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All Journal Indonesian Journal of Chemistry Journal of Sport Coaching and Physical Education BERNAS: Jurnal Pengabdian Kepada Masyarakat Kolaborasi Jurnal Pengabdian Masyarakat Jurnal Kesehatan Amanah Jurnal Pengabdian kepada Masyarakat Jurnal Pengabdian Kepada Masyarakat: Kesehatan (JPKMK) Riset Informasi Kesehatan Faedah: Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia Al Mu'azarah: Jurnal Pengadian kepada Masyarakat Jurnal Sistem Informasi Komputer dan Teknologi Informasi ACTIVE: Journal of Physical Education, Sport, Health and Recreation
Agustin, Ayu Tri
Universitas Dr. Soebandi Jember
Religion Agriculture, Biological Sciences & Forestry Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Analisis Pertandingan Final Kejuaraan NBA Musim 2020-2021 Wicaksono, Anggit; Candra, Adiska Rani Ditya; Agustin, Ayu Tri
Journal of Sport Coaching and Physical Education Vol 6 No 2 (2021): November 2021
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jscpe.v6i2.52046

Abstract

Tujuan dari penelitian ini adalah untuk menganalisis pertandingan final NBA musim 2020-2021 antara Milwaukee Bucks melawan Phoenix Suns berdasarkan statistik pertandingan. Dibutuhkan 6 pertandingan sampai akhirnya Milwaukee Bucks dinobatkan menjadi juara NBA dengan 4 kali menang dan 2 kali kalah dari Phoenix Suns. Penelitian ini menggunakan metode deskriptif kuantitatif. Data yang digunakan menggunakan data sekunder yang diambil dari website resmi NBA. Hasil penelitian menunjukkan bahwa: 1) faktor penentu kemenangan Phoenix Suns dalam pertandingan pertama adalah FTM dan FT%. Faktor kekalahan Milwaukee Bucks adalah pada FTM dan FT%, 2) Faktor penentu kemenangan Phoenix Suns dalam pertandingan kedua adalah 3PM, 3P%, dan DRB. Faktor kekalahan Milwaukee Bucks adalah 3PM, 3) Milwaukee Bucks mendominasi pertandingan ketiga dengan unggul dalam 9 komponen statistik, khususnya dalam 3PM dan 3P, 4) Faktor penentu kemenangan Milwaukee Bucks pada pertandingan keempat adalah FTM dan ORB. Faktor kekalahan Phoenix Suns adalah FTM yang rendah, 5) Faktor yang mempengaruhi kemenangan Milwaukee Bucks pada pertandingan kelima adalah 3PM, AST, dan ORB. Faktor kekalahan Phoenix Suns adalah tidak memaksimalkan 3P% yang cukup tinggi yaitu 68,3% dan FT% yaitu 90,9% dengan memperbanyak percobaan tembakan, 6) Faktor yang mempengaruhi kemenangan Milwaukee Bucks pada pertandingan keenam adalah FG%, FTM, FT%, AST, ORB, dan DRB. Faktor kekalahan Phoenix Suns adalah FTM dan rebounds yang kurang baik.
Bioactive Compound Profile and Biological Modeling Reveals the Potential Role of Purified Methanolic Extract of Sweet Flag (Acorus calamus L.) in Inhibiting the Dengue Virus (DENV) NS3 Protease-Helicase Yuli Arif Tribudi; Ayu Tri Agustin; Dian Eka Setyaningtyas; Dwi Gusmalawati
Indonesian Journal of Chemistry Vol 22, No 2 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.68317

