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Journal of Tropical Pharmacy and Chemistry
Published by Universitas Mulawarman
ISSN : 20877099     EISSN : 24076090     DOI : 10.25026/jtpc
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Journal of Tropical Pharmacy and Chemistry is a Six monthly (June and December), international, open access, journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry publishes manuscripts (Original research Article, review articles, Mini-reviews, and Short communication) on original work, either experimental or theoretical in the following areas: Pharmaceutics & Biopharmaceutics, Novel &Targeted Drug Delivery, Nanotechnology & Nanomedicine, Pharmaceutical Chemistry, Pharmacognosy & Ethnobotany, Phytochemistry, Pharmacology & Toxicology, Pharmaceutical Biotechnology & Microbiology, Pharmacy practice & Hospital Pharmacy, Pharmacogenomics, Pharmacovigilance, Natural Product Research, Drug Regulatory Affairs, Case Study & Full clinical trials, Biomaterials & Bioactive polymers, Analytical Chemistry, Organic Chemistry, Physical Pharmacy, Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 298 Documents
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Flavonoid Level Determination in Jamu Pegel Linu in Magelang Regency Using Uv-Visible Spectrophotometry Selma Septi Pratiwi; Perdana Priya Haresmita; Missya Putri Kurnia Pradani; Arief Kusuma Wardani
Journal of Tropical Pharmacy and Chemistry Vol. 7 No. 2 (2023): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v7i2.551

Abstract

Jamu is made from the toga plant, which is still used medicinally in Indonesia. Rutin, a type of flavonoid component, is frequently present in herbal medicine pegel linu. Rutin serves as an antioxidant and anti-inflammatory by neutralizing free radicals, which helps to prevent tissue damage and relieve soreness. This research's objective was to evaluate the amounts of flavonoids in samples using UV-Visible spectrophotometry, employing three samples of herbal medicine (A, B and C) as well as the standard solution, reagents AlCl3 and sodium acetate. In this investigation, the protocol utilized to determine the maximum wavelength was 400–800 nm, and the result was 413.5 nm. The linear regression equation is y = 0.0471x + 0.0624 with a correlation coefficient of R2 of 0.9934 and a LOD value of 3.9694 mg / L and a LOQ value of 13.231 mg / L. The determination of total flavonoid levels considered as rutin uses concentrations of 10, 12.14, 16 and 18 ppm with operating time of 30 minutes. The findings of rutin content analysis for samples A, B, and C were 1.6683%, 2.8763%, and 3.0923%, respectively.
Cost-Effectiveness of Antibiotics for Typhoid Fever at Hermana Lembean Hospital Teodhora, Teodhora; Musnelina, Lili; Tanama, Celin Gracela
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 1 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i1.554

Abstract

Salmonella typhi bacteria, which contaminate ingested food and beverages and sufferers' feces, urine, or other secretions, are typically to blame for typhoid fever. This study's objectives were to identify the traits of inpatient typhoid fever patients who received antibiotics evaluating the cost-effectiveness of antibiotics for typhoid fever patients receiving inpatient typhoid fever at Hermana Lembean Public Hospital.  The cost-effectiveness of antibiotic therapy for inpatients with typhoid fever was examined in this study utilizing descriptive research, which involved retrospective data collecting using secondary data, such as medical record data and record costs of patients who had received inpatient care at Hermana Lembean General Hospital. According to the calculations from the Cost-Effectiveness Analysis, ceftriaxone injectable therapy has an ACER value of Rp. 15.987, and an efficacy of 100%, is the most economical antibiotic treatment.
Evaluation of the Suitability of Using Anticholesterol Drugs in Cholesterol Patients at Sekip Public Health Centre Palembang Dhiny Zsa Zsa Aulia; Tahoma Siregar; Ritha Widyapratiwi
Journal of Tropical Pharmacy and Chemistry Vol. 7 No. 2 (2023): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v7i2.571

