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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 26 Documents
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Search results for , issue "Vol 9 No 2 (2024)" : 26 Documents clear
REVIEW: POTENCY OF AMIDE DERIVATES AS CO-CRYSTAL FORMERS AND ITS IMPACT ON THE PHYSICOCHEMICAL OF ACTIVE PHARMACEUTICAL INGREDIENTS Dina Apriani; Fikri Alatas
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.914

Abstract

Enhancing the physicochemical properties of active pharmaceutical ingredients (APIs) has been achieved by utilizing solid modification through the formation of co-crystals. Co-crystal was formed from active pharmaceutical ingredients and co-crystal former, more commonly called coformers. The occurrence of hydrogen bonds in the formation of co-crystals depends on the presence of groups that act as hydrogen bond donors or acceptors in API. Amide-derived coformers are widely used to form hydrogen bonds with API. This review aims to examine the potential of amide derivates as co-crystal-forming materials (coformers), groups in active pharmaceutical ingredients that can form hydrogen bonds with amide derivates and their impact on the physicochemical properties of API. Initial search results yielded 88 articles. Furthermore, the authors then conducted a screening based on exclusion and inclusion criteria, so that a total of 54 articles were obtained as review material. Data analysis in this journal review was carried out using descriptive analysis. Amide derivates have great potential to be used as co-crystal-forming materials due to the presence of amide or carboxamide groups (-CONH2), which can act as donors as well as acceptors of hydrogen bonds. Most of the amide-derived coformers with aliphatic amide groups, aromatic amides, pyridine carboxamides, and sulfonylcarboxamide form heterosynthon bonds with carboxylic groups on API. However, the formation of homosynthon bonds between amide and amide groups can occur, as in the 5-fluorouracil-urea co-crystal. Most of the amide derivates as coformers can change the physicochemical properties of APIs, especially in increasing the solubility and dissolution rate.
CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY TEST OF HONEY, LEMON, GINGER FERMENTATION AGAINST BACTERIA CAUSING ACUTE RESPIRATORY INFECTIONS (ARI) Andi Dian Astriani; Muhammad Iqbal
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.931

Abstract

Acute respiratory infection (ARI) is a disease that attacks one or more parts of the airway, from the nose to the alveoli. The most common bacteria found in the samples of patients with ARI were Streptococcus pneumonia, Staphylococcus aureus, and Klebisilia pneumonia. Honey contains flavonoids, amino acids and potassium as antibiotics that are bactericidal (kill bacteria) and bacteriostatic (inhibit bacterial growth). Gingerol in ginger (Zingiber officinale) and lemon (Citrus limon) has antibacterial activity. Honey fermentation is believed to have great potential as an antibacterial compound. This study aimed to determine the inhibitory activity and physical characteristics of fermented honey, lemons, and ginger against ARI bacteria. The test bacteria used were Streptococus pneumonia, Stahpylococcus aureus, and Klebsilia pneumonia. Fermentation of honey, lemon, and ginger was performed with variations in fermentation time (days 1, 3, 5, and 7) and honey without fermentation to determine the effect of fermentation time on inhibitory activity. The inhibition activity was tested using the agar diffusion method. Measurement of inhibition diameter using a caliper. Determination of ginger lemon fermented honey characteristics, including water content, sucrose content, and total sugar content, using gravimetric and titrimetric methods. Based on the activity test, honey fermented for 1 day had the greatest inhibitory activity of 9.71 mm; 9.20 mm; and 9.86 mm against Stahpylococcus aureus, Staphylococcus pneumonia, Klebsilia pneumonia compared to honey fermented for 3 days, 5 days, 7 days and honey without fermentation. ...
ACTIVITY TEST OF RED BETEL LEAF ETHANOL EXTRACT (Piper crocatum Ruiz & Pav) AS AN ACTIVE INGREDIENT IN SUNSCREEN PREPARATIONS Siti Hindun; Nopi Rantika; Aji Najihudin; Nurul Auliasari; Winna Khoerunisa
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1007