Abstract

Dengue fever is an infectious disease caused by the dengue virus, and there is no yet effective drug to treat this disease successfully. Our study aimed to identify the bioactive compounds of Acorus calamus L. and its potential role in inhibiting dengue virus NS3 protease-helicase. Liquid Chromatography-Mass Spectrometry analyzed phytochemical constituents. Drug-likeness of the predominant compound methanol extract of Acorus calamus L. was investigated through the SWISS ADME server. Complex molecular interactions were investigated by Hex 8.0 docking program and Discovery studio 2016. Our study revealed that the five largest phytochemicals in the extract were acoric acid, acorone, acoradin, acoronene, and calamendiol. All predominant compounds are potent to be developed as drug candidates. Molecular docking results showed that the five compounds bind to the Arg599, Pro291, Lys388, Pro431, and His487 of the dengue virus NS3 protease-helicase, the ligand-binding site that plays an essential role in viral replication. The ligand-protein binding pattern exhibited hydrogen and hydrophobic interactions. The interaction of the acoradin-NS3 protease-helicase complex had the lowest binding energy of -299.7 kcal/mol. In summary, we conclude that Acorus calamus L. extract may have prospects as a drug for dengue virus infection.
Java Red Rice (Oryza sativa L.) Nutritional Value and Anthocyanin Profiles and Its Potential Role as Antioxidant and Anti-Diabetic Ayu Tri Agustin; Anna Safitri; Fatchiyah Fatchiyah
Indonesian Journal of Chemistry Vol 21, No 4 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.64509

Abstract

This study investigates nutritional value, amino acid profile, and total anthocyanin in pigmented rice as an antioxidant and anti-diabetic agent. Six rice varieties were extracted using 0.1% HCl in methanol, namely four red rice, one black rice, and one white rice. Rice extract was used for proximate analysis and amino acid profiling. Total anthocyanin was measured and identified by ultraviolet-visible (UV-Vis) spectrophotometer and thin-layer chromatography (TLC). The antioxidant activity was determined using Ferric-reducing antioxidant power (FRAP) assay, and the α-amylase enzyme-inhibited by anthocyanin extract of red rice as anti-diabetic was measured. The study result showed that the proximate level (carbohydrate, protein, lipid, water, and ash) in pigmented rice was different. Cempo merah red rice is a source of amino acids, both essential and non-essential amino acids that act as good nutrition. The highest total anthocyanin level between red rice varieties of 10.87 mg/g was found in Aek sibundong red rice. High biological function activities as an antioxidant were indicated by Aek sibundong red rice with an IC50 value of 6.65 µg/mL. Aek sibundong red rice shows the lowest IC50 value of 144.46 µg/mL in anti-diabetic activity. Thus, Aek sibundong red rice may have the potential as α-amylase inhibitor for diabetes prevention.
Peningkatan Pengetahuan dan Skrining Penyakit Infeksi dan Degeneratif: Tuberkulosisi dan Diabetes Melitus: Increased Knowledge and Screening of Infectious and Degenerative Diseases: Tuberculosis and Diabetes Mellitus Wijaya, Anas Fadli; Destiawan, Rian Anggia; Agustin, Ayu Tri
Jurnal Pengabdian Kepada Masyarakat: Kesehatan Vol. 3 No. 4 (2023): Desember
Publisher : Sekolah Tinggi Ilmu Kesehatan Notokusumo Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstrak: Kabupaten Jember merupakan salah satu kabupaten yang masih memiliki masalah terhadap penyakit tuberkulosis dan diabetes melitus di Indonesia, sehingga perlu adanya edukasi dan pemeriksaan terhadap penyakit tuberkulosis dan diabetes melitus kepada masyarakat.  Pengabdian masyarakat ini  bertujuan  untuk  untuk meningkatkan pengetahuan dan skrining penyakit tuberkulosis dan diabetes melitus. Metode yang digunakan yaitu  metode Participation Action Research  (PAR)  melalui  kegiatan perencanaan, intervensi (ceramah,   diskusi   dan   pemeriksaan)terkait  penyakit tuberkulosis dan diabetes melitus dan evaluasi. Setelah dilakukan pemberian edukasi kepada respondens, terdapat peningkatan pengetahuan masyarakat terhadap penyakit tuberkulosis dan diabetes melitus yaitu mencapai 100% dan dari hasil skrining melalui pemeriksaan darah didapatkaan rerata masyarakat yang memiliki penyakit diabetes melitus sebesar 16,7% dari total responden.   Abstract: Jember Regency is one of the districts that still has problems with tuberculosis and diabetes mellitus in Indonesia, so there is a need for education and examination of tuberculosis and diabetes mellitus to the community.  This community service aims to increase knowledge and screening of tuberculosis and diabetes mellitus. The method used Participation Action Research (PAR) method through planning, intervention (lectures, discussions and examinations) related to tuberculosis and diabetes mellitus and evaluation. After providing education to respondents, there was an increase in public knowledge about tuberculosis and diabetes mellitus, reaching 100% and from the results of screening through blood tests, the average number of people who had diabetes mellitus was 16.7% of the total respondents.
Pemberdayaan Lansia Dalam Pembuatan RAMEN (Rempah Permen) Untuk Meningkatkan Kesehatan Pada KOSTI Kabupaten Jember Mayasari, Shinta; Martina, Ina; Atmanegara, Stivani Yanti; Hidayati, Sholihatil; Agustin, Ayu Tri; Permatasari, Shafira Restu; Aisyah, Siti; Putra, Zulkarnain Permana
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 1 (2025)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v6i1.11363

