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Hartalina Mufidah
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Journal of Medical Laboratory in Infectious and Degenerative Diseases
Published by Universitas dr. Soebandi
ISSN : -     EISSN : 30325447     DOI : https://doi.org/10.36858/jmid.v1i2
Core Subject : Health, Science, Education,
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Public Health
Journal of Medical Laboratory in Infectious and Degenerative Diseases is a scientific journal with the scope of research conducted by lecturers, practitioners, and students. The purpose of publishing this journal is to accommodate scientific writings that have the substance of research activities, which are the downstream results of research carried out based on an analysis of the needs of the community for scientific and technological contributions in the fields of Parasitology, Bacteriology, Virology, Hematology, Clinical Chemistry, Immunology, Molecular Biology, Cytohistotechnology, Micology, Clinical Toxicology, and Degenerative Diseases.
Arjuna Subject : Profesi Kesehatan - Teknologi Laboratorium Medis
Articles 5 Documents
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Search results for , issue "Vol. 3 No. 2 (2025): Desember" : 5 Documents clear
The Effect of Papaya Leaf Extract (Carica papaya L.) on Erythrocyte Values in Anemia-Model Rats Dwi Susanto, Fajar; Yulia Widia Sari, Leny; Imroatul Muflihah, Ahdiah; Wijaya, Anas Fadli; Agustin, Ayu Tri
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 3 No. 2 (2025): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v3i2.34

Abstract

Background: Anemia remains a significant public health challenge with a global prevalence of 40-88%. Papaya leaf extract (Carica papaya L.) contains bioactive compounds such as flavonoids, vitamin C, and vitamin E that potentially enhance erythrocyte production. Purpose: This study aimed to determine the effect of papaya leaf extract on erythrocyte values in anemia-model rats (Rattus novergicus). Methods: An experimental laboratory study was conducted from April to June 2025 using 25 rats divided into 5 groups: positive control (sodium nitrite), negative control (aquadest), and three treatment groups receiving papaya leaf extract at doses of 100, 200, and 400 mg/kg BW. Anemia was induced using sodium nitrite at 50 mg/kg BW via intraperitoneal injection. Erythrocyte measurements were performed using a hematology analyzer. Data were analyzed using Shapiro-Wilk normality test, Levene's homogeneity test, one-way ANOVA followed by Tukey HSD (α=0.05). Results: Treatment group P3 (dose 400 mg/kg BW) demonstrated the highest erythrocyte value of 12.066±0.84 (10⁶/µL), followed by P1 (11.576±0.71), P2 (11.496±1.19), negative control (10.728±1.01), and positive control (6.220±1.96). ANOVA test revealed significant differences between groups (p<0.001). Conclusions: Papaya leaf extract increases erythrocyte values in anemia-model rats, with 400 mg/kg BW being the most effective dose.
Study Of Use Of Antituberculosis Drugs (OAT) In One Of The Hospitals In Jember District Fitri Amirah Nahdah Salsabilah; Wima Anggitasari
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 3 No. 2 (2025): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v3i2.38

Abstract

Abstract Background: Tuberculosis (TB) is a long-term infectious disease caused by the bacterium Mycobacterium tuberculosis. Successful management of pulmonary TB will reduce the rate of disease transmission and the risk of death. TB treatment is carried out routinely over a period of time under the supervision of a Drug Companion (PMO).] Purpose: This study aims to identify the type of TB treatment received by patients and the duration of treatment. Methods: This is a descriptive study. Data collection on study subjects was conducted retrospectively using medical records of TB patients undergoing anti-TB treatment (OAT) therapy from January to December 2023. Sampling used a purposive sampling technique, with a sample size of 73. Results: The study showed that the majority of patients were male (60.3%), and the majority were aged 17-25 years (32.9%). Most patients used FDC drugs with a treatment duration of 0-6 months. Conclusions: Most study subjects received anti-TB therapy with a treatment duration of 0-6 months.
The Optimization of a Spray Gel : Formula with Acalypha Leaf Extract (Acalypha wilkesiana Müell. Arg.) Nufus, Galuh Maulidatun; Isnawati, Nafisah
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 3 No. 2 (2025): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v3i2.39

