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Journal of Tropical Pharmacy and Chemistry
Published by Universitas Mulawarman
ISSN : 20877099     EISSN : 24076090     DOI : 10.25026/jtpc
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Journal of Tropical Pharmacy and Chemistry is a Six monthly (June and December), international, open access, journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry publishes manuscripts (Original research Article, review articles, Mini-reviews, and Short communication) on original work, either experimental or theoretical in the following areas: Pharmaceutics & Biopharmaceutics, Novel &Targeted Drug Delivery, Nanotechnology & Nanomedicine, Pharmaceutical Chemistry, Pharmacognosy & Ethnobotany, Phytochemistry, Pharmacology & Toxicology, Pharmaceutical Biotechnology & Microbiology, Pharmacy practice & Hospital Pharmacy, Pharmacogenomics, Pharmacovigilance, Natural Product Research, Drug Regulatory Affairs, Case Study & Full clinical trials, Biomaterials & Bioactive polymers, Analytical Chemistry, Organic Chemistry, Physical Pharmacy, Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 298 Documents
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Pengaruh Kadar Polietilen Glikol (PEG) 400 terhadap Pelepasan Natrium Diklofenak dari Sediaan Transdermal Patch Type Matriks Aditya Fridayanti; Esti Handayani; Isnaeni Isnaeni
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 1 (2010): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v1i1.1

Abstract

The sodium diclofenac realeased from transdermal patch of combination of EC N–20 and PVP K–30 with ratio 6:4 with plasticizer PEG 400 5% (formula 1), PEG 400 10% (formula 2) and PEG 400 20% (formula 3) was investigated. The percentage of moisture contents was calculated as a difference between initial and final weight with respect to final weight. The homogeneity of patch surface was determined using fluorescence microscope and scanning electron microscope (SEM). Released test using dissolution apparatus were carried out in 500 mL of phosphate buffer saline pH 7.4 ± 0.05 at temperature 37 ± 0.5°C with speed of swirl 50 rpm. Results were analyzed by statistic programmed of SPSS using one way analysis of variance with degree of believed 95% (α = 0,05), showed that that the combination of EC N–20 and PVP K–30 at ratio 6:4 with plasticizer PEG 400 5% was the best choice for manufacturing transdermal patch based on physicochemical and the release profile. ABSTRAK Telah dilakukan penelitian pelepasan sodium diklofenak dari transdemal Patch kombinasi matriks EC N–20 dan PVP K–30 dengan rasio 6:4 dan plasticizier PEG 400 5 % (formula 1), PEG 400 10% (formula 2), dan PEG 400 20 %. Persentase kadar air dihitung sebagai perbedaan antara berat awal dan akhir. Homogenitas dari permukaan Patch di determinasi menggunakan Mikroskop flourescence dan SEM. Uji pelepasan dilakukan menggunakan alat uji dissolusi dalam 500 mL larutan salin fosfat buffer pH 7.4 ± 0.05 pada suhu 37 ± 0.5°C dengan kecepatan pengadukan 50 rpm. Hasil di analisis menggunakan program statistik SPSS analisis one way variance (ANAVA) dengan tingkat kepercayaan 95% (α = 0,05), menunjukkan bahwa kombinasi dari EC N–20 and PVP K–30 pada rasio 6:4 dengan plasticizer PEG 400 5% merupakan pilihan terbaik untuk industri Patch transdemal berdasarkan fisikokimia dan profil pelepasan.
Pengaruh Propilen Glikol terhadap Laju Difusi Krim Natrium Diklofenak dengan Basis Hidrofobik Secara Invitro Angga Cipta Narsa; Boesro Soebagio; Sriwidodo Sriwidodo
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 1 (2010): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v1i1.2