Abstract

KOSTI (Komunitas Sepeda Tua Indonesia) Kabupaten Jember memiliki 45 pengurus yang berlatar belakang dari SMP, SMA, Sarjana dan Pasca Sarjana Profil mitra berdasarkan kategori usia adalah lansia dengan persentase 70%,  sejumlah 30% kategori dewasa produktif. Kondisi mitra saat ini sejumlah 70% pensiun dari pekerjaannya, 25% bekerja serabutan, dan 5% bekerja wiraswasta. Permasalahan kesehatan banyak terjadi pada kategorisasi dewasa hingga lansia di mitra, mengingat sebagian besar anggota berusia diatas 40 tahun. Permasalahan yang terjadi seperti linu-linu pada asam urat, kolesterol, tekanan darah tinggi dan diabetes melitus. Tujuan PKM ini adalah meningkatkan pengetahuan kesehatan mitra dalam membuat suatu produk herbal. Pendidikan atau edukasi dan pelatihan dalam membuat inovasi RAMEN (rempah permen) sebagai terapi. Sejumlah 45 pengurus KOSTI yang mengikuti kegiatan Pemberdayaan Kemitraan Masyarakat (PKM) dengan rincian yaitu 30 orang (68%) berjenis kelamin laki-laki dan 15 orang (32%) kemudian berjenis kelamin perempuan. Berdasarkan hasil pre-test dan post- test yang diberikan terdapat peningkatan pengetahuan kesehatan pada KOSTI sejumlah 89,87%. KOSTI mampu membuat produk herbal seperti permen berbasis rempah, sesuai dengan kondisi keluhan yang menyertainya
GERAKAN BIJAK REM NIKAH (GEBRAK) BAGI REMAJA DESA KRAMAT SUKOHARJO DAN SISWA SMPN 6 TANGGUL Risnitasari, Mithaqul; Agustin, Ayu Tri
PRAXIS: Jurnal Pengabdian kepada Masyarakat Vol. 3 No. 2 (2024): PRAXIS
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47776/praxis.v3i2.1179

