preparation, the better the exfoliator effectiveness.
Translucent Solid Soap Preparation from Turmeric Rhizome Juice (Curcuma domestica Val.): Formulation and Physical Characterization Aulia, Meisyah; Lubis, Minda Sari; Dalimunthe, Gabena Indrayani; Yuniarti, Rafita
Indonesian Journal of Science and Pharmacy Vol. 2 No. 2 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i2.82

Abstract

The formulation and physical characterization of translucent solid soap preparations from turmeric rhizome juice (Curcuma domestica Val.) have been carried out. The manufacture of translucent soap was carried out by varying the concentration of turmeric rhizome juice from 0%, 2%, 4%, and 6% into the soap formula. The multi-physical tests of translucent soap preparations included organoleptic tests, pH tests, water content tests, foam stability height tests, irritation tests and preference tests. The obtained turmeric rhizome squeezed translucent soap had good characteristics and met the requirements as translucent soap because it had good hardness, appropriate water content, pH between 9-11, and good foam stability. The results of the skin irritation test of soap preparations of all concentration variations did not find any side effects in the form of redness, itching and roughness on the volunteer's skin so that all soap preparations with various comparisons were safe to use. The results of the preference test which included color, translucency, texture and aroma showed that on average the panelists liked the soap preparation with a turmeric rhizome juice concentration of 2%.
Manufacturing Transparent Soap from Tomato Juice (Solanum lycopersicum L.) as a Skin Moisture Aliza, Ulfa; Yuniarti, Rafita
Indonesian Journal of Science and Pharmacy Vol. 2 No. 2 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i2.83

Abstract

Transparent soap is soap that has the highest level of transparency, capable of producing softer foam on the skin. Transparent soap is often referred to as glycerin soap, because in the process of making transparent soap, about 10-15% glycerin is added. The attractive appearance of transparent soap is luxurious and classy, causing transparent soap to be sold at a relatively higher price. Tomatoes are one of the best sources for lycopene production, lycopene has potential as an antioxidant and free radical scavenger so it is very beneficial for human skin health. The purpose of this study was to formulate a transparent soap from tomato juice as a skin protecting property and can moisturize the skin. The method used in this research is experimental method. Transparent soap formulation using tomato juice with a concentration of 20%, 30%, 40%. Evaluation of the transparent bath soap formulation includes organoleptic tests, water content, foam height, pH, irritation, humidity and hedonic preferences The results of the moisture test on the blank obtained a difference with a value of 0.66%, whereas in formula I there was a difference of 3.66%, in formula II there was a difference of 5.33%, and in formula III there was a difference of 8%. The results of the moisture test on the skin showed that the highest moisture was found in the formula with a concentration of 40%, there was a difference of 8%. Tomato essence transparent soap on the test for water content, foam height, and pH test has results that meet the requirements according to SNI (Indonesian National Standard). The conclusion from this study is that tomato juice can be formulated into transparent soap and meets SNI requirements.

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