Abstract

ABSTRACT The research on effect of propylene glycol in diffusion of cream diclofenac sodium from hydrophobic base with in-vitro. The research has been used for concentrations propylene glycol (0, 3, 5, and 7%). The stability test included organoleptic, pH, viscosity, consistency, flow type for 56 days of storge, and diffusion test used diffusion franz cell and membrane spangler. The result showed that formula diclofenac sodium cream contained propylene glycol 7% was the one best in diffusion of 0.0203 ppm/menit. Key words : Propylene glycol, diffusion, hydrophobic base ABSTRAK Telah dilakukan penelitian mengenai pengaruh propilen glikol terhadap laju difusi krim natrium diklofenak basis hidrofobik secara invitro. Dalam penelitian ini dibuat formula dengan variasi konsentrasi propilen glikol yaitu 0, 3, 5, dan 7%. Pengujian stabilitas fisik sediaan krim meliputi organoleptis, pH, viskositas, konsistensi, dan uji sifat aliran selama 56 hari penyimpanan, serta uji difusi menggunakan alat difusi Franz dan membran spangler. Dari hasil penelitian ini didapat bahwa formula krim natrium diklofenak yang mengandung propilen glikol 7% memiliki laju difusi paling baik yaitu 0,0203 ppm/menit. Kata kunci : Propilen glikol, laju difusi, basis hidrofobik
Potensi Antibakteri Ekstrak Diethyl Ether Daun Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl) terhadap Bakteri Pseudomonas aeruginosa dan Staphylococcus aureus Arsyik Ibrahim; Rusli Rusli
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 1 (2010): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v1i1.4

Abstract

ABSTRACT This study aims to test the antibacterial potential of diethyl ether extract of mahkota dewa leaves (Phaleria macrocarpa (Scheff.) Boerl) with the test method Minimum Inhibitory Concentration (MIC) and Minimum Kill Concentration (MBC) against the microbe, Pseudomonas aeruginosa and Staphylococcus aureus. The test materials were obtained by maceration of leaves with methanol, followed by partition using diethyl ether and n–butanol, each extract was tested its activity with solid dilution method. Solid dilution test results showed the active extract is extract of diethyl ether. Active extracts were further tested by using MIC and MBC. Value of MIC and MBC is determined by the most active and liquid dilution method followed by scratches on solid media. The results show that diethyl ether extract of mahkota dewa leaves (Phaleria macrocarpa [Scheff] Boerl.) Has the potential antibacterial against bacterium Staphylococcus aureus and Pseudomonas aeruginosa with MIC value of 0.025%, and the value of MBC, respectively - each is 0.4% for the bacterium Staphylococcus aureus, and 0.1% for the bacterium Pseudomonas aeruginosa. Keywords: Mahkota dewa folium, Antibacterials, Potential, Minimum Inhibitory Concentration (MIC) and Minimum Kill Concentration (MBC) ABSTRAK Penelitian ini bertujuan untuk menguji potensi antibakteri ekstrak dietil eter daun mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl) dengan metode pengujian Kadar Hambat Minimal (KHM) dan Kadar Bunuh Minimal (KBM) terhadap mikroba Pseudomonas aeruginosa dan Staphylococcus aureus. Bahan uji diperoleh dengan maserasi daun dengan metanol, dilanjutkan dengan partisi menggunakan dietil eter dan n–butanol, masing-masing ekstrak diuji aktivitasnya dengan metode dilusi padat. Hasil pengujian dilusi padat menunjukkan ekstrak aktif adalah ekstrak dietil eter. Ekstrak aktif selanjutnya diuji dengan metode KHM dan KBM. Nilai KHM dan KBM teraktif ditentukan dengan metode dilusi cair dan dilanjutkan dengan goresan pada media padat. Hasil pengujian menunujukkan bahwa ekstrak dietil eter daun mahkota dewa (Phaleria macrocarpa [Scheff] Boerl.) memiliki potensi antibakteri terhadap bakteri Pseudomonas aeruginosa dan Staphylococcus aureus dengan nilai KHM 0,025%, dan nilai KBM masing–masing adalah 0,1 % untuk bakteri Pseudomonas aeruginosa dan 0,4 % untuk bakteri Staphylococcus aureus. Kata Kunci: Daun mahkota dewa, Antibakteri, Potensi, Kadar Hambat Minimum (KHM) dan Kadar Bunuh Minimum (KBM)
Evaluasi Efektivitas Penggunaan Antibiotika pada Pasien Rawat Inap Penderita Infeksi Saluran Pernapasan Bawah di Rumah Sakit Panti Rapih Yogyakarta Periode Januari-Juni 2005 Fajar Prasetya; Zullies Ikawati
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 1 (2010): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v1i1.5

