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Nanang Yunarto
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Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan Kementerian Kesehatan RI Jl. Percetakan Negara No. 23 - Jakarta 10560
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INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 10 Documents
 1 
Search results for , issue "VOLUME 6, NOMOR 2, AGUSTUS 2016" : 10 Documents clear
Validasi Metode HPLC untuk Penetapan Aspirin dan Asam Salisilat dalam Plasma Kelinci (Lepus curpaeums) secara Simultan Siswanto, Agus; Fudholi, Achmad; Nugroho, Akhmad Kharis; Martono, Sudibyo
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2922

Abstract

Aspirin is a nonsteroidal anti-inflammatory drug which also has the effect of antiplatelet for stroke prevention. Aspirin inside human body is very easy to break down into salicylic acid as the main metabolite. The aim of this study is to develop and validate the method for determinating aspirin and salicylic acid concentration in plasma by HPLC. Method validation including system suitability test, linearity test, determination of LOD and LOQ, recovery, accuracy and precision. Concentration of analytes in blood is measured by HPLC using benzoic acid as internal standard, with condition Purospher column Endcapped Star RP-18 (250 x 4.6 mm id, 5 m), acetonitrile : buffer phosphate 20 mM pH 2.5 (30:70 v/v) as mobile phase, injection volume 20 mL, flow rate 1.5 mL/minute, and UVVis detector λ 230 nm. The results showed that the proposed method meets the requirements of system suitability and good linearity (r > 0,990) with LOQ (aspirin = 0.024 mg/mL, salicylic acid = 0.336 mg/mL) and LOD (aspirin = 0.007 mg/mL, salicylic acid = 0.101 mg/mL). The method of analysis provides recovery of 85-115 %, accuracy and precision in accordance with the requirements for bioanalytical with CV < 5 %. Therefore, the proposed method is applicable to determine of aspirin and salicylic acid concentration in plasma.
Formulasi Emulgel yang Mengandung Ekstrak Etanol Daun Binahong (Anredera cordifolia (Ten.) Steenis) dan Uji Aktivitasnya terhadap Propionibacterium acnes secara In Vitro Yani, Tri Nofi; Anwar, Effionora; Saputri, Fadlina Chany
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2923

Abstract

Binahong (Anredera cordifolia (Ten.) Steenis) leaves have been known to have antibacterial activity but the activity against Propionibacterium acnes as one of the bacteria that play a role in acne’s pathogenesis is still unknown. Binahong leaves ethanolic extract containing 1,28% of ursolic acid in this study were tested by in vitro against Propionibacterium acnes giving result minimum bactericidal concentration of 0,05%. Emulgel of binahong leaves ethanolic extract in this study had physical stability for 12 weeks. Inhibition zone of binahong leaves ethanolic extract emulgel is larger than clindamycin phosphate 1,2% against Propionibacterium acnes, which is in formula 1 (extract equivalen with MIC 0,05%) is 19,67±1,25 mm and formula 2 (extract equivalen double MIC 0,05%) is 20,67±0,47 mm, while inhibition zone of clindamycin phosphate 1,2% is 16,3±0,47 mm.
Uji Aktivitas Antioksidan dan Penghambatan Tirosinase serta Uji Manfaat Gel Ekstrak Kulit Batang Taya (Nauclea subdita) terhadap Kulit Charissa, Meiliana; Djajadisastra, Joshita; Elya, Berna
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2924

Abstract

Dayak women in Borneo treat their skin with natural ingredients, one of which is taya cortex (Nauclea subdita). Flavonoids that can be found in natural ingredients have antioxidant effect and can inhibit the activity of tyrosinase in melanogenesis process. The research objectives were to measure the antioxidant activity and the inhibition of tyrosinase of taya cortex extract, to obtain a stable formulation of taya cortex extract gel, and to determine the safety and efficacy on human skin. The method used for antioxidant activity test was DPPH method. The inhibition of tyrosinase was conducted with kojic acid as control. The safety and efficacy test were conducted to healthy women ages 35-50 with healthy and normal skin. The results show IC50 value of 568.58 µg/mL in L-tyrosine and 1374.69 µg/mL in L-DOPA for inhibiton of tyrosinase. Antioxidant activity assay of the extract shows IC50 value of 48.78 µg/mL and can be categorized as a powerful antioxidant (
Efek Ekstrak Bawang Dayak (Eleutherine palmifolia (L.)Merr) dan Ubi Ungu (Ipomoea batatas L) terhadap Penurunan Kadar Kolesterol dan Trigliserida Darah pada Tikus Jantan Kusuma, Anjar Mahardian; Asarina, Yupin; Rahmawati, Yeni Indah; Susanti, Susanti
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2925

Abstract

Bawang Dayak (Eleutherine palmifolia (L.)Merr) and Ubi Ungu (Ipomoea batatas L.) are potential medicinal plant in lowering cholesterol. This study aims to measure the effect of bawang dayak extract and ubi unggu extract on lowering cholesterol and triglyceride blood levels in male rats fed with 10 ml/Kg BW quail egg yolk. The cholesterol and triglyceride blood levels of rats were measured with 50, 100 and 200 mg/Kg BW dose variations for each extract for 14 days. Cholesterol and triglyceride levels were measured at day 15th by ‘Multicare’. As controls were rats fed with 1,26 mg/Kg BW simvastatin, 1 % (b/v) Na-CMC, and normal diet. The data was analyzed by Anova statistical tests and LSD (α = 0,05). The result shows that both extracts can reduce cholesterol and triglyceride blood levels with 200mg/Kg BW dose. Bawang dayak extract can reduce cholesterol and triglyceride blood levels to 80.8 ± 9.2 mg/dL and 95 ± 7.9 mg/dL, respectively. Ubi ungu extract can reduce cholesterol and triglyceride blood levels to 72 ± 8.2 mg/dL and 86.4 ± 4.3 mg/dL, respectively.
Karakterisasi Simplisia dan Ekstrak Kulit Buah Duku (Lansium domesticum Corr) dari Provinsi Sumatera Selatan dan Jambi Salim, Milana; Sulistyaningrum, Novi; Isnawati, Ani; Sitorus, Hotnida; Yahya, Yahya; Ni'mah, Tanwirotun
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2947

