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Journal of Tropical Pharmacy and Chemistry
Published by Universitas Mulawarman
ISSN : 20877099     EISSN : 24076090     DOI : 10.25026/jtpc
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Journal of Tropical Pharmacy and Chemistry is a Six monthly (June and December), international, open access, journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry publishes manuscripts (Original research Article, review articles, Mini-reviews, and Short communication) on original work, either experimental or theoretical in the following areas: Pharmaceutics & Biopharmaceutics, Novel &Targeted Drug Delivery, Nanotechnology & Nanomedicine, Pharmaceutical Chemistry, Pharmacognosy & Ethnobotany, Phytochemistry, Pharmacology & Toxicology, Pharmaceutical Biotechnology & Microbiology, Pharmacy practice & Hospital Pharmacy, Pharmacogenomics, Pharmacovigilance, Natural Product Research, Drug Regulatory Affairs, Case Study & Full clinical trials, Biomaterials & Bioactive polymers, Analytical Chemistry, Organic Chemistry, Physical Pharmacy, Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 298 Documents
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Preliminary Phytochemistry and Antioxidant Activities of the Ethanol Extract of Ficus abutilifolia Leaves Attama, Chika; Lawrence, Luka; Chidama, Ndakudu Bulama
Journal of Tropical Pharmacy and Chemistry Vol. 9 No. 1 (2025): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v9i1.620

Abstract

Medicinal plants harbor bioactive compounds utilized for addressing various health challenges. This current research focuses on the study of Ficus abutilifolia, collected from Askira Uba, Borno State, Nigeria. Ethanol was employed to extract compounds from the plant leaves. The extracts underwent qualitative phytochemical screening using established procedures. The screening identified the presence of Alkaloids, Saponins, Tannins, Anthraquinones, Steroids, Glycosides, Flavonoids, reducing sugar, amino acids, and terpenoids, while Phytosterol was notably absent. The antioxidant activity of the crude extracts was assessed using two complementary test systems: 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide free-radical scavenging assays, with Ascorbic acid serving as the standard. The free radical scavenging activity of the leaf crude extracts at different concentrations (2.5, 5, 7.5, and 10 µl/mL) demonstrated a concentration-dependent increase. In the DPPH method, the crude extract at a concentration of 10 ?g/mL exhibited 58.2 % antioxidant activity. Similarly, in the hydrogen peroxide radical scavenging assay, it was observed that at a concentration of 10 ?g/mL, the crude extract demonstrated an inhibition of 72.7 %. In conclusion, the ethanol extract from the plant exhibited potent inhibition of free radicals, possibly attributed to the presence of secondary metabolites.
Front Cover, Editorial Information, Table of Content, Author Guidelines, Back Cover Editor, Journal
Journal of Tropical Pharmacy and Chemistry Vol. 9 No. 1 (2025): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v9i1.657

Abstract

Evaluation of Protective Role of Date Palm Pollen against Cisplatin-Induced Reproductive Toxicity in Rats Abdelrahim, Musab A. M.; Ahmed, Elhadi M. M.; Taj-Eldin, Imad M.; Mohammed, Abd-Elwahab H.
Journal of Tropical Pharmacy and Chemistry Vol. 9 No. 2 (2025): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v9i2.643

Abstract

Date palm pollen (DPP) is herbal mixture that widely used in traditional medicine to improve fertility. The current study aimed to determine the protective role of the DPP extract against cisplatin-induced reproductive toxicity in rats. Sixty rats were used (30 of each sex) and allocated to normal, negative, and test control groups of males and females (10 animals per group). Reproductive toxicity was induced by an intraperitoneal injection of cisplatin (4.5 mg/kg/72 hour) in the negative and test groups, whereas the test groups also received daily oral doses of DPP methanolic extract (250 mg/kg). At the end of the experimental period (30 days), the rats were sacrificed to determine the fertility parameters. The obtained results showed that, oral administration of DPP extracts exhibited protective effects as demonstrated by a prominent increase in serum estradiol concentration, recovery from reduction in gonads weight, and a considerable enhancement on histological observations among male and female rats. Moreover, elevation in epididymal sperm count and motility in male animals was observed compared to that in cisplatin-treated rats. DPP had a significant effect on estradiol levels, as well as protective effects against cisplatin-induced reproductive toxicity in both male and female rats. Keywords:          Cisplatin, date palm, epididymal characteristics, Phoenix dactylifera
A Serious Medical Case Confirming the Significance of Clinical Pharmacists’ Role Inside Community Pharmacists Amer, Ahmed; Osman, Samir
Journal of Tropical Pharmacy and Chemistry Vol. 9 No. 2 (2025): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v9i2.648