Abstract

Dyslipidemia is a condition that increases plasma cholesterol, LDL, and triglyceride levels, decreases HDL levels, or causes a combination of abnormalities. In amounts sufficient for what the body needs, cholesterol works to produce hormones, vitamin D, and other components. Cholesterol is produced by the liver and can also be found in animal products. This study aims to determine the profile of treatment and the suitability of the use of anticholesterol drugs in patients with high cholesterol at Sekip Public Health Centre Palembang. This research is non-experimental, using quantitative methods and 40 samples. The demographic results of the total cholesterol levels of patients who experienced a decrease were 100 patients (100%). Demographics of patients by gender: mostly female, as many as 30 patients (75%). Demographics of patients by age: mostly in the age category 56–65 years, as many as 16 patients (40%). Demographics of patients based on comorbidities: the most common was diabetes mellitus, with as many as 12 patients (30%) The highest use of anticholesterol drugs is in the statin group, namely simvastatin (100%). The suitability of the selection of anticholesterol drugs was 100% for 100 patients. The suitability of the selection of the anticholesterol dose in 100 patients (100%)
Larvicidal Effect of 96% Ethanol Extract of Lime (Citrus aurantifolia) Leaves with PEG 400 Diluent on Aedes aegypti Larvae Dewi, Listiana Masyita; Mufidah, Fathin; Sutrisna, Em; Nurhayani, Nurhayani
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 1 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i1.574

Abstract

Larval control is remain the best method in reducing the high incidence of Dengue Fever, but temephos-resistance has also been reported. Lime (Citrus aurantifolia) leaves are thought to be a promising material to replace temephos. This study aim to identify the larvicidal effect of lime leaves ethanolic extract on Aedes aegypti. Lime leaves were extracted by maceration method and PEG 400 diluent was added as a dispersing agent. Total of 400 Aedes aegypti larvae at stages III-IV were enrolled. At 24 hours of observation, mortality rate of Aedes aegypti larvae in group with extract concentration of 0.3% and 0.4% was 92% and 100%, respectively. From post-hoc Mann Whitney test, p-value of <0.05 was only found when any study group were compared to negative control group. As as conclusion is 96% ethanol extract of lime leaves in addition of PEG 400 diluent has larvicide effect on Aedes aegypti larvae.
The Effect of Solvent Concentration Against Specific and Non Specific Parameters of Standardization: Ethanolic Extract of Papaya Seed (Carica papaya Linn.) Reza Wilorianza; Emelda Emelda; Muhammad Abdurrahman Munir; Annisa Fatmawati
Journal of Tropical Pharmacy and Chemistry Vol. 7 No. 2 (2023): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v7i2.577

Abstract

Papaya plants (Carica papaya L.) can be used as traditional medicine. The parts of the plant commonly used as medicine are the seeds and leaves. Assurance of the quality of the extract obtained needs to be carried out by testing specific and non-specific parameters. The aim of the study was to determine the effect of the percentage of ethanol solvent concentration on specific parameters (organoleptic, phytochemical screening, and total phenolic content) and non-specific parameters (moisture content, ash content, and specific gravity) of papaya seed extract (Carica papaya L.). This type of laboratory experimental qualitative research was done to determine the effect of the percentage of ethanol solvent concentration (70% and 95%) on specific and non-specific parameters. Specific and non-specific parameter testing is based on work procedures listed in the Indonesian Herbal Pharmacopoeia. The results of testing the specific parameters on organoleptics showed no difference in the extract obtained, which was viscous and dark brown in color with a characteristic odor. Based on qualitative phytochemical screening, 70% ethanol extract contains alkaloids, flavonoids, tannins, and saponins. However, the 95% ethanol extract was only positive for alkaloids, flavonoids, and tannins. The phenolic content test of 70% ethanol and 95% ethanol extracts was 4.31 ± 0.65 mg GAE/g and 2.69 ± 0.41 mg GAE/g, respectively (Sig 0.022 < 0.05). Extract non-specific parameter test results. The ash content test for 70% and 95% ethanol extracts was 9.5% ± 0.21% w/w and 8.5% ± 0.06% w/w (Sig 0.043 < 0.05). The respective water contents were 8.7 ± 0.11% w/w and 9.7 ± 0.26% w/w (Sig 0.046 < 0.05). The specific gravity of each obtained was 0.88 ± 0.006 % g/ml and 0.75 ± 0.006% g/ml (Sig 0.043 < 0.05). The conclusion of this study is that the concentrations of 70% ethanol  and 95% ethanol in papaya seed ethanol extract have an effect on specific parameters, namely the measurement of total phenolic content. While the non-specific parameters affect the water content, total ash content, and specific gravity.
Isolation and Cytotoxic Activity Test of Alkaloids from Dichloromethane Fraction of Bark of Tampa Badak (Voacanga foetida (Blume) Rolfe) Against T47D Cell Line Adriani Susanty; Nurdina Putri; Ihsan Ikhtiarudin; Novia Sinata; Dira Dira; Fatma Sri Wahyuni; Dachriyanus Dachriyanus
Journal of Tropical Pharmacy and Chemistry Vol. 7 No. 2 (2023): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v7i2.583