Abstract

Skin that is continuously exposed to sunlight can cause a reduction in the structure and elasticity of the skin and other bad effects, so it is necessary to have a skin protective agent, one of which is using sunscreen preparations. In the cosmetics sector, making products from natural ingredients is more profitable. They have a good tolerance for the skin because they do not cause severe irritation to sensitive skin. This research aims to determine the activity of red betel leaf ethanol extract as a sunscreen by looking at the SPF (Sun Protection Factor) value. The determination of the SPF value of red betel leaf ethanol extract was carried out in vitro using UV-Vis spectrophotometers at a wavelength range of 290 – 320 nm. Phytochemical testing is carried out to determine the content of chemical compounds that play a role in sunscreen activity. The research results show that the SPF values obtained from concentrations of 100, 200, 300, 400, 500, and 600 ppm, respectively, are 8.486 (extra-protection), 10,849 (maximum protection), 13,709 (maximum protection), 17.1 (ultra protection), 22 (ultra protection) and 25 (ultra protection). Based on the results of phytochemical tests, the ethanol extract of red betel leaves positively contains phenolics, flavonoids, alkaloids, tannins, saponins, steroids, and/or terpenoids. Keywords: Red betel leaves (Piper crocatum Ruiz &Pav), Sunscreen, SPF, In-Vitro, Ultra-protection
PHYSICAL AND ACTIVITY ACTIVITY TONER OF ESSENTIAL OIL OF BAY LEAF (SYZYGIUM POLYANTHUM) AGAINST PROPIONIBACTERIUM ACNE Anna Yusuf; Davit Nugraha; Marlina Indriastuti; Siti Rahmah KR; Laela Tri Fadila
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1080

Abstract

Indonesian people have been using natural ingredients for generations as traditional medicines to treat various diseases or as a preventative measure. One of the plants often used is bay leaf (Syzygium polyanthum). Bay leaves (Syzygium polyanthum) contain 0.2% essential oil, with methyl chavicol, eugenol, and citral as the main compounds. The purpose of this study was to determine the physical properties of essential oil toner preparations from bay leaf plants (Syzygium polyanthum) and to understand the activity of the essential oil toner preparation from bay leaf plants (Syzygium polyanthum) against Propionibacterium acnes as an acne treatment. The physical test results produced the following data: organoleptic test, thin liquid form, distinctive bay leaf smell, clear slightly cloudy color, homogeneity test all preparations were homogeneous, pH test for average F0 5.75 ± 0.5016, F1 5.62±0.1039, F2 5.70±0.08083 and F3 5.64±0.05508 all met the requirements in the pH range of 4.5-6.5. ...
HEALTH-RELATED QUALITY OF LIFE IN POSTMENOPAUSAL WOMEN WITH ADVANCED BREAST CANCER RECEIVING ADJUVANT HORMONE THERAPY (RIBOCICLIB AND LETROZOLE) Syahru Rohman; Wawang Anwarudin; Nur Azizah; Mochammad Nur Isnaeni Mauludin; Anna Khalida Sya’bany
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1092

Abstract

Breast cancer is a type of cancer that affects many women in Indonesia. Adjuvant hormone therapies, such as letrozole and ribociclib, have succeeded in improving the patient's quality of life. This study aimed to assess the quality of life of postmenopausal women with advanced breast cancer who received adjuvant hormone therapy with ribociclib and letrozole. A cross-sectional study was conducted using retrospective data from postmenopausal female breast cancer patients at Dharmais Cancer Hospital between 2020 and 2023 who met the inclusion criteria. To determine the impact of sociodemographics on patient quality of life, data were examined using the quality of life score (EQ5D5L) and Spearman test. There were 29 patients, with a mean age of 54.9 years (SD = 8.65); the highest education level was high school (34.5%); The majority of occupations are housewives (69%), and the majority are stage IV (34.5%). The mean utility and VAS values of Ribociclib were 0.885 and 81.66, respectively, whereas those for letrozole were 0.725 and 78.46, respectively. Analysis of the relationship between quality of life and patient characteristics showed that the quality of life of patients with breast cancer treated with adjuvant ribociclib and letrozole therapy was influenced by the stage of breast cancer (p = 0.008). These findings indicate that patients receiving ribociclib and letrozole therapy have a good quality of life, which quality of life quality of life is influenced by the stage of malignancy.  Keywords: breast cancer, quality of life, letrozole, ribociclib, post menopause
ADAPTATION AND VALIDATION OF THE INDONESIAN VERSION OF THE HEALTH BELIEF MODEL INSTRUMENT FOR PARENTS Eka Wuri Handayani; Fredrick Dermawan Purba; Dyah Aryani Perwitasari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1101