Abstract

Diclofenac and ketorolac are prescribed as nonsteroidal anti-inflammatory drugs (NSAIDs) used to manage pain and inflammation. However, co-administration of them could lead to serious health problems. We seek to highlight the potential dangers of their concurrent use.  We discuss the increased risk of severe gastrointestinal complications, including ulceration, bleeding, and perforation, associated with combining these medications. The case emphasizes the importance of clinician awareness of this drug interaction and advocates for safer prescribing practices. Also, we shed light on the significant role of clinical pharmacists in each community pharmacy, hospital, and medical centre. Keywords:          Diclofenac, Ketorolac, Drug-Drug Interactions, Clinical pharmacist, Community Pharmacy
Nutritional Constituents, Phytochemical Analysis and Biological Evaluation of Momordica charantia (Bitter Gourd) Leaf and Stem Ethanol Extracts Anomi, Etudaiye; Ndukaire, Victoria; Afolayan, Michael
Journal of Tropical Pharmacy and Chemistry Vol. 9 No. 2 (2025): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v9i2.662

Abstract

Momordica charantia L. (Cucurbitaceae), locally known as Ejirin or bitter gourd, is widely used in Nigerian traditional medicine for its purported health-promoting properties. This study aimed to evaluate the proximate, nutritional, phytochemical profile, antioxidant and antimicrobial efficacy of the leaves and stems of M. charantia. Ethanolic extracts were prepared and subjected to standard analytical protocols. Proximate analysis revealed that the leaves contained 18.22% ash, 39.43% crude fiber, 4.02% crude protein, and a metabolizable energy value of 96.52 kJ, indicating significant nutritional potential. In contrast, the stems exhibited an exceptionally high fiber content (77.65%) but a negative calculated energy value (?39.44 kJ). Phytochemical screening confirmed the presence of alkaloids, flavonoids, tannins, resins, and saponins in the leaves, while the stem contained alkaloids, tannins, steroids, triterpenoids, and phenols. The leaf extract demonstrated potent antioxidant activity, with 74.96% DPPH radical scavenging at 2 mg/mL. Antimicrobial assays showed that the leaf extract was effective against Staphylococcus aureus, Escherichia coli, and Candida krusei, while the stem extract exhibited broad-spectrum activity against both Gram-positive and Gram-negative bacteria. These findings provide a scientific basis for the traditional use of M. charantia leaves as a wellness supplement and highlight the stems as a potential source of dietary fiber. Keywords:          Momordica charantia, bitter gourd, phytochemicals, antioxidant activity, antimicrobial activity
Nutritional and Therapeutic Effects of Banana on Blood Pressure and Liver Health Hoque, Majedul; Uddin, Md. Mayen; Rafi, Iftear Kazim
Journal of Tropical Pharmacy and Chemistry Vol. 9 No. 2 (2025): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v9i2.664

Abstract

Although the prevalence of hypertension and related conditions is rising, there is currently little usage of functional foods as a therapy. Nutrients and bioactive substances found in bananas can help to prevent and treat a number of degenerative diseases. This study is to ascertain the impact of banana (Musa acuminata) on teenage student’s liver function, cholesterol levels, and blood pressure. The 32 respondents that made up the complete population provided samples for this experimental study. Blood pressure, liver function, and lipid function were assessed both before and after consuming bananas. The data in this study were analyzed using a paired t test. The majority of responders were in the fourteen-year-old age group, with the number of 13(40.62%) and 17(53.12%) in the ninth grade, while fewer number were in the eighth grade, with 5(15.62%). The results of the study showed that students liver function did not show considerable outcome, but their blood pressure changed considerably before and after eating bananas over the allotted time period and their lipid function levels (triglycerides and total cholesterol) also differed considerably. In conclusion, eating bananas might help to prevent degenerative diseases by decreasing blood pressure and maintaining low lipid levels in young people. Keywords:          Blood pressure, Liver function, Lipid function, Potassium, Triglycerides
In Silico Assessment of GSK-3? Inhibition Activity by Secondary Metabolites of Centella asiatica in the Development of Alzheimer’s Therapy Azariani, Wiwin; Ananto, Agus Dwi; Maulidya, Selvira Anandia Intan
Journal of Tropical Pharmacy and Chemistry Vol. 9 No. 2 (2025): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v9i2.671

Abstract

Alzheimer’s disease involves excessive activity of glycogen synthase kinase-3? (GSK-3?), leading to tau hyperphosphorylation and neurofibrillary tangle formation. This study evaluated the potential of secondary metabolites from Centella asiatica as GSK-3? inhibitors using in silico molecular docking. The GSK-3? structure (PDB ID: 1Q5K) and ten test compounds were docked using YASARA-structure, with method validation yielding an RMSD of 1.890 Å. Naringin, luteolin, and betulinic acid demonstrated the strongest binding affinities -9.2670, -8.1520, and -7.9730 kcal/mol, surpassing the native ligand. Naringin and luteolin interacted with key ATP-binding residues (Asp133, Tyr134, Val135, Lys85), indicating strong competitive inhibitory potential. These findings suggest that C. asiatica metabolites, particularly naringin and luteolin, are promising natural candidates for GSK-3? inhibitor Alzheimer’s therapy.   Keywords:          Centella asiatica; GSK-3?; Molecular Docking; Alzheimer’s Disease; Secondary Metabolites
Front Cover, Editorial Information, Table of Content, Author Guidelines, Back Cover Editor, Journal
Journal of Tropical Pharmacy and Chemistry Vol. 9 No. 2 (2025): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v9i2.691

Abstract

Page 30 of 30 | Total Record : 298

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