Abstract

ABSTRACT The non-TBC lower respiratory infection is a kind of infection that can attack bronchus, bronchioles and lung, the clinical manifestation can chronicle and severe. Generally the caused in children is virus and bacteria while in adult is bacteria, which is using antibiotics in medical attention. The purpose of research is to find out the infection pattern and the kind of antibiotics and to evaluate the using antibiotics based on effectivity. The non-experimental research that was form in a retrospective survey was done through medical record of patient with the lower respiratory infection in the time limit of january-june 2005 in Panti Rapih Hospital. The using of antibiotics was surveyed from medical record then analyzed using quantitative descriptive and presented in percentage. The result was that the most infection from patient with lower respiratory infection is bronchitis 45 % from 132 patients with 137 cases, the biggest percentage is man 58 % and placed in children age between 0-14 years old 52 % with the length of medical attention 6 days in average. Based on this research 95 % gave clinical respond of fever decerease within 2-6 days and 45 % showed heal conditions, 40 % better, 10 % not heal and 5 % died. Keywords: lower respiratory infection, usage, antibiotics evaluation ABSTRAK Infeksi saluran pernapasan bawah non TBC merupakan suatu golongan infeksi yang dapat menyerang bronkus, bronkiolis, dan paru, manifestasi kliniknya dapat bersifat akut dan kronis. Umumnya pada anak-anak penyebabnya adalah virus dan bakteri, sedangkan pada orang dewasa adalah bakteri, yang dalam pengobatannya menggunakan antibiotika. Penelitian ini bertujuan mengetahui pola infeksi dan jenis antibiotika serta mengevaluasi penggunaan antibiotika berdasarkan efektivitas. Penelitian non eksperimental yang berbentuk survei retrospektif dilakukan melalui rekam medik pasien dengan infeksi saluran pernapasan bawah yang menjalani rawat inap pada kurun waktu Januari-Juni 2005 di RS Panti Rapih Yogyakarta, kemudian dianalisis secara deskriftif kuantitatif yang dinyatakan dengan presentase. Hasil penelitian yang diperoleh menunjukan bahwa jenis infeksi yang terbanyak pada pasien dengan infeksi salauran pernapasan bawah adalah bronkitis 45 % dari 132 pasien dengan 137 kasus, presentase terbesar pada pria 58 % dan terdapat pada anak-anak dengan umur 0-14 tahun 52 %, dengan lama rawat rata-rata 6 hari. Berdasarkan penelitian 95 % memberikan respon klinik turunnya demam dalam 2-6 hari, dan sebanyak 45 % menunjukan kesembuhan, membaik 40 %, tetap belum sembuh 10 %, serta meninggal 5 %. Kata Kunci: infeksi saluran pernapasan bawah, penggunaan, evaluasi antibiotika
Mekanisme Aksi ?-Mangostin dari Garcinia Tetranda Pierre terhadap P.falciparum Secara In Vitro Hadi Kuncoro; Aty Widyawaruyanti; Taslim Ersam
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 1 (2010): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v1i1.6

Abstract

ABSTRACT Development stage of parasite resistance assay and the Globin accumulation using SDS-PAGE Method has been done to parasite P. falciparum by giving α-mangostin from G. tetranda. α-Mangostin cause delays in the development stage of the parasite P. falciparum from stage schizont to stage trofozoit and cause parasite death after 48 hour. Swelling of the parasite of abnormal parasite food vacuole occurred after administration of α-Mangostin show from the results of SDS-PAGE. Key word : α- Mangostin, G. tetranda, P. falciparum, globin accumulation ABSTRAK Telah dilakukan pengujian hambatan perkembangan stadium parasit dan akumulasi globin menggunakan metode SDS- PAGE terhadap P. falciparum dengan pemberian α-Mangostin dari G. tetranda. Diketahui α-Mangostin menyebabkan penundaan perkembangan parasit P. falciparum dari stadium trofozoit menjadi stadium skizon dan menyebabkan parasit mati setelah jam ke 48. Pembengkakan vakuola makanan parasit yang abnormal terjadi setelah pemberian α- Mangostin terlihat dari hasil SDS-PAGE. Kata Kunci : α-Mangostin, G. tetranda, P. falciparum, , akumulasi globin
Analisis Kuantitatif Neodimium, Praseodimium, Cerium, dan Lantanum dalam Monasit dengan KCKT Pertukaran Ion Herman Herman; Husein H. Bahti; Muljadji Agma
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 1 (2010): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v1i1.7