Abstract

Early marriage is defined as an anomaly that continues to occur and is increasingly widespread, Lack of understanding about young marriage makes children experience deep wounds. (Darmawan, 2021). The implementation of GEBRAK (wise marriage brake movement) was carried out in two places. The first place is in the village hall and the second is at SMPN 6 Tanggul. This research is qualitative research. From the results presented, several steps to overcome early marriage have been taken not only from the KUA and village officials but also several students who are having duty obligations in this Kramat village. Forms of Student Implementation to Overcome Early Marriage We are required to provide solutions to reduce various existing problems. Someday the knowledge taught when in someone else's village can be brought, moreover it can be implemented into the village of his birth. Based on the survey results, it was found that early marriage is caused by internal & external factors. Through discussions in the “GEBRAK” socialization, it is hoped that it can reduce the number of early marriages in Jember Regency, especially in Kramat Sukoharjo Village.
Skrining Penyakit Diabetes Melitus Dengan Pemeriksaan Gula Darah Sewaktu Pada Lansia Di Desa Sumberjambe Kabupaten Jember Syahrial Dwi Meidiansyah; Maralodia Almira Lubis; Dhea Adelina Br Ginting; Wulan Ratna Nur Kholidiya; Muhammad Rizky Suryadinata; Nur Halimatus Sa’diyah; Aisyah Salsabila Oktivani Yunita; Faidatur Rohma; Taufiki Nurul Yahya; Maimunah Maimunah; Sulton Auliya; Alisa Alfiya Makki; Alisyah Pratiwi; Cahyaning Dewi Kusuma Wardani; Diana Nadhifah; Ayu Tri Agustin
Faedah : Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia Vol. 2 No. 1 (2024): Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia
Publisher : FKIP, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59024/faedah.v2i1.676

Abstract

Diabetes mellitus (DM) is a disease caused by excessive levels of sugar in the blood due to a lack of the hormone insulin. DM screening is done because there are some residents who have the disease. This examination is specifically for the elderly because they also have the potential to be infected without being detected. The activity was carried out using two methods, namely socialization and followed by blood pressure and random blood sugar checks which were carried out in two hamlets, namely Slangak and Semek hamlets. The results of the screening showed that 14.29% of the participants had sugar levels > 200 mg/dl, which means that there is a DM factor, so it is necessary to do short-term prevention to control DM disease.
Implementasi Program Golden Moral untuk Membentuk Generasi Khairu Ummah bagi Santri TPQ Pelangi Nusantara Azizah, Agtika Yasyfa Nur; Agustin, Ayu Tri; Dewi, Dyah Mustika Chandra; Anisa, Mutiara Nur; Azizah, Zahroh Nur; Wicaksono, Anggit
Al Mu'azarah: Jurnal Pengabdian Kepada Masyarakat Vol. 2 No. 2 (2025): Maret
Publisher : Universitas Islam Internasional Darullughah Wadda'wah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38073/almuazarah.v2i2.2354

Abstract

TPQ Pelangi Nusantara has several issues, including the absence of a standardized curriculum, limited teaching staff, and lack of parental involvement in children's character education. As a solution, the Golden Moral program is implemented by adjusting the principles of golden habits, a concept that emphasizes the formation of good habits in daily life. The program aims to improve children's morals and the quality of TPQ education through various activities such as program socialization and distribution of supporting books, Qur'an and Iqro reading and writing training, and strengthening speaking skills through speech training. In addition, there is also literacy corner (pojok literasi), worship education (wudhu, tayamum, salat), game-literasi (garasi), and creation event (ajang kreasi). The program runs for four months, from August to November 2023. This program succeeded in changing the behavior of students to be better and have a positive character and succeeded in improving the quality of learning in TPQ. Santri also experienced an increase in the ability to read and write the Qur'an of the students, the students' understanding of speech materials, worship, and other islamic materials, as well as fostering creativity in their work.
Uji Potensi Senyawa Bioaktif Ekstrak Antosianin Jagung Ungu sebagai Inhibitor Cyclin-Dependent Protein Kinase 6 (CDK6) Ayu Tri Agustin; Anas Fadli Wijaya
Jurnal Kesehatan Amanah Vol. 7 No. 2 (2023): Oktober: Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v7i2.758