Abstract

Cancer is a problem in the health sector because this disease has an increasing incidence of morbidity and mortality. While the treatment still leaves some drug side effects, which cause discomfort for cancers sufferers. The arises because most cancer drugs work non-selectively. Because of some of the problems above, it is necessary to encourage the search for alternative drugs treatment of cancer. Voacanga foetida (Blume) Rolfe (Apocynaceae) is a species of plant from the genus Voacanga known as the tampa badak from West Sumatra. This plant is known to be source of indole alkaloids and also bis-indole alkaloids potential as cancer drugs. Therefore, in this study we are interested to explore the potency of this plant as natural product sources with potential cytotoxic activity. The study was started from the isolation process and continued by characterization of the isolated compounds and then testing their cytotoxic activity T47D breast cancer cell line. The isolation process of alkaloid compounds were performed by acid-base extraction, liquid-liquid fractionation, and followed by separation using column chromatography. Then,the potency of cytotoxic activity of the isolates were screened through Brine Shrimp Lethality Test (BSLT) method and evaluated by MTT assay. The structure of three isolated alkaloids (VFB-DB1.1; VFB-DB2.1; and VFB-DB2.2) were charachterized using spectroscopic analyses, including UV and FT-IR. One isolated compound (VFB-DB1.1) was also characterized using 1H NMR spectroscopy. Based on the similarity of 1H NMR spectra of isolated compound when compared with the literature, compound VFB-DB1.1 was identified as voacangine. Then, the BSLT and MTT assay result showed that VFB-DB1.1 exhibited LC50 value of 15.8 µg/mL againt Artemia salina L.and IC50 value of 8.9 µg/mL against T47D breast cancer cells, respectively.
Effect of Education on Knowledge and Attitude Level Related to Vitamin D in Pharmacy Students Amelia Lorensia; Rifaatul Laila Mahmudah; Matina Naim; Dian Natasya Raharjo
Journal of Tropical Pharmacy and Chemistry Vol. 7 No. 2 (2023): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v7i2.594

Abstract

Indonesia is a country located in the tropics with sun exposure throughout the season. Sun exposure is the best source of vitamin D and there have been no cases of vitamin D intoxication due to excessive sun exposure. Pharmacy students tend to lack knowledge of vitamin D. Changes in lifestyle and modernization lead to high use of sunscreens which can lead to a decrease in the synthesis of vitamin D in the skin. This research was conducted to determine the differences in knowledge and attitudes towards sun exposure using cross sectional method on 100 first semester pharmacy students and 100 final semester students. Test differences in aspects of knowledge and attitudes using odds ratios. The results of the knowledge aspect odds ratio test are 1,000 and the attitude aspect odds ratio test results were 0.583 so that it can be concluded that both knowledge and attitudes towards sun exposure have the same risk tendency for first semester and final semester pharmacy students.
Test of Antidiabetic Effect of Taro Leaf Extract (Colocasia esculenta L.) on Zebrafish (Danio rerio) Adelia Nurrochifah; Hendra Stevani; Ratnasari Dewi
Journal of Tropical Pharmacy and Chemistry Vol. 7 No. 2 (2023): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v7i2.605