Abstract

ABSTRACT Neodymium, Praseodymium, Cerium, and Lanthanum are rare earth elements with considerably high concentration in monazite and xenotime. Samples used in this research are monazite sands from PT Timah Bangka and obtained from Dowa Mining product. The determination and separation of these rare earth elements carried out with ion exchange HPLC method using ion exchanger column Supelcosil LC-SCX with column length 25 cm, diameter 4.6 mm and particle size 5 mm, and using conductometer detector of Waters 432 type. The optimum condition for these rare earth elements were: using ethylendiamin solution of 1.50 mM, and tatrate acid 2.00 mM as moving phase and complexing agent at pH 4.5 with flow rate 0.8 mL per minute and sample volume 10 mL. Research results showed that ion exchange HPLC method can be used to separate and to determinate the concentration of Neodymium, Praseodymium, Cerium, and Lanthanum. Chromatograms obtained of these four of rare earth elements were well separated. This was showed from their resolutions (R) which range from 2 to 4 at concentration 100 ppm for Neodymium, Praseodymium, Cerium, and Lanthanum with retention time 9.66, 10.87, 13.42, 16.29 minutes respectively. The concentration of Neodymium, praseodymium, cerium, and lanthanum in monazite (w/w) were 4.580±0.003, 7.860±0.002, 4.200±0.003, 4.160±0.005% respectively. Key Words: Neodymium, Praseodymium, Cerium, Lanthanum, Monasit, HPLC ABSTRAK Neodimium, Praseodimium, Serium, dan Lantanum merupakan unsur tanah jarang dengan kadar tinggi yang terdapat dalam monasit dan senotim. Sampel yang digunakan dalam penelitian ini adalah pasir monasit dari PT Timah Bangka yang diperoleh melalui hasil Dowa Mining. Penentuan dan pemisahan unsur tanah jarang ini dilakukan dengan metode KCKT pertukaran ion menggunakan kolom penukar ion Supelcosil LC-SCX panjang kolom 25 cm, diameter 4,6 mm, dan ukuran partikel 5 µm dengan menggunakan detektor konduktometer jenis Waters 432. Kondisi optimum pemisahan unsur tanah jarang: menggunakan larutan etilendiamin 1,50 mM dan asam tartrat 2,00 mM sebagai fasa gerak dan pengompleks pada pH 4,5 dengan kecepatan alir 0,8 mL/menit dan volume sampel 10 µL. Hasil penelitian menunjukkan bahwa metode KCKT pertukaran ion dapat digunakan untuk memisahkan dan menentukan kandungan Neodimium, Praseodimium, Serium, dan Lantanum. Kromatogram campuran dari keempat unsur tanah jarang yang diperoleh dapat terpisah dengan baik, hal ini dapat dilihat dari resolusinya (R) berkisar 2 sampai 4 pada konsentrasi 100 ppm untuk Neodimium, Praseodimium, Serium, dan Lantanum dengan waktu retensi berturut-turut 9,66; 10,87; 13,42; 16,29 menit. Kandungan Neodimium, Praseodimium, Serium, dan Lantanum dalam monasit (b/b) berturut turut yaitu: 4,580±0,003; 7,860±0,002; 4,200±0,003; 4,160±0.005 %, dengan batas deteksi berturut-turut yaitu: 261, 386, 424, 334 ng. Kata Kunci: Neodimium, Praseodimium, Serium, Lantanum, Monasit, KCKT
Bioaktivitas Biji Kolowe (Chydenanthus excelsus) terhadap Larva Nyamuk Aedes aegypty Laode Rijai
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 1 (2010): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v1i1.8