Abstract

Duku (Lansium domesticum Corr var duku) is a seasonal native plant from South Sumatra and Jambi. Peel of Duku is useful as botanical insecticide. in South Sumatra and Jambi. The research proves that the skin duku can be useful as an insecticide plant. Quality of compounds in plants can be affected by the origin area of plant, body parts of plants, and extract characters. This study aims to characterize the simplicia and duku peel extract from South Sumatra and Jambi Province. The sample were collected from Simpang Agung Village, OKU Selatan District and Rengas Bandung Village, Muaro Jambi District. The peel was extracted using acetone, while the charactherization based on standardization method from Badan POM Indonesia. Non-Specific parameters which measured were water content, water soluble ash and acid insoluble ash. Specific parameters which measured were water soluble extract, ethanol soluble extract, chromatogram, and chemical compound. Simplicia from Simpang Agung Village contain lower water content, water soluble ash, and acid insoluble ash than simplicia from Rengas Bandung Village. Chromatogram pattern of the peel extract from both village were similar and contain terpenoid and fenolic compound. However hexane yield extract from Simpang Agung Village higher than extract from Rengas Bandung Village therefore contain more insecticides material (terpenoid).
Formulasi dan Uji Penetrasi Sediaan Gel Transfersom yang Mengandung Kojyl 3 Amino Propil Fosfat sebagai Pencerah Kulit Andini, Septia; Jufri, Mahdi; Djajadisastra, Joshita
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2948

Abstract

Kojyl 3 APPA is a compound used for skin lightening. Kojyl 3 APPA has a good solubility in water. This causes the hydrophilic nature kojyl 3 APPA difficult to penetrate through the skin. Transfersom is a carrier system that can improve the effectiveness of drug penetration. This study aims to formulate, characterize and evaluate transfersom preparations containing kojyl 3 APPA. Further more transfersom formulated in a gel formulation. Preparation gel was tested its physical stability and in vitro penetration test against non transfersom kojyl 3 APPA. Transfersom gel formulation is physically proven stable at room temperature, low temperature and high temperature storage. In vitro penetration tests showed that kojyl 3 APPA penetration loaded in transfersom gel was 11,16% while for non transfersom gel 8,02%
Efek Ekstrak Campuran Kulit Batang Pulai (Alstonia scholaris) dan Meniran (Phyllanthus niruri) pada Mencit Swiss Webster yang Diinfeksi Plasmodium berghei Intan, Putri Reno; Winarno, M. Wien; Prihatini, Nita
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2949

Abstract

Pulai and meniran is one of the medicinal plants that have been studied as a possible antimalarial drugs. This study aims to evaluate the antimalarial activity of a mixture of pulai bark and meniran extracts as antimalarial drugs. Acute toxicity tests was performed using male and female Wistar rats each 25 animals with four doses of treatment. Antimalarial test using 72 mice were divided into six dose groups: group CMC, DHP, dose mixture of 1330; 443.34; 147.78 mg/kg bw and doses of pulai groups 1330 mg /kg bw. All the mice were infected with Plasmodium berghei (D0) and given the extracts orally for 14 days. Giemsa blood stainning taken on days D1-D7 and D14 were analyzed for percentage of parasitaemia, lymphocytes, monocytes and granulocytes. Results of acute toxicity test (LD50) values obtained from extract mixture was more than 14285 mg/kg bw, are classified as non-toxic materials. The most effective dose of the test antimalarial obtained from the percentage of parasites reducing and leukocytes differential, was 147.78 mg/kg. A mixture of pulai bark and meniran extract can be considered to be used as an alternative drug in the treatment of malaria. Further research is needed to isolate and characterized the active ingredients which have the effect of antimalarial to be recommended as an antimalarial drug in the future.
Sarana dan Prasarana Rumah Sakit Pemerintah dalam Upaya Pencegahan dan Pengendalian Infeksi di Indonesia Herman, Max Joseph; Handayani, Rini Sasanti
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2950

Abstract

Nosocomial infections is an important issue around the world. Hospitals are required to provide qualified, efficient and effective service to ensure patient safety. The Ministry of Health has revitalized prevention and control of infection program (PPI) in hospitals which is one of the cornerstones towards patient Safety. The purpose of this study is to identify the preparedness of hospitals to implement the PPI program. The data source is Health Facility Research of 2011 which was done by National Institute of Health Research and Development. The aspects examined include facility, infrastructure, human resource, organization, guidelines, compliance in prescribing, the availability of clean water and hospital sewage treatment. The results show that many hospitals are not yet ready to conduct PPI, especially in terms of infrastructure, clean water sterilization and processing waste, mostly hospitals of classes C and D. Sewage treatment is important in the control or prevention of spread of antimicrobial resistance. This program gives many benefits especially in preventing the occurrence of total resistance or back to the era before antibiotics. The PPI program does require a large fee such that hospital management often disapproves, although the result of available cost analysis indicates that PPI is highly cost-effective.
Front Matter Volume 6 No 2 Tahun 2016 JKI, Editor
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.3811

Abstract

Back Matter Volume 6 No 2 Tahun 2016 JKI, Editor
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.3812

Abstract

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