Abstract

Children are a crucial population requiring COVID-19 vaccination. With the global rollout of COVID-19 vaccines, the increasing number of unvaccinated children and adolescents has raised concerns. To was translated, adapted, and validate the Health Belief Model instrument for parents of children aged 6–11 years regarding COVID-19 vaccination in the Indonesian language. Cross-cultural translation and adaptation were conducted according to international standards. The instrument testing process, according to Beaton et al., (2020), involves five stages: forward translation, synthesis of the translation results, back translation, review of the back translation, and readability testing. Respondents were purposively selected from the parents of children aged 6–11 years. Face and content validity were achieved for the Indonesian version of Health Belief Model for parents of children aged 6–11 years. The validity of each statement item was assessed using Pearson Correlation with a significance level of 0.05 and 193 respondents, resulting in an r table value of 0.1406. The constructs within the Health Belief Model were deemed valid based on the Pearson Correlation values, as the coefficient values were greater than the r-table value (r > 0.1406; p < 0.05). The constructs in the Health Belief Model were also reliable, with a Cronbach’s alpha value of 0.657. The culturally adapted Indonesian version of the Health Belief Model instrument for parents of children aged 6–11 years regarding COVID-19 vaccination is considered valid and reliable for use in research among the parent population of children aged 6–11 years in the context of COVID-19 vaccination.
EFFECT OF COCAMIDOPROPYL BETAINE (CAPB) CONCENTRATION ON PHYSICAL CHARACTERISTIC OF BASIL LEAVES (Ocimum basilicum L.) ESSENTIAL OIL FACIAL Vania Santika Putri; Verawati Hadi; Anita Dwi Nuryani; Ayu Ambarwati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1115

Abstract

Atopic dermatitis or often called eczema is a chronic inflammatory skin disorder that often occurs around the face, legs and arms. Decreased skin barrier function can increase the spread of bacteria on the skin surface, especially Staphylococcus aureus. This study aimed to formulate facial wash preparations of basil leaf essential oil using varying concentrations of cocamydopropyl betaine (CAPB) as a surfactant and foam booster. The basil leaf essential oil facial wash was formulated into three formulas with varying concentrations of cocamydopropyl betaine (CAPB), namely F1 (8%), F2 (9%), and F3 (10%). Physical evaluation included organoleptic observations, homogeneity, pH, foam height, and viscosity. Based on the results of organoleptic and homogeneity evaluations, the three facial wash formulas are homogeneous, white in color, and have a distinctive basil smell, with an increasingly watery consistency from F1 to F3, while the pH in the range 4.97 - 5.26, the height foam test of the three formulas was 37–42 mm, and the viscosity was in the range of 2647,1 - 3516,5 cPs. Variations in the CAPB concentration used in the facial wash formulas have a significant effect on the resulting pH and viscosity values, where the higher the CAPB concentration used, the lower pH and viscosity values of the facial wash. However, an increase in CAPB concentration in the facial wash formula (8 %, 9 %, and 10 %) did not have a significant effect on the foam height of the basil leaf essential oil facial wash.
REVIEW: HERBAL POTENTIAL IN THE USE OF SPF 30 AND 50 SUNSCREENS Siti Fatimah Sultan; Nina Salamah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1139