Abstract

ABCTRACT Kolowe seed (Chydenanthus excelsus) bioactivity against Aedes aegypti masquito larvae was investegated. Assay of Kolowe seed preparation used fresh seed powder, dry powder, rough extract (methanol extract), n- butanol extract fraction, and aethyl acetate extract fraction. Plant material taken from Kamaru, Buton, Indonesia on March 2007. Fresh powder bioactivity (LC50 = 230.60 ppm); dry powder (LC50 = 225.55 ppm); rough extract/ methanol (LC50 = 245.70 ppm); n- butanol extract fraction (LC50 = 235.75 ppm); aethyl acetate extract fraction (LC50 = 250.55 ppm). The research results illustrated that the bioactivity seed from kolowe strong enough against mosquito larvae A. aegypti and dry powder has a stronger bioactivity than the other. Keywords : Kolowe Seed (Chydenanthus excelsus), Aedes aegypti mosquito larvae ABSTRAK Penelitian bioaktivitas biji kolowe (Chydenanthus excelsus) terhadap larva nyamuk Aedes aegypti telah dilakukan. Sediaan biji kolowe yang diuji adalah serbuk biji segar, serbuk kering, ekstrak kasar (ekstrak metanol), ekstrak fraksi n-butanol, dan ekstrak fraksi etilasestat. Bahan tumbuhan diambil dari Kamaru, Buton, Indonesia pada bulan Maret 2007. Bioaktivitas serbuk segar (LC50 = 230,60 ppm); serbuk kering (LC50 = 225,55 ppm); ekstrak kasar/metanol (LC50 = 245,70ppm); ekstrak fraksi n-butanol (LC50 = 235,75 ppm); ekstrak fraksi etilasetat (LC50 = 250,55 ppm). Hasil penelitian tersebut menggambarkan bahwa bioaktivitas biji kolowe cukup kuat terhadap larva nyamuk A. aegypti dan serbuk kering memiliki bioaktivitas lebih kuat dari lainnya. Kata Kunci: Biji Kolowe (Chydenanthus excelsus), larva nyamuk Aedes aegypti
Sintesis Oksida Aurivillius Sr2Bi4Ti5-xFexO18 (x = 0,25; 0,5; 0,75; dan 1) Rolan Rusli; Ismunandar Ismunandar
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 1 (2010): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v1i1.9

Abstract

Aurivillius oxides Sr2Bi4Ti5-xFexO18 have been synthesized using the solid state reaction method. Powder X-ray diffraction data were refined using Le Bail method implemented in Rietica have space group B2cb, Z = 4, and parameter cell are a = 5.542(8), b = 5.474(9), c = 48.947(1); a = 5.565(5), b = 5.491(9), c = 49,097(1); a = 5.533(7), b = 5.464(7), c = 48.595(2) and a = 5.621(1), b = 5.492(9), c = 49.78(4); respectively for x = 0.25, 0.5, 0.75, and 1. The substitution of cation Fe3+ in these Aurivillius oxides was showed increasing of magnetic moment are μ = 2.67, 3.21, 3.98, and 4.62 for x = 0.25, 0.5, 0.75, and 1 respectively. Keywords: Aurivillus oxide, solid state reaction, Le Bail method, magnetic moment ABSTRAK Oksida Aurivillius Sr2Bi4Ti5-xFexO18 telah disintesis dengan menggunakan metode reaksi kimia padat. Data difraksi sinar-x serbuk yang penghalusan strukturnya menggunakan metode rietveld dengan program rietica menunjukkan bahwa oksida ini memiliki grup ruang B2cb, Z = 4, dan parameter selnya adalah a = 5,542(8), b = 5,474(9), c = 48,947(1); a = 5,565(5), b = 5,491(9), c = 49,097(1); a = 5,533(7), b = 5,464(7), c = 48,595(2) dan a = 5,621(1), b = 5,492(9), c = 49,78(4); berturut-turut untuk x = 0.25; 0,5; 0,75; dan 1. Substitusi kation Fe3+ pada oksida Aurivillius ini menunjukkan terjadinya peningkatan momen magnet oksida ini yaitu μ = 2,67; 3,21; 3,98; dan 4,62 berturut-turut untuk x = 0,25; 0,5; 0,75; dan 1. Kata kunci: Oksida Aurivillius, reaksi kimia padat, metode Le Bail, momen magnet
Analisis Kadar Asam Sianida dalam Solanum melongena L dan Solanum quitoense L Sebelum dan Sesudah Perebusan Sabaniah Indjar Gama; Alimuddin Alimuddin; Eva Marliana
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 1 (2010): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v1i1.10