Abstract

Diabetes mellitus (DM) is a common metabolic disorder defined as chronic hyperglycemia. In addition to the symptoms associated with hyperglycemia itself such as thirst, polyuria and weight loss, it can also cause acute hyperglycemia emergencies that are potentially life threatening. One of the traditional plants that has potential as an antidiabetic drug is the taro plant (Colocasia esculenta L) because it contains chemical compounds such as alkaloids, flavonoids, saponins, tannins and polyphenols which are known to have antidiabetic effects. This study aims to determine the effectiveness and what dose of Taro Leaf Extract gives the best effect of reducing blood glucose levels in zebrafish. This study used zebrafish (Danio rerio) induced with alloxan and glucose to raise blood glucose levels. The 20 test animals used were divided into 6 groups, namely group 1 without treatment (normal), group 2 control (-) alloxan induction 0.1% + glucose 1%, group 3 control (+) metformin, group 4 taro leaf extract 200 mg, group 5 taro leaf extract 300 mg, group 6 taro leaf extract 400 mg. Then glucose levels were measured using a glucometer. Data analysis was carried out statistical tests. The results showed that a dose of 400 mg/2L had the ability to reduce blood glucose levels that were not significantly different from normal zebrafish glucose levels.
Exploring the Relationship between PheSA Scores and Ligand Efficiency in the Discovery of Potent Antimalarials: A Computational Perspective Ayodele, Agede O.; Ayodele, Ogunmodede J.; Nasiru, Sanni; Musa, Wasagu I.; Sunday, Oyedepo Dapo; Stephen, Aiyedun Olawale; Olufunke, Falade C.
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 1 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i1.609

Abstract

Pharmacophore Enhanced Shape Alignment (PheSA) compares the similarities of compounds based on their pharmacophoric and geometrical  characteristics. Ligand efficiency is a notion used to maximize the potency and effectiveness of medication candidates by taking into account their molecular weight and binding affinity. This study mainly focused on Cycloguanil analogues to evaluate the association between PheSA scores and ligand efficiency in the identification of effective antimalarials. Information on 36 PfDHFR inhibitors, their structures and biological activity was retrieved from the ChEMBL database. Based on shape and pharmacophore similarity, the PheSA algorithm was used to compare the 3D structures of the inhibitors. Based on a de novo synthesis method, 257 new compounds with greater PheSA similarity scores that have a striking resemblance to cycloguanil were created. The PheSA score and ligand efficiency have a moderately positive link (correlation coefficient of 0.675) according to the analysis. However, the virtual screening of cycloguanil analogues based on PheSA similarity scores offers a useful initial evaluation of structural similarity, directing further experimental studies to find interesting substances for the creation of effective antimalarial drug.
Evaluation of Acute and Subacute Oral Toxicity of Erlangea tomentosa (Oliv. & Hiern) S. Moore (Asteraceae) Methanol Leaf Extract in Experimental Wistar Albino Rats Mboneye, Anselme; Onchweri, Albert Nyanchoka; Neeza, Timothy; Odoma, Saidi
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 1 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i1.610

Abstract

Erlangea tomentosa (Oliv. & Hiern) S. Moore's leaves, which are in the Asteraceae family, were tested for acute and subacute toxicity in experimental Wistar rats.  Lorke’s (bi-phasic) method was used to evaluate the acute toxicity profile of the plant extract. In phase 2, twelve rats of both sexes were administered a maximum dosage of 5000 mg/kg of extract. Observations of toxicity signs were made and recorded for 2 hours consecutively, for 24 hours intermittently, as well as for the next 14 days. For the subacute study, rats were orally administered water and plant extract daily for 28 days. Toxicological effects were recorded daily, and body weights were documented weekly. Hematological, biochemical, and histopathological tests as well as relative organ weights were evaluated at the conclusion of the study. In phase 2 of the acute toxicity study, it was found that the plant extract was toxic at doses of 1600, 3100, and 5000 mg/kg, with only one death at the highest dose. In the subacute toxicity study, animals that were administered 800 mg/kg of extract for 28 days showed symptoms of toxicity. The weight of the kidneys increased; urea and ALT levels increased; as well as total protein and albumin levels decreased compared to the control group. At the same dose, histopathology examination revealed alterations of the liver and kidneys, while hematopoietic cells were significantly disrupted compared to the control animals. Based on the findings, the methanol-extracted leaves of E. tomentosa showed a moderate level of acute toxicity. The administration of the extract at a dose of 400 mg/kg was safe, but 800 mg/kg was toxic. This caused damage to their livers and kidneys. This led to an increase in ALT and ALP, changes in blood parameters like Hb, RBC, and PLT, as well as the development of inflammatory cells.

Page 27 of 30 | Total Record : 298

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