Abstract

Background: According to research from the Ministry of Health, in 2020 the average was 89.65% and in East Java it was 54.3%, while in Jember 49.6% of people washed their hands properly, one of which was using soap. Hand sanitizer can be used as an alternative to cleaning hands without using soap and running water. One of the plants used as an active ingredient in hand sanitizers is akalifa leaves. Carbopol 940 is a gelling agent that is widely used in spray gel preparations for pharmaceutical products, while TEA is an alkalizing agent. Objective: To identify the effect of carbopol 940 as a gelling agent and TEA as an alkalizing agent on the physical characteristics of akalifa leaf extract spray gel (Acalypha wilkesiana Müell. Arg.). Methods: This study used an experimental method with the Simplex Lattice Design. Research result: Evaluation of the physical properties of spray gel preparations with variations in the concentration of the gelling agent and alkalizing agent produced the best pH value, namely in formula 2 with a pH value of 5.2, the best viscosity value was found in formula 2, namely with a value of 223 cPs, and drying time the best is also found in formula 2 with a value of 3.35 minutes. Conclusion: evaluation of the physical properties of spray gel preparations, variations in the concentration of the gelling agent and alkalizing agent affect pH, viscosity, spraying pattern and drying time.
In-Silico Study Of Bioactive Compounds In Bawang Dayak (Eleutherine palmifolia (L) Merr.) Bulbs On The Main Protease Receptor Of COVID-19 (6LU7) As A Candidate For SARS-CoV-2 Antivirus Drug Septiana, Ulfa Dwi; Wulandari, Septyaningtyas Eka; Kamalia, Nabila; Hezni, Tiara Anjelina; Usman, Mohammad Rofik; Setyaningrum, Lindawati
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 3 No. 2 (2025): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v3i2.40

Abstract

: The COVID-19 viral disease is a new name given by the World Health Organization (WHO) to patients with the novel COVID-19 virus infection which was first reported from the city of Wuhan, China at the end of 2019. The COVID-19 pandemic is still a major problem in the world health. One antiviral regimen that is widely used to treat moderate to severe Covid- 19 patients is favipiravir. Many studies discuss alternative antiviral therapy for COVID-19 patients from active compounds contained in plants. One of the medicinal plants that has an antiviral effect on CoV-2 is Dayak onion (Eleutherine Palmifolia (L.) Merr). Consuming herbal plants can increase the body's immunity as the main key in preventing the Sars-Cov-2 virus. Purpose: This research aims to determine the effect of anchoring the active compound of Dayak onion bulbs on the growth of the corona virus on the main protease receptor for Covid 19 (6LU7). Methods: This type of research uses a molecular docking research method which consists of docking validation stages, a docking process and continues with docking visualization using Discovery Studio Visualizer and PyRx combined with Autodocktool Results: The results of the molecular docking simulation show that the Lysine sulfate compound has the lowest binding affinity value compared to Favipiravir, namely -4.75 kcal/mol with a Ki value of 96.41 μM and has the same interaction as the positive control ligand on the hydrophobic bond of MET A:165
The Effect of Propylene Glycol and Menthol as Enhancers on the Physical Properties and Skin Irritation Index of Meloxicam Gel Falahi, Asa; Rohman, Anies
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 3 No. 2 (2025): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v3i2.41

Abstract

Abstract Background: The drawback of meloxicam when used orally is that it slows the onset time of meloxicam. Other side effects of oral use include gastrointestinal disorders, dyspepsia, nausea, diarrhea, upper gastrointestinal infections, abdominal pain, swelling, and bloating. These side effects have been reported in 15–20% of patients. There is a need to develop a transdermal meloxicam formulation with a modified penetration system. Purpose: This study aims to develop a formulation of meloxicam gel preparations with a direct release system towards the skin barrier and within a period of time is extended by using 10% propylene glycol and 3% menthol as an enhancer to get the optimum formula of meloxicam gel with good physical properties and does not irritate the skin. Methods: This research method is a laboratory experimental study. Gel preparations were made by varying the enhancer agents, namely propylene glycol and menthol. The gel preparations were made by developing the gelling agent to an optimal level. Other additional ingredients were mixed with various enhancer variations. Results: The observed physical properties of the gel included organoleptic characteristics, pH, viscosity, spreadability, and irritation tests. Overall, the test results showed data that met the applicable requirements. All four formulas showed significant differences in each test and did not show signs of skin irritation. Conclusions: The results show that variation concentration of enhancer has an effect to gel form, smell viscosity and spreadability but has no effect to gel colour and pH. All formulas show not irritate the skin.

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