Abstract

Sunscreen is a substance that can reflect or absorb light, protecting the skin from damage caused by exposure to UV radiation. Soursop juice extract (Annona muricata L.), lime peel extract (Citrus aurantifolia), shallot skin extract (Allium cepa L.), celery leaf extract (Apium graveolens L.), and ethanol extract of kersen leaves (Muntingia calabura) are some plants that can be used as natural sunscreens. According to the SPF value and the protective power category, the soursop juice extract has an SPF value of 5.188, 12.242, and 17.247. Lime peel extract has SPF values of 28.6, 42.2, and 81.8 (max-ultra). Onion peel extract has SPF values of 11.4, 20.12, 31.8, and 34.83 (max-ultra). Celery leaf extract had SPF values of 1.7873, 4.5553, 7.3183, and 8.1573 (max-ultra). Kersen leaf ethanol extract had concentrations of 1.528, 3.890, 3.971, 4.585, and 5.252 (max-ultra). Phenolic components, polyphenols, flavonoids, tannins, and vitamin C are known as bioactive compounds in the five plant extracts that function as sunscreens. The polarity of the solvent influenced the SPF rating and protective power category. It is concluded that the SPF value and protective power of the plant extracts have SPF values and protective power categories with extracts in ultra categories. The bioactive compounds contained in the five plant extracts that act as sunscreens are phenolic compounds, polyphenols, flavonoids, tannins, and vitamin C ...
ANTIOXIDANT ACTIVITY TEST OF GUAVA LEAVES ETHANOL EXTRACT (Syzygium aqueum Burm F) WITH DPPH METHOD (1,1-Diphenyl-2-picrylhydrazil) Fina Fitriani; Siti Nur Hikmah; Fawwaz Muhammad Fauzi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1148

Abstract

Free radicals are compounds that can cause damage to human body cells, which can be prevented with antioxidants. Antioxidants can be found in several natural ingredients, such as water guava leaves. This study aims to determine the antioxidant activity of an ethanol extract from water guava leaves (Syzygium aqueum Burm F). The water guava leaves used came from the Kempek Palimanan Cirebon area. Extraction was carried out using the maceration method using a 96% ethanol solvent until a concentrated extract was obtained. The extract was identified for secondary metabolite content using a reagent test. An antioxidant activity test was carried out using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. Analysis of the strength of antioxidant activity is carried out by calculating the IC50 value, which is based on the percent inhibition of free radicals by the test sample by comparing Vitamin C. Identification of active compounds in the concentrated ethanol extract of water guava leaves indicated the presence of flavonoids, alkaloids, saponins, and tannins. The antioxidant activity of an ethanolic 96% extract of water guava leaves (Syzygium aquarium) in this study had an IC50 value of 6.89 ppm, which shows very strong antioxidant activity in warding off free radicals. Keywords: antioxidants, water guava leaves, DPPH
THE POTENCY OF BAJAKAH TAMPALA (Spatholobus littoralis Hassk) AN INDIGENOUS INDONESIAN HERBAL MEDICINE : A BIBLIOMETRIC APPROACH Davit Nugraha; Nurkhasanah; Sapto Yuliani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1169

Abstract

Bajakah tampala (Spatholobus littoralis Hassk) has significant potential in the pharmaceutical field and could become a source for drug discovery and development in the future. This bibliometric analysis aimed to map existing research to identify novelties and gaps for future studies. The research method involved a literature review using bibliometric analysis, using the keyword "bajakah tampala" in Publish or Perish 8, followed by metadata organization using Mendeley and VOSviewer to map research trends. The research findings indicate that Bajakah tampala exhibits variability and gaps in its antioxidant and anti-inflammatory properties, and there is still limited research on this topic. Further research is needed to establish a link between antioxidant and anti-inflammatory effects. Keywords: Bibliometrics, Bajakah tampala, antioxidants, anti-inflammatory, Publish or Perish (POP), VOSviewer

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