Abstract

Cancer is characterized by uncontrolled cell proliferation. The upregulation and activation of the Cyclin-Dependent Protein Kinase 6 (CDK6) signaling pathway can induce unregulated breast cancer cell proliferation. Therefore, CDK6 inhibition continues to be developed as a potential target for drug design and development to treat breast cancer. This study aims to predict the biofunction of anthocyanin compounds from purple corn extract as inhibitors of Cyclin-Dependent Protein Kinase 6 (CDK6) using an in silico approach. The research methods included data mining, ligand and receptor preparation, molecular docking, docking visualization, and data analysis. Our results indicate that six compounds from purple corn extract (cyanidin, cyanidin 3-glucoside, pelargonidin-3-glucoside, pelargonidin, peonidin, and peonidin-3-glucoside) can bind to CDK6 at the C-terminal and N-terminal domains. The binding pattern suggests that cyanidin, cyanidin 3-glucoside, pelargonidin-3-glucoside, pelargonidin, peonidin, and peonidin-3-glucoside interact with CDK6 residues in the same manner as Palbociclib (control). This finding indicates that compounds from purple corn have the potential to act as competitive CDK6 inhibitors. Peonidin-3-glucoside exhibited the lowest binding energy of -282.5 kcal/mol, approaching that of Palbociclib (-329.4 kcal/mol).
Uji Potensi Senyawa Bioaktif Ekstrak Antosianin Jagung Ungu sebagai Inhibitor Cyclin-Dependent Protein Kinase 6 (CDK6) Ayu Tri Agustin; Anas Fadli Wijaya
Jurnal Kesehatan Amanah Vol. 8 No. 2 (2024): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v8i2.761

Abstract

Cancer is characterized by uncontrolled cell proliferation. The upregulation and activation of the Cyclin-Dependent Protein Kinase 6 (CDK6) signaling pathway can induce unregulated breast cancer cell proliferation. Therefore, CDK6 inhibition continues to be developed as a potential target for drug design and development to treat breast cancer. This study aims to predict the biofunction of anthocyanin compounds from purple corn extract as inhibitors of Cyclin-Dependent Protein Kinase 6 (CDK6) using an in silico approach. The research methods included data mining, ligand and receptor preparation, molecular docking, docking visualization, and data analysis. Our results indicate that six compounds from purple corn extract (cyanidin, cyanidin 3-glucoside, pelargonidin-3-glucoside, pelargonidin, peonidin, and peonidin-3-glucoside) can bind to CDK6 at the C-terminal and N-terminal domains. The binding pattern suggests that cyanidin, cyanidin 3-glucoside, pelargonidin-3-glucoside, pelargonidin, peonidin, and peonidin-3-glucoside interact with CDK6 residues in the same manner as Palbociclib (control). This finding indicates that compounds from purple corn have the potential to act as competitive CDK6 inhibitors. Peonidin-3-glucoside exhibited the lowest binding energy of -282.5 kcal/mol, approaching that of Palbociclib (-329.4 kcal/mol).
Co-Authors AHDIAH IMROATUL MUFLIHAH Aisyah Salsabila Oktivani Yunita Alisa Alfiya Makki Alisyah Pratiwi Anas Fadli Wijaya Anggit Wicaksono Anisa, Mutiara Nur Anna Safitri Atmanegara, Stivani Yanti Azizah, Agtika Yasyfa Nur Azizah, Zahroh Nur Cahyaning Dewi Kusuma Wardani Candra, Adiska Rani Ditya Dewangga Yudhistira Dewi, Dyah Mustika Chandra Dhea Adelina Br Ginting Dian Eka Setyaningtyas Diana Nadhifah Dwi Gusmalawati Eko Julianto Elnaja, Dinar Anisa Faidatur Rohma Fatchiyah Fatchiyah Hayati, Farhatul Hidayati, Sholihatil Humaidah, Fitria Humairoh, Riska Tsamarah Jaya, Heru Sipta Julianus, Julianus Made Suandika Maimunah Maimunah Maralodia Almira Lubis Martina, Ina Mufidah, Hartalina Muhammad Rizky Suryadinata Nur Halimatus Sa’diyah Permatasari, Shafira Restu PRAMBAYUN, ARIF Purwanti, Ananda Kamila Nurcahya Putra, Zulkarnain Permana RIAN ANGGIA DESTIAWAN Riranto, Jepri Risnitasari, Mithaqul Shinta Mayasari Sigit Purwanto Siti Aisyah Soedjatmiko Sulton Auliya Syahrial Dwi Meidiansyah Tandiyo Rahayu Taufiki Nurul Yahya Wulan Ratna Nur Kholidiya Yuli Arif Tribudi