Abstract

ABSTRACT Analysis cyanide acid in Solanum melongena and Solanum quitoense L before and after boiling. Cyanide acid is esthabushed by argonometricm method (Volhard) with three times repetition, for each kinds of eggplants Solanum melongena L dan Solanum quitoense L. The research showed have endireated that before boiling the content of cyanide acid Solanum melongena L (Craigi eggplant 71,712 mg/kg, kopek eggplant 46,310 mg/kg, gelatik eggplant 0 mg/kg) and Solanum quitoense L (asam eggplant 30,434 mg/kg) after boiling, the cyanide acid to slop Solanum melongena (Craigi eggplant 19,321 mg/kg, kopek eggplant 6.620 mg/kg, gelatik eggplant 0 mg/kg and Solanum quitoense L (asam eggplant 3.445 mg/kg). There is significant content have been reduced of cyanide acid in Solanum melongena L dan Solanum quitoense L Keywords: Solanum melongena dan Solanum quitoense L, Cyanide acid ABSTRAK Telah dilakukan analisis asam sianida dalam Solanum melongena dan Solanum quitoense L sebelum dan sesudah perebusan menggunakan metode Volhard dengan tiga kali pengulangan. Data hasil penelitian menunjukkan kandungan asam sianida sebelum perebusan Solanum melongena (terong Craigi 71,712 mg/kg, terong kopek 46,310 mg/kg, terong gelatik 0 mg/kg) dan Solanum quitoense L (terong asam 30,434 mg/kg) sedangkan setelah dilakukan perebusan (terong Craigi 19,321 mg/kg, terong kopek 6.620 mg/kg, terong gelatik 0 mg/kg) and Solanum quitoense L (terong asam 3.445 mg/kg). Terdapat perbedaan kandungan penting yang dapat mengurangi kadar asam sianida dalam Solanum melongena L dan Solanum quitoense L. Kata kunci: Solanum melongena dan Solanum quitoense L, Asam Sianida
Studi Efek Samping Obat pada Pasien Neonatus yang Menjalani Rawat Inap Di Rumah Sakit Angkatan Laut Dr. Ramelan Surabaya Victoria Yulita Fitriani; Widyati Widyati; Azis Huibeis; Retno Wisanti
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 1 (2010): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v1i1.11

Abstract

ABSTRACT Rational drug treatments to avoid adverse drug reactions in neonates are depend on physiologic immaturity and age-related changes in pharmacokinetic and pharmacodynamic factor. This condition lead neonates more prone to adverse drug reaction than adults.The aim of this study was to estimate the prevalence of adverse drug reactions that occured at Dr. Ramelan Navy Hospital's NICU observed in November 26th 2007 to January 26th 2008. It was also to analyze kind of medication that caused adverse drug reactions.The study employed 94 patients (5 premature neonates and 89 term neonates) who were observed perspectively from November 26th 2007 to January 26th 2008. Demographic data, drug therapy, relevant medical histories, laboratory data were recorded in this study. The study result was assessed by literature study. The study result were analysed with Descriptive analysis. The most common adverse drug reaction occurred in this population was potential adverse drug reaction (99.5%). The most adverse drug reaction generated from this study was come from the use of ampicillin sulbactam (42.7%), gentamisin (31.4%), ceftriaxone (16.2 %), amikacin (7.6 %), aminofilin (1.1 %), ampicillin (0.5 %), and dexamethasone (0.5 %). The study showed that almost all of adverse drug reaction occurred in this study was potential adverse drug reaction (99.5%). Keywords: neonates; adverse drug reactions; NICU ABSTRAK Terapi obat yang rasional untuk menghindari efek samping dari obat pada neonatus bergantung pada ketidakmatangan fisiologik dan perubahan faktor farmakokinetika dan farmakodinamika yang terkait usia. Kondisi ini membawa neonatus lebih mudah terpapar efek samping obat daripada orang dewasa. Tujuan dari penelitian ini adalah untuk memperkirakan angka kejadian efek samping obat yang terjadi di NICU Rumah Sakit Angkatan Laut Dr. Ramelan Surabaya diamati secara prospektif sejak 26 November 2007 hingga 26 Januari 2008. Penelitian ini juga menganalisa jenis obat yang menyebabkan efek samping obat. Penelitian ini melibatkan 94 pasien (5 neonatus premature dan 89 neonatus term) yang diamati secara prospektif sejak 26 November 2007 hingga 26 Januari 2008. Penelitian ini mencatat data demografi, terapi obat, sejarah penyakit yang terkait, dan data laboratorium. Data tersebut dianalisa melalui studi literatur. Hasil penelitian dianalisa dengan menggunakan analisis deskriptif. Efek samping obat yang sering muncul pada penelitian ini adalah efek samping potensial (99.5%). Efek samping yang terjadi pada penelitian ini terjadi akibat penggunaan ampisilin sulbaktam (42.7%), gentamisin (31.4%), ceftriaxon (16.2%), amikasin (7.6%), aminofilin (1.1%), ampisilin (0.5%), dan deksametason (0.5%). Penelitian ini menunjukkan bahwa sebagian besar efek samping obat yang terjadi pada penelitian ini adalah efek samping obat potensial. Kata kunci: neonatus; efek samping obat; NICU

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